Tag: 100-200

On January 29, 2014, Wang, Yansong; Hausch, Felix published a patent.Electric Literature of 97483-79-9 The title of the patent was Preparation of bicyclic aza-amides for treatment of psychiatric disorders. And the patent contained the following:

The invention relates to bicyclic aza-amides of formula I as inhibitors of FK506 binding proteins (FKBP) useful in the prophylaxis and/or treatment of psychiatric, neurodegenerative diseases. Compounds of formula I wherein X is CH2, CH2CH2, CH(CH=CH2), etc.; R1 is H, Me, Et, etc.; R2 is substituted Ph, substituted cyclohexyl, substituted pyridyl, etc. and enantiomers, stereoisomeric forms, mixtures of enantiomers, anomers, deoxyforms, diastereomers, mixtures of diastereomers, prodrugs, tautomers, hydrates, solvates and racemates of the above mentioned compounds, are claimed. Example compound II was prepared by alkylation of benzyl 2-oxo-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate with 4-(2-bromoethoxy)-1,2-dimethoxybenzene; the resulting benzyl 3-(2-(3,4-dimethoxyphenoxy)ethyl)-2-oxo-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate underwent Cbz-deprotection followed by sulfonylation with 3,5-dichlorobenzene sulfonyl chloride. From the assay, it was determined that example II exhibited IC50 value of 12.2±3.7 μM, 8.8±1.1 μM and 0.14±0.01 μM towards FKBP52, FKBP51 and FKBP12, resp. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Electric Literature of 97483-79-9

The Article related to bicyclic aza amide preparation fkbp inhibitor psychiatric neurol disease, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 97483-79-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 30, 2014, Wang, Yansong; Hausch, Felix published a patent.Reference of Ethyl 6-cyanopicolinate The title of the patent was Preparation of bicyclic aza-amides for treatment of psychiatric disorders. And the patent contained the following:

The invention relates to bicyclic aza-amides of formula I as inhibitors of FK506 binding proteins (FKBP) useful in the prophylaxis and/or treatment of psychiatric, neurodegenerative diseases. Compounds of formula I wherein X is CH2, CH2CH2, CH(CH=CH2), etc.; R1 is H, Me, Et, etc.; R2 is substituted Ph, substituted cyclohexyl, substituted pyridyl, etc. and enantiomers, stereoisomeric forms, mixtures of enantiomers, anomers, deoxyforms, diastereomers, mixtures of diastereomers, prodrugs, tautomers, hydrates, solvates and racemates of the above mentioned compounds, are claimed. Example compound II was prepared by alkylation of benzyl 2-oxo-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate with 4-(2-bromoethoxy)-1,2-dimethoxybenzene; the resulting benzyl 3-(2-(3,4-dimethoxyphenoxy)ethyl)-2-oxo-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate underwent Cbz-deprotection followed by sulfonylation with 3,5-dichlorobenzene sulfonyl chloride. The invention compounds were evaluated for their FKBP binding affinity in which II inhibited FKBP51 and FKBP52 with an IC50 of 1.3±0.13 μM and 2.5±0.38 μM, resp. From the assay, it was determined that example II exhibited IC50 value of 12.2±3.7 μM, 8.8±1.1 μM and 0.14±0.01 μM towards FKBP52, FKBP51 and FKBP12, resp. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Reference of Ethyl 6-cyanopicolinate

The Article related to bicyclic aza amide preparation fkbp inhibitor psychiatric neurol disease, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of Ethyl 6-cyanopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 21, 2022, Fasching, Bernhard; Ryckmans, Thomas; Flohr, Alexander; Ritzen, Andreas; Harvey, Freya; McAllister, Laura published a patent.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of isoindolinone compounds as modulators of cereblon. And the patent contained the following:

This invention relates to the title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with the N atom of the carbamate forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, (un)substituted cycloalkyl, aryl, etc.; L1 = a covalent bond, alkyl; L2 = a covalent bond, alkyl; L3 = a covalent bond, alkyl, O, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, useful as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially humans. E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 23, 1974, Bowden, Roy D.; Seaton, Thomas published a patent.Safety of 4-Chloro-2,6-difluoropyridine The title of the patent was Chlorofluoropyridines. And the patent contained the following:

Chlorofluoropyridines were prepared by vaporization of CCl4, CCl3F, or F2ClCCFCl2 solutions of fluoropyridines at 290-350° with solvent and reactant feed rates 0.18-0.6 and 0.025-0.125 mole/hr, resp., and contacting the vapor with Cl feed rate 0.5-1.10 mole/hr at 335-695° for 9.0-25.0 sec. Thus, CCl4 solution of 2-fluoropyridine, feed rates 0.3 and 0.025 mole/hr, resp., was vaporized at 290° and the vapor contacted with Cl feed rate 0.52 mole/hr at 375° for 23.5 sec to give 70% 6-chloro-2-fluoropyridine and traces of 5,6-, 4,6-, and 3,6-dichloro-2-fluoropyridines. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Safety of 4-Chloro-2,6-difluoropyridine

The Article related to chlorofluoropyridine, pyridine chlorofluoro, chlorination fluoropyridine, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of 4-Chloro-2,6-difluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 29, 2008, Costero, Ana M.; Gil, Salvador; Parra, Margarita; Huguet, Nuria; Allouni, Zouhir; Lakmiri, Rajae; Atlamsani, Ahmed published an article.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the article was 3,3′-Disubstituted 2,2′-bipyridines as carboxylate receptors: conformational regulation of the bipyridine moiety. And the article contained the following:

Two bipyridine derivates were synthesized and characterized and their ability to act as sensors for carboxylates was evaluated by UV/Vis and fluorescence studies. The influence of the substituents of the thiourea groups on the stoichiometry of the resulting dicarboxylate complexes was established. Conformational changes in the bipyridine moiety under different conditions were evaluated. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to bipyridinedithiourea preparation complexation nickel dicarboxylate, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Weglinski, Zbigniew; Talik, Tadeusz published an article in 1982, the title of the article was Synthesis of some derivatives of nicotinic acid.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate And the article contains the following content:

Hydroxynicotinic acids I (R = 4-Me, 5-Me; R1 = HO) and II (R = 5-Me, 6-Me; R1 = HO) were esterified in EtOH containing H2SO4 to give I and II (R1 = EtO) which were autoclaved with (NH4)2CO3 at 373°K to give I and II (R1 = H2N). Treatment of the Et esters with N2H4 in EtOH gave I and II (R1 = NHNH2). The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

The Article related to nicotinate methylhydroxy amidation, nicotinamide methylhydroxy, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 30, 2007, Rao, Chepuri R. K.; Trivedi, D. C. published an article.Synthetic Route of 636-73-7 The title of the article was Tailoring the gold-polypyrrole nanostructures at water-toluene interphase. And the article contained the following:

A method is described to obtain gold-polypyrrole nanostructures by reacting gold chloride with pyrrole at toluene-water interphase. By adjusting the concentration of the stabilizer, namely, pyridine-3-sulfonate, the shape of the nanostructures formed at the interphase can be tailored. This novel method facilitates the fabrication of Au-Ppy composite material that gives wider scope for biosensing applications. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Synthetic Route of 636-73-7

The Article related to gold polypyrrole nanocomposite biosensor, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Synthetic Route of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1985, Tsiropoulos, G. J. published an article.Computed Properties of 636-73-7 The title of the article was Dietary administration of antivitamins affected the survival and reproduction of Dacus oleae. And the article contained the following:

Fifteen antivitamins were tested, at various concentrations, on the adult olive fruit fly, D. oleae. Fly survival was affected by the following antivitamins, indicating in parenthesis the antagonized vitamin: benzimidazole  [51-17-2] (B-12), α-picolinic acid  [98-98-6] (nicotinic acid), deoxypyridoxine  [61-67-6] (pyridoxine), neopyrithiamine  [534-64-5] (thiamin), and α-tocopherol quinone  [7559-04-8] (vitamin E). Egg production was significantly reduced by the same antivitamins, plus, dl-desthiobiotin  [636-20-4] (biotin), aminopterin  [54-62-6] (folic acid), isonicotinic acid  [55-22-1], nicotinic acid diethylamide  [59-26-7] (nicotinic acid), and dehydroascorbic acid  [490-83-5] (vitamin C). Fertility was significantly affected by: benzimidazole (B-12), dl-desthiobiotin (biotin), aminopterin (folic acid), isonicotinic acid (nicotinic acid), deoxypyridoxine (pyridoxine), neopyrithiamine (thiamin), tocopherol quinone (vitamin E), and dehydroascorbic acid (vitamin C). The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to dacus feed antivitamin reproduction, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 6, 1996, Suzuki, Masashi published a patent.Formula: C7H10N2 The title of the patent was Preparation of methylaminopyridine derivatives in high-yield. And the patent contained the following:

The title compounds (I; R = C1-4 alkyl, n = 1-2, X = NHMe) can be efficiently and economically produced by reaction of I (X = NH2, R, n = same as above) with a mixture of (HCO)2O and (AcO)2O or with HCO2H in the presence of (AcO)2O, followed by reduction of formyl group. I are useful intermediates in the production of drugs and pesticides. Thus, I (Rn = 4-Me and 6-Me, X = NH2) was reacted with HCO2H in the presence of (AcO)2O to give 85% I (Rn = 4-Me and 6-Me, X = NHCHO), which was reduced by LiAlH4 to give 97% I (Rn = 4-Me and 6-Me, X = NHMe). The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Formula: C7H10N2

The Article related to methylaminopyridine preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, T. D.; Phillips, D. C.; Smith, J. D. B. published an article in 1977, the title of the article was Organoparticulate analysis of amine arenesulfonates.Formula: C5H5NO3S And the article contains the following content:

Thermal decompn of PhSO3H, p-MeC2H4SO3H, 3-pyridinesulfonic acid, and 1-naphthalenesulfonic acid and of 17 amine salt derivatives were studied by the title method. Vapor phase association of the end product was observed The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to organoparticulate analysis decomposition arenesulfonate, sulfonate amine decomposition, Physical Organic Chemistry: Degradation Reactions and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem