Tag: 100-200

《Iron-cobalt-catalyzed heterotrimerization of alkynes and nitriles to polyfunctionalized pyridines》 was written by Xie, Yufang; Wu, Chengjuan; Jia, Changhao; Tung, Chen-Ho; Wang, Wenguang. Related Products of 100-48-1 And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

Based on the reactivity of half-sandwich complexes [Cp*Fe(NCMe)3]PF6 and Cp*Co(1,2-Ph2PC6H4NH), (Cp* = Me5C5-), the iron(II)-cobalt(II) co-catalysis of the cycloaddition of alkynes to nitriles under mild reaction conditions was studied. This method enabled the synthesis of polysubstituted pyridines in a single step and especially valuable for the preparation of 2,3,4,5,6-pentafunctionalized pyridines. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Related Products of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Oxalato bridged coordination polymer of manganese(III) involving unconventional O···π-hole(nitrile) and antiparallel nitrile···nitrile contacts: antiproliferative evaluation and theoretical studies》 was written by Dutta, Debajit; Sharma, Pranay; Frontera, Antonio; Gogoi, Anshuman; Verma, Akalesh K.; Dutta, Diksha; Sarma, Bipul; Bhattacharyya, Manjit K.. Product Details of 100-48-1 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A new oxalato bridged polymeric Mn(III) coordination compound, {[Mn2(η2-C2O4)(H2O)2Cl4]2(4-CNpy)}n (1) (C2O4 = oxalate, 4-CNpy = 4-cyanopyridine), was synthesized and characterized using elemental anal., and spectroscopic (IR, electronic, XPS) and single crystal X-ray diffraction techniques. Electronic and XPS analyses of the compound justify the presence of a Mn(III) center that is charge compensated by the two chlorido ligands and the oxygen atom of the bridged oxalate. 4-CNpy mols. in the lattice form unconventional H-bonded supramol. dimers in the solid state assisted by antiparallel CN···CN dipole···dipole interactions, which was confirmed using QTAIM and NCI plot anal. and supported by MEP surface anal. Remarkably, this dimer concurrently establishes a weak anion-π interaction with the coordinated chlorido ligand. Unexpectedly, QTAIM anal. reveals the existence of an interesting O···π-hole (nitrile) contact involving the coordinated water mol. and the nitrile moiety that also contributes to the stabilization of the dimer in the crystal structure. To the best of our knowledge, the existence of such π-hole interaction involving nitrile derivatives was not reported before. Compound 1 was further screened for anticancer activity in the malignant Dalton’s lymphoma (DL) cell line and the results were confirmed by mol. docking and pharmacophore features. The authors’ findings indicated that the cytotoxicity of compound 1 is initially increased in a dose dependent manner (0.01-1μM) and then decreased (5-10μM), which is also affected by the reactive oxygen species (ROS) in the cells. Very low cytotoxicity (5-14%) was observed in the case of healthy cells (PBMC) for similar exptl. conditions. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Product Details of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Product Details of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications》 was written by Wang, Kangnan; Ma, Wen; Xu, Yuchun; Liu, Xin; Chen, Gui; Yu, Meng; Pan, Qiling; Huang, Chaobo; Li, Xiaochuan; Mu, Qingchun; Sun, Yongbing; Yu, Zhiqiang. Synthetic Route of C7H7NO And the article was included in Chinese Chemical Letters in 2020. The article conveys some information:

Considering that hydrogen peroxide (H2O2) plays significant roles in oxidative stress, the cellular signal transduction and essential biol. process regulation, the detection and imaging of H2O2 in living systems undertakes critical responsibility. Herein, we have developed a novel two-photon fluorescence turn on probe, named as Pyp-B for mitochondria H2O2 detection in living systems. Selectivity studies show that probe Pyp-B exhibit highly sensitive response toward H2O2 than other reactive oxygen species (ROS) and reactive nitrogen species (RNS) as well as biol. relevant species. The fluorescence colocalization studies demonstrate that the probe can localize in the mitochondria solely. Furthermore, as a bio-compatibility mol., the highly selective and sensitive of fluorescence probe Pyp-B have been confirmed by its cell imaging application of H2O2 in living A549 cells and zebrafishes under the physiol. conditions. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Charge-assisted hydrogen bond and nitrile···nitrile interaction directed supramolecular associations in Cu(II) and Mn(II) coordination complexes: anticancer, hematotoxicity and theoretical studies》 was published in New Journal of Chemistry in 2020. These research results belong to Sharma, Pranay; Gogoi, Anshuman; Verma, Akalesh K.; Frontera, Antonio; Bhattacharyya, Manjit K.. COA of Formula: C6H4N2 The article mentions the following:

Two new coordination complexes of Cu(II) and Mn(II), viz., [Cu(bpy)(H2O)4]SO4·2H2O (1) and [Mn(4-CNpy)2(H2O)3SO4]·H2O (2) (bpy = 2,2′-bipyridine, 4-CNpy = 4-cyanopyridine), were synthesized and characterized by using single crystal x-ray diffraction, elemental anal., FTIR spectroscopy, electronic spectroscopic techniques and TGA. The crystal structure of 1 uncovers the formation of sulfate-H2O assemblies involving lattice and coordinated H2O mols., while 2 reveals unconventional weak T-shaped CN···CN contacts in the layered architecture. The authors analyzed the unconventional interesting interactions using DFT calculations, mol. electrostatic potential (MEP), the NCI plot and QTAIM computational tools. The interaction energies of the two H-bonded dimers in 1 are very large because of the coulombic attraction between the dicationic H-bonded donor and the dianionic acceptor. It is interesting to observe that despite the energy of the H-bonds being very small compared to the total dimerization energy, the final geometry of the assembly in 1 is due to the charge assisted directional H-bonds instead of the nondirectional ion-pair interactions. The DFT study reveals that the T-shaped CN···CN interaction in 2 is very weak, in good agreement with the small MEP energy at the nitrile C atom. Anticancer studies of the compounds were carried out using Dalton’s lymphoma cell line using MTT and apoptosis assay. The results of compound 1 and 2 mediated cell cytotoxicity on the DL cancer cell line showed a significant concentration-dependent reduction in cell viability, while negligible cytotoxicity was observed in normal (PBMC) cells. The docking simulation results also confirm the interaction of the complexes with the active sites of amino acids of the target proteins. Also, pharmacophore models (2-dimensional and 3-D) for the compounds were mapped to the H-bond donor, pos. ionizable area and hydrophobic features that are important for establishing biol. activities. No hematotoxicity was recorded for the compounds after treatment in normal mice. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《CuO grafted triazine functionalized covalent organic framework as an efficient catalyst for C-C homo coupling reaction》 was published in Molecular Catalysis in 2020. These research results belong to Das, Sabuj Kanti; Krishna Chandra, Bijan; Molla, Rostam A.; Sengupta, Manideepa; Islam, Sk. Manirul; Majee, Adinath; Bhaumik, Asim. Synthetic Route of C5H6BNO2 The article mentions the following:

A new copper oxide immobilized covalent organic framework (COF) material CuII-TRIPTA by grafting of CuO nanoparticles at the surface of a nitrogen rich porous COF material TRIPTA was reported. TRIPTA was synthesized through the extended Schiff base reaction between 2,4,6-triformylphloroglucinol and 1,3,5-tris-(4-aminophenyl)triazine. The COF as well as CuO loaded materials were characterized by powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), XPS, N2 adsorption-desorption, Fourier transform IR spectroscopy (FT-IR), thermogravimetry (TG) and EPR spectroscopic analyses. CuII-TRIPTA material was successfully applied as heterogeneous nanocatalyst for the C-C homo-coupling reaction of phenylboronic acids to synthesize wide range of biaryl compounds under mild and eco-friendly conditions (60°, methanol solvent). Remarkably high sp. surface area of CuII-TRIPTA (583 m2 g-1) and highly accessible catalytic sites in the 2D-hexagonal COF nano-architecture potentially makes it excellent catalyst in the C-C bond formation reaction, which was evident from the high TON of the catalyst in this reaction. The catalyst was recollected and reused till 6th cycles without any noticeable change of its catalytic activity, suggesting its high catalytic efficiency in this C-C bond formation reaction. The experimental process involved the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Synthetic Route of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chiral Imidazo[1,5-a]pyridine-Oxazolines: A Versatile Family of NHC Ligands for the Highly Enantioselective Hydrosilylation of Ketones》 was published in Organometallics in 2020. These research results belong to Chinna Ayya, Swamy .P.; Varenikov, Andrii; de Ruiter, Graham. SDS of cas: 1122-54-9 The article mentions the following:

Herein the authors report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcs. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with Rh(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcs. are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-95% ee). The reported hydrosilylation occurs at ambient temperatures (40°), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines》 was published in Catalysis Communications in 2020. These research results belong to Azouzi, Karim; Bruneau-Voisine, Antoine; Vendier, Laure; Sortais, Jean-Baptiste; Bastin, Stephanie. COA of Formula: C7H7NO The article mentions the following:

A series of com. available chiral amino-phosphines, in combination with Mn(CO)5Br, was evaluated for the asym. reduction of ketones to secondary alcs. RCH(OH)R1 [R = c-hexyl, Ph, 1-naphthyl, etc.; R1 = Me, Et, i-Pr, etc.] using isopropanol as hydrogen source. With the most selective ligand, the corresponding manganese complex was synthesized and fully characterized. A series of ketones was hydrogenated in the presence of 0.5 mol% of the manganese pre-catalyst affording the chiral alcs. in high yields with enantiomeric excesses up to 99%. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Formation of benzodiazepines and pyrazinylquinoxalines from aromatic and heteroaromatic ketones via deoximation》 was published in Asian Journal of Chemistry in 2020. These research results belong to Song, J. H.; Bae, S. M.; Lee, E. J.; Cho, J. H.; Jung, D. I.. Recommanded Product: 1122-54-9 The article mentions the following:

In the course of present investigations, it was found that dichloroamine T could be an efficient reagent for the conversion of oximes into the corresponding carbonyl compounds Herein the synthesis of 1H-1,5-benzodiazepine derivatives I [R = pyrrol-2-yl, 2-pyridinyl, 2-thienyl, etc.] from heteroaromatic ketones and acetone equivalent was obtained using dichloroamine-T. On the other hand, when diamine (1,2-phenylene diamine or 1,2-naphthalene diamine) with heterocyclic ketone (acetyl pyridine or acetyl pyrazines) in the presence of concentrate HCl and SiO2 was refluxed, quinoxaline derivatives, II [R = 2-pyrazinyl, 2-pyridinyl, 2-thienyl, etc.] as yellow crystalline solids were isolated in high yields. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Facile one-pot protocol of derivatization nitropyridines: access to 3-acetamidopyridin-2-yl 4-methylbenzenesulfonate derivatives》 were Lin, Ling; Chen, Xiaoguang; Zhao, Junhao; Lin, Suitao; Ma, Guojian; Liao, Xiaojian; Feng, Pengju. And the article was published in Heterocyclic Communications in 2019. Application In Synthesis of 6-Bromopyridin-3-amine The author mentioned the following in the article:

An efficient one-pot protocol for conversion of easily accessible 3-nitropyridines to 3-acetamidopyridin-2-yl 4-methylbenzenesulfonate derivatives which were core structures of many pharmaceutical mols was reported. The strategy successfully combined a three-step reaction in one-pot via progressively adding different reactants at rt. The reaction displayed good functional group tolerance and regioselectivity. Structurally diversified 3-nitropyridine was time-efficiently (3.5 h) derivatized to various functional 2-O,3-N-pyridines which were apt for further elaborations. The transformation was amenable to gram-scale synthesis. After reading the article, we found that the author used 6-Bromopyridin-3-amine(cas: 13534-97-9Application In Synthesis of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application In Synthesis of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A near infrared light emitting electrochemical cell with a 2.3 V turn-on voltage》 were Nemati Bideh, Babak; Shahroosvand, Hashem; Sousaraei, Ahmad; Cabanillas-Gonzalez, Juan. And the article was published in Scientific Reports in 2019. COA of Formula: C12H12N2 The author mentioned the following in the article:

We report on an organic electroluminescent device with simplified geometry and emission in the red to near IR (NIR) spectral region which, has the lowest turn-on voltage value, 2.3 V, among light emitting electrochem. cells (LEECs). We have synthesized and characterized three novel ruthenium π-extended phenanthroimidazoles which differ on their NN̂ ligands. The use of di-Me electron donating groups along with the π-extended phenanthroimidazole moiety promotes ambipolar transport thereby avoiding the use of addnl. charge transport layers. Furthermore, a facile cathode deposition method based on transfer of a molten alloy (Ga:In) on top of the active layer is deployed, thus avoiding high vacuum thermal deposition which adds versatile assets to our approach. We combine ambipolar charge transport organic complex design and a simple ambient cathode deposition to achieve a potentially cost effective red to NIR emitting device with outstanding performance, opening new avenues towards the development of simplified light emitting sources through device optimization. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6COA of Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.COA of Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem