Tag: 100-200

Related Products of 1122-54-9In 2022 ,《Preparation of chiral aryl alcohols: a controllable enzymatic strategy via light-driven NAD(P)H regeneration》 appeared in New Journal of Chemistry. The author of the article were Xing, Xiu; Liu, Yan; Shi, Ming-Liang; Li, Kun; Fan, Xin-Yue; Wu, Zhong-Liu; Wang, Na; Yu, Xiao-Qi. The article conveys some information:

Controllable and mild photoenzymic production of chiral alcs. RCH(OH)R1 [R = Ph, 4-pyridyl, 2-naphthyl, etc.; R1 = H, Me, CH2CO2Me, etc.] was realized by coupling a versatile photochem. NAD(P)H regeneration system with (R)- or (S)-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcs. Various chiral alcs. with complementary (R)- and (S)-conformations could be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee). The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-BromonicotinaldehydeIn 2019 ,《Ligand Structure Effects on Molecular Assembly and Magnetic Properties of Copper(II) Complexes with 3-Pyridyl-Substituted Nitronyl Nitroxide Derivatives》 appeared in ACS Omega. The author of the article were Sherstobitova, Tatiana; Maryunina, Kseniya; Tolstikov, Svyatoslav; Letyagin, Gleb; Romanenko, Galina; Nishihara, Sadafumi; Inoue, Katsuya. The article conveys some information:

Reaction of Cu(hfac)2 with methyl- and bromo-3-pyridyl-substituted nitronyl nitroxides (LR) leads to assemble a diverse set of coordination complexes: mononuclear [Cu(hfac)2L2-Me], binuclear [{Cu(hfac)2}2(H2O)L2-Me], trinuclear [{Cu(hfac)2}3(L6-Br)2], pentanuclear [{Cu(hfac)2}5(L2-Me)2], and [{Cu(hfac)2}5(L2-Me)4], cocrystals [Cu(hfac)2(L2-Br)2]·[Cu(hfac)2(H2O)2] and [Cu(hfac)2(L2-Br)2]·2[Cu(hfac)2H2O], one-dimensional polymers [Cu(hfac)2L2-Br]n and [Cu(hfac)2L6-Br]n, and cyclic dimers [Cu(hfac)2L5-Me]2, [Cu(hfac)2L5-Br]2, and [Cu(hfac)2L6-Me]2. The mol. structures of the obtained complexes are strongly affected by the substituent type and its location in the pyridine heterocycle. Occupation of the second position of the pyridine ring increases the steric hindrance of both imine and nitroxide coordination sites of L2-R, which is favorable for the formation of various conformers and precipitation of complexes with different mol. structures. The pentanuclear [{Cu(hfac)2}5(L2-Me)2] and [{Cu(hfac)2}5(L2-Me)4] complexes do not have prior analogs and are valuable model objects for investigation of the mechanism of formation of various coordination polymers. The arrangement of long Cu-ONO bonds in {CuO6} square bipyramids due to the weakening nitroxide donor site in complexes, based on L2-Me, L2-Br, and L6-Br ligands, results in ferromagnetic exchange interactions between spins of Cu2+ ions and nitroxides. Complexes with substituents that do not considerably affect the coordination ability of ligands (L5-Me, L5-Br, and L6-Me) exhibit strong antiferromagnetic exchange interactions between spins of Cu2+ ions and nitroxides. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2019 ,《The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation》 appeared in Nature Chemistry. The author of the article were Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J.. The article conveys some information:

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2020 ,《A cyclometalated trinuclear Ir(III)/Pt(II) complex as a luminescent probe for histidine-rich proteins》 appeared in Dalton Transactions. The author of the article were Sarkar, Ankita; Kumar, Ravi; Das, Bishnu; Ray, Partho Sarothi; Gupta, Parna. The article conveys some information:

Organometallic complexes have important application in the field of protein staining, with potential for use in proteomic anal. The rational synthesis of a trinuclear luminescent organometallic complex with two platinum(II) centers appended to the cyclometalated ligand of the iridium(III) center is reported here. Two di-2-picolylamine groups bonded to the cyclometalated Ph pyridine moiety provide three coordinating sites to each platinum center. The replacement of chloride in the fourth coordination site of two square planar platinum metal centers with the imidazole nitrogen or sulfur atom of histidine/cysteine is evident from the change in luminescence intensity upon binding these amino acids. The increase in luminescence emission intensity upon binding of histidine to the organometallic complex allowed it to be used as a protein staining agent. Reversibility of staining upon washing with imidazole enhances the possibility of its application in mass spectrometric anal. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Synthesis and application of self-healing elastomers with high healing efficiency and mechical properties based on multi-healing systems》 appeared in European Polymer Journal. The author of the article were Zhou, Xing; Wang, Hao; Li, Shaonan; Liu, Mengyue. The article conveys some information:

Intrinsic self-healing materials designed by combining reversible valence bonds or ionic coordination have attracted much attention due to their ability to recover from mech. damage. However, their mech. properties tend to deteriorate due to the increased rigidity of the chain. In this work, we report a self-healing polyurethane elastomer with multiple healing systems. 3,3′-dithiodipropionic acid (TDPA) and iron ion-2,6-diaminopyridine (DAP) were used as dynamic chain extenders and ionic ligands, resp. They can be effectively unsealed at a certain temperature to ensure that the self-healing efficiency is not affected by the material formula. By changing the content of hard and soft segments, the mech. properties and self-healing properties of the material can be adjusted in a large range. When the molar ratio of TDPA and DAP is 0.5:0.5, the polyurethane based on multiple healing system only needs to be healed at 70 °C for 12 h, and the self-healing efficiency can reach 93.48%. The structural rigidity and high reversibility of metal complexing agent DAP and iron ions play an important role in enhancing mech. strength and maintaining self-healing efficiency at 70 °C. Based on the above research, we prepared the strain sensor by combining self-healing polyurethane and conductive graphene. The sensor can respond to external force quickly and stably. This work provides a feasible strategy for the preparation of mech. robust polyurethane elastomers and self-healing flexible stress sensors with high self-healing efficiency at 70 °C. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C12H12N2In 2019 ,《Syntheses, X-Ray Crystal Structures, Emission Properties and DFT Calculations of Monoprotonated Polypyridines》 appeared in ChemistrySelect. The author of the article were Yoshikawa, Naokazu; Yamazaki, Shoko; Kato, Natsumi; Kubota, Akari; Sawai, Mika; Noda, Kaoru; Kanehisa, Nobuko; Inoue, Tsuyoshi; Nakata, Eiji; Takashima, Hiroshi. The article conveys some information:

Monoprotonated compounds [(L)HPF6] were prepared by the reaction of (L=bpy, phen, dpphen, bqn and ppy) with concentrated HCl in water. Monoprotonated pyridine rings are hydrogen bonded intramolecularly to the adjacent pyridine ring and intermolecularly to the adjacent PF6- in compounds These hydrogen bonds restrain the nonradiative decay to produce intense emission. D. functional theory was applied to interpret the planarity in compounds The attachment of one proton to the nitrogen in [(dpphen)HPF6] and [(bqn)HPF6] leads to the strong emission in acetonitrile (Φ = 0.046 and 0.097, resp.). In particular, the attachment of one proton to the ppy nitrogen results in exhibiting a strong emission with a large quantum yield (Φ = 0.264). The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Feng-Gui; Xu, Wei; Chen, Jing; Xiao, Hong-Ping; Wang, Hai-Ying; Chen, Zhongyan; Ge, Jing-Yuan published an article in Inorganic Chemistry. The title of the article was 《Dysprosium(III) Metal-Organic Framework Demonstrating Ratiometric Luminescent Detection of pH, Magnetism, and Proton Conduction》.SDS of cas: 1134-35-6 The author mentioned the following in the article:

A multifunctional metal-organic framework, (Hdmbpy)[Dy(H2dobdc)2(H2O)]·3H2O (Dy-MOF, H4dobdc = 2,5-dihydroxyterephthalic acid, dmbpy = 4,4′-dimethyl-2,2′-bipyridine), was synthesized and structurally characterized. The metal center DyIII is connected by four carboxyl groups to form the [Dy2(CO2)4] binuclear nodes, which are further interconnected by eight sep. H2dobdc2- ligands to form a three-dimensional (3D) framework including hydrophilic triangular channels and abundant hydrogen-bonding networks. Dy-MOF has good stability in aqueous solution as well as in harsh acidic or alk. solutions (pH range: 2.0-12.0). Furthermore, the luminescence signal of Dy-MOF undergoes a visualized color change as the acidity of the solution alters, which is the typical behavior of pH ratiometric probe. At a 100% relative humidity, Dy-MOF exhibits a high proton conductivity σ (1.70 x 10-4 S cm-1 at 303 K; 1.20 x 10-3 S cm-1 at 343 K) based on the proton hopping mechanism, which can be classified as a superionic conductor with σ exceeding 10-4 S cm-1. Addnl., the ferromagnetic interaction and magnetic relaxation behavior are simultaneously achieved in Dy-MOF. Herein, the combination of luminescence sensing, magnetism, and proton conduction in a single-phase 3D MOF may offer great potential applications in smart multitasking devices. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Cauley, Anthony N.; Ramirez, Antonio; Barhate, Chandan L.; Donnell, Andrew F.; Khandelwal, Purnima; Sezen-Edmonds, Melda; Sherwood, Trevor C.; Sloane, Jack L.; Cavallaro, Cullen L.; Simmons, Eric M. published an article in Organic Letters. The title of the article was 《Ni/Photoredox-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Alkyl Pinacolboronates and (Hetero)Aryl Bromides》.HPLC of Formula: 3510-66-5 The author mentioned the following in the article:

Utilizing quinoline as a mild, catalytic additive, broadly applicable conditions for the Ni/photoredox-catalyzed C(sp2)-C(sp3) cross-coupling of (hetero)aryl bromides RBr (R = N-bocpiperidin-4-yl, N-bocindol-5-yl) and alkyl pinacolboronate esters R1R2CH(Bpin) [R1 = H, Me; R2 = Me, Ph, 2-methylphenyl, pyridin-3-yl, pyrimidin-5-yl, etc.; R1R2 = -(CH2)3-, -(CH2)5-, -(CH2)3O(CH2)2-, etc.] were developed, which can be applied to both batch and flow reactions. In addition to primary benzylic nucleophiles, both stabilized and non-stabilized secondary alkyl boronic esters are effective coupling partners. D. functional theory calculations suggest that alkyl radical generation occurs from an alkyl-B(pin)-quinoline complex, which may proceed via an energy transfer process. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5HPLC of Formula: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wang, Ming; Zhang, Feng; Luo, Yang; Li, Shuo; Wang, Ming-Qi published an article in Chemistry & Biodiversity. The title of the article was 《DPA-Substituted Carbazole Derivative as a Fluorescent Ligand for G4 DNA》.Electric Literature of C12H13N3 The author mentioned the following in the article:

Herein a conjugated dipicolylamine/carbazole (Car-DPA) mol. was designed and synthesized to enhance the performance for the application as a G4 fluorescent ligand. This ligand has been found to display distinct and specific fluorescence enhancements in the presence of various G4 DNA structures, but limited with ssDNA or dsDNAs. The detail binding characteristics of the ligand with c-MYC G4 DNA were investigated by fluorescence, UV/VIS absorption, CD spectroscopy, and mol. docking. The present study demonstrated that Car-DPA bound to c-MYC G4s with a two-step complex formation, in which the binding mode appeared to be end-stacking. Confocal fluorescence images indicated that ligand Car-DPA could locate in nucleus, which is quite prominent from the cellular internalization studies. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Smits, N. W. G.; Rademaker, D.; Konovalov, A. I.; Siegler, M. A.; Hetterscheid, D. G. H. published an article in Dalton Transactions. The title of the article was 《Influence of the spatial distribution of copper sites on the selectivity of the oxygen reduction reaction》.COA of Formula: C12H13N3 The author mentioned the following in the article:

Moving towards a hydrogen economy raises the demand for affordable and efficient catalysts for the oxygen reduction reaction. Cu-bmpa (bmpa = bis(2-picolyl)amine) is shown to have moderate activity, but poor selectivity for the 4-electron reduction of oxygen to water. To enhance the selectivity towards water formation, the cooperative effect of three Cu-bmpa binding sites in a single trinuclear complex is investigated. The catalytic currents in the presence of the trinuclear sites are lower, possibly due to the more rigid structure and therefore higher reorganization energies and/or slower diffusion rates of the catalytic species. Although the oxygen reduction activity of the trinuclear complexes is lower than that of mononuclear Cu-bmpa, the selectivity of the copper mediated oxygen reduction was significantly enhanced towards the 4-electron process due to a cooperative effect between three copper centers that have been positioned in close proximity. These results indicate that the cooperativity between metal ions within biomimetic sites can greatly enhance the ORR selectivity. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem