Tag: 100-200

Application In Synthesis of 4-CyanopyridineIn 2020 ,《P-cymene complexes of ruthenium(II) as antitumor agents》 was published in Molecules. The article was written by Pujante-Galian, Maria Angeles; Perez, Sergio A.; Montalban, Mercedes G.; Carissimi, Guzman; Fuster, Marta G.; Villora, Gloria; Garcia, Gabriel. The article contains the following contents:

In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η6-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(η6-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, resp. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Picolinic acidIn 2020 ,《The multiple faces of tryptophan in bone biology》 appeared in Experimental Gerontology. The author of the article were Al Saedi, Ahmed; Sharma, Shilpa; Summers, Matthew A.; Nurgali, Kulmira; Duque, Gustavo. The article conveys some information:

A review. Osteoporosis is highly prevalent in older persons. While many advances have been made in the field of osteoporosis, current treatments have been affected by unexpected side effects and limited efficacy; therefore, new approaches to identify disease mechanisms and pathways are required. This review focuses on the influence of tryptophan metabolites, particularly kynurenines and serotonin on bone. The kynurenine (KYN) pathway is associated with osteoblastogenesis and can be linked to the pathophysiol. of osteoporosis. The activity of osteoblasts is reduced by 3-hydroxykynurenine (3-HKYN), a product of KYN. In addition, decreasing concentrations of 3-hydroxyanthranilic acid with aging can be one of the causes of bone loss. In contrast, picolinic acid, an end-product of the KYN pathway, acts as a bone anabolic. On the other hand, gut-derived serotonin (GDS) inhibits bone formation, whereas brain-derived serotonin enhances bone formation and decreases bone resorption. Overall, understanding the exact mechanisms of action of tryptophan metabolites on bone could have great potential to develop effective treatments for osteoporosis and other bone diseases. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2022 ,《Ruthenium(II)-arene complexes as anti-metastatic agents, and related techniques》 appeared in RSC Medicinal Chemistry. The author of the article were Sonkar, Chanchal; Sarkar, Sayantan; Mukhopadhyay, Suman. The article conveys some information:

A review. With the discovery of cisplatin, a vast area of applications of metallodrugs in cancer treatment was opened but due to the side effects caused by the cisplatin complexes, researchers began to look for alternatives with similar anticancer properties but fewer side effects. Ruthenium was found to be a promising candidate, considering its significant anticancer properties and low side effects. Several ruthenium complexes, viz. NAMI-A, KP1019, KP1339, and TLD1433, have entered clin. trials. Some other arene ruthenium complexes such as RM175 and RAPTA-C have also entered clin. trials but very few of them have shown anti-metastatic properties. Herein, we provide information and probable mechanistic pathways for ruthenium(II)-arene complexes that have been studied, so far, for their anti-metastatic activities. Also, we discuss the techniques and their significance for determining the anti-metastatic effects of the complexes. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Related Products of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1692-25-7In 2022 ,《Design, synthesis and antitumor evaluation of novel quinazoline analogs in hepatocellular carcinoma cell》 appeared in Journal of Molecular Structure. The author of the article were Yu, Pan; Cao, Weiya; Yang, Shilong; Wang, Yuan; Xia, Aixin; Tan, Xinlan; Wang, Luyi. The article conveys some information:

In this paper, five quinazoline analogs I (R = Cl, 1H-indol-5-yl, 4-chlorophenyl, pyridin-3-yl, 4-aminophenyl) were preliminary designed through scaffold shopping from mTOR inhibitors and synthesized in four steps. Five compounds I exhibited potent antitumor activity against the HepG2 cell line by MTT assay. Compound I (R = 1H-indol-5-yl) (II) (IC50 = 4.06μM) was found as the most potent analog and showed better antiproliferative ability than sorafenib (IC50 = 6.14μM). The result of the wound healing assay and transwell migration assay indicated II strong potential to suppress HepG2 cell migration in a dose- and time-dependent manner. The underlying mechanism of its cytotoxicity was also investigated and the results of western blotting confirmed that compound II exposure could block the cell cycle, promote apoptosis and inhibit AKT and mTOR phosphorylation in HepG2 cells. Mol. docking further supported that compound II showed a high affinity to mTOR kinase. The results favored rational design intention and hinted that the new quinazolines I might be helpful in the further explorations of potent agents. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H5BrN2In 2021 ,《Modular Approach to Substituted Pyridoazepinones》 appeared in Organic Letters. The author of the article were Dorokhov, Valentin S.; Zard, Samir Z.. The article conveys some information:

Pyridoazepinones are potentially interesting structures, yet they are still underexploited in the medicinal chem. field and hard to obtain synthetically. Here, a general and flexible synthetic route to substituted pyridoazepinones, enabled by the xanthate addition-transfer process, which furnishes the target mols. from readily available starting materials in generally good yields is presented. The method shows good functional group tolerance and allows the preparation of pyridoazepinone scaffolds on gram scale. After reading the article, we found that the author used 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1122-54-9In 2019 ,《The positional isomeric effects induced various phosphorescence: Switchable properties through acid-base vapor stimulation》 appeared in Journal of Molecular Structure. The author of the article were Li, Bin; Yong, Guoping. The article conveys some information:

Three novel positional isomers, namely (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-2-yl)prop-2-en-1-one , (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-3-yl)prop-2-en-1-one and (E)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one, were obtained through a mild approach. Powder x-ray diffraction patterns demonstrate their various stacking structures, attributed to positional isomeric effects. Furthermore, these positional isomers exhibit different phosphorescent colors and quantum yields. These positional isomers also reveal reversible phosphorescent color switching in the response to acid-base vapor stimuli. The present work provides a promising approach for synthesizing organic materials and a new access to develop dynamic functional materials which can be reversibly switched between different phosphorescence based on external acid-base vapor stimuli. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2019 ,《Mechanistic insights on the non-innocent role of electron donors: reversible photocapture of CO2 by RuII-polypyridyl complexes》 appeared in Dalton Transactions. The author of the article were Queyriaux, Nicolas; Swords, Wesley B.; Agarwala, Hemlata; Johnson, Ben A.; Ott, Sascha; Hammarstroem, Leif. The article conveys some information:

The ability of [RuII(tButpy)(dmbpy)(MeCN)]2+ (1-MeCN) to capture CO2, with the assistance of triethanolamine (TEOA), has been assessed under photocatalytically-relevant conditions. The photolability of 1-MeCN has proven essential to generate a series of intermediates which only differ by the nature of their monodentate ligand. In DMF, ligand photoexchange of 1-MeCN to give [RuII(tButpy)(dmbpy)(DMF)]2+ (1-DMF) proceeds smoothly with a quantum yield of 0.011. However, in the presence of TEOA, this process was disrupted, leading to the formation of a mixture of 1-DMF and [RuII(tButpy)(dmbpy)(TEOA)]+ (1-TEOA). An equilibrium constant of 3 was determined Interestingly, 1-TEOA demonstrated an ability to reversibly catch and release CO2 making it a potentially crucial intermediate towards CO2 reduction4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eremina, J. A.; Lider, E. V.; Kuratieva, N. V.; Samsonenko, D. G.; Klyushova, L. S.; Sheven’, D. G.; Trifonov, R. E.; Ostrovskii, V. A. published their research in Inorganica Chimica Acta in 2021. The article was titled 《Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives》.Category: pyridine-derivatives The article contains the following contents:

A series of mixed-ligand copper(II) complexes {[Cu(phen)(L1)2]·H2O}n (1), [Cu(dmphen)(L1)2] (2), [Cu(bipy)(L1)2] (3) and [Cu2(dmbipy)2(L1)4] (4), where HL1 – 5-methyltetrazole, bipy – 2,2′-bipyridine, dmbipy – 4,4′-dimethyl-2,2′-bipyridine, phen – 1,10-phenanthroline, dmphen – 4,7-dimethyl-1,10-phenanthroline, has been synthesized. The complexes have been characterized by elemental anal., IR spectroscopy and powder x-ray diffraction. Crystal structures of some complexes have been determined by single-crystal x-ray diffraction anal. and showed distorted tetragonal-pyramidal (1) and square pyramidal ([Cu2(bipy)2(L1)4]·DMSO and 4) geometries. The crystal structure of {(H3O)0.5[Cu(phen)(μ3-H2L2)0.5(μ3-HL2)0.5]·H2O}n (5) with alkyl tetrazole H4L2 (1,3,3,5-tetra-(1H-tetrazol-5-yl)-pentane) has also been determined The complexes 1 and 5 have a zig-zag polymeric structure in which each copper(II) ion is coordinated by five N atoms, belonging to three different tetrazolate rings and one 1,10-phenantroline ligand, while [Cu2(bipy)2(L1)4]·DMSO and 4 are binuclear complexes. The effect of the compounds on viability of MCF-7 and Hep-2 cell lines has been investigated. Complexes 1, 2, 4 possess significant dose-dependent cytotoxic effect and 1, 2 are the most cytotoxic. In addition, stability of copper(II) complexes 1-4 in water-ethanol solution and phosphate buffer saline has been investigated by UV-vis spectroscopy. The interaction of complexes 1 and 3 with calf thymus DNA (CT-DNA) has also been studied by UV-vis spectroscopy. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stevens, Matthew P.; Spray, Emily; Vitorica-Yrezabal, Inigo J.; Singh, Kuldip; Timmermann, Vanessa M.; Sotorrios, Lia; Macgregor, Stuart A.; Ortu, Fabrizio published an article in 2022. The article was titled 《Synthesis, characterisation and reactivity of group 2 complexes with a thiopyridyl scorpionate ligand》, and you may find the article in Dalton Transactions.Computed Properties of C7H5N The information in the text is summarized as follows:

Herein we report the reactivity of the proligand tris(2-pyridylthio)methane (HTptm) with various Alk. Earth (AE) reagents: (1) dialkylmagnesium reagents and (2) AE bis-amides (AE = Mg-Ba). Heteroleptic complexes of general formulas [Mg(Tptm)(R)] (R = Me, Bu) and [AE(Tptm)(NR2)] (AE = Mg-Ba; R = SiMe3) were targeted from the reaction of HTptm with R2Mg or [AE(NR2)2]2. Reaction of the proligand with dialkylmagnesium reagents led to formation of [{Mg(κ3C,N,N-CBu{S-C5H4N}2)(μ-S-C5H4N)}2] (1) and [{Mg(κ3C,N,N-CMe{S-C5H4N}2)(μ-OSiMe3)}2] (2) resp., as a result of a novel transfer of an alkyl group onto the methanide carbon with concomitant C-S bond cleavage. However, reactivity of bis-amide precursors for Mg and Ca did afford the target species [AE(Tptm)(NR2)] (3-AE; AE = Mg-Ca), although these proved susceptible to ligand degradation processes. DFT calculations show that alkyl transfer in the putative [Mg(Tptm)(Bu)] (1m’) system and amide transfer in 3-Ca is a facile process that induces C-S bond cleavage in the Tptm ligand. The complexes 3-Mg and 3-Ca were also tested as catalysts for the hydrophosphination of selected alkenes and alkynes, including the first example of mono-hydrophosphination of 4-ethynylpyridine which was achieved with high conversions and excellent regio- and stereochem. control. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Su; Li, Rui; Zhang, Zhichao; Gu, Minyang; Zhu, Hongyan; Fang, Jing; Ji, Zhiwen; Xu, Xiaodong; Tang, Liming published an article in 2021. The article was titled 《Analysis of mutagenic components of oxidative hair dyes with the Ames test》, and you may find the article in Human & Experimental Toxicology.Application In Synthesis of 2,6-Diaminopyridine The information in the text is summarized as follows:

Oxidative hair dyes consist of two components (I and II) that are mixed before use. Aromatic amines in component I and their reaction with hydrogen peroxide after mixing them with component II have been of primary concern. In addition, two in vitro genotoxicity assays are still required for the approval of the final products of oxidative hair dyes in China, and the substance in the oxidative hair dye that causes the high rate of pos. results in genotoxicity tests, especially the Ames test, has not been fully elucidated. In this study, we analyzed the formulation of 55 different oxidative hair dyes from 7 color series and performed Ames tests in the strain TA98 with the S9 mix (oxidative hair dyes Number 1-30) and in strain TA97a without the S9 mix (oxidative hair dyes Number 31-55). We found that toluene-2,5-diamine sulfate (2,5-diaminotoluene sulfate, DATS) in component I may be the cause of mutagenicity in TA98, and hydrogen peroxide in component II may be the cause of mutagenicity in TA97a, and their pos. concentrations were consistent with those that we calculated from Ames tests. The results suggest that the pos. results for the oxidative hair dye in the Ames test were inevitable because of the existence of DATS in component I and of hydrogen peroxide in component II. Therefore, we should carry out safety assessments on each raw material and carry out risk assessments on the final products of oxidative hair dyes instead of genotoxicity tests in China. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem