Tag: 100-200

On April 24, 2014, Xu, Wei; Wang, Yong; Ma, Sunghoon; Koltun, Elena S.; Kim, Byung Gyu; Jeong, Joon Won; Dhar, T.g. Murali; Bannen, Lynn Canne published a patent.Recommanded Product: 4-Chloro-2,6-difluoropyridine The title of the patent was Pyrimidine derivatives as RORγ modulators and their preparation. And the patent contained the following:

Described are RORγ modulators of formula I, and N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, and their compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune. Compounds of formula I wherein R1 is H, halo, CN, NO2, OH, etc.; dashed bonds are single and double bond; R2 is H, halo, CN, NO2, N3, etc.; R4 and R5 are independently H, Me and F; m and n are independently 0, 1, 2, and 3; each R6 is halo, CN, NO2, N3, OH, etc.; each Ra is H, halo, CN, NO2, etc.; Z is CO, CS, SO2 and CH2; G is a single bond, CH2, CHD, CD2, etc.; B is Ph, pyridyl, naphthyl, thiazolyl and pyrimidinyl; L is CONHCH2, CONHCH2CH2O, oxadiazolyl, etc.; A is Ph, pyridyl, pyrimidinyl, thiazolyl, pyrazolyl and pyrazinyl; and stereoisomeric forms, N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their RORγ modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 4.7 nM. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Recommanded Product: 4-Chloro-2,6-difluoropyridine

The Article related to pyrimidine preparation rorgamma modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 4-Chloro-2,6-difluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 1, 2011, Danila, Ion; Riobe, Francois; Piron, Flavia; Puigmarti-Luis, Josep; Wallis, John D.; Linares, Mathieu; Agren, Hans; Beljonne, David; Amabilino, David B.; Avarvari, Narcis published an article.Electric Literature of 75449-26-2 The title of the article was Hierarchical Chiral Expression from the Nano- to Mesoscale in Synthetic Supramolecular Helical Fibers of a Nonamphiphilic C3-Symmetrical π-Functional Molecule. And the article contained the following:

The controlled preparation of chiral structures is a contemporary challenge for supramol. science because of the interesting properties that can arise from the resulting materials, and here we show that a synthetic nonamphiphilic C3 compound containing π-functional tetrathiafulvalene units can form this kind of object. We describe the synthesis, characterization, and self-assembly properties in solution and in the solid state of the enantiopure materials. CD measurements show optical activity resulting from the presence of twisted stacks of preferential helicity and also reveal the critical importance of fiber nucleation in their formation. Mol. mechanics (MM) and mol. dynamics (MD) simulations combined with CD theor. calculations demonstrate that the (S) enantiomer provides the (M) helix, which is more stable than the (P) helix for this enantiomer. This relationship is for the first time established in this family of C3 sym. compounds In addition, we show that introduction of the “wrong” enantiomer in a stack decreases the helical reversal barrier in a nonlinear manner, which very probably accounts for the absence of a “majority rules” effect. Mesoscopic chiral fibers, which show inverted helicity, i.e. (P) for the (S) enantiomer and (M) for the (R) one, have been obtained upon reprecipitation from dioxane and analyzed by optical and electronic microscopy. The fibers obtained with the racemic mixture present, as a remarkable feature, opposite homochiral domains within the same fiber, separated by points of helical reversal. Their formation can be explained through an “oscillating” crystallization mechanism. Although C3 sym. disk-shaped mols. containing a central benzene core substituted in the 1,3,5 positions with 3,3′-diamido-2,2′-bipyridine based wedges have shown peculiar self-assembly properties for amphiphilic derivatives, the present result shows the benefits of reducing the nonfunctional part of the mol., in our case with short chiral isopentyl chains. The research reported herein represents an important step toward the preparation of functional mesostructures with controlled helical architectures. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to hierarchical chiral expression nanoscale mesoscale synthetic supramol helical fiber, Physical Organic Chemistry: Optical Rotatory Dispersion and Circular Dichroism and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 16, 2002, Horikiri, Tomonari published a patent.HPLC of Formula: 75449-26-2 The title of the patent was Liquid crystal composition and liquid crystal device and liquid crystal apparatus including the composition. And the patent contained the following:

A liquid crystal composition is principally constituted by at least a liquid crystal and a gel-forming compound forming a gel with the liquid crystal. The gel-forming compound has a discotic liquid crystal phase and has a property of assuming a supermol. structure when it is in mixture with the liquid crystal. The supermol. structure may preferably have at least one intermol. interacting side having at least one -CONH- group allowing multidimensional intermol. interaction. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).HPLC of Formula: 75449-26-2

The Article related to liquid crystal display gelation agent intermol hydrogen bond, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.HPLC of Formula: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 10, 2021, Bartolome-Nebreda, Jose Manuel; Trabanco-Suarez, Andres Avelino; De Lucas Olivares, Ana Isabel published a patent.Related Products of 1227595-34-7 The title of the patent was Synthesis of heterocyclic Oga inhibitors treating tauopathies, in particular Alzheimer’s and Parkinson’s diseases. And the patent contained the following:

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors I, tautomers, or stereoisomers such that Ra can be a six- or five-membered heteroaryl ring system or nine, ten membered bicyclic heterocyclic ring; L is selected from O, OCH2, or CH2O; R1a-b an R2a-b are independently H, Me or (un)substituted C1-3 alkyl; R is H or methyl; Rb can be a bicyclic heteroaryl ring systems are prepared as pharmaceutically acceptable salts and solvates. Of note, II was prepared for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer’s disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathol., in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations; or alpha synucleinopathies, in particular Parkinson’s disease, dementia due to Parkinson’s (or neurocognitive disorder due to Parkinson’s disease), dementia with Lewy bodies, multiple system atrophy, or alpha synucleinopathy caused by Gaucher’s disease. The experimental process involved the reaction of 4-(Chloromethyl)-2-methoxy-6-methylpyridine(cas: 1227595-34-7).Related Products of 1227595-34-7

The Article related to heterocyclic oga inhibitor preparation alzheimers parkinson tauopathy, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Related Products of 1227595-34-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 12, 2007, Korthals, Brigitte; Goettker-Schnetmann, Inigo; Mecking, Stefan published an article.Quality Control of Pyridine-3-sulfonic acid The title of the article was Nickel(II)-Methyl Complexes with Water-Soluble Ligands L [(salicylaldiminato-κ2N,O)NiMe(L)] and Their Catalytic Properties in Disperse Aqueous Systems. And the article contained the following:

Neutral (salicylaldiminato)nickel(II) Me complexes [{6-C(H):NAr-2,4-I2C6H2O-κ2N,O}NiMe(L)] (Ar = 2,6-{3,5-(F3C)2C6H3}2C6H3) with different water-soluble ligands L (2a, L = 1,3,5-triaza-7-phosphaadamantane; 2b, L = hexamethylenetetramine (urotropine); 2c, L = tetraethylammonium pyridine-3-sulfonate; 2d, L = amino-terminated poly(ethylene glycol) monomethoxy ether) were prepared 2A-d are potentially water-soluble catalyst precursors for ethylene polymerization, which form a water-insoluble active site [{κ2-N,O}NiR(ethylene)] (R = growing chain). Only complex 2d was water-soluble (>2 mmol L-1); 2c is soluble in water/2-propanol mixtures In toluene as a reaction medium, only the relatively weakly coordinated tertiary amine complex 2b is polymerization active (1.7 × 104 TO). In aqueous systems 2c,d are also active due to compartmentalization of the active site in the polymer particles and of L in the aqueous phase. Polyethylene particle sizes vary from 18 nm (dispersions formed with 2d) to over 0.5 μm (2c) to suspensions (2b) depending on the initial state of the reaction mixture, correlated with catalyst solubility The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Quality Control of Pyridine-3-sulfonic acid

The Article related to salicylaldiminato nickel methyl water soluble ligand complex preparation catalyst, polymerization catalyst salicylaldiminato nickel methyl water soluble ligand complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Quality Control of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 7, 2000, Davenport, Adam J.; Davies, David L.; Fawcett, John; Garratt, Shaun A.; Russell, David R. published an article.Quality Control of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine The title of the article was Arene ruthenium complexes with pyridyloxazolines: synthesis and applications as asymmetric catalysts for Diels-Alder reactions. And the article contained the following:

Reaction of the dimers [RuCl2(arene)]2 (arene = mesitylene, p-cymene, benzene, C6Me6) with pyridyloxazolines (pymox) gave complexes [RuCl(pymox)(arene)][SbF6] which have been fully characterized. Using chiral ligands diastereomers are formed, the diastereoselectivity depending on the substituents on the arene and on the oxazoline. The complexes [RuCl(Me2-pymox)(mes)][SbF6], [RuCl(Ph-pymox)(mes)][SbF6], [RuCl(iPr-pymox)(mes)][SbF6] and [RuCl(indanyl-pymox)(mes)][SbF6] (mes = mesitylene) have been characterized by x-ray crystallog. Treatment of these cations with AgSbF6 generates dications which in some cases can be isolated as aqua species [Ru(OH2)(pymox)(arene)]2+; these dications are enantioselective catalysts for Diels-Alder reactions of acroleins and dienes; a mechanism is proposed which accounts for the observed enantioselectivity. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Quality Control of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to arene ruthenium pyridyloxazoline preparation asym catalyst diels alder, crystal mol structure arene ruthenium pyridyloxazoline complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Quality Control of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 1, 1992, Schmuelling, M.; Ryabov, A. D.; Van Eldik, R. published an article.Computed Properties of 636-73-7 The title of the article was Steric and electronic tuning of the lability of square planar d8 metal complexes: platinum(II) ≡ palladium(II). And the article contained the following:

Electronic tuning of PtII complexes via cyclometalation, i.e. the introduction of a Pt-C bond trans to the leaving ligand, can increase their lability to that of related PdII complexes. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to ortho platinated aminomethylphenyl preparation substitution kinetics, platinum square planar aminomethylphenyl substitution kinetics, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1977, Mulvaney, R. L.; Bremner, J. M. published an article.Name: Pyridine-3-sulfonic acid The title of the article was Evaluation of antimetabolites for retardation of urea hydrolysis in soils. And the article contained the following:

Studies to evaluate 3 antimetabolites patented as inhibitors of urea [57-13-6] hydrolysis in soils (pyridine-3-sulfonic acid [636-73-7], desthiobiotin [533-48-2] and oxythiamine chloride [582-36-5]) showed that they had no effect on production of urease [9002-13-5] by soil microorganisms and did not retard urea hydrolysis in soils or reduce gaseous loss of urea N as NH3, even when applied at rates far exceeding those recommended for inhibition of urea hydrolysis. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Name: Pyridine-3-sulfonic acid

The Article related to soil urea hydrolysis antimetabolite, Fertilizers, Soils, and Plant Nutrition: Fertilizer-Soil Relations, Including Amendments and other aspects.Name: Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 23, 2013, Wang, Yansong; Kirschner, Alexander; Fabian, Anne-Katrin; Gopalakrishnan, Ranganath; Kress, Christoph; Hoogeland, Bastiaan; Koch, Uwe; Kozany, Christian; Bracher, Andreas; Hausch, Felix published an article.Formula: C9H8N2O2 The title of the article was Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control. And the article contained the following:

The design of efficient ligands remains a key challenge in drug discovery. In the quest for lead-like ligands for the FK506-binding protein 51 (FKBP51), we designed two new classes of bicyclic sulfonamides to probe the contribution of conformational energy in these ligands. The [4.3.1] scaffold had consistently higher affinity compared to the [3.3.1] or monocyclic scaffolds, which could be attributed to better preorganization of two key recognition motifs. Surprisingly, the binding of the rigid [4.3.1] scaffold was enthalpy-driven and entropically disfavored compared to the flexible analogs. Cocrystal structures at at. resolution revealed that the sulfonamide nitrogen in the bicyclic scaffolds can accept an unusual hydrogen bond from Tyr113 that mimics the putative FKBP transition state. This resulted in the first lead-like, functionally active ligand for FKBP51. Our work exemplifies how atom-efficient ligands can be achieved by careful conformational control even in very open and thus difficult binding sites such as FKBP51. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Formula: C9H8N2O2

The Article related to conformational control ligand fk506 binding protein 51, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Formula: C9H8N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2014, Cha, Sun Uk; Jung, Gyeong Seok; Park, Seok Bae; Kim, Hui Dae; Lee, Yu Rim; Song, Ju Man; Hwang, Mun Chan published a patent.Safety of 6-(tert-Butyl)pyridin-3-amine The title of the patent was Amine group substituted asymmetric pyrene derivative comprising pyridinyl group as electroluminescent dopant and/or organic semiconductor materials for organic light-emitting device. And the patent contained the following:

The present invention relates to an amine group substituted asym. pyrene derivative, and an organic light-emitting device comprising the same. The amine group substituted asym. pyrene derivative comprising pyridinyl group is represented by formula I (Py1, Py2 = substituted or unsubstituted pyridinyl group; Ar1, Ar2 = substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C50 aryl group, C2-C50 heteroaryl group having one or more substituted or unsubstituted atoms selected from oxygen, nitrogen, sulfur and silicon; Z = hydrogen, deuterium, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C5-C50 aryl group, substituted or unsubstituted C2-C30 alkenyl group, substituted or unsubstituted C2-C20 alkynyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C30 cycloalkenyl group, etc.; and m = integer of 1-8, where the substituted or unsubstituted substitution is selected from deuterium, cyano group, halogen, hydroxyl group, nitro group, C1-C24 alkyl group, etc.). The organic light-emitting device comprises: a first electrode; a second electrode placed opposite to the first electrode; and an organic layer placed between the first and second electrodes, where the organic layer includes an organic light-emitting compound i.e. amine group substituted asym. pyrene derivative The organic layer is selected from hole injection layer having hole injection function, hole transport layer having hole transport function, functional layer, light-emitting layer, electron transport layer, and electron injection layer. According to the present invention, the amine group substituted asym. pyrene derivative has excellent luminous efficiency and high-color purity, and is utilized in the organic light-emitting device for producing full-color display. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Safety of 6-(tert-Butyl)pyridin-3-amine

The Article related to amine group asym pyrene derivative pyridinyl electroluminescent dopant oled, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Safety of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem