Tag: 100-200

《Biotin-tagged cis-dichlorido-oxidovanadium(IV) complex for DNA crosslinking and photo-induced apoptotic cytotoxicity》 was written by Kumar, Arun; Sahoo, Somarupa; Dixit, Akanksha; Karande, Anjali A.; Chakravarty, Akhil R.. COA of Formula: C12H13N3This research focused onvanadium oxo chloro biotin appended dipicolylamine complex preparation anticancer; crystal structure vanadium oxo chloro biotin appended dipicolylamine complex. The article conveys some information:

Cis-dichlorido-oxidovanadium(IV) complexes [VO(dpa/L1)Cl2] (1, 2) of dipicolylamine (dpa, 1 as control species) and 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid (biotin)-appended dpa (L1, 2 as active species) were prepared and their anticancer activity studied. Single crystal X-ray diffraction anal. of complex 1 revealed a cis arrangement of two chloride ligands in a distorted octahedral geometry with VIVON3Cl2. The dpa ligand displayed a facial mode of coordination. The complexes were 1:1 electrolytic in an aqueous medium and showed a significant enhancement of conductivity on irradiation with visible light. Complex 2 having the biotin moiety showed cytotoxicity in visible light of 400-700 nm giving IC50 value of 15.0(±0.2) μM in HeLa cells and 5.0(±1.2) μM in HepG2 cells. The complex did not show any apparent generation of reactive oxygen species (ROS) in dichlorofluorescein diacetate (DCFDA) assay. The complex displayed apoptotic photo-induced cytotoxicity following DNA crosslinking pathway as ascertained from the comet assay. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1539-42-0In 2022 ,《[99mTc-BBPA]: A possible SPECT agent to understand the role of 18-kDa translocator protein (PBR/TSPO) during neuro-glial interaction》 was published in Bioorganic Chemistry. The article was written by Kumari, Neelam; Kaul, Ankur; Deepika; Srivastava, Krishna; Mishra, Gauri; Bhagat, Sunita; Singh, Vinay Kumar; KumarTiwari, Anjani. The article contains the following contents:

The translocator protein (TSPO, 18 kDa) is one of the most promising biomarker to understand the role of neuroinflammation in human as well as in different animal species. Here we report a new TSPO-selective ligand 2-(5-(2-(bis(pyridin-2-yl methyl)amino)acetamido)-2-oxobenzo[d] oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide, BBPA, which is supposed to be a potential probe to understand the role of TSPO in neuro-glial interaction through SPECT modality. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1122-54-9In 2022 ,《Pd(II) Complexes with Pyridine Ligands: Substituent Effects on the NMR Data, Crystal Structures, and Catalytic Activity》 was published in Inorganic Chemistry. The article was written by Kurpik, Gracjan; Walczak, Anna; Goldyn, Mateusz; Harrowfield, Jack; Stefankiewicz, Artur R.. The article contains the following contents:

A wide range of functionalized pyridine ligands were employed to synthesize a variety of Pd(II) complexes [PdL4](NO3)2 and [PdL2Y2], where L = 4-X-py and Y = Cl- or NO3-. Their structures were unambiguously established via anal. and spectroscopic methods in solution (NMR spectroscopy and mass spectrometry) as well as in the solid state (x-ray diffraction). This in-depth characterization showed that the functionalization of ligand mols. with groups of either electron-withdrawing or -donating nature (EWG and EDG) results in significant changes in the physicochem. properties of the desired coordination compounds Downfield shifts of signals in the 1H NMR spectra were observed upon coordination within and across the complex families, clearly indicating the relation between NMR chem. shifts and the ligand basicity as estimated from pKa values. A detailed crystallog. study revealed the operation of a variety of weak interactions, which may be factors explaining aspects of the solution chem. of the complexes. The Pd(II) complexes are efficient and versatile precatalysts in Suzuki-Miyaura and Heck cross-coupling reactions within a scope of structurally distinct substrates, and factors were identified that have contributed to efficiency improvement in both processes. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 103-74-2In 2019 ,《Novel silver(I) complexes bearing mefenamic acid and pyridine derivatives: Synthesis, chemical characterization and in vitro anticancer evaluation》 was published in Inorganica Chimica Acta. The article was written by Altay, Ahmet; Caglar, Sema; Caglar, Bulent; Sahin, Zarife Sibel. The article contains the following contents:

Two Ag(I) complexes [Ag2(μ-mef)2(2-pymet)2] (1), [Ag2(μ-mef)2(2-pyet)2] (2) containing mefenamic acid, 2-pyridinemethanol and 2-pyridineethanol were synthesized and characterized by using SCXRD, FTIR, elemental and thermal anal. techniques. 1 Was synthesized as a single crystal whereas 2 was obtained as a microcrystalline powder. 1 Consists of binuclear structure. The argentophilic interaction occurs among silver(I) ions due to the short Ag···Ag distance (2.8710(10) Å). Two Ag(I) centers are connected by carboxylato oxygen-bridge to form the binuclear metal core. The FTIR spectra and thermal anal. studies confirmed that both complexes exhibited similar structures. In vitro antiproliferative activity of both complexes were evaluated against MCF-7, HT-29 and HepG2 cancer cell lines. The apoptotic effects and intracellular ROS generation from both complexes were investigated in MCF-7 cell line by flow cytometry anal. The XTT and LDH assays revealed that both complexes showed strong antiproliferative activity with higher selectivity towards cancer cells compared to the normal cells. Annexin V/propidium iodide assay exhibited that apoptotic cell number was increased in MCF-7 cells with increasing concentrations of Ag(I) complexes. Also, both complexes induced the ROS generation considerably in MCF-7 cells suggesting the possible pro-oxidant activity of the novel synthesized Ag(I) complexes. Taken together, these findings provide a notable support for potential utility of Ag(I) complexes as novel anticancer agents against numerous kind of carcinogenesis. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. HPLC of Formula: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2In 2019 ,《Pyridyl-urea catalysts for the solvent-free ring-opening polymerization of lactones and trimethylene carbonate》 appeared in European Polymer Journal. The author of the article were Feng, Rui; Jie, Suyun; Braunstein, Pierre; Li, Bo-Geng. The article conveys some information:

The ring-opening polymerization (ROP) of lactones is an effective method for the preparation of biocompatible and biodegradable aliphatic polyesters, for which the development of efficient organocatalysts with high activity and good controllability is highly desirable. A series of novel pyridyl-urea catalysts was synthesized and applied in the solvent-free ROP of lactones and trimethylene carbonate. Combined with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), the pyridyl-urea/MTBD systems showed a fast and living/controlled behavior in the ROP, generating polymers with narrow mol. weight distributions. The influences of catalyst structure, type of base, pyridyl-urea/base ratio, feed ratio of monomer/initiator and reaction temperature on the catalytic properties were investigated. A possible mechanism was proposed on the basis of NMR titration and dilution experiments In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Bis(pyridin-2-ylmethyl)amineIn 2020 ,《Influence of ligand field on magnetic anisotropy in a family of pentacoordinate CoII complexes》 appeared in Dalton Transactions. The author of the article were Acharya, Joydev; Sarkar, Arup; Kumar, Pawan; Kumar, Vierandra; Flores Gonzalez, Jessica; Cador, Olivier; Pointillart, Fabrice; Rajaraman, Gopalan; Chandrasekhar, Vadapalli. The article conveys some information:

A family of mononuclear pentacoordinated CoII complexes, [Co(L)Cl2]·CH3OH (1), [Co(L)Br2] (2) and [Co(L)(NCS)2] (3) (L is 1-mesityl-N,N-bis(pyridin-2-ylmethyl)methanamine) were synthesized and characterized. In these complexes, the neutral non-planar ligand, L, binds to three coordination sites around the metal center while two others are bound by anionic halide/pseudo halide ligands. The coordination geometry of the complexes is dictated by the coordinated anionic ligands. Thus, the coordination geometry around the metal ion is distorted trigonal bipyramidal for complexes 1 and 3, while it is distorted square pyramidal for complex 2. Ab initio CASSCF/NEVPT2 calculations on the complexes reveal an easy plane magnetic anisotropy with the D and E/D values being, 13.3 and 0.14 cm-1 for 1; 36.1 and 0.24 cm-1 for 2 and ±8.6 and 0.32 cm-1 for 3. These values are in good agreement with the values that were extracted from the exptl. d.c. data. AC magnetic measurements reveal a field-induced slow relaxation of magnetization. However, clear maxima in the out-of-phase susceptibility curves were not observed for 1 and 3. For complex 2, peak maxima were observed when the measurements were carried out under an applied field of 1400 Oe which allowed an anal. of the dynamics of the slow relaxation of magnetization. The relaxation is mainly controlled by the Raman and direct processes with the values of the parameters found to be: B = 0.77(15) s-1 K-6.35, n = 6.35(12) and A = 3.41(4) x 10-10 s-1 Oe-4 K-1 and m = 4 (fixed). The ab initio calculation which showed the multifunctional nature of the electronic states of the complexes justifies the absence of zero-field SIM behavior of the complexes. The magnitude and sign of the D and E values and their relation with the covalency of the metal-ligand bonds was analyzed by the CASSCF/NEVPT2 as well as AILFT calculations In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Mandler, Michael D.; Degnan, Andrew P.; Zhang, Shasha; Aulakh, Darpandeep; Georges, Ketleine; Sandhu, Bhupinder; Sarjeant, Amy; Zhu, Yeheng; Traeger, Sarah C.; Cheng, Peter T.; Ellsworth, Bruce A.; Regueiro-Ren, Alicia published an article in Organic Letters. The title of the article was 《Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Owing to their participation in Click reactions, bifunctional azides are valuable intermediates in the preparation of medicines and biochem. tool compounds Despite the privileged nature of pyridines among pharmaceutical scaffolds, reports of the synthesis and characterization of azidopyridines bearing a halogen substituent for further elaboration are almost completely unknown in the literature. As azidopyridines carry nearly equal numbers of nitrogen and carbon atoms, we hypothesized that safety concerns limited the application of these useful bifunctional building blocks in medicinal and biol. chem. To address this concern, we prepared and characterized nine azidopyridines bearing a single fluorine, chlorine, or bromine atom. All were examined by differential scanning calorimetry (DSC), in which they demonstrated exotherms of 228-326 kJ/mol and onset temperatures between 119 and 135°C. Selected azidopyridines were advanced to mech. stress testing, in which impact sensitivity was noted for one regioisomer of C5H3FN4. The utility of these versatile intermediates was demonstrated through their use in a variety of Click reactions and the diversification of the halogen handles.4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yamaguchi, Koji; Miyaguchi, Hajime; Ohno, Youkichi; Kanawaku, Yoshimasa published an article in Forensic Toxicology. The title of the article was 《Qualitative analysis of 7- and 8-hydroxyzolpidem and discovery of novel zolpidem metabolites in postmortem urine using liquid chromatography-tandem mass spectrometry》.Related Products of 3510-66-5 The author mentioned the following in the article:

Forensic anal. of Zolpidem (ZOL) is a hypnotic sometimes used in drug-facilitated crimes. Understanding ZOL metabolism is important for proving ZOL intake. In this study, we synthesized standards of hydroxyzolpidems with a hydroxy group attached to the pyridine ring and analyzed them to prove their presence in postmortem urine. We also searched for novel ZOL metabolites in the urine sample using liquid chromatog.-triple quadrupole mass spectrometry (LC-QqQMS) and liquid chromatog.-quadrupole time-of-flight mass spectrometry (LC-QqTOFMS). 7- and 8-Hydroxyzolpidem (7OHZ and 8OHZ, resp.) were synthesized and analyzed using LC-QqQMS. Retention times were compared between the synthetic standards and extracts of postmortem urine. To search for novel ZOL metabolites, first, the urine extract was analyzed with data-dependent acquisition, and the peaks showing the characteristic fragmentation pattern of ZOL were selected. Second, product ion spectra of these peaks at various collision energies were acquired and fragments that could be used for multiple reaction monitoring (MRM) were chosen. Finally, MRM parameters were optimized using the urine extract These peaks were also analyzed using LC-QqTOFMS. The presence of 7OHZ and 8OHZ in urine was confirmed. The highest peak among hydroxyzolpidems was assigned to 7OHZ. The novel metabolites found were zolpidem dihydrodiol and its glucuronides, cysteine adducts of ZOL and dihydro(hydroxy)zolpidem, and glucuronides of hydroxyzolpidems. The presence of novel metabolites revealed new metabolic pathways, which involve formation of an epoxide on the pyridine ring as an intermediate. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient synthesis of dibenzazepine lactams via a sequential Pd-catalyzed amination and aldol condensation reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Song, Ha-Jeong; Yoon, Eunyoung; Heo, Jung-Nyoung. Quality Control of 2-Bromonicotinaldehyde The article mentions the following:

A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives e.g., I. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination and an aldol condensation. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A cyanobiphenyl-based ratiometric fluorescent sensor for highly selective and sensitive detection of Zn2+》 was published in Inorganica Chimica Acta in 2020. These research results belong to Bie, Fusheng; Cao, Han; Yan, Peng; Cui, Haizhu; Shi, Yijun; Ma, Jie; Liu, Xuejing; Han, Ying. COA of Formula: C12H13N3 The article mentions the following:

A novel fluorescent sensor (BCN, I) based on cyanobiphenyl and di-2-picolylamine (DPA) was designed, synthesized and characterized by the UV-vis absorption, fluorescence spectra and NMR studies. This sensor demonstrated ratiometric response, high selectivity and sensitivity for the detection of Zn2+ without the interference of other metal ions particularly the Cd2+ in HEPES buffer/DMSO solution The Job’s plot, HRMS (high-resolution mass spectroscopy) and single-crystal X-ray diffraction revealed the formation of 1:1 stoichiometry for BCN-Zn2+ complex. The binding constant (Ka) of the complex was determined to be 3.67 x 104 M-1 and the detection limit for Zn2+ was calculated to be 0.77μM. The entire results certificated that BCN can be an advantageous sensor for Zn2+ detection. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem