Tag: 100-200

《Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination》 was written by Liang, Yumeng; Zhao, Zhengyu; Taya, Akihito; Shibata, Norio. HPLC of Formula: 128071-75-0 And the article was included in Organic Letters in 2021. The article conveys some information:

A novel reagent system to obtain acyl fluorides such as benzoyl fluoride, 4-cyclohexylbenzoyl fluoride, dodecanoyl fluoride, etc. directly from three different functional group precursors: carboxylic acids such as benzoic acid, thiophene-2-carboxylic acid, dodecanoic acid, etc. aldehydes such as benzaldehyde, picolinaldehyde, cyclopropanecarboxaldehyde, etc. or alcs. such as benzyl alc., 2-bromonicotinyl alc., 4-bromobenzyl alc., etc. was described. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug mols. that contain a carboxylic acid, an aldehyde, or an alc. group. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Access to 2-Alkyl/Aryl-4-(1H)-Quinolones via Orthogonal “”NH3″” Insertion into o-Haloaryl Ynones: Total Synthesis of Bioactive Pseudanes, Graveoline, Graveolinine, and Waltherione F》 was written by Singh, Shweta; Nerella, Sharanya; Pabbaraja, Srihari; Mehta, Goverdhan. Category: pyridine-derivatives And the article was included in Organic Letters in 2020. The article conveys some information:

An efficient one-pot synthesis of 4-(1H)-quinolones through an orthogonal engagement of diverse o-haloaryl ynones with ammonia in the presence of Cu(I), involving tandem Michael addition and ArCsp2-N coupling, is presented. The substrate scope of this convenient protocol, wherein ammonium carbonate acts as both an in situ ammonia source and a base toward diverse 2-substituted 4-(1H)-quinolones, has been mapped and its efficacy validated through concise total synthesis of bioactive natural products pseudanes (IV, VII, VIII, and XII), graveoline, graveolinine, and waltherione F. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Regiodirected Annulations for the Rapid Synthesis of π-Extended Oligomers》 was written by Nitti, Andrea; Osw, Peshawa; Calcagno, Giuseppe; Botta, Chiara; Etkind, Samuel I.; Bianchi, Gabriele; Po, Riccardo; Swager, Timothy M.; Pasini, Dario. Recommanded Product: 128071-75-0 And the article was included in Organic Letters in 2020. The article conveys some information:

Synthesis of fused benzoheterocycles e.g. I [R = H, Me] and II [X = S, O, N-Me; R1 = H, CO2Me] via one-pot regiospecific palladium catalyzed direct arylation (DHA) and cross aldol condensation of ortho-bromoaldehydes and 3-thiopheneacetic acid was reported. Direct arylation of 2-octyldodecyl benzo[b]thienobenzothiophene-4-carboxylates with 4,7-dibromobenzo[c][1,2,5]thiadiazole using palladium catalyst afforded benzodithiophene-containing oligomers III [R2 = R3 = H, R4 = 2-octyldecyl] and IV [R5 = R5 = H, R7 = 2-octyldecyl]. Preparation of benzodithiophene-containing oligomers III [R2 = R3 = F, R4 = 2-octyldecyl ] and IV [R5 = R6 = F, R7 = 2-octyldecyl] was developed via palladium catalyzed Stille reaction of 2-octyldodecyl 2-(tributylstannyl)benzo[b]thienobenzothiophene-4-carboxylates with 4,7-dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst》 was published in ChemSusChem in 2020. These research results belong to Baeumler, Christoph; Bauer, Christof; Kempe, Rhett. Related Products of 1122-54-9 The article mentions the following:

Iron-catalyzed synthesis of primary amines through reductive amination was realized. A broad scope and a very good tolerance of functional groups were observed Ketones, including purely aliphatic ones, aryl-alkyl, dialkyl, and heterocyclic, as well as aldehydes were converted smoothly into their corresponding primary amines. In addition, the amination of pharmaceuticals, bioactive compounds, and natural products was demonstrated. Many functional groups, such as hydroxy, methoxy, dioxol, sulfonyl, and boronate ester substituents, were tolerated. The catalyst is easy to handle, selective, and reusable and ammonia dissolved in water could be employed as the nitrogen source. The key feature of this method includes the use of a specific Fe complex for the catalyst synthesis and an N-doped SiC material as catalyst support. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones》 was published in Organic Letters in 2020. These research results belong to Guo, Yuan-Qiang; Wang, Ruiguo; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. Electric Literature of C5H6BNO2 The article mentions the following:

Herein, we describe an efficient, practical photocatalytic deoxygenation/defluorination protocol for the synthesis of γ,γ-difluoroallylic ketones from com. available aromatic carboxylic acids, triphenylphosphine, and α-trifluoromethyl alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this method, we accomplished the late-stage functionalization of several bioactive mols. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Arabidopsis PIC30 encodes a major facilitator superfamily transporter responsible for the uptake of picolinate herbicides》 was published in Plant Journal in 2020. These research results belong to Kathare, Praveen K.; Dharmasiri, Sunethra; Vincill, Eric D.; Routray, Pratyush; Ahmad, Idrees; Roberts, Daniel M.; Dharmasiri, Nihal. COA of Formula: C6H5NO2 The article mentions the following:

However, its mechanism of transport into plants is poorly understood. In a genetic screen for picloram resistance, we identified three Arabidopsis mutant alleles of PIC30 (PICLORAM RESISTANT30) that are specifically resistant to picolinates, but not to other auxins. PIC30 is a previously uncharacterized gene that encodes a major facilitator superfamily (MFS) transporter. Similar to most members of MFS, PIC30 contains 12 putative transmembrane domains, and PIC30-GFP fusion protein selectively localizes to the plasma membrane. In planta transport assays demonstrate that PIC30 specifically transports picloram, but not indole-3-acetic acid (IAA). Functional anal. of Xenopus laevis oocytes injected with PIC30 cRNA demonstrated PIC30 mediated transport of picloram and several anions, including nitrate and chloride. Consistent with these roles of PIC30, three allelic pic30 mutants are selectively insensitive to picolinate herbicides, while pic30-3 is also defective in chlorate (analog of nitrate) transport and also shows reduced uptake of 15NO3-. Overexpression of PIC30 fully complements both picloram and chlorate insensitive phenotypes of pic30-3. Despite the continued use of picloram as an herbicide, a transporter for picloram was not known until now. This work provides insight into the mechanisms of plant resistance to picolinate herbicides and also shed light on the possible endogenous function of PIC30 protein. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6COA of Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.COA of Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Modulating the blue shift of phosphorescence with fluorine-free group in iridium (III) complexes》 were Gao, Ying; Ding, Shuang; Su, Zhong-Min; Geng, Yun. And the article was published in Journal of Luminescence in 2019. Recommanded Product: 98-98-6 The author mentioned the following in the article:

In this work, iridium complexes 1-8 bearing bipyridine or pyridine-pyrimidine main ligand and picolinate ancillary ligand have been designed by varying the position of -OCH3 and Ph groups at the ligands aiming at finding a better choice to design blue phosphors. The results indicate that an appropriate combination of -OCH3 and pyridine-pyrimidine ligand makes the emission wavelength a noticeable blue-shift. Moreover, the further introduction of Ph group shifts the emission wavelength to a shorter region. In terms of the radiative decay rate constant (kr), the position of -OCH3 has a slight influence on it, but the introduction of Ph group is conductive to enhancing this value. In particular, the 7 has the largest kr among the designed complexes up to 7.68 × 105 s-1. As for the non-radiative process, 1-6 have high barriers between 3MLCT and 3MC, indicating the difficulty of electron relaxation to the non-emissive 3MC structure. There is no transition state of 3MLCT↔3MC is found for 7 and 8 bearing pyridine-pyrimidine ligand. However, the barriers of all complexes for the S0/3MC min. energy crossing point reaction are high, which is in favor of avoiding the system relaxes to the S0 geometry by non-radiative path. In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Dalton Transactions included an article by Wang, Yaqin; Xu, Xinxin; Liu, Luyao; Chen, Jin; Shi, Guimei. Related Products of 1134-35-6. The article was titled 《A coordination polymer-derived Co3O4/Co-N@NMC composite material as a Zn-air battery cathode electrocatalyst and microwave absorber》. The information in the text is summarized as follows:

Zn-air batteries, promising energy storage equipment with high energy d., light weight and a compact structure, are a perfect power source for elec. vehicles. For a Zn-air battery, the activity of the air cathode electrocatalyst plays an important role in its performance. Here, employing a coordination polymer as a precursor, a composite material built from Co3O4 and Co-N active centers with nitrogen-doped mesoporous carbon as a matrix has been synthesized successfully. This composite material possesses outstanding activity and stability in the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) processes. It possesses a small half-wave potential (ORR1/2 = 0.786 V) and low overpotential (OER10 = 1.575 V) for the ORR and OER, resp. With this composite material as an air cathode electrocatalyst, a rechargeable Zn-air battery was assembled successfully. During the discharge process, the maximum power d. of this Zn-air battery is 122 mW cm-2 at 0.76 V. The specific capacity of this battery is 505 mA h g-1 at 25 mA cm-2. The voltage gap between the charge and discharge processes is only 0.744 V at 10 mA cm-2 and 1.308 V at 100 mA cm-2. This rechargeable battery also shows promising stability after long-term charge-discharge experiments Furthermore, the composite material also exhibits outstanding microwave adsorption properties. Its maximum reflection loss (RL) arrives at -13.9 dB with a thickness of only 1.0 mm. Thus, we find that coordination polymers are an ideal precursor for Zn-air battery cathode electrocatalysts and microwave absorbers. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Related Products of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Related Products of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages》 were Lucy, Daniel; Purvis, Gareth S. D.; Zeboudj, Lynda; Chatzopoulou, Maria; Recio, Carlota; Bataille, Carole J. R.; Wynne, Graham M.; Greaves, David R.; Russell, Angela J.. And the article was published in ACS Chemical Biology in 2019. Related Products of 103-74-2 The author mentioned the following in the article:

GPR84 is an orphan G-protein-coupled receptor that is expressed on immune cells and implicated in several inflammatory diseases. The validation of GPR84 as a therapeutic target is hindered by the narrow range of available chem. tools and consequent poor understanding of GPR84 pathophysiol. Here we describe the discovery and characterization of DL-175, a potent, selective, and structurally novel GPR84 agonist and the first to display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells. By comparing DL-175 with reported GPR84 ligands, we show for the first time that biased GPR84 agonists have markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement. This work demonstrates that biased agonism at GPR84 enables the selective activation of functional responses in immune cells and delivers a high-quality chem. probe for further investigation. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Molecular design and structural pecularities of the 3- and 4-pyridylboron-capped tris-glyoximate and tris-dichloroglyoximate iron(II) clathrochelates with apical donor groups》 were Zelinskii, Genrikh E.; Belov, Alexander S.; Vologzhanina, Anna V.; Limarev, Ilya P.; Dorovatovskii, Pavel V.; Zubavichus, Yan V.; Lebed, Ekaterina G.; Voloshin, Yan Z.; Dedov, Alexey G.. And the article was published in Polyhedron in 2019. Reference of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Tris-glyoximate and tris-dichloroglyoximate iron(II) clathrochelates with apical pyridyl groups were obtained through one-pot template condensation of the corresponding α-dioxime with 3- or 4-pyridylboronic acids on the iron(II) ion as a matrix under vigorous reaction conditions using the boiling CF3COOH as a solvent. The initially formed mixtures of mono- and diprotonated clathrochelate species were converted into the target macrobicyclic intracomplexes under basic conditions. These complexes were characterized using elemental anal., MALDI-TOF mass spectrometry, IR, UV-visible, 1H and 13C NMR spectroscopies, and by single crystal x-ray diffraction as well. In their mols., the encapsulated iron(II) ion is situated in the center of its FeN6-coordination polyhedron. The geometry of all the FeN6-coordination polyhedra is intermediate between a trigonal prism and a trigonal antiprism with the average distortion angles φ from 16.7 to 17.7°. Their heights h fall from 2.36 to 2.38 Å and the averaged bite angles α vary in a narrow range 78.2-78.4°. Characteristic feature of the 3- and 4-pyridylboron-capped glyoximate clathrochelate mols., as compared with their aliphatic and aromatic analogs, is shortening of the chelate C-C bonds from 1.45 to 1.42 Å. Comparison of the values of a ligand aspect ratio for the obtained new pyridyl-terminated iron(II) clathrochelates with those for their known aliphatic tris-dioximate analogs was performed. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem