Tag: 100-200

《High performance of nitrogen-doped carbon-supported cobalt catalyst for the mild and selective synthesis of primary amines》 was written by Liu, Xixi; Wang, Yanxin; Jin, Shiwei; Li, Xun; Zhang, Zehui. Recommanded Product: 100-48-1 And the article was included in Arabian Journal of Chemistry in 2020. The article conveys some information:

A nitrogen-doped carbon-supported Co catalyst (Co/N-C-800) was discovered to be highly active for the reductive amination of carbonyl compounds with NH3 and the hydrogenation of nitriles into primary amines using H2 as the hydrogen source. Structurally diverse carbonyl compounds were selectively transformed into primary amines with good to excellent yields (82.8-99.6%) under mild conditions. The Co/N-C-800 catalyst showed comparable or better catalytic performance than the reported noble metal catalysts. The Co/N-C-800 catalyst also showed high activity for the hydrogenation of nitriles, affording the corresponding primary amines with high yields (81.7-99.0%). An overall reaction mechanism is proposed for the reductive amination of benzaldehyde and the hydrogenation of benzonitrile, which involves the same intermediates of phenylmethanimine and N-benzylidenebenzylamine. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structural Variety in Mn(NCS)2 4-Cyanopyridine Coordination Compounds: Synthesis, Structures, Isomerism, and Magnetic Properties》 was written by Wellm, Carsten; Neumann, Tristan; Gallo, Gianpiero; Dziubyna, Anna M.; Rams, Michal; Dinnebier, Robert E.; Naether, Christian. Quality Control of 4-Cyanopyridine And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

The reaction of Mn(NCS)2 with 4-cyanopyridine (CNpy) gives discrete complexes [Mn(NCS)2(CNpy)4] (1), [Mn(NCS)2(H2O)2(CNpy)2] (2-I and 2-II), and [Mn(NCS)2(H2O)2(CNpy)2]·xCNpy (x = 4, 3; x = 2, 4), in which the Mn(II) centers are octahedrally coordinated by two terminal N-bonded thiocyanate anions and by four (1) or two CNpy coligands and two H2O mols. (2-I, 2-II, 3, and 4). If an excess of Mn(NCS)2 was used, [Mn(NCS)2(CNpy)2]n (5) and [Mn(NCS)2(CNpy)]n (6-I and 6-II) were obtained. In all compounds the Mn(II) cations are octahedrally coordinated and linked into linear chains (5), into layers (6-I), or into a 3-dimensional network (6-II) by the thiocyanate anions. Studies using TG-DTA and temperature-dependent powder x-ray diffraction prove that the discrete complexes 2-II, 3, and 4 decompose in several steps, giving Mn(NCS)2 via 5 and 6-I as intermediates. For compounds 2-II, 4, and 6-II only one batch was obtained, indicating that these compounds are metastable. Magnetic measurements for 5 and 6-I reveal dominating antiferromagnetic interactions and susceptibility curve maxima at 20 K (5) and 24 K (6-I), reproduced by quantum Monte Carlo simulations. The sp. heat proves magnetic ordering at 2.8 K (5) and 12.4 K (6-I). The ordering of 6-I is associated with a weak ferromagnetism. Several Mn(NCS)2 4-cyanopyridine coordination compounds including polymorphic and isomeric modifications were synthesized and structurally characterized by SC-XRD and PXRD. Their thermal reactivity and magnetic behavior were studied. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Coumarin-Based Reversible Fluorescent Probe for Selective Detection of Cu2+ in Living Cells》 was published in Journal of Fluorescence in 2020. These research results belong to Ahmed, Nadeem; Zareen, Wajeeha; Zhang, Di; Yang, Xiaopeng; Ye, Yong. HPLC of Formula: 1539-42-0 The article mentions the following:

Abstract: Copper ion plays an important role in many biol. processes in human body. H2S is considered as the third gasses transmitter after carbon monoxide and nitric oxide. Here a novel ICT-based fluorescent ON-OFF-ON probe for Cu2+ and H2S detection was developed. Selectivity and sensitivity of probe was confirmed in aqueous Tris-HCl buffer (10 mM, pH 7.4, containing 90% acetonitrile). Probe DF-CU shows high selectivity over other analytes. The degree of fluorescence quenching is linearly associated with the concentration of Cu2+ (R2 = 0.9919). The limit of detection (LOD, calculated according to the 3σ/slope) for Cu2+ was 6.4μM. Probe can work in almost all pH. The probe shows a very fast response to Cu2+ (within 10 s). Its response to copper ion could be reversed by H2S. The complex of probe with Cu2+ could be used for H2S detection. Furthermore, this ON-OFF-ON fluorescent probe successfully applied in the living cells for the detection of Cu2+ and H2S. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A visible-light-photocatalytic water-splitting strategy for sustainable hydrogenation/deuteration of aryl chlorides》 was published in Science China: Chemistry in 2020. These research results belong to Ling, Xiang; Xu, Yangsen; Wu, Shaoping; Liu, Mofan; Yang, Peng; Qiu, Chuntian; Zhang, Guoqiang; Zhou, Hongwei; Su, Chenliang. Application In Synthesis of 5-Bromo-2-chloropyridine The article mentions the following:

Abstract: Hydrogenation/deuteration of carbon chloride (C-Cl) bonds is of high significance but remains a remarkable challenge in synthetic chem., especially using safe and inexpensive hydrogen donors. In this article, a visible-light-photocatalytic water splitting hydrogenation technol. (WSHT) is proposed to in-situ generate active H-species (i.e., Had) for controllable hydrogenation of aryl chlorides instead of using flammable H2. When applying heavy water-splitting systems, we could selectively install deuterium at the C-Cl position of aryl chlorides under mild conditions for the sustainable synthesis of high-valued added deuterated chems. Sub-micrometer Pd nanosheets (Pd NSs) decorated crystallined polymeric carbon nitrides (CPCN) is developed as the bifunctional photocatalyst, whereas Pd NSs not only serve as a cocatalyst of CPCN to generate and stabilize H (D)-species but also play a significant role in the sequential activation and hydrogenation/deuteration of C-Cl bonds. This article highlights a photocatalytic-WSHT for controllable hydrogenation/deuteration of low-cost aryl chlorides, providing a promising way for the photosynthesis of high-valued added chems. instead of the hydrogen evolution. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases》 was published in Inorganic Chemistry in 2020. These research results belong to Miller, Kelsey R.; Paretsky, Jonathan D.; Follmer, Alec H.; Heinisch, Tillmann; Mittra, Kaustuv; Gul, Sheraz; Kim, In-Sik; Fuller, Franklin D.; Batyuk, Alexander; Sutherlin, Kyle D.; Brewster, Aaron S.; Bhowmick, Asmit; Sauter, Nicholas K.; Kern, Jan; Yano, Junko; Green, Michael T.; Ward, Thomas R.; Borovik, A. S.. Name: Bis(pyridin-2-ylmethyl)amine The article mentions the following:

An important class of non-heme dioxygenases contains a conserved Fe binding site that consists of a 2-His-1-carboxylate facial triad. Results from structural biol. show that, in the resting state, these proteins are six-coordinate with aqua ligands occupying the remaining three coordination sites. We have utilized biotin-streptavidin (Sav) technol. to design new artificial Fe proteins (ArMs) that have many of the same structural features found within active sites of these non-heme dioxygenases. An Sav variant was isolated that contains the S112E mutation, which installed a carboxylate side chain in the appropriate position to bind to a synthetic FeII complex confined within Sav. Structural studies using X-ray diffraction (XRD) methods revealed a facial triad binding site that is composed of two N donors from the biotinylated ligand and the monodentate coordination of the carboxylate from S112E. Two aqua ligands complete the primary coordination sphere of the FeII center with both involved in hydrogen bond networks within Sav. The corresponding FeIII protein was also prepared and structurally characterized to show a six-coordinate complex with two exogenous acetato ligands. The FeIII protein was further shown to bind an exogenous azido ligand through replacement of one acetato ligand. Spectroscopic studies of the ArMs in solution support the results found by XRD. Biol. O2 activation is often accomplished with dioxygenases that contain non-heme iron centers with a common 2-His-1-carboxylate endogenous binding site for iron. We have engineered an artificial protein to model this site using biotin-streptavidin technol. Structural and spectroscopic studies support formation of an Fe(II) artificial protein with features similar to those in the native proteins, including hydrogen bonds within the secondary coordination sphere. This work highlights the utility of embedding metal complexes with protein hosts.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A nitrogen and phosphorus enriched pyridine bridged inorganic-organic hybrid material for supercapacitor application》 were Dhiman, Nisha; Mohanty, Paritosh. And the article was published in New Journal of Chemistry in 2019. Safety of 2,6-Diaminopyridine The author mentioned the following in the article:

A new class of N- and P-enriched pyridine bridged inorganic-organic hybrid material is synthesized via the condensation of phosphonitrilic chloride trimer and 2,6-diaminopyridine at 140°C for 18 h. It was used as the active electrode material for supercapacitor application. The role of mass loading on the overall performance of the HPHM supercapacitor electrode has been investigated. Specific capacitances of 243 and 107 F g-1 are estimated from cyclic voltammetry and galvanostatic charge-discharge measurements at a scan rate of 1 mV s-1 and c.d. of 0.5 A g-1, resp. The high retention of 81% of the initial Csp value is observed after 2000 cycles at a c.d. of 5 A g-1. A fabricated solid-state sym. supercapacitor device made with the optimal mass loading shows power and energy densities of 244 W kg-1 and 14.4 W h kg-1, resp., and it could light up a green LED display (23 in total) for up to 50 s upon charging for 5 s at 3 V. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Metal Catalyzed Synthesis of Dihydropyridobenzodiazepines》 were Maddess, Matthew L.; Li, Chaomin. And the article was published in Organometallics in 2019. Quality Control of 2-Bromonicotinaldehyde The author mentioned the following in the article:

A versatile synthesis of dihydropyridobenzodiazepines that proceeds via a palladium-catalyzed C-N coupling and catalytic hydrogenation cascade is reported. The intermediate 2-anilinonicotinaldehydes may be efficiently protected to ultimately afford N6 differentiated dihydropyridobenzodiazepines, which facilitates further elaboration. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Bioreducible Zinc(II)-Dipicolylamine Functionalized Hyaluronic Acid Mediates Safe siRNA Delivery and Effective Glioblastoma RNAi Therapy》 were Zheng, Meng; Yang, Zhipeng; Chen, Shizhu; Wu, Haigang; Liu, Yang; Wright, Amanda; Lu, Jeng-Wei; Xia, Xue; Lee, Albert; Zhang, Jinchao; Yin, Huijun; Wang, Yingze; Ruan, Weimin; Liang, Xing-Jie. And the article was published in ACS Applied Bio Materials in 2019. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clin. application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Mazur, D.; Pariiska, O.; Kurys, Y.. Synthetic Route of C5H7N3. The article was titled 《Co-N-C electrocatalysts derived from nitrogen containing conjugated polymers for hydrogen evolution》. The information in the text is summarized as follows:

New Co-N-C electrocatalysts for hydrogen evolution reaction (HER) were successfully prepared via heat treatment of a series of nitrogen containing conjugated polymers – N-CP (poly-m-phenylenediamine, poly-8-aminoquinoline, poly-2,6-diaminopyridine, poly-5-aminoindole) with carbon black and Co(NO3)2. For the first time, we demonstrated influence of the N-CP type, like a nitrogen precursor, on activity toward HER of Co-N-C composites in acidic media, which may be related, in particular, to the differences in the mol. structure of polymers. It was found, that the best HER performance inherent to an electrocatalyst obtained based on poly-5-aminoindole (overpotential at 5 mA/cm2 ∼ 177 mV, Tafel slope – 132 mV/dec). According to obtained exptl. data, it was assumed that the hydrogen evolution on Co-N-C catalysts takes place by the Volmer-Heyrovsky mechanism and the Volmer step is rate-limiting. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Hong; Wang, Guanghui; Li, Pengfei published 《Iridium-catalyzed intermolecular directed dehydrogenative ortho C-H silylation》.Organic Chemistry Frontiers published the findings.Computed Properties of C7H9NO The information in the text is summarized as follows:

An efficient method for iridium-catalyzed direct silylation of C(sp2)-H and C(sp3)-H bonds using HSiMe(OSiMe3)2 as the silylating reagent is described. The reaction is amenable to various directing groups under simple and mild conditions leading to the mono- and regioselective synthesis of versatile organosilane compounds2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem