Tag: 100-200

Theeramunkong, Sewan; Maicheen, Chirattikan; Krongsil, Rinnara; Chaichanasap, Waritsara; Asasutjarit, Rathapon; Vajragupta, Opa published an article in 2022. The article was titled 《Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents》, and you may find the article in Chemical Papers.Electric Literature of C7H5N The information in the text is summarized as follows:

Two series of triazole derivatives I [Ar = 1-naphthyl, pyridin-3-yl, isoquinolin-4-yl, etc.; R = 2-methoxyphenyl, 4-tert-butylphenyl, 2-cyanophenyl, etc.] were designed and synthesized as potential anticancer agents. A series of eighteen novel 1,2,3-triazole derivatives I were synthesized through copper catalyzed click reaction. The compounds were evaluated for their cytotoxicity activity against HepG2, HeLa cell and HEK293 cell lines using MTT assay. The results showed that compounds [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HepG2 cell with IC50 values 9.6 and 13.3μM, resp. Addnl., the compounds I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HeLa cell with IC50 values 5.7 and 5.8μM, resp. The results of tubulin polymerization assay demonstrated that lead compound I [Ar = 4-isoquinolyl; R = tert-butyl] and compound I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could inhibit in vitro tubulin polymerization In addition, a mechanism study displayed that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] blocked cell cycle arrest at G2/M phase. Furthermore, a mol. docking study demonstrated that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could bind to the colchicine site of tubulin and form hydrogen bonds in the active site of β-tubulin. In summary, this study recommended a promising isoquinoline-triazole scaffold for further development as more efficient microtubule polymerization inhibitors in the field of cancer treatment.4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mandal, Vivekananda; Ghosh, Narendra Nath; Mitra, Prashanta Kumar; Mandal, Sukhendu; Mandal, Vivekananda published an article in 2022. The article was titled 《Production and characterization of a broad-spectrum antimicrobial 5-butyl-2-pyridine carboxylic acid from Aspergillus fumigatus nHF-01》, and you may find the article in Scientific Reports.Reference of Picolinic acid The information in the text is summarized as follows:

Abstract: The present study aims at the production optimization, purification, and characterization of a potent broad-spectrum antimicrobial compound (AMC) produced by Aspergillus fumigatus nHF-01 (GenBank Ac. Number MN190286). The culture conditions were optimized for a higher amount of AMC. The AMC was solvent extracted and characterized by UV-Vis, FT-IR, ESI-MS, and 1H-NMR spectroscopy. The MIC, MBC and mode of action were determined against a set of Gram-pos. and Gram-neg. human pathogenic bacteria. Its antibiofilm, synergistic and cytotoxic effects were also tested. The putative target site of action was evaluated through in silico mol. docking study. The stain A. fumigatus nHF-01 produced the maximum AMC (5-butyl-2-pyridine carboxylic acid) in 2% MEB (w/v) and 4% YE (w/v) at pH 6.0 and 20 °C temperature with 100 rpm agitation for ten days. It caused complete lethality of the Gram-pos. and Gram-neg. human pathogenic bacteria at a 129 μg/mL dose by rupture and entire dissolution of cell integrity. It showed moderate antibiofilm activity and had a synergistic activity with streptomycin and additive effects with ciprofloxacin and vancomycin. It targets a respiratory enzyme, Quinol-Fumarate Reductase (1l0v), with the highest binding affinities. It had cytotoxicity against human lung carcinoma A549 cell line and was stable up to 100 °C. Thus, the study revealed that the strain A. fumigatus nHF-01 produces a potent broad-spectrum AMC 5-butyl-2-pyridine carboxylic acid that could be used against human food and topical pathogenic bacteria. This is the first report of such a compound produced from the A. fumigatus. In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Reference of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Reference of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Zhewen; Zhao, Jun; Liu, Yuhang; Li, Guangfeng; Wang, Heng; Hou, Yali; Zhang, Mingming; Li, Xiaopeng; Yan, Xuzhou published an article in 2021. The article was titled 《Conformational effect on fluorescence emission of tetraphenylethylene-based metallacycles》, and you may find the article in Chinese Chemical Letters.Application In Synthesis of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

Herein, the authors designed and constructed two metallacycles, 1 and 2, to illustrate the conformational effect of isomeric AIE fluorophores on the platform of supramol. coordination complexes (SCCs). Specifically, the dangling Ph rings in TPE units of the metallacycle 1 align completely outside the main cyclic structure, while in the metallacycle 2, these Ph rings align half inside and half outside. The exptl. results showed that two metallacycles exhibited different behaviors in terms of AIE fluorescence and chem. sensing, which could be attributed to the subtle structural difference of the TPE units. This work represents the unification of topics such as self-assembly, AIE, and chem. sensing, and further promotes the understanding for the structure-property relationship of isomeric AIE fluorophores.Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Das, Athulya; Rajeev, Anjana; Bhunia, Sarmistha; Arunkumar, Manivel; Chari, Nithya; Sankaralingam, Muniyandi published an article in 2021. The article was titled 《Synthesis, characterization and antimicrobial activity of nickel(II) complexes of tridentate N3 ligands》, and you may find the article in Inorganica Chimica Acta.SDS of cas: 1539-42-0 The information in the text is summarized as follows:

The desire to develop new antimicrobial agents against the rising threat of extensive antibiotic resistance led to the exploration of many natural and synthetic compounds Herein, the authors report the isolation and structural characterization of Ni(II) complexes [Ni(L)2]2+ (1 and 2) of tridentate N3 ligands such as bis(pyridin-2-ylmethyl)amine (L1) and 1-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-2-ylmethyl)methanamine (L2). Both the complex cations of [Ni(L1)2]2+ (1) and [Ni(L2)2]2+ (2) possess a distorted octahedral coordination geometry in which Ni(II) is chelated to two equivalent of the tridentate L1 and L2 ligand in facial coordination, resp. 1 And 2 exhibit the bands in the visible region in UV-visible spectra and peaks in the downfield region in paramagnetic NMR spectra suggesting the octahedral coordination geometry of the complexes in solution as well. Further, complexes 1 and 2 were evaluated for their antimicrobial activity against various clin. pathogens. With in vitro studies, 1 displayed activity against Vibrio parahaemolyticus and V. alginolyticus, Staphylococcus aureus, Candida albicans, and Salmonella typhi, and 2 displayed activity against S. aureus, S. typhi, and C. albicans. With in vivo studies, complex 1 was effective in inhibiting Vibrio infection in brine shrimp larvae while having no toxicity on the larvae. The authors believe these results will encourage medicinal chemists to further the study on metal complexes against multi-resistant pathogens.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sakla, Rahul; Amilan Jose, D. published an article in 2021. The article was titled 《New fluorinated manganese carbonyl complexes for light controlled carbon monoxide (CO) release and the use of bench-top 19F-NMR spectroscopy》, and you may find the article in Inorganica Chimica Acta.HPLC of Formula: 1539-42-0 The information in the text is summarized as follows:

CO is used as an essential therapeutic agent. Control delivery and tracking of CO is the important concern for using in therapeutics. The authors report fluorinated Mn(I) tricarbonyl complexes PF-DPA perfluorobenzyl-dipicolinylamine, Mn and CF-DPA·Mn (CF-DPA = trifluoromethylbenzyl-dipicolinylamine) as a new photoCORMs for photo-controlled CO release. For the 1st time, the bench-top 19F-NMR on-off signal was used to monitor light-controlled CO release along with other traditional methods. 19F-NMR signal was initially on which attenuates on irradiating with blue light due to conversion of Mn(I) to Mn(II). CO release behavior of new complexes was also supported by Myoglobin assay, time-dependent IR study and UV-visible experiments Fluorinated Mn carbonyl complexes with 19F-NMR open up vast opportunities for researchers to develop a fast and reliable technique for tracking CO release. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qian, Jianying; Gong, Jinsong; Xu, Zhenghong; Jin, Jian; Shi, Jinsong published an article in 2021. The article was titled 《Significant improvement in conversion efficiency of isonicotinic acid by immobilization of cells via a novel microsphere preparation instrument》, and you may find the article in Bioresource Technology.Safety of 4-Cyanopyridine The information in the text is summarized as follows:

An instrument for the automatic preparation of microspheres was designed and manufactured, and by which cells were immobilized as efficient biocatalyst with small particle diameter, high crosslinking uniformity, and high porosity. The concentration of polymer solution, crosslinking agent and other conditions for preparing the cells microspheres were determined, and the conversion conditions of isonicotinic acid from 4-cyanopyridine were optimized to minimize mass-transfer limitations, and improve thermal and storage stability. The immobilized cells microspheres, which were continuously used for 23 batches, showed a total transformation capacity of 4.6 mol/L 4-cyanopyridine and a cumulative mass of 566.31 g/L of isonicotinic acid, which demonstrated the potential of the durable biocatalyst with efficient conversion capacity. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hassan, Mirja Mahamudul Md; Hoque, Emdadul Md; Dey, Sayan; Guria, Saikat; Roy, Brindaban; Chattopadhyay, Buddhadeb published an article in 2021. The article was titled 《Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines》, and you may find the article in Synthesis.Recommanded Product: 3510-66-5 The information in the text is summarized as follows:

The authors report a convenient method for the highly site-selective borylation of 8-arylquinoline. The reaction proceeds smoothly in the presence of a catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed into various important synthons by using known transformations. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohtsu, Hiroyoshi; Kim, Joonsik; Kanamaru, Tatsuya; Inoue, Daishi; Hashizume, Daisuke; Kawano, Masaki published an article in 2021. The article was titled 《Stepwise Observation of Iodine Diffusion in a Flexible Coordination Network Having Dual Interactive Sites》, and you may find the article in Inorganic Chemistry.Reference of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

We created dual interactive sites in a porous coordination network using a CuI cluster and a rotation-restricted ligand, tetra(3-pyridyl)phenylmethane (3-TPPM). The dual interactive sites of iodide and Cu ions can adsorb I2 via four-step processes including two chemisorption processes. Initially, one I2 mol. was physisorbed in a pore and successively chemisorbed on iodide sites of the pore surface, and then the next I2 mol. was physisorbed and chemisorbed on Cu ions to form a cross-linked network. We revealed the four-step I2 diffusion process by single-crystal X-ray structure determination and spectroscopic kinetic anal. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Joyce, Justin P.; Portillo, Romeo I.; Nite, Collette M.; Nite, Jacob M.; Nguyen, Michael P.; Rappe, Anthony K.; Shores, Matthew P. published their research in Inorganic Chemistry in 2021. The article was titled 《Electronic Structures of Cr(III) and V(II) Polypyridyl Systems: Undertones in an Isoelectronic Analogy》.Safety of 4,4′-Dimethyl-2,2′-bipyridine The article contains the following contents:

A recently reported description of the photophys. properties of V2+ polypyridyl systems has highlighted several distinctions between isoelectronic, d3, Cr3+, and V2+ tris-homoleptic polypyridyl complexes of 2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen). Here, we combine theory and exptl. data to elucidate the differences in electronic structures. We provide the first crystallog. structures of the V2+ complexes [V(bpy)3](BPh4)2 (V-1B) and [V(phen)3](OTf)2 (V2) and observe pronounced trigonal distortion relative to analogous Cr3+ complexes. We use electronic absorption spectroscopy in tandem with TD-DFT computations to assign metal-ligand charge transfer (MLCT) properties of V-1B and V2 that are unique from the intraligand transitions, 4(3IL), solely observed in Cr3+ analogs. Our newly developed natural transition spin d. (NTρα,β) plots characterize both the Cr3+ and V2+ absorbance properties. A multideterminant approach to DFT assigns the energy of the 2E state of V-1B as stabilized through electron delocalization. We find that the profound differences in excited state lifetimes for Cr3+ and V2+ polypyridyls arise from differences in the characters of their lowest doublet states and pathways for intersystem crossing, both of which stem from trigonal structural distortion and metal-ligand π-covalency. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zooming in on the hydrated imidazoline ring expansion: Factors influencing the rate of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines》 was written by Lavit, Kseniya; Reutskaya, Elena; Grintsevich, Sergey; Sapegin, Alexander; Krasavin, Mikhail. Product Details of 197958-29-5 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

The influence of electronic factors on the rates of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines was examined Electron-withdrawing substituents on the aroyl group weakly accelerate the reaction (in linear correlation with the Hammett σp constants). Much stronger influence came from the nitrogen-bound aromatic group which gave a strong linear correlation with the Hammett σ-p constants For electron-deficient heteroaromatics and nitroaroms., the migration was nearly instantaneous in basic medium. These findings will significantly impact the planning of mechanistically related transformations of N-(2-aminoethyl) lactams through the hydrated imidazoline ring expansion (HIRE) process. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Product Details of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem