Tag: 100-200

On October 15, 2014, Cha, Sun Uk; Jung, Gyeong Seok; Park, Seok Bae; Kim, Hui Dae; Lee, Yu Rim; Song, Ju Man; Hwang, Mun Chan published a patent.Safety of 6-(tert-Butyl)pyridin-3-amine The title of the patent was Amine group substituted asymmetric pyrene derivative comprising pyridinyl group as electroluminescent dopant and/or organic semiconductor materials for organic light-emitting device. And the patent contained the following:

The present invention relates to an amine group substituted asym. pyrene derivative, and an organic light-emitting device comprising the same. The amine group substituted asym. pyrene derivative comprising pyridinyl group is represented by formula I (Py1, Py2 = substituted or unsubstituted pyridinyl group; Ar1, Ar2 = substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C50 aryl group, C2-C50 heteroaryl group having one or more substituted or unsubstituted atoms selected from oxygen, nitrogen, sulfur and silicon; Z = hydrogen, deuterium, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C5-C50 aryl group, substituted or unsubstituted C2-C30 alkenyl group, substituted or unsubstituted C2-C20 alkynyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C30 cycloalkenyl group, etc.; and m = integer of 1-8, where the substituted or unsubstituted substitution is selected from deuterium, cyano group, halogen, hydroxyl group, nitro group, C1-C24 alkyl group, etc.). The organic light-emitting device comprises: a first electrode; a second electrode placed opposite to the first electrode; and an organic layer placed between the first and second electrodes, where the organic layer includes an organic light-emitting compound i.e. amine group substituted asym. pyrene derivative The organic layer is selected from hole injection layer having hole injection function, hole transport layer having hole transport function, functional layer, light-emitting layer, electron transport layer, and electron injection layer. According to the present invention, the amine group substituted asym. pyrene derivative has excellent luminous efficiency and high-color purity, and is utilized in the organic light-emitting device for producing full-color display. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Safety of 6-(tert-Butyl)pyridin-3-amine

The Article related to amine group asym pyrene derivative pyridinyl electroluminescent dopant oled, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Safety of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2014, Cha, Sun Uk; Jung, Gyeong Seok; Park, Seok Bae; Kim, Hui Dae; Lee, Yu Rim; Song, Ju Man; Hwang, Mun Chan published a patent.Formula: C9H14N2 The title of the patent was Asymmetric pyrene derivative comprising heteroaryl amine as electroluminescent dopant for organic light-emitting device. And the patent contained the following:

The present invention relates to an asym. pyrene derivative comprising heteroaryl amine, and an organic light-emitting device comprising the same. The asym. pyrene derivative comprising heteroaryl amine is represented by formula I or II (Py = substituted or unsubstituted pyridinyl; Het1-Het3 = heterogeneous atom selected from oxygen, nitrogen, sulfur and silicon, C2-C50 heteroaryl group; Z = hydrogen, deuterium, C1-C30 alkyl group, C5-C50 aryl group, C2-C30 alkenyl group, C2-C20 alkynyl group, C3-C30 cycloalkyl group, C5-C30 cycloalkenyl group, etc.; m = integer of 1-8 for formula I and 1-9 for formula II, where the substitution is selected from deuterium, cyano group, halogen, hydroxyl group, nitro group, C1-C24 alkyl group, etc.). The organic light-emitting device comprises: a first electrode; a second electrode placed opposite to the first electrode; and an organic layer placed between the first and second electrodes, where the organic layer includes an organic light-emitting compound i.e. asym. pyrene derivative The organic layer is selected from hole injection layer having hole injection function, hole transport layer having hole transport function, functional layer, light-emitting layer, electron transport layer, and electron injection layer. According to the present invention, the asym. pyrene derivative has excellent luminous efficiency and high-color purity, and is utilized in the organic light-emitting device such as flat panel display device, flexible display device, monochromatic or white flexible lighting device, etc. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Formula: C9H14N2

The Article related to asym pyrene heteroaryl amine electroluminescent dopant flat panel display, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Formula: C9H14N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shirra, Alexander; Suckling, Colin J. published an article in 1977, the title of the article was Pyridinium salts and dihydropyridines; mechanistic studies of the redox reaction between pyridinium salts and alkoxides in tetrahydrofuran.SDS of cas: 636-73-7 And the article contains the following content:

A model system for NAD-dependent redox reactions was designed to assess the involvement of covalent adducts as intermediates. The system consisted of 3-substituted 1-n-heptylpyridinium salts and substituted benzyl alkoxides. Although covalent adducts were found in the reaction mixture, studies of substituent effects and other structural variations did not show that A covalent intermediate is on the reaction path. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to redox pyridinium alkoxide mechanism, nad redox model system, Physical Organic Chemistry: Oxidation-Reduction Reactions (Including Hydrogenation) and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 8, 2014, Neudeck, Sven; Maji, Somnath; Lopez, Isidoro; Meyer, Steffen; Meyer, Franc; Llobet, Antoni published an article.Electric Literature of 636-73-7 The title of the article was New Powerful and Oxidatively Rugged Dinuclear Ru Water Oxidation Catalyst: Control of Mechanistic Pathways by Tailored Ligand Design. And the article contained the following:

A new powerful and oxidatively rugged pyrazolate-based water oxidation catalyst of formula {[RuII(py-SO3)2(H2O)]2(μ-Mebbp)}-, 1(H2O)2-, has been prepared and thoroughly characterized spectroscopically and electrochem. This new catalyst has been conceived based on a specific ligand tailoring design, so that its performance has been systematically improved. It was also demonstrated how subtle ligand modifications cause a change in the O-O bond formation mechanism, thus revealing the close activation energy barriers associated with each pathway. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Electric Literature of 636-73-7

The Article related to powerful oxidatively rugged dinuclear ruthenium water oxidation catalyst, control mechanistic pathway tailored ligand design, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Reaction Kinetics and other aspects.Electric Literature of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 3, 1994, Rewcastle, Gordon W.; Denny, William A. published an article.Quality Control of N,3-Dimethylpyridin-2-amine The title of the article was Lithiation routes to oxindoles and 2-indolinethiones: precursors to 2,2′-dithiobisindoles with tyrosine kinase inhibitory properties. And the article contained the following:

N-Substituted oxindoles, e.g. I, and 2-indolinethiones can be prepared by lithiation of carboxyl protected N,2-dimethylanilines followed by quenching with CO2 or CS2 resp. 2-Indolinethione derivatives are also available via demethylation of 2-methylthioindoles, which are prepared by lithiation of N-substituted indoles and treatment with di-Me disulfide. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Quality Control of N,3-Dimethylpyridin-2-amine

The Article related to dithiobisindole preparation tyrosine kinase inhibitory, oxindole substituted, indolinethione substituted, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 7, 1995, Dobrusin, Ellen M.; Showalter, Howard D. H.; Denny, William A.; Palmer, Brian D.; Rewcastle, Gordon W.; Tercel, Moana; Thompson, Andrew M. published a patent.Related Products of 156267-13-9 The title of the patent was Preparation of 2-indolyldisulfides and analogs as protein tyrosine kinase inhibitors and antitumor agents. And the patent contained the following:

Title compounds [I; R1 = H, halo, alkyl, alkoxy, etc.; R2 = (acyl)alkyl, acyl, CH:CHCO2H, etc.; R3 = H, alkyl, CH2Ph; R4 = SH, SnR, SeH, SenR, etc.; R = H, alkyl, (hetero)aryl, I in which R4 = bond, etc.; R4R5 = S, Se; R5R6 = bond; R6 = H; n = 1-3] were prepared 2Hus, 1-methyl-2-indolinone was treated with P2S5 and the product condensed with PhNCO to give, after oxidation, title compound II which had IC50 of 3-4μM against growth factor mediated mitogenesis in vitro. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Related Products of 156267-13-9

The Article related to indolyldisulfide preparation protein tyrosine kinase inhibitor, antitumor indolyldisulfide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 156267-13-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 20, 2011, Minter, Aaron; Stokes, Berlin published a patent.Name: 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutaronitriles. And the patent contained the following:

A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Name: 3-Methylpyridine-2,6-diamine

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.Application of 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutaronitriles. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutaronitrile (3.0 g, 31.9 mmol) was combined with Pd-C (3.39 g, 3.19 mmol, 10 mol% of 10% Pd on carbon) and mixed with liquid NH3 (1.0 g, 58.7 mmol), then heated at 200° for 45 h and a pressure of approx. 90 psi to give 2.43 mmol of 2,6-diaminopyridine in 7.6 % net yield. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Application of 51566-22-4

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 19, 2002, Owa, Takashi; Yoshino, Hiroshi; Okauchi, Tatsuo; Okabe, Tadashi; Ozawa, Yoichi; Hata Sugi, Naoko; Yoshimatsu, Kentaro; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke published an article.Computed Properties of 636-73-7 The title of the article was Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents. And the article contained the following:

The synthesis and antitumor activity of E7070 analogs containing a 3-pyridinesulfonamide moiety is reported. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clin. trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogs examined, ER-35745 (I), a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to pyridinesulfonamide indolyl derivative preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 15, 2021, Flohr, Alexander; Eidam, Olive; Fasching, Bernhard; Meniconi, Mirco; Sadok, Amine; Chopra, Rajesh; Zhuai Wang, Hannah; Caldwell, John Jamieson; Collins, Ian; Ryckmans, Thomas published a patent.Recommanded Product: 39919-70-5 The title of the patent was Isoindolinone compounds as cereblon inhibitors and GSPT1 degraders and their preparation. And the patent contained the following:

Disclosed herein is a compound of formula I or pharmaceutically acceptable salts or stereoisomers thereof. Compounds of formula I wherein X1 is (un)branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl-C3-6 cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, etc.; X2 is H, C6-10 aryl, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 4- to 8-membered heterocycloalkyl, etc.; n is 0, 1 and 2; and pharmaceutically acceptable salts, and stereoisomers thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their cereblon inhibitory activity and GSPT1 degradation activity. From the assay, it was determined that compound II exhibited IC50 value of 1037 nM and a DC50 value of > 300 nM. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 39919-70-5

The Article related to isoindolinone preparation cereblon inhibitor gspt1 degrader, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem