Tag: 100-200

On December 20, 2018, Fahrni, Christoph J.; McCallum, Adam M.; Morgan, Michael Thomas published a patent.Quality Control of Ethyl 6-cyanopicolinate The title of the patent was Preparation of substituted phenylthiazole compounds as zinc-selective fluorescent probes for emission-ratiometric imaging. And the patent contained the following:

The title compounds I [Z = II; X1-X4 = (independently) N and CH; Y1 = NR4, S, and O; Y2 = NR5, S, and O; R = Ar, OR4, N((CH2)qAr)2; R1-R4 = (independently) H, halo, alkyl, etc.; R5 = Cn-alkyl optionally substituted with OR4 or Ar; Ar = (independently) aryl and heteroaryl; n = 1-3; q = 1-3; and wherein any one of the aforementioned can be substituted or unsubstituted], useful for detecting zinc in a biol. sample (two-photo excitation microscopy (TPEM) or conventional fluorescence microscopy), were prepared E.g., a multi-step synthesis of III, starting from Et 6-bromopicolinate, was described. The latter was tested for Zn(II)-binding affinity and its analyte selectivity (data given). To evaluate the Zn(II)-dependent ratiometric response of III within the chem. complexity of a live cell, the authors performed a perfusion experiment with NIH 3T3 mouse fibroblasts as model system (data given). The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Quality Control of Ethyl 6-cyanopicolinate

The Article related to phenylthiazole preparation zinc selective fluorescent probe emission ratiometric imaging, two photo excitation microscopy tpem phenylthiazole preparation zinc probe, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Ethyl 6-cyanopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2021, Oh, In-Chan; Kim, Ho-Young; Hyun, Soong-Keun; Byoun, Young-Min published an article.Quality Control of Pyridine-3-sulfonic acid The title of the article was Characterization of palladium electrodeposition in ammonia-free electrolyte with additives. And the article contained the following:

Electrodeposition of Pd provides excellent chem. and low-contact resistance with good elec. properties, such as different types of elec. contacts in the electronics industry. The conventional Pd plating process utilizes ammonia-based electrolytes. Ammonia was added continuously to maintain the optimum pH range in Pd electrolyte. In addition, the harmful and strong odor of the evaporating ammonia necessitates the use of a ventilator. A further disadvantage is that the brass substrate is corroded by ammonia vapor, and the corrosion products can contaminate the electrolytes, thereby changing the technol. properties of the deposited plating for the worse. Ethylenediamine has been proposed as an alternative to ammonia; however, Pd electrodeposition occurs as microcracks via hydrogen evolution. In this study, the effects of Pd electrolyte on ethylenediamine as a complexing agent and the properties of various additives are investigated to improve c.d. and internal stress in Pd electrodeposition that occurs on a brass substrate. Therefore, complexing agents such as 3-pyridine sulfonic acid, sodium nicotinate, butyne 1-4 diol, and sodium allylsulfonate are selected as additives, to serve as an alternative to ammonia in Pd electrolyte. In this study, the properties of electrodeposited Pd with various additives were examined The effect of additives on Pd electrolytes can be classified as dense surfaces without defects such as microcracks and pinholes, which improved surface roughness and corrosion resistance. Particularly, Pd electrolyte using sodium nicotinate has relatively improved surface roughness and properties. Pd electrolyte was optimized under ammonia-free conditions by the addition of sodium nicotinate. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Quality Control of Pyridine-3-sulfonic acid

The Article related to palladium electrodeposition ethylenediamine electrolyte additive surface roughness elec property, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Quality Control of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 20, 2017, Zhu, Yinggui; Zhao, Min; Hu, Xiaojuan; Wang, Xiaofang; Wang, Ling published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Electrogenerated chemiluminescence behavior of Tb complex and its application in sensitive sensing Cd2+. And the article contained the following:

The authors report a novel rare earth metal complex with the weak ligand of aromatic sulfonic acid (pyridine-3-sulfonic acid, 3-pSO3H), and characterized by FTIR, UV-visible, energy-dispersive x-ray spectroscopy (EDX), electrochemiluminescence spectra, etc. Then an excellent electrochemiluminescence (ECL) signal was observed with K2S2O8 as the coreactant in NaAc-HAc buffer solution For another thing, the electrochem. properties of the compound were thoroughly studied in MeCN solution, the possible ECL reaction mechanism is proposed as well. Also, a simple and straightforward ECL platform is reported for sensitive and selective detection of Cd2+ due to the effective quenching after addition of Cd2+. Other heavy/transition metal ions do not interfere with the sensing. The limit of detection is determined as 0.13 nM, the results suggested that as-prepared complex could be a promising material for developing ECL sensors to detect the Cd2+ rapidly indwell in environmental and practical samples. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

The Article related to electrogenerated chemiluminescence terbium complex sensing cadmium, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 1, 2019, Steinlechner, Christoph; Roesel, Arend F.; Oberem, Elisabeth; Paepcke, Ayla; Rockstroh, Nils; Gloaguen, Frederic; Lochbrunner, Stefan; Ludwig, Ralf; Spannenberg, Anke; Junge, Henrik; Francke, Robert; Beller, Matthias published an article.Application of 109660-12-0 The title of the article was Selective Earth-Abundant System for CO2 Reduction: Comparing Photo- and Electrocatalytic Processes. And the article contained the following:

The valorization of CO2 via photo- or electrocatalytic reduction constitutes a promising approach toward the sustainable production of fuels or value-added chems. using intermittent renewable energy sources. For this purpose, mol. catalysts are generally studied independently with respect to the photo- or the electrochem. application, although a unifying approach would be much more effective with respect to the mechanistic understanding and the catalyst optimization. In this context, we present a combined photo- and electrocatalytic study of three Mn diimine catalysts, which demonstrates the synergistic interplay between the two methods. The photochem. part of our study involves the development of a catalytic system containing a heteroleptic Cu photosensitizer and the sacrificial BIH reagent. The system shows exclusive selectivity for CO generation and renders turnover numbers which are among the highest reported thus far within the group of fully earth-abundant photocatalytic systems. The electrochem. part of our investigations complements the mechanistic understanding of the photochem. process and demonstrates that in the present case the sacrificial reagent, the photosensitizer, and the irradiation source can be replaced by the electrode and a weak Bronsted acid. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Application of 109660-12-0

The Article related to carbon dioxide reduction photo electrocatalytic process earth, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Application of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz published an article in 1985, the title of the article was Bipyridines. Part XVI. Synthesis of novel 1,2,3,7-oxatriazepine and 1,2,3-triazine fused systems by the diazotization of [2,2′-bipyridine]-3,3′-diamine.Computed Properties of 75449-26-2 And the article contains the following content:

In the diazotization reaction of [2,2′-bipyridine]-3,3′-diamine the corresponding tetrazonium salt I was formed. I was transformed, depending upon pH of the post-reaction solution, into 3a,4,5,8a,9,10-hexaaza-3a,8a-dihydropyrene 3a-oxide (II) or 6-oxa-4,5,6a,10,11,11a-hexaaza-6,6a,11a-trihydrocyclohepta[d,e,f]phenanthrene (III). III is isomerized to II in acidic media. Both isomers were transformed in acid into a mixture of (3-nitrosamino-2-pyridyl)-2-pyridin-3-ol and (3-amino-2-pyridyl)-2-pyridin-3-ol. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to oxahexaazacycloheptaphenanthrene, hexazapyrene oxide, oxatriazepine fused, triazine fused, bipyridinediamine diazotization, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 24, 2019, Yu, Henry; Clark, Michael; Bemis, Guy; Boyd, Michael; Chandupatla, Kishan; Collier, Philip; Deng, Hongbo; Dong, Huijun; Dorsch, Warren; Hoover, Russell R.; Johnson, Mac Arthur, Jr.; Kukarni, Shashank; Penney, Marina; Ronkin, Steven; Takemoto, Darin; Tang, Qing; Waal, Nathan D.; Wang, Tiansheng published a patent.Recommanded Product: 1227002-03-0 The title of the patent was Preparation of substituted oxazepanyl pyrimidinamines as antiproliferation compounds. And the patent contained the following:

The present invention provides compounds I [ring A = Ph, 5-7 membered saturated or partially unsaturated carbocyclic ring, 8-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from N, O, or S, etc.; each R1 = (independently) H, or (halo)alkyl; or two R1 groups are optionally taken together with their intervening atoms to form 5-8 membered partially unsaturated fused carbocyclic ring; each of R2 = (independently) H, halo, CN, etc.; or two R2 groups are optionally taken together to form :O; or two R2 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; each R3 = (independently) H, OH, or alkyl; or two R3 groups are optionally taken together to form :O or :CH2; or two R3 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; or 5-8 membered saturated bridged bicyclic ring having 0-2 heteroatoms independently selected from N, O or S; X = O, S, CH2, etc.; m = 0-2; n = 0-5; p = 0-2] or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer). E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 3-(tributylstannylmethoxy)propan-1-amine and 2-chloro-5-nitrobenzaldehyde, was described. Exemplified compounds I were evaluated in the Colo 205 reporter assay, HepG2 XBP1 reporter assay, and in the Calcium Flux assay (data given for representative compounds I). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Recommanded Product: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 15, 2013, Duan, Lele; Wang, Lei; Inge, A. Ken; Fischer, Andreas; Zou, Xiaodong; Sun, Licheng published an article.Category: pyridine-derivatives The title of the article was Insights into Ru-Based Molecular Water Oxidation Catalysts: Electronic and Noncovalent-Interaction Effects on Their Catalytic Activities. And the article contained the following:

A series of Ru-bda water oxidation catalysts [Ru(bda)L2] (H2bda = 2,2′-bipyridine-6,6′-dicarboxylic acid; L = [HNEt3][3-SO3-pyridine], 1; 4-(EtOOC)-pyridine, 2; 4-bromopyridine, 3; pyridine, 4; 4-methoxypyridine, 5; 4-(Me2N)-pyridine, 6; 4-[Ph(CH2)3]-pyridine, 7) were synthesized with electron-donating/-withdrawing groups and hydrophilic/hydrophobic groups in the axial ligands. These complexes were characterized by 1H NMR spectroscopy, high-resolution mass spectrometry, elemental anal., and electrochem. In addition, complexes 1 and 6 were further identified by single crystal X-ray crystallog., revealing a highly distorted octahedral configuration of the Ru coordination sphere. All of these complexes are highly active toward CeIV-driven (CeIV = Ce(NH4)2(NO3)6) water oxidation with oxygen evolution rates up to 119 mols of O2 per mol of catalyst per s. Their structure-activity relationship was investigated. Electron-withdrawing and noncovalent interactions (attraction) exhibit pos. effect on the catalytic activity of Ru-bda catalysts. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Category: pyridine-derivatives

The Article related to ruthenium based mol water oxidation catalyst electronic noncovalent interaction, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Reaction Kinetics and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 8, 2014, Yang, Yonggang; Li, Yi; Li, Baozong; Wang, Qingfeng published a patent.Application of 75449-26-2 The title of the patent was Chiral silsesquioxane containing arylene, manufacture method, and application in absorbent, chiral separation, and asymmetric catalysis. And the patent contained the following:

Title chiral silsesquioxane is homopolymer of I (OEt)3Si(CH2)mNHC(O)NHCH(R)C(O)NH-A-NHC(O)CH(R)NHC(O)NH(CH2)mSi(OEt)3; wherein R is residual group of valine, isoleucine, alanine, or phenylalanine, A is aromatic group of diamine, and m is integer of 3-10. Title manufacture method comprises the steps: (1) reacting Boc-protected amino acid with aromatic diamine to give Boc-protected intermediate; (2) deprotecting Boc group; (3) reacting deprotected intermediate with isocyanate (EtO)3Si(CH2)mNCO (m is integer of 3-10) to give monomer; and (4) polycondensing the monomer to obtain chiral silsesquioxane. Title chiral silsesquioxane has stable chem. property, simple production, and convenient use, has good adsorption effect on aryl compound and heavy metal ion, also has great application value in chiral resolution and asym. catalysis. In an example, I (R = iPr, A = biphenylene, m = 3) was manufactured from Boc-L-valine, 4,4′-diaminobiphenyl, and (3-isocyanato)propyltriethoxysilane; I was polymerized to give right-hand helical fiber with diameter 50-100 nm and length 2-10 μm. The obtained silsesquioxane 50 mg was added to nitrobenzene/cyclohexane solution (volume ratio 1:99) 850 μl; after 5 h, nitrobenzene 19.3 % was absorbed by silsesquioxane, which indicated that the silsesquioxane could be used as absorbent to absorb aromatic compound The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Application of 75449-26-2

The Article related to chiral silsesquioxane arylene manufacture absorbent resolution asym catalysis, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Application of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 13, 2015, Liu, Jun; Dou, Chuandong published a patent.Electric Literature of 75449-26-2 The title of the patent was Bis(boron-nitrogen-bridged) bipyridyl and organic/high polymer material prepared with the same. And the patent contained the following:

The present invention relates to a kind of bis(boron-nitrogen-bridged) bipyridyl (I, R1 is 4-20 alkyl group, R2, e.g., Ph, F, Et etc.), and organic/high polymer material prepared with the same, belonging to organic/high polymer area of solar cell. The object of the invention is to take classic pyrene unit as starting point to develop new BN receptor unit for further expanding receptor material system. The bis(boron-nitrogen-bridged) bipyridyl in this invention contains BN unit so that it has a number of advantages: such as complanation structure is conducive to orderly close accumulation of material mol., so as to increase mobility of material carrier; BN coordination has strong electron-drawing action, which is conducive to reducing mol. energy level; introducing alkyl chain with different lengths contributes to regulating material dissoly.; reaction site with functionalization can be used for preparing organic/high polymer material, and it has good application prospect if applied to solar cell. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to boron nitrogen bridged bipyridyl organic polymer material solar cell, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 25, 2022, Lee, Hee Jin; Park, Jin Young; Lee, Hye Mi; Yang, Deok Mo; Nam, Eun Hye; Kim, Hak Do; Jung, Hui Jin; Choung, Won Ken published a patent.SDS of cas: 868551-99-9 The title of the patent was Preparation of pyrimidine-fused ring compounds with DNA-PK inhibition activity and use thereof. And the patent contained the following:

The invention relates to a pyrimidine-fused ring compounds of formula I, stereoisomers, pharmaceutically acceptable salts, or pharmaceutical compositions thereof that are useful for the prevention or treatment of cancer. The pyrimidine-fused ring compounds of the present invention exhibits excellent inhibitory activity against DNA-PK and thus can be advantageously used as a therapeutic agent for DNA-PK-related diseases. Compounds of formula I wherein the normalized bond is a single or double bond; n is 0-2; X1 is NR1 or CR2R3; X2 and X3 are independently -CR2R3-, -CR2-, -(C=O)-, or -(C=S)-; L1 is null or alkylene; Y is alkoxy, Q1, Q2, or (un)substituted (hetero)aryl; W1 is -CH2-, -NH-, -O-, or -S-; W2 is -CH- or -N-; a – d are independently 0-3; L2 is null or alkylene; Z is -Z1-L3-Z2; Z1 is (un)substituted (hetero)aryl or (un)substituted benzene-fused ring; L3 is alkylene, -(C=O)-, -(C=O)NH-, -NH-, etc.; Z2 is H, alkyl, hydroxyalkyl, alkoxyalkyl, etc.; R is H or alkyl; R1 – R3 are independently H or alkyl; are claimed. Example compound II was prepared by palladium-catalyzed cross-coupling reaction of 2-chloro-7-methyl-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one with 2,5-dimethylbenzo[d]thiazol-6-amine in 11% yield. The invention compounds were evaluated for the DNA-pk inhibition activity (biol. data given). The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).SDS of cas: 868551-99-9

The Article related to pyrimidine fused ring preparation dnapk inhibition cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 868551-99-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem