Tag: 100-200

In 2022,Oppermann, Malte; Zinna, Francesco; Lacour, Jerome; Chergui, Majed published an article in Nature Chemistry. The title of the article was 《Chiral control of spin-crossover dynamics in Fe(II) complexes》.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Iron-based spin-crossover complexes hold tremendous promise as multifunctional switches in mol. devices. However, real-world technol. applications require the excited high-spin state to be kinetically stable-a feature that has been achieved only at cryogenic temperatures Here the authors demonstrate high-spin-state trapping by controlling the chiral configuration of the prototypical iron(II)tris(4,4′-dimethyl-2,2′-bipyridine) in solution, associated for stereocontrol with the enantiopure Δ- or Λ-enantiomer of tris(3,4,5,6-tetrachlorobenzene-1,2-diolato-κ2O1,O2)phosphorus(V) (P(O2C6Cl4)3- or TRISPHAT) anions. The authors characterized the high-spin-state relaxation using broadband ultrafast CD spectroscopy in the deep UV in combination with transient absorption and anisotropy measurements. The authors find that the high-spin-state decay is accompanied by ultrafast changes of its optical activity, reflecting the coupling to a symmetry-breaking torsional twisting mode, contrary to the commonly assumed picture. The diastereoselective ion pairing suppresses the vibrational population of the identified reaction coordinate, thereby achieving a fourfold increase of the high-spin-state lifetime. More generally, the authors’ results motivate the synthetic control of the torsional modes of iron(II) complexes as a complementary route to manipulate their spin-crossover dynamics. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Lee, Yujeong; Onishi, Yoshiyuki; McPherson, Lisa; Kietrys, Anna M.; Hebenbrock, Marian; Jun, Yong Woong; Das, Ishani; Adimoolam, Shanthi; Ji, Debin; Mohsen, Michael G.; Ford, James M.; Kool, Eric T. published an article in ACS Chemical Biology. The title of the article was 《Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1》.SDS of cas: 2510-22-7 The author mentioned the following in the article:

Here, it is reported that selected tyrosine kinase (TK) inhibitors including nilotinib, employed clin. in the treatment of chronic myeloid leukemia, are activators of the repair enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses the oxidatively damaged cellular nucleotide pool by hydrolyzing the oxidized nucleotide 8-oxo-2′-deoxyguanosine (8-oxo-dG)TP, which is a highly mutagenic lesion when incorporated into DNA. Structural optimization of analogs of TK inhibitors resulted in compounds such as SU0448, which induces 1000 +/- 100% activation of MTH1 at 10μM and 410 +/- 60% at 5μM. The compounds are found to increase the activity of the endogenous enzyme, and at least one (SU0448) decreases levels of 8-oxo-dG in cellular DNA. The results suggest the possibility of using MTH1 activators to decrease the frequency of mutagenic nucleotides entering DNA, which may be a promising strategy to suppress tumorigenesis in individuals with elevated cancer risks. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Roy, Sebastien A.; Zgheib, Jose; Zhou, Cuihan; Arndtsen, Bruce A. published an article in 2021. The article was titled 《Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes》, and you may find the article in Chemical Science.Formula: C6H6BrN The information in the text is summarized as follows:

Authors report herein the development of a palladium-catalyzed, multicomponent synthesis of indolizines. The reaction proceeds via the carbonylative formation of a high energy, mesoionic pyridine-based 1,3-dipole, which can underwent spontaneous cycloaddition with alkynes. Overall, this provides a route to prepare indolizines in a modular fashion from combinations of com. available or easily generated reagents: 2-bromopyridines, imines and alkynes. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Yuan-Ping; Yang, Sizhuo; Wang, Peng; Guo, Jin-Han; Huang, Jier; Sun, Wei-Yin published their research in Dalton Transactions in 2021. The article was titled 《Iron(III)-bipyridine incorporated metal-organic frameworks for photocatalytic reduction of CO2 with improved performance》.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine The article contains the following contents:

Metal-organic frameworks (MOFs) represent an emerging class of platforms to assemble single site photocatalysts for artificial photosynthesis. In this work, we report a new CO2 reduction photocatalyst (UiO-68-Fe-bpy) based on a robust Zr(IV)-MOF platform with incorporated Fe(bpy)Cl3 (bpy refers to the 4′-methyl-[2,2′-bipyridine] moiety) via amine-aldehyde condensation. We show that this hybrid catalyst can reduce CO2 to form CO under visible light illumination with excellent selectivity and enhanced activity with respect to its parent MOF and corresponding homogeneous counterpart. Using steady state and transient absorption (TA) spectroscopy, we show that the enhanced photocatalytic activity of UiO-68-Fe-bpy is attributed to the elongated excited state lifetime of Fe(bpy)Cl3 after being incorporated to the UiO-68-NH2 platform. This work demonstrates the great potential of MOFs as a next generation platform for solar fuel conversion. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bag, Sukdev; Jana, Sadhan; Pradhan, Sukumar; Bhowmick, Suman; Goswami, Nupur; Sinha, Soumya Kumar; Maiti, Debabrata published their research in Nature Communications in 2021. The article was titled 《Imine as a linchpin approach for meta-C-H functionalization》.Reference of 5-Bromo-2-chloropyridine The article contains the following contents:

An temporary directing group (TDG) for meta-C-H functionalization via reversible imine formation were reported. By overruling facile ortho-C-H bond activation by imine-N atom, a suitably designed pyrimidine-based TDG successfully delivered selective meta-C-C bond formation. Application of this temporary directing group strategy for streamlining the synthesis of complex organic mols. without any necessary pre-functionalization at the meta position were explored.5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phosphate and Water Sensing with a Zinc-Dipicolylamine-Based Charge-Transfer Dye》 was written by Gayton, Jacqueline; Autry, Shane A.; Kolodziejczyk, Wojciech; Hill, Glake A.; Hammer, Nathan I.; Delcamp, Jared H.. Recommanded Product: Bis(pyridin-2-ylmethyl)amine And the article was included in ChemistrySelect in 2020. The article conveys some information:

A D-π-A (donor-π bridge-acceptor) dye with a conjugated dipicolylamine group as the donor was synthesized and characterized. When zinc is bound to the dipicolylamine ligand, charge transfer strength from the donor is decreased resulting in a large blue-shift in the absorption spectrum with a quenching of dye emission. Upon addition of phosphate, changes in both the absorption and emission spectrum are observed with intermediate states between the starting zinc complex and free dye observed The zinc-dye complex was found to react with two equivalent of phosphate or trace water to give the free dye. The water response is unexpected given the widespread use of the dipicolylamine group as an anion sensor in water. When the dipicolylamine group is part of conjugated D-π-A dye designs with zinc complexes, the dye is observed to act as a humidity sensor at low water amounts In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《ON/OFF Photoswitching and Thermoinduced Spin Crossover with Cooperative Luminescence in a 2D Iron(II) Coordination Polymer》 was written by Ghosh, Subrata; Kamilya, Sujit; Pramanik, Titas; Rouzieres, Mathieu; Herchel, Radovan; Mehta, Sakshi; Mondal, Abhishake. Related Products of 2510-22-7 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

A 2D coordination polymer, {[Fe(L)2(NCSe)2]·6MeOH·14H2O}n (1; L = 2,5-dipyridylethynylene-3,4-ethylenedioxythiophene), has been synthesized based on a redox active luminescence ligand. 1 possesses a 2D [4 x 4] square-grid network where the iron(II) center is in a FeN6 octahedral coordination environment. 1 displays reversible thermoinduced high-spin (HS; S = 2) to diamagnetic low-spin (LS; S = 0) ON/OFF spin-state switching with a T1/2 value of 150 K. Interestingly, optical reflectivity and photomagnetic studies at 10 K under light irradiation revealed an efficient conversion to a photoinduced metastable HS excited state from a LS ground state. Remarkably, the photoexcited HS state can be reversibly switched ON and OFF by using 625 and 850 nm light-emitting-diode lights. Intriguingly, the thermal dependence of the luminescence intensity of the maximum emission at 524 nm for 1 shows a min. at around the spin-crossover (SCO) temperature, indicating a cooperative nature between the SCO and luminescence properties. Theor. calculations confirmed the above findings. A 2D [4 x 4] square-grid iron(II) coordination polymer based on a 3,4-ethylenedioxythiophene-containing redox active luminescence ligand has been investigated. Temperature and/or light irradiation significantly alters the cooperative magnetic and optical properties, implying that the material exhibits reversible thermo- and photoinduced ON/OFF spin-state switching behavior with cooperative luminescence properties. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis》 was written by Landstrom, Evan B.; Akporji, Nnamdi; Lee, Nicholas R.; Gabriel, Christopher M.; Braga, Felipe C.; Lipshutz, Bruce H.. Application In Synthesis of 2-Bromo-5-methylpyridine And the article was included in Organic Letters in 2020. The article conveys some information:

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technol. includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigmatropic rearrangement reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Jing, Hua-qing; Li, Hong-liang; Antilla, Jon C.. Application In Synthesis of 2-Bromo-5-methylpyridine The article mentions the following:

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigmatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, characterization of peripherally tetra-pyridine-triazole-substituted phthalocyanines and their inhibitory effects on cholinesterases (AChE/BChE) and carbonic anhydrases (hCA I, II and IX)》 was published in Dalton Transactions in 2020. These research results belong to Arslan, Tayfun; Bugrahan Ceylan, M.; Bas, Huseyin; Biyiklioglu, Zekeriya; Senturk, Murat. Quality Control of 4-Ethynylpyridine The article mentions the following:

In this study, phthalocyanine precursors (5 and 9) and 1,2,3-triazole-substituted metal-free and metallo phthalocyanines (9a-c) were designed and synthesized for the first time and evaluated in vitro for key mol. targets. The structures of the novel compounds were characterized via FT-IR, 1H/13C NMR, UV-Vis, and mass spectroscopy. The inhibitory activities of the compounds were tested against human carbonic anhydrase isoforms hCA I, II (cytosolic, ubiquitous isoenzymes), and IX (transmembrane, cancer-associated isoenzyme) and cholinesterases (AChE and BChE, which are associated with Alzheimer’s disease). Among the three phthalocyanines and starting compounds, 9b showed the most interesting profile as a nanomolar selective inhibitor of hCA I (Ki = 37.2 nM) and 9c showed the most effective inhibitory effect on hCA II, IX, AChE and BChE (Ki = 41.9, 27.4, 5.8 and 45.8 nM, resp.). This study is also the first example of cancer-associated isoenzyme hCA IX inhibition by phthalocyanines. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem