Tag: 100-200

In 2019,Organic Letters included an article by Begam, Hasina Mamataj; Choudhury, Rajarshee; Behera, Ashok; Jana, Ranjan. Electric Literature of C6H5NO2. The article was titled 《Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System》. The information in the text is summarized as follows:

A practical copper-catalyzed, 2-picolinamide-directed ortho C-H amination of anilines with benzoyl-protected hydroxylamines was disclosed that proceeds smoothly without any external stoichiometric oxidant or additives. Remarkably, besides anilines, bicyclic naphthyl or heterocyclic amines furnished amination products with five- and six-membered cyclic and acyclic amines at the ortho position selectively. This electrophilic C-H amination also proceeds smoothly in water under slightly modified reaction conditions.Picolinic acid(cas: 98-98-6Electric Literature of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Electric Literature of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Viju, G.; Chandrasekar, M.; Sundhari, D.; Sivakumar, S.; Raja Saravanan, M. E.; Uthrakumar, R.; Inmozhi, C.. Electric Literature of C6H5NO2. The article was titled 《Growth and characterization of an organic non linear Optical single crystal: BisPicolonium Tartrate》. The information in the text is summarized as follows:

BisPicolonium tartrate (BPT) is an organic nonlinear optical crystal has been synthesized and grown by slow evaporation technique. Single crystal X-ray diffraction study reveals that the crystal belongs to triclinic system. Powder X-ray diffraction was recorded and the peaks were indexed. The functional groups present in the crystal were interpreted by FTIR spectral anal. Optical absorption spectrum shows that the crystal is transparent in the entire visible region. The study of dielec. constant and dielec. loss for the grown crystal were carried out. The relative SHG efficiency of the material was investigated. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Electric Literature of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Electric Literature of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Nature Communications included an article by Zhu, Shengqing; Qin, Jian; Wang, Fang; Li, Huan; Chu, Lingling. COA of Formula: C6H4N2. The article was titled 《Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine》. The information in the text is summarized as follows:

A catalytic, branch-selective pyridylation of alkenes via a sulfinate assisted photoredox catalysis was reported. This reaction proceeded through a sequential radical addition/coupling/elimination, by utilizing readily available sodium sulfinates as reusable radical precursors as well as traceless elimination groups. This versatile protocol allows for the installation of important vinylpyridines with complete branched selectivity under mild conditions. Furthermore, this catalytic manifold was successfully applied to the expedient synthesis of Triprolidine. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Green Chemistry included an article by Kucinski, Krzysztof; Hreczycho, Grzegorz. Synthetic Route of C7H7NO. The article was titled 《Lithium triethylborohydride as catalyst for solvent-free hydroboration of aldehydes and ketones》. The information in the text is summarized as follows:

Com. available and inexpensive lithium triethylborohydride (LiHBEt3) acts as an efficient catalyst for the solvent-free hydroboration of a wide range of aldehydes and ketones, which were subsequently transformed to corresponding 1° and 2° alcs. in one-pot procedure at room temperature (rt). In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Green Chemistry included an article by Chakrabarti, Kaushik; Mishra, Anju; Panja, Dibyajyoti; Paul, Bhaskar; Kundu, Sabuj. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources》. The information in the text is summarized as follows:

A Ru(II) complex mediated synthesis of various N,N-di-Me and N-monomethyl amines from organic azides using methanol as a methylating agent was reported. This methodol. was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gawinecki, Ryszard; Rasala, Danuta; Obrzut, Jan; Tamasik, Piotr published their research in Chemica Scripta on December 31 ,1985. The article was titled 《The ortho effect in pyridines. VI. Singlet → singlet π → π* excited state of 2- and 4-substituted 3-nitropyridines》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:

The UV absorption spectra in ethanol were measured for o-substituted nitrobenzenes, 2-substituted-3-nitropyridines and 4-substituted-3-nitropyridines. Based on bathochromic shift of the ICT band and its intensity, the ortho effect is discussed in the singlet→singlet π→π* excited state of investigated compounds In the experiment, the researchers used 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 116383-98-3On May 7, 1999 ,《Selective palladium-catalyzed carbonylations of dichloroquinoline and simple dichloropyridines》 appeared in Tetrahedron Letters. The author of the article were Najiba, Douja; Carpentier, Jean-Francois; Castanet, Yves; Biot, Christophe; Brocard, Jacques; Mortreux, Andre. The article conveys some information:

Dichloroquinoline and some dichloropyridines undergo selective alkoxycarbonylation in the presence of carbon monoxide, an alc. and PdCl2(PPh3)2 as a catalyst, affording chloro-monoester and/or diesters in good yields under selected reaction conditions. In addition to this study using Methyl 3-chloropicolinate, there are many other studies that have used Methyl 3-chloropicolinate(cas: 116383-98-3HPLC of Formula: 116383-98-3) was used in this study.

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 116383-98-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Selective approach to N-substituted tertiary 2-pyridones》 was written by Wang, Yu; Xu, Yaoyao; Khan, Shahid; Zhang, Zhunjie; Khan, Ajmal. Product Details of 197958-29-5This research focused onvinyl cyclic carbonate hydroxypyridine palladium catalyst regioselective enantioselective amination; allyl pyridone preparation. The article conveys some information:

The regio- and enantioselective amination of readily available vinyl cyclic carbonates with ambivalent 2-hydroxypyridines was achieved using a Pd(0)/DACH-naphthyl catalyst system. The reaction proceeded under simple conditions, providing access to chiral N-substituted 2-pyridones that bear elusive tertiary carbon centers. A significant drawback previously related to making these products via transition metal-catalyzed allylic substitution procedures was overcome by this catalytic method. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Product Details of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterogeneous palladium-catalysed intramolecular C(sp3)-H α-arylation for the green synthesis of oxindoles》 was written by Salameh, Nihad; Anastasiou, Ioannis; Ferlin, Francesco; Minio, Francesco; Chen, Shaomin; Santoro, Stefano; Liu, Ping; Gu, Yanglong; Vaccaro, Luigi. Formula: C5H5BrN2 And the article was included in Molecular Catalysis on April 30 ,2022. The article conveys some information:

The development of a waste-minimized protocol for the synthesis of oxindoles I [R = H, Me; R1 = Me, Et, Bn; R2 = H, Me, F; R3 = H, F, Me, CF2; R4 = H, Me, Cl, CN, etc.; R5 = CH, N] using cyclopentyl Me ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst was presented. This protocol is efficiently applied to a variety of substrates 2-R2-3-R3-4-R4-5-R5-6-X-C6N(R1)C(O)CH3 [X = Br, Cl] affording products I with excellent yields, minimal metal contamination and min. waste production The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products I were isolated by simple precipitation from heptane with no need for chromatog. separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol. In the experiment, the researchers used many compounds, for example, 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chemoselective Synthesis of 1,1-Disubstituted Vinyl Triflates from Terminal Alkynes Using TfOH in the Presence of TMSN3》 was written by Tummatorn, Jumreang; Punjajom, Kunlayanee; Rodphon, Warabhorn; Ruengsangtongkul, Sureeporn; Chaisan, Nattawadee; Lumyong, Kanyapat; Thongsornkleeb, Charnsak; Nimnual, Phongprapan; Ruchirawat, Somsak. Quality Control of 4-EthynylpyridineThis research focused onvinyl triflate regioselective chemoselective preparation; terminal alkyne regioselective chemoselective triflation triflic acid silyl azide; hydrazoic acid generated triflation toxic explosive. The article conveys some information:

1,1-Disubstituted vinyl triflates were prepared chemoselectively and regioselectively by direct hydrotriflation of terminal alkynes with TfOH and TMSN3 in DCM at room temperature; internal alkynes did not react under these conditions. Aryl alkynes with both terminal and internal alkyne moieties reacted only at their terminal alkyne moieties. Hydrazoic acid generated in situ in the triflation reaction is toxic and potentially explosive; the reactions should be performed in a well-ventilated fume hood.4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem