Tag: 100-200

On November 1, 1981, Dommisse, Roger; Freyne, Eddy; Esmans, Eddy; Lepoivre, Josef; Alderweireldt, Frank published an article.Product Details of 73591-69-2 The title of the article was Carbon-13 NMR shift increments for 3-substituted pyridines. And the article contained the following:

The 13C NMR spectra of sixteen 3-substituted and 3,5-disubstituted pyridines are assigned. The substituent shift increment for the 3-Ac group is reassigned, and new shift increments for 3- and 5-substituents are proposed. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Product Details of 73591-69-2

The Article related to nmr pyridine substituent effect, acetylpyridine carbon nmr, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Product Details of 73591-69-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2004, Schilf, Wojciech published an article.Electric Literature of 75449-26-2 The title of the article was The spectroscopic study of hydrogen bonding in some 3,3′-derivatives of 2,2′-bipyridyl. And the article contained the following:

Four 3,3′-derivatives of 2,2′-bipyridyl have been investigated by multinuclear NMR, IR and X-ray methods. In all cases the weak intramol. hydrogen bonds between exocyclic nitrogen-containing substituent and pyridine-type ring nitrogen atom were found. In contrast to the previous results the nitrogen chem. shifts of pyridine ring atom do not provide valuable information about hydrogen bond strength. The presence of intramol. hydrogen bonds was confirmed by nitrogen chem. shifts of exocyclic amino and acetamide groups, deuterium isotope effects in the solid state and IR measurements in both chloroform solution and the solid state. The X-ray structures obtained for asym. 3-amino-3′-methylamino and 3,3′-diacetamide derivatives confirmed conclusions made on the base of spectral results. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to hydrogen bond bipyridyl derivative nmr ir crystallog, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 7, 2021, Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine The title of the article was NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules. And the article contained the following:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to hydrogen bond accepting ability nmr chem shift, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 1998, Yang, Fang-zu; Xu, Shu-kai; Huang, Ling; Zhang, Xue-ying; Zhou, Shao-min published an article.SDS of cas: 636-73-7 The title of the article was A study on the effect of bath composition on the internal stress of a palladium electrodeposit. And the article contained the following:

The effects of bath composition on the internal stress of palladium electrodeposits are studied in neutral media with Pd(NH3)2Cl2, K3C6H5O7, (NH4)2C2O4 and the additives of the mixture of the synthesized products of nicotinic acid and nicotiamide (NANA), pyridine-3-sulfonic acid (PSA), α-furan formic acid (FF) and cetyl tri-Me ammonium bromide (CTMAB). The internal stress of electrodeposits is quite changeable at the beginning of electrodeposition, later becoming stable gradually. Deposits obtained from pulse electrodeposition have lower stress than that from d.c. After electrodeposition, all the deposits keep the tensile stress which increases with time. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to palladium electroplating residual stress, Nonferrous Metals and Alloys: Surface Treatment, Metallic and Nonmetallic Coating, Sealing, Cleaning, Polishing, Etching, and Pickling and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 12, 1998, Daines, Robert A. published a patent.Name: N,3-Dimethylpyridin-2-amine The title of the patent was Preparation of 3,4-dinitrobenzamides as calcitonin gene related peptide receptor ligands.. And the patent contained the following:

Title compounds [I; R1 = H, Me, alkyl, phenylalkyl, heterocyclylalkyl, aminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, etc.; R2 = (substituted) aryl, heteroaryl, arylalkyl, heteroarylalkyl; R1R2N = (benzo-fused) 5-6 membered heterocyclyl], were prepared Thus, N-methylaniline in CH2Cl2 was treated with Et3N and then with 3,4-dinitrobenzoyl chloride and the mixture was shaken overnight to give N-methyl-N-phenyl-3,4-dinitrobenzamide. I antagonized CGRP receptors with IC50 = 0.001-100 μM. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Name: N,3-Dimethylpyridin-2-amine

The Article related to nitrobenzamide preparation cgrp related disease treatment, calcitonin gene related peptide antagonist dinitrobenzamide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Name: N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 17, 2019, Ahmad, Nadia; Anderson, Corey; Arumugam, Vijayalaksmi; Asgian, Iuliana Luci; Camp, Joanne Louise; Fanning, Lev Tyler Dewey; Hadida Ruah, Sara Sabina; Hurley, Dennis; Schmidt, Yvonne; Shaw, David; Sheth, Urvi Jagdishbhai; Thomson, Stephen Andrew published a patent.Recommanded Product: Methyl 5-amino-4-methylpicolinate The title of the patent was Preparation of (hetero)aromatic carboxamides as modulators of sodium channels for the treatment of diseases. And the patent contained the following:

The invention relates to preparation of aryl heteroaryl carboxamides and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The example compound I was prepared by multistep synthesis (procedure given). Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Recommanded Product: Methyl 5-amino-4-methylpicolinate

The Article related to aryl heteroaryl carboxamide preparation sodium channel modulator disease treatment, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: Methyl 5-amino-4-methylpicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 9, 2016, Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; Truong, Yen published a patent.Safety of Methyl 2-amino-5-chloroisonicotinate The title of the patent was Thio-substituted benzamides as antiviral agents for the treatment of treatment HBV infection and their preparation. And the patent contained the following:

The invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of formula I. Compounds of formula I wherein each R1, R2, and R3 are halo; R4 is (un)substituted C3-7 cycloalkyl (un)substituted C1-6 alkyl-C3-7 cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by thioetherification of N-(3,4,5-trifluoromethylphenyl)-4-fluoro-3-iodobenzamide with 1-(mercaptomethyl)cyclopropylacetic acid. The invention compounds were evaluated for their antiviral activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Safety of Methyl 2-amino-5-chloroisonicotinate

The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-amino-5-chloroisonicotinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 1, 2013, Zhao, Hong-Wu; Yue, Yuan-Yuan; Li, Hai-Long; Song, Xiu-Qing; Sheng, Zhi-Hui; Yang, Zhao; Meng, Wei; Yang, Ze published an article.Synthetic Route of 75449-26-2 The title of the article was Novel axially unfixed biaryl-based water-compatible organocatalysts: design, synthesis and their asymmetric catalysis in direct aldol reactions in water. And the article contained the following:

A family of novel axially unfixed biaryl-based, water-compatible bifunctional organocatalysts I [R = 4-MeC6H4, 4-MeC6H4, 1-naphthyl; X = CH, N] were designed and synthesized for asym. catalytic direct aldol reactions in water. These organocatalysts are comprised of prolinamide, aromatic sulfonamide and biaryl motifs. Under the optimal reaction conditions, one organocatalyst in particular delivered excellent stereocontrol (up to 99% ee and 99:1 dr) in direct aldol reactions of cyclohexanone with a variety of aromatic aldehydes in water. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to asym aldol addition biaryl catalyst preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pop, Flavia; Melan, Caroline; Danila, Ion; Linares, Mathieu; Beljonne, David; Amabilino, David B.; Avarvari, Narcis published an article in 2014, the title of the article was Hierarchical Self-Assembly of Supramolecular Helical Fibres from Amphiphilic C3-Symmetrical Functional Tris(tetrathiafulvalenes).Name: [2,2′-Bipyridine]-3,3′-diamine And the article contains the following content:

The preparation and self-assembly of the enantiomers of C3-sym. compounds incorporating three tetrathiafulvalene (TTF) residues is reported. The chiral citronellyl and dihydrocitronellyl alkyl chains lead to helical one dimensional stacks in solution Mol. mechanics and dynamics simulations combined with exptl. and theor. CD support the observed helicity in solution These stacks self-assemble to give fibers that have morphologies that depend on the nature of the chiral alkyl group and the medium in which the compounds aggregate. An inversion of macroscopic helical morphol. of the citronellyl compound is observed when compared to analogous 2-methylbutyl chains, which is presumably a result of the stereogenic center being further away from the core of the mol. This composition still allows both morphologies to be observed, whereas an achiral compound shows no helicity. The morphol. of the fibers also depends on the flexibility at the chain ends of the amphiphilic components, as there is not such an apparently persistent helical morphol. for the dihydrocitronellyl derivative as for that prepared from citronellyl chains. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Name: [2,2′-Bipyridine]-3,3′-diamine

The Article related to hierarchical self assembly supramol helix amphiphilic c3 sym tetrathiafulvalene, c3 symmetry, circular dichroism, electronic microscopy, supramolecular chirality, tetrathiafulvalene and other aspects.Name: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 1982, McPheat, W. L.; Wardlaw, A. C. published an article.Related Products of 636-73-7 The title of the article was Inhibition of nicotinic acid and nicotinamide uptake into Bordetella pertussis by structural analogs. And the article contained the following:

The nicotinic acid (I) and nicotinamide (II) structural analogs, 3-pyridinecarboxaldehyde (III) and 3-pyridinealdoxime (IV) (both 500 and 50 μM), but not isonicotinamide, isonicotinic acid, 6-aminonicotinic acid, 6-aminonicotinamide, isoniazid, 3-acetylpyridine, 3-pyridylacetic acid, N,N-diethylnicotinamide, or 3-pyridinesulfonic acid, were effective and specific inhibitors of the uptake of I and II by B. pertussis, although neither compound inhibited the growth of the bacteria in liquid medium or the oxidation of glutamate by washed suspensions. 3-Pyridylcarbinol, at the same dose, was inhibitory, but less so than III and IV. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Related Products of 636-73-7

The Article related to nicotinate nicotinamide transport metabolism bordetella, pyridinecarboxaldehyde bordetella nicotinamide uptake inhibition, pyridinealdoxime bordetella nicotinamide uptake inhibition and other aspects.Related Products of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem