Tag: 100-200

On May 14, 1991, Yamaji, Mitsuharu published a patent.Safety of 3-Methylpyridine-2,6-diamine The title of the patent was Preparation of 3-alkyl-2,6-diaminopyridines as developers for hair dyes. And the patent contained the following:

The diaminopyridines are prepared by treating 3-alkyl-2-aminopyridines with alkali metal amides in inert solvents and quenching the reaction mixtures with OH-containing compounds Thus, a solution of NaNH2 in Tetralin was treated dropwise with 2-amino-3-methylpyridine, then the mixture was quenched with H2O to give 62% 3-methyl-2,6-diaminopyridine. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Safety of 3-Methylpyridine-2,6-diamine

The Article related to hair dye developer alkyldiaminopyridine, aminopyridine amination alkali amide, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.Safety of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 22, 2014, Chatterjee, Arnab Kumar; Nagle, Advait Suresh; Paraselli, Prasuna; Leong, Seh Yong; Roland, Jason Thomas; Mishra, Pranab Kumar; Yeung, Bryan K. S.; Zou, Bin published a patent.Formula: C7H10N2 The title of the patent was Preparation of imidazopyrazines for treating parasitic diseases. And the patent contained the following:

The invention is related to the preparation of title compounds I [n = 0-2; p = 0-3; A = aryl, heteroaryl, and fused bycyclyl comprising a heterocycloalkyl fused to a phenyl; B = the imidazo[1,2-a]pyrazine fused ring depicted in I; D = Ph, heteroaryl, cycloalkyl, heterocycloalkyl, fused bicyclyl comprising a heterocycloalkyl fused to a phenyl; L = *CO, alkylene, *NR2CO, *CH2NR2, etc.; * represents the point of attachment of L to ring B; R2 = H, alkyl, R0-alkylene ; R0 = alkoxyamino, heteroaryl, alkylamino, etc.; R1 = independently at each occurrence halo, CN, NH2 and derivatives; R15, R16 = independently H, alkyl, haloalkyl; R17 = independently at each occurrence halo, OH and derivatives, SO2NH2 and derivatives, etc.], or a pharmaceutical acceptable salt, tautomer or stereoisomer, useful for treating, preventing, inhibiting, ameliorating, or eradicating the pathol. and/or symptomol. of a disease, such as malaria, caused by a Plasmodium parasite. Thus, a multi-step synthesis starting from chloroacetaldehyde and 5-amino-2-pyrazinecarboxylic acid Et ester was given for II. I were tested for their capacity to inhibit proliferation of parasitemia in 3D7 Plasmodium falciparum infected red blood cells and had EC50 of 10 μM or less. I showed delay of the proliferation of P. yoelii in liver cells in a P. yoelii sporozoite invasion assay (EC50 for II = 14 nM). The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Formula: C7H10N2

The Article related to imidazopyrazine preparation antimalarial plasmodium falciparum, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 24, 1994, Rewcastle, Gordon W.; Palmer, Brian D.; Dobrusin, Ellen M.; Fry, David W.; Kraker, Alan J.; Denny, William A. published an article.COA of Formula: C7H10N2 The title of the article was Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2′-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide). And the article contained the following:

A series of indole-substituted 2,2′-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamides) I (R = H, 5-Cl, 6-Me, 7-OH, 5-MeO, etc.) were prepared and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60v-src tyrosine kinase. The compounds were synthesized by conversion of appropriate 1-methyloxindoles to 1-methyl-2-indolinethiones with P2S5 followed by subsequent reaction with NaH and Ph isocyanate and oxidative dimerization of the resulting 2,3-dihydro-N-phenyl-2-thioxo-1H-indole-3-carboxamides. The parent compound and many of the substituted analogs were moderately potent inhibitors of both kinase enzymes, but no clear relationships were seen between substitution on the indole ring and inhibitory activity. While 4-substituted compounds were generally inactive, 5-substituted derivatives with electron-withdrawing groups showed inhibitory activity. However, none of the substituted compounds showed significantly better activity than the unsubstituted parent compound There was generally a good correlation between activity against the EGFR and pp60v-src kinases, but several compounds did show some specificity (>20-fold) of inhibition; 5-Cl and 5-Br derivatives preferentially inhibited pp60v-src, while the 5-CF3 compound preferentially inhibited EGFR. Selected compounds from the series were found to inhibit the growth of Swiss 3T3 fibroblasts with IC50s in the range 2-25 μM, the most active being 4-substituted derivatives The compounds inhibited bFGF-mediated protein tyrosine phosphorylation in intact cells more effectively than EGFR- or PDGF-mediated phosphorylation. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).COA of Formula: C7H10N2

The Article related to dithiobismethylphenylindolecarboxamide protein tyrosine kinases inhibitor, indolecarboxamide dithiobismethylphenyl protein tyrosine kinases inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 31, 2014, Zhao, Hongwu; Meng, Wei; Yang, Zhao; Tian, Ting; Sheng, Zhihui; Li, Hailong; Song, Xiuqing; Zhang, Yutong; Yang, Sen; Li, Bo published an article.SDS of cas: 75449-26-2 The title of the article was Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts. And the article contained the following:

In this work, six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were designed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives I (R1 = H, 5-O2N, 5-Br; R2 = H, Bn; R3, R4 = -(CH2)2-, -CH2OCH2-, -CH2SCH2-, etc.) via aldol reactions in water. Organocatalyzed by II, the direct aldol reactions of isatins with enolisable ketones underwent readily in water, furnishing the structurally diverse I in various stereoselectivities (up to>99% dr and >99% ee). Moreover, a plausible transition state of the conducted aldol reactions was hypothesized to shed light on the observed stereoselectivities of the obtained I. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

The Article related to alkyl hydroxy oxindole enantioselective preparation, isatin ketone aldol biaryl organocatalyst water compatible, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 24, 1991, Karaman, Rafik; Bruice, Thomas C. published an article.Computed Properties of 636-73-7 The title of the article was Synthesis and characterization of the first water-soluble closely interspaced cofacial porphyrin dimer. And the article contained the following:

The only documented example of a quadruply-bridged, closely-interspaced cofacial porphyrin dimer was synthesized by Kagan (1977). The target of this communication is the synthesis and characterization of the first water soluble quadruply-bridged, closely-interspaced cofacial porphyrin I (R = R1). Reaction of meso-tetrakis(3-bromomethylphenyl)porphyrin with m-pyridinesulfonamide provides the closely-interspaced cofacial porphyrin dimer I (R = R2) which on quaternization with MeI provides the water soluble I (R = R1). Reactions of I with Zn(OAc)2 provided the corresponding bis-zinc complexes I. Porphyrins I and their bis-zinc complexes, exist in a closed down conformation with closely approaching porphyrin planes or in an open conformation. It was established, on the basis of 1H-NMR UV/vis, and emission spectrophotometries, and I (R = R2) exists in a closed down conformation in DMSO or acetone and a more open conformation is CHCl3. With zinc complexes of I (or protonated I) the conformation is open regardless of the solvent. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to porphyrin dimer quadruply bridged conformation, tetrakisbromoethylphenylporphyrin alkylation pyridinesulfonamide, Biomolecules and Their Synthetic Analogs: Corrinoids, Porphyrins, and Bilines and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Chisholm, Danielle M.; McDonald, Robert; McIndoe, J. Scott published an article.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the article was 3,3′-N,N’-Bis(amino)-2,2′-bipyridine – An unusually methylation-resistant amine. And the article contained the following:

Methylation of aromatic amino groups is usually straightforward, but the formation of two intramol. hydrogen bonds in 3,3′-N,N’-bis(amino)-2,2′-bipyridine and (or) the potential for ring methylation prevents the clean tetramethylation of this mol. Numerous attempts to make 3,3′-N,N’-bis(dimethylamino)-2,2′-bipyridine produced only complex mixtures of variously methylated products, and the only isolated mol. was 3,3′-N,N’-bis(methylamino)-2,2′-bipyridine, for which an X-ray crystal structure was obtained. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to bisaminobipyridine methylation resistant amine, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 3, 1992, Karaman, Rafik; Blasko, Andrei; Almarsson, Orn; Arasasingham, Ramesh; Bruice, Thomas C. published an article.Electric Literature of 636-73-7 The title of the article was Symmetrical and unsymmetrical quadruply aza-bridged, closely interspaced, cofacial bis(5,10,15,20-tetraphenylporphyrin)s. 2. Synthesis, characterization, and conformational effects of solvents. And the article contained the following:

Title compounds I [X = NR, R = 3-pyridylsulfonyl (R1), 1-methylpyridinium-3-sulfonyl (R2), CONH2, cyano, tosyl; X = OCO2, R = R1, cyano] have been synthesized and fully characterized by 2-dimensional 1H-1H NMR (COSY), 2-dimensional 13C-1H NMR, fast-atom-bombardment mass spectrometry, UV/vis, IR, and fluorescence spectral techniques. It was established, on the basis of 1H NMR, UV/vis, and emission spectrophotometries, that I (X = NR, R = R1, R2, tosyl) exist in more than one conformational in DMSO and in only one sym. conformation in CHCl3. Their biszinc complexes and tetraprotonated derivatives exist in one conformation regardless of the solvent. These observations have been attributed to an interaction between DMSO and the pyrrolic N-H protons of the porphyrin cores which is inhibited by metalation or protonation. Mol. dynamics calculations reveal that the intracavity interactions of I (X = NR, R = R1) with DMSO are more important than the intercavity interactions which result in discrete, unsym. conformations of the dimer. In contrast, I (X = OCO2, R = R1, cyano; X = NR, R = cyano, CONH2) do not show any conformational changes upon switching from CHCl3 to DMSO. This is attributed to the long interplanar distances calculated for the porphyrin dimers which prevent intracavity coordination of DMSO with both porphyrin moieties. 1H NMR variable-temperature experiments of I (X = NR, R = R1) in DMSO show that the conformation of the dimer is greatly affected by temperature While at room temperature I (X = NR, R = R1) exists in more than one conformation, at higher temperatures (150°) only one conformation is populated. It is proposed that at room temperature, the existence of a H-bonding network between DMSO and the dimer results in more than one conformation, while at higher temperatures the network is destroyed to furnish an average conformation. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Electric Literature of 636-73-7

The Article related to porphyrin dimer preparation conformation, Biomolecules and Their Synthetic Analogs: Corrinoids, Porphyrins, and Bilines and other aspects.Electric Literature of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2008, Ramya, G.; Renugadevi, C.; Rao, Chepuri R. K.; Trivedi, D. C. published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Investigations on pyridine-3-sulfonic acid doped polyaniline and polypyrrole: Metal loading through dopant molecules. And the article contained the following:

Polyniline and polypyrrole were chem. and electrochem. synthesized in presence of pyridine-3-sulfonic acid. These conducting polymers were characterized by FT-IR, UV-vis, XRD, TGA and SEM techniques. Polyaniline showed a conductivity of 4 × 10-4 S/cm while polypyrrole exhibited a conductivity of 6.2 × 10-2 S/cm. The presence of pyridine ring in the dopant enabled the polymers to anchor Pd/or PdO through which the composite can work as catalytic material. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to pyridine sulfonic acid dopant polyaniline polypyrrole metal conductivity elec, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 10, 2004, Winther-Jensen, Bjorn; Chen, Jun; West, Keld; Wallace, Gordon published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Vapor Phase Polymerization of Pyrrole and Thiophene Using Iron(III) Sulfonates as Oxidizing Agents. And the article contained the following:

Vapor phase polymerization is a versatile technique that can be used to obtain highly conducting coatings of conjugated polymer on both conducting and nonconducting substrates. This is demonstrated here by preparation of polypyrrole, polybithiophene, and polyterthiophene, coatings that otherwise must be prepared electrochem. in order to achieve the desired high conjugation. The method is based on the use of organic ferric sulfonates as oxidant as these salts easily form smooth, noncrystalline films. By proper choice of the sulfonate anion, the oxidizing power of the ferric salt can be varied over a wide range. The described technique can easily be adapted to different patterning techniques. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to pyrrole thiophene vapor phase polymerization iron sulfonate oxidant, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 20, 2018, Fahrni, Christoph J.; McCallum, Adam M.; Morgan, Michael Thomas published a patent.Quality Control of Ethyl 6-cyanopicolinate The title of the patent was Preparation of substituted phenylthiazole compounds as zinc-selective fluorescent probes for emission-ratiometric imaging. And the patent contained the following:

The title compounds I [Z = II; X1-X4 = (independently) N and CH; Y1 = NR4, S, and O; Y2 = NR5, S, and O; R = Ar, OR4, N((CH2)qAr)2; R1-R4 = (independently) H, halo, alkyl, etc.; R5 = Cn-alkyl optionally substituted with OR4 or Ar; Ar = (independently) aryl and heteroaryl; n = 1-3; q = 1-3; and wherein any one of the aforementioned can be substituted or unsubstituted], useful for detecting zinc in a biol. sample (two-photo excitation microscopy (TPEM) or conventional fluorescence microscopy), were prepared E.g., a multi-step synthesis of III, starting from Et 6-bromopicolinate, was described. The latter was tested for Zn(II)-binding affinity and its analyte selectivity (data given). To evaluate the Zn(II)-dependent ratiometric response of III within the chem. complexity of a live cell, the authors performed a perfusion experiment with NIH 3T3 mouse fibroblasts as model system (data given). The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Quality Control of Ethyl 6-cyanopicolinate

The Article related to phenylthiazole preparation zinc selective fluorescent probe emission ratiometric imaging, two photo excitation microscopy tpem phenylthiazole preparation zinc probe, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Ethyl 6-cyanopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem