Tag: 100-200

On December 27, 2011, Minter, Aaron; Stokes, Berlin published a patent.Quality Control of 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutarimidines. And the patent contained the following:

A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Quality Control of 3-Methylpyridine-2,6-diamine

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Quality Control of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.HPLC of Formula: 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutarimidines. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutarimidine (111 mg, 0.99 mmol) was combined with Pd-C (100 mg, 0.10 mmol, 10 mol% of 10% Pd on carbon), and then mixed with liquidNH3 (1.0 g, 58.7 mmol) then heated at 200° for 45 h to give 0.14 mmol of 2,6-diaminopyridine in yield 13.7%. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).HPLC of Formula: 51566-22-4

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 15, 2018, Moustani, Chrysavgi; Anagnostopoulou, Eleni; Krommyda, Kalliopi; Panopoulou, Christina; Koukoulakis, Konstantinos G.; Bakeas, Evangelos B.; Papadogianakis, Georgios published an article.Product Details of 636-73-7 The title of the article was Novel aqueous-phase hydrogenation reaction of the key biorefinery platform chemical levulinic acid into γ-valerolactone employing highly active, selective and stable water-soluble ruthenium catalysts modified with nitrogen-containing ligands. And the article contained the following:

High catalytic activities (TO = 000 -1) have been achieved by novel water-soluble ruthenium catalysts modified with nitrogen-containing ligands such as the bathophenanthrolinedisulfonic acid disodium salt (BPhDS) in the hydrogenation reaction of the renewable polar platform chem. levulinic acid (LA) which possesses a central relevance in the development of biorefineries of the future in a sustainable way to produce with essentially quant. selectivity of 99.9 mol% γ-valerolactone (GVL) in aqueous media. The apparent activation energy of the Ru/BPhDS catalyst was calculated and amounts a relative low value of 53.3 J/mol when one considers that in the LA hydrogenation reaction this catalyst reduces a less reactive keto group into alc. functionality. A recycling experiment of the Ru/BPhDS catalyst by extraction after addition of di-Et ether has shown that the catalyst is stable without loss of activity and selectivity in a consecutive run. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Product Details of 636-73-7

The Article related to hydrogenation m levulinate gamma valerolactone catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Product Details of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 1997, Kawano, Eiji; Nagai, Masashi; Inubushi, Atsurou; Shimada, Keiichi; Tobari, Hiroko published a patent.Category: pyridine-derivatives The title of the patent was Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient. And the patent contained the following:

A nitrogen monoxide synthetase (NOS) inhibitor which contains as the active ingredient 2-aminopyridines or pharmaceutically acceptable salts thereof. It has been found that 2-aminopyridines and pharmaceutically acceptable salts thereof have potent effects of inhibiting nitrogen monoxide synthetase. Namely, a medicinal composition containing 2-aminopyridines and pharmaceutically acceptable salts thereof is useful as a nitrogen monoxide formation inhibitor for treatment of NOS-related diseases e.g. septic shock, rheumatism, allergy, parkinsonism, cardiovascular diseases, obesity, and pain. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Category: pyridine-derivatives

The Article related to nitrogen monoxide synthetase inhibitor aminopyridine preparation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz; Nantka-Namirski, Pawel published an article in 1979, the title of the article was Bipyridines. XI. Synthesis of 4,5-diazacarbazole.Category: pyridine-derivatives And the article contains the following content:

3,3′-Dinitro-2,2′-bipyridine (I) was reduced with SnCl2 in concentrated HCl to give 71% 3,3′-diamino-2,2′-bipyridine (II), which was also prepared in 34% yield by heating 2-chloro-3-acetylaminopyridine with Cu in DMF and subsequently deacetylating the product in acidic medium. Hydrogenation of I (Pd/C, 2.5 atm) converted both NO2 groups into NHOH groups in 79% yield; subsequent cyclization in polyphosphoric acid at 300° gave 77% III. II with H2SO4-HNO3 gave 40% IV (R = NO2), with PhNCO, 94% IV (R = CONHPh), with Ac2O, 65% IV (R = Ac, V), with CS2, 25% VI, and with ZnCl2 at 350-400°, 55% VII. V was converted in 70% yield into the N,N’-dioxide by the action of 3-ClC6H4CO3H. in vivo Biol. tests with sarcoma 180 and leukemias were neg. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Category: pyridine-derivatives

The Article related to bipyridinediamine preparation reaction, diazacarbazole, dipyridopyrazine, dipyridodiazepinethione, dipyridopyrrole, neoplasm inhibitor bipyridinediamine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 2, 2009, Yi, Chae S.; Kwon, Ki-Hyeok; Lee, Do W. published an article.Category: pyridine-derivatives The title of the article was Aqueous Phase C-H Bond Oxidation Reaction of Arylalkanes Catalyzed by a Water-Soluble Cationic Ru(III) Complex [(pymox-Me2)2RuCl2]+BF4-. And the article contained the following:

The cationic complex [(pymox-Me2)RuCl2]+BF4- was found to be a highly effective catalyst for the C-H bond oxidation reaction of arylalkanes in water. For example, the treatment of ethylbenzene (1.0 mmol) with t-BuOOH (3.0 mmol) and 1.0 mol % of the Ru catalyst in water (3 mL) cleanly produced PhCOCH3 at room temperature Both a large kinetic isotope effect (kH/kD = 14) and a relatively large Hammett value (ρ = -1.1) suggest a solvent-caged oxygen rebounding mechanism via a Ru(IV)-oxo intermediate species. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Category: pyridine-derivatives

The Article related to aqueous carbon hydrogen bond oxidation arylalkane cationic ruthenium complex, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 4, 2021, Behenna, Douglas; Deckhut, Charlotte; Rovira, Alexander; Goldberg, Steven; Kummer, David; Keith, John; Woods, Craig; Rhorer, Timothy; Tanis, Virginia; Martin, Connor; Meduna, Steven; McCarver, Stefan; Valdes, Alexander; Loskot, Steven; Xue, Xiaohua published a patent.Safety of 5-Isopropylnicotinic acid The title of the patent was Imidazopyridazines as modulators of IL-17 in the treatment of inflammatory disorders. And the patent contained the following:

The invention relates compounds of formula I, preparation and use in treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease. Compound I, wherein R1 is (un)substituted C1-6 alkyl, (un)substituted C0-2 alkyl-C3-6 cycloalkyl, and (un)substituted 5- and 6-membered heterocyclyl having 1 and 2 nitrogen atoms; R2 is H, C3-5 cycloalkyl and (un)substituted C1-4 alkyl; R3 is (un)substituted C0-1 alkyl-C3-6 cycloalkyl, (un)substituted C3-6 alkyl and (un)substituted C1-2 alkyl-O-C1-3 alkyl; R4 is (un)substituted C3-6 cycloalkyl, (un)substituted Ph and (un)substituted 5- and 6-membered heteroaryl having 1 to 4 heteroatoms selected from N, O and S; R5 is H and halo; and pharmaceutically acceptable salts thereof, are claimed. Compound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for IL-17A modulatory activity resulting in an IC50 of 0.18μM and 0.30μM using Eu-HTRF and NHK assays, resp. Compounds of the invention were evaluated for IL-17A modulatory activity (data given). The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Safety of 5-Isopropylnicotinic acid

The Article related to imidazopyridazine preparation modulator il 17 inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Safety of 5-Isopropylnicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 5, 2018, Groarke, Michelle; Shiomi, Takushi; Kawamura, Masahiro; Nagashima, Hideaki published a patent.Electric Literature of 75449-26-2 The title of the patent was Nitrogen-containing heterocyclic compounds for organic light emitting devices. And the patent contained the following:

A compound represented by a chem. formula I (A1, A2, A3 = (un)substituted C6-C30 ring aromatic hydrocarbon, (un)substituted C5-C30 heterocyclic group; Z1 = N, CR1; R1 = H, (un)substituted C1-C30 alkyl, (un)substituted C3-C30 cycloalkyl etc.; B1 = H, CN, (un)substituted C6-C30 ring aromatic hydrocarbon, etc.; L = single bond, (un)substituted alkylene having C1-C30; (un)substituted C3-C30 cycloalkylene; l = 1, 2 or 3), a material for an organic electroluminescence device comprising at least one compound of formula I; an organic electroluminescence device which comprises an organic thin film layer between a cathode and an anode, wherein the organic thin film layer comprises one or more layers and comprises a light emitting layer, and at least one layer of the organic thin film layer comprises at least one compound with formula I; an electronic equipment. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to nitrogen heterocyclic organic light emitting device electroluminescent material, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 15, 2011, Jung, Hyeon Cheol; Yoo, In Seon; Lee, Jeong Ae; Park, Seong Hui published a patent.Product Details of 39919-70-5 The title of the patent was Organic electroluminescent device having novel electron transport/injection materials comprising aromatic compound. And the patent contained the following:

The title organic electroluminescent device comprises stacked anode, hole injection layer, hole transport layer, host + dopant layer, electron transport layer, electron injection layer, and cathode. The compound shown in chem. formula I is used in the electron transport layer and the electron injection layer, wherein, R1, R2 and R3 are the same or not, and are substituted or unsubstituted aromatic groups, heterocyclic groups or aliphatic groups. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Product Details of 39919-70-5

The Article related to organic electroluminescent device electron injection transport aromatic, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Product Details of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 2014, Soll, Mark David; Le Hir de Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms published a patent.Formula: C6H3ClN2O3 The title of the patent was Preparation of arylazol-2-yl cyanoethylamino derivatives useful as pesticides. And the patent contained the following:

The invention relates to arylazol-2-yl-cyanoethylamino derivatives of formula I and their preparation, useful as pesticides, particularly for controlling endoparasitic or ectoparasitic pests on animals. Compounds of formula I, in which group P is N; Q is CR2 and N; V is CR8; W is CR9 and N; X is CR10 and N; Y is CR11 and N; R2, R8, R9, R10, and R11 are each independently H, amino, amido, CN, etc.; R3, R4, and R5 are each independently H, halo, alkyl, etc.; and CR4R5 taken together form cycloalkyl ring; n = 1 – 3; R6 and R7 are independently H, (alkoxy)alkyl, alkylcarbonyl, etc.; Z is direct bond, CO, CS, and S(O)p; p = 0 – 2; or salts thereof, are claimed. Example compound II was prepared by amidation of 2-amino-3-(5-chloro-2H-benzotriazol-2-yl)-2-methylpropionitrile with 4-trifluoromethoxybenzoyl chloride. Invention compounds were evaluated for their pesticidal activity. From the assay, it was determined that compound II exhibited >95% reduction in nematode infestation after 3 days. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Formula: C6H3ClN2O3

The Article related to arylazole benzotriazole indazole pyrazolopyridine cyanoethylamine preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Formula: C6H3ClN2O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem