Tag: 100-200

The author of 《Diacetyl as a “”traceless”” visible light photosensitizer in metal-free cross-dehydrogenative coupling reactions》 were Huang, Chia-Yu; Li, Jianbin; Liu, Wenbo; Li, Chao-Jun. And the article was published in Chemical Science in 2019. Reference of 4-Cyanopyridine The author mentioned the following in the article:

Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to sustainability and safety concerns. Herein a new strategy using diacetyl (2,3-butanedione) as an abundant, visible light-sensitive and “”traceless”” hydrogen atom abstractor to achieve metal-free cross-dehydrogenative Minisci alkylation under mild conditions is reported. Mechanistic studies supported hydrogen atom transfer (HAT) between an activated C(sp3)-H substrate and diacetyl. Moreover, with the assistance of di-tert-Bu peroxide (DTBP), the scope of the reaction could be extended to strong aliphatic C-H bonds via diacetyl-mediated energy transfer. The robustness of this strategy was demonstrated by functionalizing complex mols. such as quinine, fasudil, nicotine, menthol and alanine derivatives In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Palladium-Catalyzed Electrochemical C-H Alkylation of Arenes》 were Yang, Qi-Liang; Li, Chuan-Zeng; Zhang, Liang-Wei; Li, Yu-Yan; Tong, Xiaofeng; Wu, Xin-Yan; Mei, Tian-Sheng. And the article was published in Organometallics in 2019. Related Products of 3510-66-5 The author mentioned the following in the article:

2-Arylpyridines were electrochem. ortho-alkylated by RBF3K, the reaction being performed in undivided cell in aqueous solutions catalyzed by Pd(OAc)2. Palladium-catalyzed electrochem. C-H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chem. oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction Herein, we report the first example of palladium-catalyzed electrochem. C-H alkylation of arenes using undivided electrochem. cells in water, thereby providing a practical solution for the introduction of alkyl group into arenes. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Song, Dan; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 197958-29-5. The article was titled 《Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximes》. The information in the text is summarized as follows:

In the presence of the iridium photocatalyst [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, four-membered cyclic ketoximes such as cyclobutanone oxime underwent ring opening and addition reactions with aryl alkenes such as 1,1-diphenylethylene or with α-trifluoromethylstyrenes such as PhC(CF3):CH2 mediated by Ph3P (via its photogenerated phosphoranyl radical cation) under blue LED light to yield 6-arylhexanenitriles such as Ph2CH(CH2)4CN or (aryl)(difluoromethylene)hexanenitriles such as F2C:CPh(CH2)4CN. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mohammad, Akbar; Ansari, Shagufi Naz; Chaudhary, Archana; Ahmad, Khursheed; Rajak, Richa; Tauqeer, Mohd.; Mobin, Shaikh M. published 《Enthralling Adsorption of Different Dye and Metal Contaminants from Aqueous Systems by Cobalt/Cobalt Oxide Nanocomposites Derived from Single-Source Molecular Precursors》.ChemistrySelect published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The cobalt/cobalt oxide nanocomposites (Co/CoO NCs), NC-1 and NC-2 were synthesized from our recently reported single-source mol. precursors (SSMPs) [Co(hep-H)(H2O)4]SO4, (1) and [Co(hep-H)2(H2O)2](NO3)2, (2), [hep-H= 2-(2-hydroxylethyl) pyridine], resp., via wet-chem. reduction method. Our purpose was to study the effect of different counter anions (i. e. SO42- and NO3-) of precursors on the surface properties of synthesized materials. Both the nanocomposites were characterized by Powder X-ray diffraction (PXRD), SEM (SEM), energy-dispersive X-ray anal. (EDAX), transmission electron microscopy (TEM), Fourier transform IR (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) anal. Two distinct morphol. as well as surface features have been obtained using 1 and 2 viz. variable spheres (NC-1) with low surface area and flakes (NC-2) with high surface area. The adsorption behavior of these nanocomposites on industrial dyes and heavy metals showed excellent dye adsorption (99.6% to 97.2%) and good to moderate metal adsorption efficiency of NC-1. The NC-1 could be recycled up to five times for dyes and three times for metals, advocating its practical applications in industry. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chotsaeng, Nawasit; Laosinwattana, Chamroon; Charoenying, Patchanee published 《Inhibitory effects of a variety of aldehydes on Amaranthus tricolor L. and Echinochloa crus-galli (L.) Beauv.》.Molecules published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

Thirty-seven com. aldehydes containing aliphatic chains and aromatic rings as well as heteroaromatic rings were evaluated for their inhibitory activities against Chinese amaranth (Amaranthus tricolor L.) and barnyardgrass (Echinochloa crus-galli (L.) Beauv). Polysorbate 80 (Tween@ 80) was used as a surfactant and the research was preliminarily conducted at 400 μM of all aldehydes. Among these aldehydes, (E)-cinnamaldehyde (7) showed the greatest inhibitory effect on seed germination, shoot and root growth of Chinese amaranth by 54.55%, 75.53%, and 85.13% resp. Similarly, (E)-crotonaldehyde (5), a related α,β-unsaturated aldehyde, inhibited the germination and seedling growth of the tested species at a high percentage. Apart from these two unsaturated aldehydes, no other aliphatic aldehydes had a harmful effect on Chinese amaranth. In terms of benzaldehyde (6), it had no effect on the tested plant; however, many of its derivatives displayed some inhibitory activity. Furthermore, for the ten common heteroaromatic aldehydes, picolinaldehyde (32) had a high inhibitory effect on Chinese amaranth which closely related to the effect of (E)-crotonaldehyde (5) and (E)-cinnamaldehyde (7), whereas, other heteroaromatic aldehydes showed lower effects. In the case of a monocot plant, barnyardgrass, no tested aldehydes reduced seed germination, however, (E)-cinnamaldehyde (7), 2,4,6-trimethoxybenzaldehyde (16) and 4-(dimethylamino)benzaldehyde (24) could inhibit the seedling growth of the plant with low to moderate levels. The herbicidal effects of the most active aldehydes were then further investigated in order to find the min. concentration of these aldehydes suppressing the germination and growth of the tested plants. At concentrations as low as 50-100 μM some aldehydes could inhibit the seedling growth of the tested species. The structure-activity relationship (SAR) study reported here demonstrates the chem. clues governing the inhibitory activity of aldehydes which could be utilized in the development of highly effective herbicides in the near future. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Biallas, Phillip; Yamazaki, Ken; Dixon, Darren J. published an article in Organic Letters. The title of the article was 《Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction》.Recommanded Product: 3510-66-5 The author mentioned the following in the article:

An iridium catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1-2 mol % of Vaska’s complex (IrCl(CO)(PPh3)2), tetramethyldisiloxane (TMDS) and difluoro-Reformatsky reagents (BrZnCF2R) for the general synthesis of medicinally relevant α-difluoroalkylated tertiary amines, is described. A broad scope (42 examples), including N-aryl and N-heteroaryl substituted lactams, demonstrated an excellent functional group tolerance. Furthermore, late-stage drug functionalizations, a gram scale synthesis and common downstream transformations proved the potential synthetic relevance of this new methodol. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Itagaki, Ren; Takizawa, Shin-ya; Chang, Ho-Chol; Nakada, Akinobu published an article in Dalton Transactions. The title of the article was 《Light-induced electron transfer/phase migration of a redox mediator for photocatalytic C-C coupling in a biphasic solution》.Synthetic Route of C12H12N2 The author mentioned the following in the article:

Photocatalytic mol. conversions that lead to value-added chems. are of considerable interest. To achieve highly efficient photocatalytic reactions, it is equally important as it is challenging to construct systems that enable effective charge separation Here, we demonstrate that the rational construction of a biphasic solution system with a ferrocenium/ferrocene (Fc+/Fc) redox couple enables efficient photocatalysis by spatial charge separation using the liquid-liquid interface. In a single-phase system, exposure of a 1,2-dichloroethane (DCE) solution containing a Ru(II)- or Ir(III)-based photosensitizer, Fc, and benzyl bromide (Bn-Br) to visible-light irradiation failed to generate any product. However, the photolysis in a H2O/DCE biphasic solution, where the compounds are initially distributed in the DCE phase, facilitated the reductive coupling of Bn-Br to dibenzyl (Bn2) using Fc as an electron donor. The key result of this study is that Fc+, generated by photooxidation of Fc in the DCE phase, migrates to the aqueous phase due to the drastic change in its partition coefficient compared to that of Fc. This liquid-liquid phase migration of the mediator is essential for facilitating the reduction of Bn-Br in the DCE phase as it suppresses backward charge recombination. The co-existence of anions can further modify the driving force of phase migration of Fc+ depending on their hydrophilicity; the best photocatalytic activity was obtained with a turnover frequency of 79.5 h-1 and a quantum efficiency of 0.2% for the formation of Bn2 by adding NBu4+Br- to the biphasic solution This study showcases a potential approach for rectifying electron transfer with suppressed charge recombination to achieve efficient photocatalysis. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cao, Liang; Zhao, He; Guan, Rongqing; Jiang, Huanfeng; Dixneuf, Pierre. H.; Zhang, Min published an article in 2021. The article was titled 《Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution》, and you may find the article in Nature Communications.SDS of cas: 1692-25-7 The information in the text is summarized as follows:

Despite the widespread applications of 2-(hetero)aryl N-heteroarenes in numerous fields of science and technol., universal access to such compounds is hampered due to the lack of a general method for their synthesis. Herein, by a H2O-mediated H2-evolution cross-coupling strategy, an iridium(III)-catalyzed facile method to direct α-arylation of N-heteroarenes with both aryl and heteroaryl boronic acids, proceeding with broad substrate scope and excellent functional compatibility, oxidant and reductant-free conditions, operational simplicity, easy scalability, and no need for prefunctionalization of N-heteroarenes is reported. This method is applicable for structural modification of biomedical mols., and offers a practical route for direct access to 2-(hetero)aryl N-heteroarenes, a class of potential cyclometalated CN̂ ligands and NN̂ bidentate ligands that are difficult to prepare with the existing α-C-H arylation methods, thus filling an important gap in the capabilities of synthetic organic chem. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7SDS of cas: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Griffin, Jeremy D.; Vogt, David B.; Du Bois, J.; Sigman, Matthew S. published an article in 2021. The article was titled 《Mechanistic Guidance Leads to Enhanced Site-Selectivity in C-H Oxidation Reactions Catalyzed by Ruthenium bis(Bipyridine) Complexes》, and you may find the article in ACS Catalysis.Product Details of 3510-66-5 The information in the text is summarized as follows:

The development of an operationally simple C-H oxidation protocol using an acid-stable, bis(bipyridine)Ru catalyst is described. Electronic differences remote to the site of C-H functionalization are found to affect product selectivity. Site-selectivity is further influenced by the choice of reaction solvent, with highest levels of 2° methylene oxidation favored in aqueous dichloroacetic acid. A statistical model is detailed that correlates product selectivity outcomes with computational parameters describing the relative “”electron-richness”” of C-H bonds. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Product Details of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Anshu; Maji, Ankur; Joshi, Mayank; Choudhury, Angshuman R.; Ghosh, Kaushik published their research in Dalton Transactions in 2021. The article was titled 《Designed pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines》.Related Products of 1122-54-9 The article contains the following contents:

Base-metal catalysts Co1, Co2 and Co3 were synthesized from designed pincer ligands L1, L2 and L3 having NNN donor atoms, resp. Co1, Co2 and Co3 were characterized by IR, UV-visible and ESI-MS spectroscopic studies. Single crystal x-ray diffraction studies were studied to authenticate the mol. structures of Co1 and Co3. Catalysts Co1, Co2 and Co3 were used to study the dehydrogenative activation of alcs. for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines. Under optimized reaction conditions, a broad range of substrates including alcs., anilines and ketones were exploited. Control experiments for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines were examined to understand the reaction pathway. ESI-MS spectral studies were studied to characterize Co-alkoxide and Co-hydride intermediates. Reduction of styrene by evolved H gas during the reaction was studied to authenticate the dehydrogenative nature of the catalysts. Probable reaction pathways are proposed for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines from control experiments and detection of reaction intermediates. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem