Tag: 100-200

The author of 《Copper-catalyzed versatile C(sp3)-H arylation: synthetic scope and regioselectivity investigations》 were Zhou, Jiadi; Zou, Yawen; Zhou, Peng; Chen, Zhiwei; Li, Jianjun. And the article was published in Organic Chemistry Frontiers in 2019. Synthetic Route of C6H4N2 The author mentioned the following in the article:

The copper-catalyzed versatile C(sp2)-C(sp3) bond formation with N-heteroaromatics and hydrogen donors was developed. Various alkanes and ethers reacted with quinolines, isoquinolins, pyridines, benzooxazole and benzothiazole to gave the corresponding C(sp2)-H alkylation products via cross-dehydrogenative coupling. The high regioselective C(sp2)-halogen alkylation of (hetero)aryl chlorides and (hetero)aryl bromides with ethers via elimination of the halogen radical. The reaction mechanism was investigated with control experiments The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Synthetic Route of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Inorganica Chimica Acta included an article by Chen, Dong-Mei; Wu, Xiao-Fan; Liu, Yong-Jie; Huang, Chao; Zhu, Bi-Xue. Computed Properties of C7H7NO. The article was titled 《Synthesis, crystal structures and vapor adsorption properties of Hg(II) and Cd(II) coordination polymers derived from two hydrazone Schiff base ligands》. The information in the text is summarized as follows:

Four coordination polymers, [HgL1Br2]n (1), {[Cd(L1)2Cl2]·2CH3OH}n (2), [HgL2Cl2]n (3) and [Cd(L2)2Cl2]n (4), were synthesized and characterized from two hydrazone Schiff base ligands (L1 and L2) with mercury(II) or cadmium(II) halide, resp. In complexes 1 and 3, each mercury(II) center is five-coordinated with distorted square pyramidal geometry in 1-dimensional coordination polymers. In complexes 2 and 4, each cadmium(II) center is six-coordinated with slightly distorted octahedral geometry in 1-dimensional looped-chain structures. The ligands show different coordination sites in the formation of coordination polymers. In complexes 2, 3 and 4, the ligands coordinate to the metal centers by pyridine nitrogen atoms and amino nitrogen atoms, whereas in complex 1 it coordinates by pyridine nitrogen atoms and carbonyl oxygen atoms instead of amino nitrogen atoms. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Devi, Namita; Hazarika, Sukanya; Gogoi, Prasanta; Barman, Pranjit published 《A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides》.Synthetic Communications published the findings.Safety of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles has been reported. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticles notably enhances the miscibility, providing a faster, high yielding and cost-effective process in an ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as byproduct leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl sym. disulfides are obtained in good to excellent yields up to 98%.5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2010,Zheng, Xiaowan; Pan, Yongmei; Acharya, Chayan; Swaan, Peter W.; Polli, James E. published 《Structural Requirements of the ASBT by 3D-QSAR Analysis Using Aminopyridine Conjugates of Chenodeoxycholic Acid》.Bioconjugate Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

The human apical sodium-dependent bile acid transporter (ASBT) is a validated drug target and can be employed to increase oral bioavailability of various drug conjugates. The aim of the present study was to investigate the chem. space around the 24-position of bile acids that influences both inhibition and uptake by the transporter. A series of 27 aminopyridine and aminophenol conjugates of glutamyl-chenodeoxycholate were synthesized and their ASBT inhibition and transport kinetics (parametrized as Ki, Kt, and Jmax) measured using stably transfected ASBT-MDCK cells. All conjugates were potent ASBT inhibitors. Monoanionic conjugates exhibited higher inhibition potency than neutral conjugates. However, neutral conjugates and chloro-substituted monoanionic conjugates were not substrates, or at least not apparent substrates. Kinetic anal. of substrates indicated that similar values for Ki and Kt implicate substrate binding to ASBT as the rate-limiting step. Using 3D-QSAR, four inhibition models and one transport efficiency model were developed. Steric fields dominated in CoMFA models, whereas hydrophobic fields dominated CoMSIA models. The inhibition models showed that a hydrophobic or bulky substitute on the 2 or 6 position of a 3-aminopyridine ring enhanced activity, while a hydrophobic group on the 5 position was detrimental. Overall, steric and hydrophobic features around the 24 position of the sterol nucleus strongly influenced bile acid conjugate interaction with ASBT. The relative location of the pyridine nitrogen and substituent groups also modulated binding. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles》 was written by Smith, Christopher D.; Greaney, Michael F.. Synthetic Route of C5H5BrN2This research focused ontriazole preparation; azide alkyne zinc dipolar cycloaddition. The article conveys some information:

A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Addnl., the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors》 was published in Tetrahedron Letters in 2011. These research results belong to Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudilliere, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger. Electric Literature of C9H12N2O2 The article mentions the following:

The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors. The experimental process involved the reaction of Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4Electric Literature of C9H12N2O2)

Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C9H12N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2021 ,《Metal-Free Hydropyridylation of Thioester-Activated Alkenes via Electroreductive Radical Coupling》 was published in Journal of Organic Chemistry. The article was written by Xu, Hehuan; Liu, Jiayu; Nie, Feiyun; Zhao, Xiaowei; Jiang, Zhiyong. The article contains the following contents:

An electrochem. hydropyridylation of thioester-activated alkenes R1R2C:CHC(O)SEt (R1 = Ph, 2-MeOC6H4, 3-BrC6H4, 1-naphthyl, N-Boc-indol-3-yl, etc.; R2 = H, Me, n-Bu) with 4-cyanopyridines has been developed. The reactions proceed via tandem electroreduction of both substrates on the cathode surface, protonation and radical cross-coupling processes, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines in high yields. These reactions require no catalyst or high temperature representing a highly sustainable synthetic method. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 98-98-6In 2020 ,《Spectroscopic and Theoretical Investigation of Color Tuning in Deep-Red Luminescent Iridium(III) Complexes》 was published in Inorganic Chemistry. The article was written by Stonelake, Thomas M.; Phillips, Kaitlin A.; Otaif, Haleema Y.; Edwardson, Zachary C.; Horton, Peter N.; Coles, Simon J.; Beames, Joseph M.; Pope, Simon J. A.. The article contains the following contents:

A series of heteroleptic, neutral iridium(III) complexes of the form [Ir(L)2(N^O)] (where L = cyclometalated 2,3-disubstituted quinoxaline and N^O = ancillary picolinate or pyrazinoate) are described in terms of their synthesis and spectroscopic properties, with supporting computational analyses providing addnl. insight into the electronic properties. The 10 [Ir(L)2(N^O)] complexes were characterized using a range of anal. techniques (including 1H, 13C, and 19F NMR and IR spectroscopies and mass spectrometry). One of the examples was structurally characterized using X-ray diffraction. The redox properties were determined using cyclic voltammetry, and the electronic properties were investigated using UV-vis, time-resolved luminescence, and transient absorption spectroscopies. The complexes are phosphorescent in the red region of the visible spectrum (λem = 633-680 nm), with lifetimes typically of hundreds of nanoseconds and quantum yields ca. 5% in aerated chloroform. A combination of spectroscopic and computational analyses suggests that the long-wavelength absorption and emission properties of these complexes are strongly characterized by a combination of spin-forbidden metal-to-ligand charge-transfer and quinoxaline-centered transitions. The emission wavelength in these complexes can thus be controlled in two ways: first, substitution of the cyclometalating quinoxaline ligand can perturb both the HOMO and LUMO levels (Cl atoms on the ligand induce the largest bathochromic shift), and second, the choice of the ancillary ligand can influence the HOMO energy (pyrazinoate stabilizes the HOMO, inducing hypsochromic shifts). Heteroleptic neutral iridium(III) complexes [Ir(L)2(N^O)] (where N^O = picolinate or pyrazinoate) that incorporate cyclometalated quinoxaline ligands demonstrate tunable emission in the red region of the visible spectrum. In the experiment, the researchers used Picolinic acid(cas: 98-98-6HPLC of Formula: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Mild and selective hydrogenation of nitriles into primary amines over a supported Ni catalyst》 was published in New Journal of Chemistry. The article was written by Wang, Jianjian; Tang, Qingjie; Jin, Shiwei; Wang, Yanxin; Yuan, Ziliang; Chi, Quan; Zhang, Zehui. The article contains the following contents:

The development of new heterogeneous non-noble catalytic systems for the selective hydrogenation of nitriles into primary amines is a challenging task. In this study, a mesoporous Al2O3-supported Ni catalyst (denoted as Ni/Al2O3-600, where 600 represents the reduction temperature) demonstrated a high catalytic activity for the hydrogenation of nitriles under mild conditions (60-80°C and 2.5 bar H2) with ammonia as the additive. This catalytic system has a wide substrate range; and the Ni/Al2O3 catalyst demonstrated a good tolerance to other functional groups, which was possibly due to its high catalytic activity under mild conditions. A plausible reaction pathway was proposed for the hydrogenation of nitriles into primary amines, and it was found that ammonia played a great role in the enhancement of the selectivity of primary amines by the inhibition of the side reaction to generate secondary amines. In addition, the Ni/Al2O3-600 catalyst could be reused five times without activity loss through convenient magnetic recovery. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Category: pyridine-derivatives)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Efficient trinuclear Ru(II)-Re(I) supramolecular photocatalysts for CO2 reduction based on a new tris-chelating bridging ligand built around a central aromatic ring》 was published in Chemical Science. The article was written by Cancelliere, Ambra M.; Puntoriero, Fausto; Serroni, Scolastica; Campagna, Sebastiano; Tamaki, Yusuke; Saito, Daiki; Ishitani, Osamu. The article contains the following contents:

We have designed and synthesized a new tris-chelating polypyridine ligand (bpy3Ph) suitable to be used as a bridging ligand (BL) for constructing various supramol. photocatalysts. The ligand bpy3Ph has been used to prepare, according to a multi-step synthetic protocol, trinuclear supramol. photocatalysts containing different metal subunits. In particular, the compounds Ru2Re and RuRe2 have been prepared, containing different ratios of components based on Ru(dmb)32+-type and Re(dmb)(CO)3Cl-type units (dmb = 4,4′-dimethyl-2,2′-bipyridine), which can play the roles of photosensitizers and catalyst units for photocatalytic CO2 reduction, resp. The trinuclear model Ru3 and mononuclear and dinuclear Ru and Ru2 precursor metal complexes, containing free chelating sites, have also been synthesized using the same bridging ligand. The absence of negligible accumulation of the mono-reduced form of the photosensitizer indicates fast electron transfer to the catalyst unit(s) through the relatively large bridging ligand and is proposed to contribute to the outstanding photocatalytic properties of the new species, including their durability. The relevant photocatalytic behavior of the new systems indicates new avenues for the design of extended bridging ligands capable of efficiently and functionally integrating photosensitizers and catalysts towards the preparation of new, larger supramol. photocatalysts for selective CO2 reduction In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem