Tag: 100-200

On July 29, 2021, Rai, Roopa; Booth, Robert; Green, Michael J. published a patent.Name: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of substituted (aza)benzimidazole-, indole-, quinolinecarboxamides and analogs as PGDH inhibitors. And the patent contained the following:

The title compounds I [X = OCH2, C(O)NH, NHC(O), etc.; each Y = (independently) N and substituted CH; each R1 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; R2 = H and R3 = CF3; or R2 and R3 are taken together to form oxo or thio; each R4 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; each R5 = (independently) halo, (halo)alkyl, cycloalkyl, etc.; n = 0-5; m = 0-4; and p = 0-10; with the proviso] or pharmaceutically acceptable salts thereof that can inhibit 15-hydroxyprostaglandin dehydrogenase, were prepared E.g., a multi-step synthesis of II, starting from 4-fluoro-3-nitrobenzoic acid, was described. Exemplified compounds I were evaluated in the hPGDH inhibitor screening biochem. assay (data given for representative compounds I). Compounds I may be administered to subjects that may benefit from modulation of prostaglandin levels. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Name: 6-(tert-Butyl)pyridin-3-amine

The Article related to benzimidazole azabenzimidazole indole quinoline carboxamide preparation pgdh inhibitor, prostaglandin level modulator benzimidazole azabenzimidazole indole quinoline carboxamide preparation, hydroxyprostaglandin dehydrogenase inhibitor benzimidazole azabenzimidazole indole quinoline carboxamide preparation and other aspects.Name: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 21, 1994, Schmuelling, Michael; Ryabov, Alexander D.; van Eldik, Rudi published an article.COA of Formula: C5H5NO3S The title of the article was To what extent can the Pt-C bond of a metallacycle labilize the trans position? A temperature- and pressure-dependent mechanistic study. And the article contained the following:

The orthoplatinated complexes [Pt{C6H3X(CH2NMe2)}(NC5H4SO3-3)(H2O)] (X = H 1a or 3-MeO 1b) were designed for mechanistic studies in H2O. The aqua ligand is located trans to the Pt-C bond of the Ph group which lies in the Pt(II) coordination plane. The rates of substitution of the aqua ligand by nucleophiles (Nu) (Cl-, Br-, I-, N3-, SCN-, thiourea, N,N’-dimethylthiourea or N,N,N’,N’-tetramethylthiourea) were studied as a function of concentration, pH, temperature, and pressure by using a stopped-flow technique. The pKa value of the aqua ligand in 1a is 9.75 ± 0.505 and the observed pseudo-first-order rate constants for the substitution reaction are given by kobs = k1[Nu] + k-1. The k-1 term arises from the reverse solvolysis reaction and is insignificant for stronger, S-donor nucleophiles. The values of k1 are ∼4 orders of magnitude higher than the corresponding rate constants for anation reactions of [Pt(dien)(H2O)]2+ (dien = diethylenetriamine) and close to the rate constants for anation of [Pd(dien)(H2O)]2+. The effect is largely due to a strong decrease in ΔH⧧, ΔS⧧ and ΔV⧧, clearly shows that the substantial rate increase is not associated with a changeover in mechanism and that the substitution process is still associative. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).COA of Formula: C5H5NO3S

The Article related to substitution kinetics nucleophile aminomethylplatinum complex, platinum aminomethyl substitution kinetics nucleophile, reactivity aminomethylplatinum complex nucleophile, reaction mechanism aminomethylplatinum complex nucleophile substitution, bond platinum carbon lability aminomethylplatinum metallacycle and other aspects.COA of Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 20, 2010, Soll, Mark David; Le Hir De Fallois, Loiec Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms; Beck, Brent Christopher published a patent.Synthetic Route of 1086838-13-2 The title of the patent was Preparation of enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds. And the patent contained the following:

The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives substantially enriched in an enantiomer of formula I (wherein P is C-R1 or N; Q is C-R2 or N; V is C-R8 or N; W is C-R9 or N; X is C-R10 or N; Y is C-R11 or N; R1, R2 R8, R9, R10 and R11 are independently H, NH2, amido, etc.; R3, R4 and R5 are independently H, halo, alkyl, etc., or R4 and R5 form part of a cycloalkyl ring; R6 is H, alkyl, alkoxyalkyl, etc. ; R7 is H, alkyl, cycloalkyl, etc.; Z is a direct bond, C(O), C(S) or S(O)p; a = 1-3; p = 0-2), compositions thereof, processes for their preparation, and their uses as pesticides, in particular for controlling endo- and ectoparasites that are harmful to mammals, fish and birds. Example compound II, prepared by reacting 4-trifluoromethoxybenzoyl chloride and (R)-2-amino-3-(6-bromopyrazolo[4,3-b]pyridin-2-yl)-2-methylpropionitrile (preparation given), showed 100% efficacy against ivermectin-resistant endoparasites at an oral dose of 1.5 mg/kg in sheep. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Synthetic Route of 1086838-13-2

The Article related to enantiomerically enriched aryloazolyl cyanoethylamino parasiticide preparation, benzotriazole cyanoethylamino preparation antiparasitic endoparasite ectoparasite, indazole cyanoethylamino preparation parasiticidal infection, endoparasite ectoparasite pesticidal pyrazolopyridine cyanoethylamino preparation and other aspects.Synthetic Route of 1086838-13-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gurak, John A. Jr.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M. published an article in Tetrahedron. The title of the article was 《N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination》.Product Details of 627501-18-2 The author mentioned the following in the article:

A selective N-alkylation reaction of 2-pyridones and related heterocycles via intermol. alkene hydroamination is reported. The reaction utilizes palladium(II) acetate as a catalyst and employs a bidentate directing group to dictate the regioselectivity for both unactivated terminal and internal alkenes. High functional group tolerance is observed across a wide range of electronically diverse 2-pyridones and other aza-heterocycles, including 1-hydroxyisoquinoline, 2-hydroxyquinoline, pyridazinone, pyrimidinone, and pyrazinone to obtain the corresponding products, e.g., I (X-ray single crystal structure shown). After reading the article, we found that the author used 5-Chloro-6-hydroxynicotinaldehyde(cas: 627501-18-2Product Details of 627501-18-2)

5-Chloro-6-hydroxynicotinaldehyde(cas: 627501-18-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 627501-18-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 102645-33-0On November 4, 2016 ,《Synthesis of Enantiomerically Pure Ring-Substituted L-Pyridylalanines by Biocatalytic Hydroamination》 appeared in Organic Letters. The author of the article were Ahmed, Syed T.; Parmeggiani, Fabio; Weise, Nicholas J.; Flitsch, Sabine L.; Turner, Nicholas J.. The article conveys some information:

Current routes to nitrogen-containing heteroarylalanines involve complex multistep synthesis and are often reliant on protection/deprotection steps and wasteful chromatog. purifications. In order to complement existing methodologies, a convenient telescopic strategy was developed for the synthesis of L-pyridylalanine analogs (12 examples) and other L-heteroarylalanines (5 examples) starting from the corresponding aldehydes. A phenylalanine ammonia lyase (PAL) from Anabaena variabilis was used as the biocatalyst to give conversions ranging between 88 and 95%, isolated yields of 32-60%, and perfect enantiopurity (>99% ee) by employing an addnl. deracemization cascade where necessary. In addition to this study using 2,5-Dichloroisonicotinaldehyde, there are many other studies that have used 2,5-Dichloroisonicotinaldehyde(cas: 102645-33-0Recommanded Product: 102645-33-0) was used in this study.

2,5-Dichloroisonicotinaldehyde(cas: 102645-33-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 102645-33-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly Efficient and Selective Visible-Light Driven CO2 Reduction by Two Co-Based Catalysts in Aqueous Solution》 was written by Zhang, Liyan; Li, Shiwei; Liu, Huiping; Cheng, Yuan-Sheng; Wei, Xian-Wen; Chai, Xiaomin; Yuan, Guozan. Category: pyridine-derivativesThis research focused onVisible Light driven CO2 reduction cobalt catalyst aqueous solution; crystal structure cobalt dipicolylamine complex; Fluorescence lifetime ruthenium phenanthroline cobalt complex catalyst. The article conveys some information:

Photocatalytic CO2 reduction has been considered as a promising approach to solve energy and environmental problems. Nevertheless, developing inexpensive photocatalysts with high efficiency and selectivity remains a big challenge. In this study, two Co-based complexes [Co2(L1)Cl2] I (1-Co) and [Co(L2)Cl] II (2-Co) were synthesized by treating two DPA-based (DPA: dipicolylamine) ligands with Co2+, resp. Under visible-light irradiation, the performance of 1-Co as a homogeneous photocatalyst for CO2 reduction in aqueous media has been explored by using [Ru(phen)3]2+ as a photosensitizer, and triethylolamine (TEOA) as a sacrificial reductant. 1-Co shows high photocatalytic activity for CO2-to-CO conversion, corresponding to the high TONCO of 2600 and TOFCO of 260 h-1 (TONCO = turnover number for CO; TOFCO = turnover frequency for CO). High selectivity of 97% for CO formation is also achieved. The control experiments catalyzed by 2-Co demonstrated that two Co(II) centers in 1-Co may operate independently and activate one CO2 mol. each. Furthermore, the proposed mechanism of 1-Co for photocatalytic CO2 reduction has been investigated via electrochem. anal., a series of quenching experiments, and d. functional theory calculations In aqueous solution, two Co-based complexes display high photocatalytic activity, selectivity, and durability for CO2-to-CO conversion. The photocatalytic mechanism of 1-Co has been investigated in detail. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2022 ,《Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives》 was published in Organic Letters. The article was written by Monteith, John J.; Scotchburn, Katerina; Mills, L. Reginald; Rousseaux, Sophie A. L.. The article contains the following contents:

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions and ease of starting material synthesis. The use of transition metal catalysis to access a diverse range of thiocarbonyl containing compounds provides a useful complementary approach when compared to previously established methodologies. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H5BrN2In 2019 ,《Lewis-Acid-Catalyzed Direct Nucleophilic Substitution Reaction of Alcohols for the Functionalization of Aromatic Amines》 was published in ChemistrySelect. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Rana, Rohit; Upadhyay, Rahul; Maurya, Sushil K.. The article contains the following contents:

Herein, an efficient catalytic activity of tin(II) triflate for the N-alkylation of secondary anilines with alcs. for the synthesis of tertiary benzylamines I (R1 = H, 3-OMe, 4-Br, etc.; R2 = H, 4-F, 3-Me, etc.; R3 = Me, Et, i-Pr, allyl) was explored. Mechanistic studies suggest that the developed protocol follows direct nucleophilic substitution pathway instead of imine or enamine pathway. The developed method is also useful for the synthesis of secondary amines as well as late stage functionalization of naturally occurring alcs. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Electric Literature of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2019 ,《CoII Complexes with a Tripyridine Ligand, Containing a 2,6-Di-tert-butylphenolic Fragment: Synthesis, Structure, and Formation of Stable Radicals》 appeared in ACS Omega. The author of the article were Dorofeeva, Victoria N.; Pavlishchuk, Anna V.; Kiskin, Mikhail A.; Efimov, Nikolay N.; Minin, Vadim V.; Lytvynenko, Anton S.; Gavrilenko, Konstantin S.; Kolotilov, Sergey V.; Novotortsev, Vladimir M.; Eremenko, Igor L.. The article conveys some information:

Interaction of tripyridine ligand, bearing 2,6-di-tert-butylphenolic fragment (L, 2,6-di-tert-butyl-4-(3,5-bis(4-pyridyl)pyridyl)phenol) with CoII pivalate or chloride gave 1D coordination polymers [Co(L)Cl2]n·nEtOH (1) and [Co3(L)2(OH)(Piv)5]n (2) or trinuclear complex Co3(H2O)4(L)2Cl6 (3) (Piv- = pivalate). Chem. oxidation of L, 1-3 by PbO2 or K3[Fe(CN)6], as well as exposure of L (in solution or solid state) and 2 (in solid state) to UV-irradiation gave free radicals with g = 2.0024, which probably originated due to oxidation of 2,6-di-tert-butylphenolic groups. These radicals were stable during several days in solutions and more than one month in solid samples. Irradiation and oxidation of the solid samples probably caused formation of the phenoxyl radical only on their surface. It was shown by DFT calculations that exchange coupling between the unpaired electron of the phenoxyl and CoII ions were negligibly weak and could not affect EPR signal of the radical, as well as exchange coupling of CoII ions could not be transmitted by L. The latter conclusion was confirmed by the anal. of magnetic properties of 1: temperature dependency of magnetic susceptibility (χM) of 1 could be simulated by a simple model for isolated CoII ions.4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Messa, Francesco; Dilauro, Giuseppe; Paparella, Andrea Nicola; Silvestri, Lavinia; Furlotti, Guido; Iacoangeli, Tommaso; Perrone, Serena; Salomone, Antonio published an article in Green Chemistry. The title of the article was 《Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C》.Product Details of 2510-22-7 The author mentioned the following in the article:

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodol. has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem