Tag: 100-200

In 2022,Wu, Yaxing; Wu, Chao; Wang, Fei; Chen, Chao published an article in New Journal of Chemistry. The title of the article was 《Cu-catalyzed [2 + 2 + 1] cascade annulation of vinyl iodonium salts with elemental sulfur/selenium for the modular synthesis of thiophenes and selenophenes》.Product Details of 2510-22-7 The author mentioned the following in the article:

A [2 + 2 + 1] annulation protocol was established for the modular synthesis of 2,4-disubstituted thiophenes/selenophenes, with excellent regioselectivity. The reactions was catalyzed by copper salt with elemental sulfur and selenium serving as the chalcogen source. The mechanistic study was revealed that this process was initiated by a trisulfur radical anion using EPR. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bennett, Troy L. R.; Wilkinson, Luke A.; Lok, Jasmine M. A.; O’Toole, Robert C. P.; Long, Nicholas J. published their research in Organometallics in 2021. The article was titled 《Synthesis, Electrochemistry, and Optical Properties of Highly Conjugated Alkynyl-Ferrocenes and -Biferrocenes》.Category: pyridine-derivatives The article contains the following contents:

Sonogashira reactions are utilized herein to react iodo-ferrocenes and -biferrocenes with terminal alkyne ligands, functionalized with both pyridine and thioanisole groups. High-yielding reactions generate both monoalkynyl and dialkynyl derivatives, the ratio of which can be altered through changes in the reaction stoichiometry. This methodol. allowed us to synthesize a large family of derivatives, comprising four sym. derivatives (3xx, where x represents a phenyl-substituted terminal alkyne) and six less-studied asym. derivatives (3xy, where x and y represent two different phenyl-substituted terminal alkynes), as well as a number of their biferrocenyl analogs (6x, 7xx, and 7xy), including the first known examples of asym. disubstituted biferrocenes. Authors examined the electrochem. behavior of all the systems in solution through the use of cyclic voltammetry and demonstrate that these highly conjugated alkynyl ligands exert delicate redox control over the central ferrocene motif. They also note that these substituents display some control over the mixed-valence character present in biferrocene monocations, with thioanisole substituents imparting almost an order of magnitude higher Kc than their pyridyl analogs, and asym. systems displaying rare characteristic properties of mixed-valence isomers. The electronic structure of these systems was further elucidated through a combination of UV/vis spectroscopy and d. functional theory calculations Their methodol. provides a facile and adaptable route toward the isolation of a number of novel ferrocene and biferrocene derivatives From their perspective, the asym. nature of these systems, along with the delicate and predictable redox control that these ligands exert on the central ferrocene unit(s), could lead to applications in mol. electronics, where these properties have previously shown promise in the fabrication of diodes and rectifiers, as well as in the synthesis of donor-π-acceptor systems. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ramirez-Palma, Lillian G.; Espinoza-Guillen, Adrian; Nieto-Camacho, Fabiola; Lopez-Guerra, Alexis E.; Gomez-Vidales, Virginia; Cortes-Guzman, Fernando; Ruiz-Azuara, Lena published their research in Molecules in 2021. The article was titled 《Intermediate Detection in the Casiopeina-Cysteine Interaction Ending in the Disulfide Bond Formation and Copper Reduction》.HPLC of Formula: 1134-35-6 The article contains the following contents:

A strategy to improve the cancer therapies involves agents that cause the depletion of the endogenous antioxidant glutathione (GSH), increasing its efflux out of cells and inducing apoptosis in tumoral cells due to the presence of reactive oxygen species. It has been shown that Casiopeina copper complexes caused a dramatic intracellular GSH drop, forming disulfide bonds and reducing CuII to CuI. Herein, through the determination of the [CuII]-SH bond before reduction, we present evidence of the adduct between cysteine and one Casiopeina as an intermediate in the cystine formation and as a model to understand the anticancer activity of copper complexes. Evidence of such an intermediate has never been presented before.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Balaraman, Kaluvu; Wolf, Christian published their research in Organic Letters in 2021. The article was titled 《Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides》.Computed Properties of C5H6BNO2 The article contains the following contents:

Suzuki cross-coupling of benzylic and unactivated aliphatic fluorides RF (R = octyl, cyclohexyl, (4-nitrophenyl)methyl, etc.) with aryl- and alkenylboronic acids R1B(OH)2 (R1 = Ph, 2-phenylethenyl, pyridin-2-yl, etc.) has been achieved via mechanistically distinct Pd and Ni catalyzed pathways that outperform competing protodeboronation, β-hydride elimination, and homocoupling processes. The utility is demonstrated with more than 20 examples e.g., 1-benzyl-4-nitrobenzene. After reading the article, we found that the author used 2-Pyridinylboronic acid(cas: 197958-29-5Computed Properties of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and Characterization of a Linear Triiron(II) Extended Metal Atom Chain Complex with Fe-Fe Bonds》 was written by Guillet, Gary L.; Arpin, Kathleen Y.; Boltin, Alan M.; Gordon, Jesse B.; Rave, Justin A.; Hillesheim, Patrick C.. COA of Formula: C5H7N3 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Extended metal atom chain (EMAC) complexes of first-row transition metals with metal-metal bonds have the potential to elicit unique magnetic properties and reactivities. Until now, the library of EMAC complexes with late-first-row transition metals was incomplete because of the omission of a triiron species with Fe-Fe bonding. Herein we report the synthesis and preliminary investigation of the first linear, triiron(II) complex containing close Fe-Fe interactions. The complex is supported by three dianionic 2,6-bis[(trimethylsilyl)amido]pyridine ligands (L), with an overall composition of Fe3L3, and pseudohelical ligand coordination stabilizing the local trigonal-planar geometry at each iron. Fe3L3 was characterized by X-ray diffraction, 1H NMR, cyclic voltammetry, electronic absorption, and Mossbauer spectroscopies. Evans method anal. indicated a large uncompensated spin and an S = 6 ground state, suggesting ferromagnetic coupling in the triiron chain, likely due to direct exchange. The first structurally characterized triiron extended metal atom chain complex is presented. The complex is composed of three ferrous ions supported by three 2,6-bis[(trimethylsilyl)amido]pyridine ligands. The iron atoms are arranged linearly with two sym. Fe-Fe bonds of 2.437 Å indicative of modest single bonds. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《In Vitro Anti-tumoral and Anti-bacterial Activity of an Octamolybdate Cluster-Based Hybrid Solid Incorporated with a Copper Picolinate Complex》 was written by Joshi, Arti; Gupta, Ruby; Vaghasiya, Kalpesh; Verma, Rahul Kumar; Sharma, Deepika; Singh, Monika. Formula: C6H5NO2 And the article was included in ACS Applied Bio Materials in 2020. The article conveys some information:

Inorganic drugs, especially polyoxometalate-based hybrids, are expected to be developed as promising future metallodrugs. Herein, an organic-inorganic hybrid solid based on pyridine-2-carboxylic acid or picolinic acid (pic), [(Cu(pic)2)2(Mo8O26)]·8H2O (1), was synthesized. A single-crystal structure of a solid possesses a discrete β-type octamolybdate cluster that supramolecularly aggregates with a {Cu2(pic)4}4- complex and eight lattice water mols. The study indicates that the solid is stable in aqueous medium and less toxic toward normal cell lines. The in vitro anti-bacterial and anti-tumor properties of the solid 1 were investigated. The results of the anti-tumor action against various human cancer cell lines, namely, lung (A549), breast (MCF-7), and liver (HepG2) cancer cells suggest that this β-octamolybdate-based solid yielded the lowest IC50 value reported so far among octamolybdate anion-based hybrid solids, i.e., 24.24μM for MCF-7, 21.56μM for HepG2, and 25μM for A549, indicating significant anti-cancer activity. The cell cycle anal. further reveals the observed anti-tumor effect to be governed by the arrest of breast cancer cells in the G2/M phase while that of lung and liver cancer cells in the S phase of the cell cycle. A fluorescence quenching study suggests the binding interaction between solid and ctDNA, which in turn induces apoptosis and necrosis pathways leading to cancer cell death. This is also the first study of {Mo8O26}4- cluster-based solids as an anti-bacterial agent against Escherichia coli, and it was found to be very effective with a minimal inhibitory concentration value of ~135μg/mL, which is the lowest so far reported for any octamolybdate-based solid. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, Structural Characterization, Enzymatic and Oxidative Polymerization of 2,6-Diaminopyridine》 was published in Journal of Fluorescence in 2020. These research results belong to Senol, Dilek. COA of Formula: C5H7N3 The article mentions the following:

Enzymic polymerization of 2,6-diaminopyridine (DAP) compound in the presence of HRP (Horse radish peroxidase) and H2O2 (hydrogen peroxide) with Poly(DAP-en) with the structures of two different types of polymers obtained by the oxidative polymerization of Poly(DAP-ox) using H2O2 in an aqueous basic environment was illuminated by 1H-NMR, 13C-NMR, FT-IR, UV-Vis spectral methods. GPC (gel permeation chromatog.), TGA (thermal gravimetric anal.), DSC (differential scanning calorimetry), CV (cyclic voltammetry), fluorescence anal. and conductivity measurements to characterize the compounds and their electronic structure were examined SEM analyzes were performed for the morphol. properties of the compounds As a result of the anal., it was observed that the polymer obtained by enzymic polymerization was better than the polymer obtained by oxidative method. It was observed that the results of the fluorescence measurements were better than Poly(DAP-en) in Poly(DAP-ox) emitting blue and green light. According to TGA anal., the first decay temperatures for poly(DAP-en) and poly(DAP-ox) were calculated as 342°C and 181°C, resp. The higher value of glass transition temperature for poly(DAP-en) confirms that the average molar mass is higher than 8650 Da for poly(DAP-en) according to GPC anal. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A new route for the synthesis of 2,4-bis(2-pyridyl)-6-(pyridyl)pyrimidines: Synthesis and characterization of Co(II), Ni(II) complexes of 2,4,6-tris(2-pyridyl)pyrimidine》 was published in Inorganica Chimica Acta in 2020. These research results belong to Bori, Jugal; Mahata, Satyajit; Manivannan, Vadivelu. Quality Control of 4-Acetylpyridine The article mentions the following:

Using 2-acetylpyridine, sodium hydroxide and 2-cyanopyridine, 2,4,6-tris(2-pyridyl)pyrimidine (L1) was synthesized in good yield. Similarly, 2,4-bis(2-pyridyl)-6-(3-pyridyl)pyrimidine (L2) and 2,4-bis(2-pyridyl)-6-(4-pyridyl)pyrimidine (L3) were also synthesized by using resp. acetylpyridine. 2-Acetylpyridine reacted with sodium hydroxide to produce 2-oxo-2-(2-pyridyl)-1-ethanide, which behaves as a nucleophile towards 2-cyanopyridine. All three pyrimidines are potential multidentate ligand and by using L1 complexes of composition [Ni(L1)(H2O)3](NO3)2·4H2O (1), [Ni(L1)2](NO3)2·2H2O (2) and [Co(L1)2](NO3)2·1.5H2O (3) were isolated and structurally characterized. In 1-3, L1 behaves as a tridentate pincer type ligand, DFT calculations performed on L1-L3 indicate that energy difference between HOMO and LUMO is 4.544, 4.643 and 4.533 eV, resp. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Quality Control of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Determination of the complexation parameters of L-asparagine with some biologically active pyridine derivatives in aqueous solutions from calorimetric results》 was published in Thermochimica Acta in 2020. These research results belong to Tyunina, Elena Yu.; Krutova, Olga N.; Lytkin, Alexandr I.. Name: Picolinic acid The article mentions the following:

Thermodn. functions (lgK, ΔcG, ΔcH, ΔcS) were determined by solution calorimetry for the complex formation process of L-asparagine in its zwitterionic form with pharmacol. active ligands, such as pyridoxine, nicotinic acid, isonicotinic acid and picolinic acid in aqueous solutions at 298.15 K. It was found that the complexation affinity of L-asparagine to the pyridine derivatives follows the order picolinic acid < isonicotinic acid < nicotinic acid < pyridoxine. The influence of the presence of hydrophilic substitutes and isomerism of ligands on the stability of amino acid complexes and their thermodn. quantities was discussed. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity》 was published in Experimental Gerontology in 2020. These research results belong to Ding, Kehong; McGee-Lawrence, Meghan E.; Kaiser, Helen; Sharma, Anuj K.; Pierce, Jessica L.; Irsik, Debra L.; Bollag, Wendy B.; Xu, Jianrui; Zhong, Qing; Hill, William; Shi, Xing-Ming; Fulzele, Sadanand; Kennedy, Eileen J.; Elsalanty, Mohammed; Hamrick, Mark W.; Isales, Carlos M.. Recommanded Product: 98-98-6 The article mentions the following:

Tryptophan is an essential amino acid catabolized initially to kynurenine (kyn), an immunomodulatory metabolite that we have previously shown to promote bone loss. Kyn levels increase with aging and have also been associated with neurodegenerative disorders. Picolinic acid (PA) is another tryptophan metabolite downstream of kyn. However, in contrast to kyn, PA is reported to be neuroprotective and further, to promote osteogenesis in vitro. Thus, we hypothesized that PA might be osteoprotective in vivo. In an IACUC-approved protocol, we fed PA to aged (23-mo-old) C57BL/6 mice for eight weeks. In an effort to determine potential interactions of PA with dietary protein we also fed PA in a low-protein diet (8%). The mice were divided into four groups: Control (18% dietary protein), +PA (700 ppm); Low-protein (8%), +PA (700 ppm). The PA feedings had no impact on mouse weight, body composition or bone d. At sacrifice bone and stem cells were collected for anal., including μCT and RT-qPCR. Addition of PA to the diet had no impact on trabecular bone parameters. However, marrow adiposity was significantly increased in PA-fed mice, and in bone marrow stromal cells isolated from these mice increases in the expression of the lipid storage genes, Plin1 and Cidec, were observed Thus, as a downstream metabolite of kyn, PA no longer showed kyn′s detrimental effects on bone but instead appears to impact energy balance. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem