Tag: 100-200

In 2013,Sharma, Sushila; Kumar, Manoranjan; Kumar, Vishal; Kumar, Neeraj published 《Vasicine catalyzed direct C-H arylation of unactivated arenes: organocatalytic application of an abundant alkaloid》.Tetrahedron Letters published the findings.Application of 13534-97-9 The information in the text is summarized as follows:

Vasicine, a quinazoline alkaloid isolated from Adhatoda vasica, has been employed as an organocatalyst for direct C-H arylation of unactivated arenes with aryl iodides/bromides without the assistance of any transition metal catalyst. A number of sensitive functional groups such as Me, methoxy, O-benzyl, acetyl, and amino were well tolerated under present reaction conditions. Mechanistic investigation supported the involvement of radical intermediates.6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2009,Butcher, Ken J.; Hurst, Jenny published 《Aromatic amines as nucleophiles in the Bargellini reaction》.Tetrahedron Letters published the findings.Related Products of 13534-97-9 The information in the text is summarized as follows:

Aromatic amines can be employed in the Bargellini condensation with piperidinone and CHCl3 in the presence of NaOH to generate useful intermediates. Rapid, practical access to functionalized, privileged structures may have utility in the synthesis of drug-like mols. An improved synthesis of carfentanil analogs illustrates this point. In the experiment, the researchers used many compounds, for example, 6-Bromopyridin-3-amine(cas: 13534-97-9Related Products of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zurwerra, Didier; Quetglas, Vincent; Kloer, Daniel P.; Renold, Peter; Pitterna, Thomas published an article in Organic Letters. The title of the article was 《Synthesis and Stability of Boratriazaroles》.Synthetic Route of C6H7BClNO2 The author mentioned the following in the article:

We describe the synthesis and stability anal. of novel boratriazaroles that can be viewed as bioisosteres of imidazoles or pyrazoles. These heterocycles could conveniently be obtained by condensing a boronic acid and amidrazone 1 in various solvents. A detailed stability anal. of selected compounds at different pH values as a function of time led to the identification of steric hindrance around the boron atom as a key element for stabilization. In addition to this study using (6-Chloro-5-methylpyridin-3-yl)boronic acid, there are many other studies that have used (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Synthetic Route of C6H7BClNO2) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C6H7BClNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Covalent immobilization of ruthenium polypyridyl complex on multi-walled carbon nanotube supports for oxygen evolution reaction in an alkaline solution》 was published in Journal of Power Sources. The article was written by Wu, Zhen-Yi; Zhang, Qian-Xin; Huang, Li-Jing; Xu, Yu-Jin; Tang, Ding-Liang. The article contains the following contents:

Electrocatalytic water splitting to realize the sustainable production of hydrogen is one of the key ways to gain renewable clean energy. The development of the ruthenium-terpyridine-bipyridine (bpyRutpy) complexes used as efficient homogeneous water oxidation catalysts is one of the currently hot research fields. All catalytic active sites of the homogeneous mol. catalyst are fully utilized, and show a high catalytic efficiency. However, the homogeneous mol. catalyst has some intrinsic shortages such as difficulty on separation, recovery and regeneration, and high cost. In view of this, we synthesized the multi-walled carbon nanotube (MWCNT)-based heterogeneous catalyst, MWCNT-bpyRutpy, by covalently bonding the ruthenium-based complex onto the carbon nanotubes, in order to achieve the maximum mol. catalytic efficiency of the complex. The synthesized catalyst is fully characterized by mass spectrometry, NMR spectroscopy, IR spectroscopy, UV-visible spectroscopy, photoelectron spectroscopy, Raman spectroscopy, and thermogravimetry. The formation of the nanocatalyst via fusing Ruthenium complexes to MWCNTs promotes the oxygen evolution reaction (OER) kinetics, enhances intrinsic activity, and increases the sp. surface area of electrochem. activity, and achieve excellent OER performance with a low overpotential of 436 mV at 10mAcm2, a low Tafel slope of 77.2 mV, and a relatively high turnover frequency (TOF) of 0.5833 s-1 at an overpotential of 400 mV. In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Picolinic acidIn 2020 ,《Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes》 appeared in Phytotherapy Research. The author of the article were Derosa, Giuseppe; D’Angelo, Angela; Maffioli, Pamela. The article conveys some information:

To evaluate if a nutraceutical compound containing Ilex paraguariensis, White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre-diabetes. We enrolled patients with IFG or IGT, not taking other hypoglycemic compounds Patients were randomized to take placebo or the nutraceutical compound for 3 mo, in a randomized, double-blind, placebo-controlled design. Both treatments were self-administered once a day, 1 tablet during the breakfast. A reduction of FPG was observed with the nutraceutical combination (-7.8%). Furthermore, there was a decrease of HOMA-IR with the nutraceutical combination (-7.9%). M value was higher (p < 0.05 vs baseline and p < 0.05 vs placebo) at the end of the treatment. We obtained a reduction of Tg with the nutraceutical combination (-8.3%). About 16.6% of patients treated with nutraceutical returned to have a normal glycemia (< 100 mg/dL), and all patients had an improvement of insulin-resistance, in particular 67% of patients returned to have a M value inside range of normal insulin sensitivity. A nutraceutical containing Ilex paraguariensis, White Mulberry and Chromium Picolinate at 500 mg can be helpful in improving glycemia and Tg value, in patients with pre-diabetes. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Jin, Yaping; Wang, Ting; Che, Xuefu; Dong, Jianhao; Li, Qingfeng; Yang, Jingshuai published an article in Journal of Power Sources. The title of the article was 《Poly(arylene pyridine)s: New alternative materials for high temperature polymer electrolyte fuel cells》.Synthetic Route of C7H7NO The author mentioned the following in the article:

Developing high-performance and low-cost high temperature polymer exchange membranes (HT-PEMs) is a huge challenge to fuel cells. Here, two poly(arylene pyridine)s (PTAP and PBAP) are synthesized through a simple one-step Friedel-Crafts polymerization of 4-acetylpyridine and para-terphenyl/biphenyl. Both PTAP and PBAP exhibit superior organic solubility and excellent thermal stability. Owing to pyridine groups, PBAP and PTAP membranes display excellent phosphoric acid (PA) absorption capability. The PTAP membrane achieves a PA uptake of 220% after immersing in 85 wt% PA solution at 100 °C, and a high conductivity of 0.102 S cm-1 at 180 °C. Specially, PBAP and PTAP also possess remarkable chem. stability. After 450 h Fenton test, the PTAP membrane still exhibits a high PA uptake of 200% and high conductivity of 0.086 S cm-1. A single H2-O2 cell based on the PTAP/220% membrane shows a peak power d. of 743 mW cm-2 at 180 °C without any back pressure, which also displays excellent durability under 200 mA cm-2 and 400 mA cm-2 at 160 °C. Thus, this work develops a facile, cost effective and up-scalable synthetic route of alternative HT-PEM under mild conditions, comparing with the state-of-the-art polybenzimidazole (PBI) membrane.4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xing, Hao; Yu, Ying; Liu, Junkai; Qin, Peng; Lam, Jacky Wing Yip; Shi, Bingbing; Xie, Guohua; Tang, Ben Zhong published an article in Advanced Optical Materials. The title of the article was 《A Discrete Platinum(II) Metallacycle Harvesting Triplet Excitons for Solution-Processed Deep-Red Organic Light-Emitting Diodes》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Platinum(II) coordination-driven architectures have exhibited unique features in fabricating functional supramol. materials. By introducing luminescent moieties into the ligand structure, various light-emitting metallacycles and metallacages have been facilely prepared, presenting specific applications in chem. sensing, light-harvesting, and bio-imaging. Except for building up the metal-ligand bonds, the platinum(II) center should also benefit the ultimate luminescence due to its unique photophys. traits. Here, a platinum(II) metallacycle with deep-red emission for solution-processed organic light-emitting diodes is reported. This metallacycle is assembled by mixing a 180° di-Pt(II) acceptor with a pyridyl-decorated ligand functionalized by a deep-red fluorescent emitter. Notably, the platinum(II) acceptor permits the efficient intramol. transfer of all elec. generated singlet and triplet excitons from itself to the fluorescent moiety, which dramatically enhances the external quantum efficiency of the device compared with the one consisting of the sole ligand. The present results reveal the function of platinum(II) metallacycles in light-emitting devices, a finding which should apply to other coordination-driven architectures with versatile properties. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Arbour, Christine A.; Imperiali, Barbara published an article in Organic Letters. The title of the article was 《Backbone-anchoring, solid-phase synthesis strategy to access a library of peptidouridine-containing small molecules》.HPLC of Formula: 2510-22-7 The author mentioned the following in the article:

Nucleoside diphosphate sugar (NDP-sugar) substrates provide the inspiration for nucleoside analog inhibitor scaffolds. By employing solid-phase synthesis, we provide a method to access a library of peptidouridine inhibitors with both minimal compound handling and purification steps. Specifically, this strategy is exemplified by generating uridine diphosphate sugar (UDP-sugar) mimics, which allow for compound elaboration by altering the dipeptide composition, the N-terminal linkage, and a pendant aryl group. To exemplify the versatility, 41 unique nucleoside analogs are presented. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7HPLC of Formula: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Gaorong; Xu, Xiaobo; Wang, Shuai; Chen, Lu; Pang, Binghan; Ma, Tao; Ji, Yafei published an article in Chinese Chemical Letters. The title of the article was 《Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines》.Recommanded Product: 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A novel method for metal-free C-H pyridine-directed borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines with BBr3 has been reported, affording complexes R1C6H3(Bpin)-2-XR2-5-FC5H4N-2 (X = N, CH; R1 = H, alkyl, halo; R2 = H, Me). The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Liu, Hao; Chi, Wei; Lin, Meng-Ling; Dong, Lin published an article in Organic Chemistry Frontiers. The title of the article was 《Iridium(III)-catalyzed two-fold C-H alkylation of BINOLs with allyl alcohols》.Synthetic Route of C6H6BrN The author mentioned the following in the article:

Ir(III)-Catalyzed C-H alkylation of BINOL units I (R1 = H, Me, MeO, Br; R2 = H, Me, Ph, etc.; R3 = pyridin-2-yl, 3-methoxypyridin-2-yl, thiazol-2-yl, etc.; R4 = Me, pyridin-2-yl, 3-methoxypyridin-2-yl, etc.) has been well examined by using allyl alcs. CH2=CHCH(R5)OH (R5 = Et, benzyl, thiophen-2-yl, etc.) as coupling partners. Under the advantage of the pyridine guiding group, the efficient protocol allows the rapid synthesis of diverse BINOL carbonyl compounds II and III with the retention of optical purity. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Synthetic Route of C6H6BrN) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem