Tag: 100-200

Yadav, Eqvinshi; Khatana, Anil Kumar; Sebastian, Sharol; Gupta, Manoj K. published their research in New Journal of Chemistry in 2021. The article was titled 《DAP derived fatty acid amide organogelators as novel carrier for drug incorporation and pH-responsive release》.Related Products of 141-86-6 The article contains the following contents:

Inflammation is associated with many different class of diseases and NSAIDs (non-steroidal anti-inflammatory drugs) are mostly preferred for long-term use. Although they are safe to use, some serious side effects are associated with these class of compounds; therefore, local drug delivery is an option to minimize the side effects. In this study, we have designed a new gel formulation for topical and transdermal applications of the NSAIDs with enhanced properties. For this purpose, low mol. mass DAP (2,6-diaminopyridine) derived fatty acid amides with varying alkyl chain lengths are synthesized. These fatty acid amides form stable self-assembled aggregates in organic solvents as well as in organic and aqueous solvent mixtures affording organogels and bigels, resp. The min. gelation concentration (MGC) of the organic gel is 0.5% w/v, which behaves as a super gelator. The various functionality present in the DAP-derived fatty acid amide gelators play an important role in the self-aggregation such as pyridine moiety stack through π-π and alkyl chain via van der Waals interactions resulting in the formation of stable organo and bigels network. The prepared organogel emulsions with these fatty acid amides are capable to encapsulate and release the drug mol. ibuprofen at room temperature without altering its structure and activity. Therefore, these analogs can be successfully utilized in pharmaceutical industries as a novel drug delivery carrier.2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Ye-bin; Wu, You-zhi; Wu, Jian; Xu, Dan; Jiang, Hui; Chang, Wen-wu; Ma, Chang-you published their research in Journal of Organic Chemistry in 2021. The article was titled 《Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds》.Synthetic Route of C7H7NO The article contains the following contents:

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chem., especially for substrates with bulky secondary alkyl groups. Herein, a copper-catalyzed regioselective coupling of tosylhydrazones and 2-pyridones/isoquinolinones for the synthesis of N-alkylated compound such as N-alkylated pyridones I [R = CH(Me)(4-MeOC6H4), R1 = H, CN, C(O)OMe; R2 = H, OMe; R3 = H, F, Br] isoquinolinones II [R1 = H, Me; R2 = Ph, 3-O2NC6H4, 2-ClC6H4, etc.] was described. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Formation, stability and catalase-like activity of mononuclear manganese(II) and oxomanganese(IV) complexes in protic and aprotic solvents》 was written by Kripli, Balazs; Garda, Zoltan; Solyom, Bernadett; Tircso, Gyula; Kaizer, Jozsef. Category: pyridine-derivatives And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

Synthetic compounds as biomimics of catalase enzymes may have potential biomedical applications as therapeutic agents for the detoxification of H2O2 and may give further information about the role of metal cofactors during the dismutation process. In this work, authors present the synthesis and characterization of manganese(II) and oxomanganese(IV) complexes of a pentadentate ligand (N4Py* = N,N-bis(2-pyridylmethyl)-1,2-di(2-pyridyl)ethylamine), [MnII(N4Py*)(CH3CN)](CF3SO3)2 (1) and [MnIV(O)(N4Py*)](CF3SO3)2 (2). Detailed pH-potentiometric titrations were also performed in order to gain insights into the complexation properties of the N4Py* ligand, and the equilibrium model used for fitting the pH-potentiometric titration data for the [Mn(N4Py*)]2+ complex was confirmed by 1H-NMR relaxometry at 0.49 T field strength and 25°. Complex 1 has been shown to catalyze the dismutation of H2O2 into O2 and H2O in both aprotic (MeCN and DMF) and protic (TFE and buffered H2O) solvents. The reactivity of 1 was higher in protic solvents, which was markedly influenced by the pH, and it revealed a Michaelis-Menten behavior at pH 10.5 at 298 K. A mononuclear oxomanganese(IV) complex, 2, as a possible intermediate in the catalytic process, was also prepared, and its stability and reactivity towards H2O2 was also investigated in TFE and buffered H2O/TFE solutions The stoichiometric oxidation of H2O2 with 2 provided clear evidence (solvent isotope effect (SIE) of 6.2, pH dependence, saturation kinetics, etc.) of the rate-determining hydrogen atom transfer (HAT) mechanism between the H2O2 and oxomanganese(IV) species. The present results provide one of the first examples of a non-heme MnIVO complex that shows a catalase-like reaction in water. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Influence of Ligand Denticity and Flexibility on the Molecular Copper Mediated Oxygen Reduction Reaction》 was written by Smits, Nicole W. G.; van Dijk, Bas; de Bruin, Iris; Groeneveld, Samantha L. T.; Siegler, Maxime A.; Hetterscheid, Dennis G. H.. Electric Literature of C12H13N3 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

To date, the Cu complex with the tris(2-pyridylmethyl)amine (tmpa) ligand (Cu-tmpa) catalyzes the ORR with the highest reported turnover frequency (TOF) for any mol. Cu catalyst. To gain insight into the importance of the tetradentate nature and high flexibility of the tmpa ligand for efficient four-electron ORR catalysis, the redox and electrocatalytic ORR behavior of the Cu complexes of 2,2′:6′,2”-terpyridine (terpy) and bis(2-pyridylmethyl)amine (bmpa) (Cu-terpy and Cu-bmpa, resp.) were studied. With a combination of cyclic voltammetry and rotating ring disk electrode measurements, the presence of the terpy and bmpa ligands results in a decrease in catalytic ORR activity and an increase in faradaic efficiency for H2O2 production The lower catalytic activity is the result of a stabilization of the CuI state of the complex compared to the earlier reported Cu-tmpa catalyst. This stabilization is most likely caused by the lower electron donating character of the tridentate terpy and bmpa ligands compared to the tetradentate tmpa ligand. The Laviron plots of the redox behavior of Cu-terpy and Cu-bmpa indicated that the formation of the ORR active catalyst involves relatively slow electron transfer kinetics which is caused by the inability of Cu-terpy and Cu-bmpa to form the preferred tetrahedral coordination geometry for a CuI complex easily. The authors’ study illustrates that both the tetradentate nature of the tmpa ligand and the ability of Cu-tmpa to form the preferred tetrahedral coordination geometry for a CuI complex are of utmost importance for ORR catalysis with very high catalytic rates. Redox and electrocatalytic ORR behavior of the mononuclear Cu complexes of 2,2′:6′,2”-terpyridine (terpy) and bis(2-pyridylmethyl)amine (bmpa) in neutral aqueous buffer solution: High faradaic efficiencies for H2O2 production were revealed along the ORR active potential window using the rotating ring disk electrode (RRDE), and the foot-of-the-wave anal. (FOWA) was applied to describe the catalytic activity quant. Addnl., the stability of the catalysts under operating conditions receives considerable attention.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer》 was published in Pharmacological Research in 2020. These research results belong to Zhang, Yu-Hang; Luo, Dong-Dong; Wan, Sheng-Biao; Qu, Xian-Jun. Computed Properties of C5H6BNO2 The article mentions the following:

In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors were designed, synthesized and evaluated for their activities of anti-FU-resistance. Among them, the most promising compound JTE-013, exhibited excellent inhibition on DPD expression and potent anti-FU-resistance activity in various human cancer cell lines, along with the in vivo HCT116DPD cells xenograft model, in which the inhibition rate of 5-FU was greatly increased from 13.01%-75.87%. The underlying mechanism was uncovered that JTE-013 demonstrated an anti-FU-resistance activity by blocking S1PR2 internalization to the endoplasmic reticulum (ER), which inhibited the degradation of 5-FU into α-fluoro-β-alanine (FBAL) by downregulating tumoral DPD expression. Overall, JTE-013 could serve as the lead compound for the discovery of new anti-FU-resistance drugs. This study provides novel insights that S1PR2 inhibitors could sensitize 5-FU therapy in colorectal cancer. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Well-defined, linear, wholly aromatic polymers with controlled content and position of pyridine moieties in macromolecules from one-pot, room temperature, metal-free step-polymerizations》 was published in Polymer Chemistry in 2020. These research results belong to Cetina-Mancilla, Enoc; Olvera, Lilian I.; Balmaseda, Jorge; Forster, Michael; Ruiz-Trevino, F. Alberto; Cardenas, Jorge; Vivaldo-Lima, Eduardo; Zolotukhin, Mikhail G.. Name: 4-Acetylpyridine The article mentions the following:

Synthesis of processable, aromatic pyridine-containing polymers has always been a great challenge. Here, we report for the first time a robust, low-cost synthesis of well defined, high mol. weight, linear, wholly aromatic polymers with rigid ether-bond-free aryl backbones, where the proportion and position of pyridine moieties and spacer lengths between them in the macromols. are fully controlled. The polymers, in nearly quant. yields, were obtained by one-pot, room temperature, metal-free, non-stoichiometric superacid catalyzed step-polymerization of 4-acetylpyridine (and its mixtures with 2,2,2-trifluoroacetophenone) with multiring aromatic hydrocarbons: biphenyl, meta- and para-terphenyl, and para-quaterphenyl, in the mixture of trifluoromethanesulfonic acid with methylene chloride and trifluoroacetic acid. The polymers are highly soluble in most common solvents and form flexible and tough films with tensile strength in the range of 72-92 MPa. 1H and 13C NMR analyses of the synthesized polymers revealed high regio-selectivity of the polymer forming reaction affording linear structures with para-substitution in the phenylene fragments of the main chains. The mol. weights of the polymers ranged from 20 000 to 100 000 g mol-1, whereas the polydispersity is generally well below 2. The polymers exhibited also high thermostability with Tg > 400°, weight loss temperatures (N2, onset) ca. 485°, char yields of 70-75 at 800° and high chem. stability. Room temperature reactions of the polymers with methyl(trifluoromethylsulfonate) afford the N-methylated cationic polymers. Certain studies on the phys. properties and gas separation of the polymers are highlighted. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits》 were Heilman, Patrick; Hill, Matthew N.; Coussons-Read, Mary; Brundin, Lena; Coccaro, Emil F.. And the article was published in Psychoneuroendocrinology in 2019. Quality Control of Picolinic acid The author mentioned the following in the article:

Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these mols. is unknown. The role of these immunobiol. mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of phys. healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also neg. associated with 2-AG levels across all subjects, independent of IL-6 levels. In our anal. of the biol. determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biol. link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Resolution of minor size differences in a family of heteroleptic coordination cages by trapped ion mobility ESI-MS》 were Ebbert, Kristina E.; Schneider, Laura; Platzek, Andre; Drechsler, Christoph; Chen, Bin; Rudolf, Robin; Clever, Guido H.. And the article was published in Dalton Transactions in 2019. Related Products of 2510-22-7 The author mentioned the following in the article:

A complex system of heteroleptic coordination cages based on the combination of 4 bis-monodentate ligands whose backbones only slightly differ in shape and length is reported. Cis-[Pd2L2L’2] assemblies cleanly form after addition of PdII cations to a 1:1 mixture of 2 shape-complementary ligands, each. When 3 or even all 4 ligands are used in combination, the unambiguous discrimination of all individual species in the product mixture becomes difficult by conventional NMR spectroscopic and mass spectrometric methods. Due to steric constraints, the system is restricted to the formation of 10 different coordination cages in total, 2 of which are isomeric. High-resolution trapped ion mobility mass spectrometry (TIMS) allows the clear differentiation of all 10 species. Observed size trends could be readily reproduced by the calculation of theor. values for collisional cross sections (CCS) from geometry-optimized models. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,New Journal of Chemistry included an article by Meti, Puttavva; Nagaraju, Goli; Yang, Jung-Won; Jung, Sun Hwa; Gong, Young-Dae. Application In Synthesis of 4-Ethynylpyridine. The article was titled 《Synthesis of dipyrrolopyrazine-based sensitizers with a new π-bridge end-capped donor-acceptor framework for DSSCs: a combined experimental and theoretical investigation》. The information in the text is summarized as follows:

The strategy of developing organic dyes with exceptional optical, thermal, and stable photovoltaic properties has attracted substantial attention in the replacement of high-cost traditional dyes in DSSCs. Herein, we synthesized four dyes with a D-π-A configuration in order to study the variation produced in the optical, thermal, redox and photovoltaic properties by substitution of different donors and acceptors in the dipyrrolopyrazine (DPP) system. These push-pull systems are based on a pyrrolopyrazine spacer, end-capped with donors (N,N-dimethylamine, and thiophene) and acceptors (pyridine, -COOH, and -CN). The multidisciplinary study concerning the optical, thermal, redox, and photovoltaic characterization of the dyes reveals that compound 3a exhibits the best overall conversion efficiency as a sensitizer in TiO2 dye sensitized solar cells. The theor. calculations together with exptl. data allow us to quantify the charge transfer character of dyes. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Zou, Faxing; Chen, Shaojun. Safety of 2,6-Diaminopyridine. The article was titled 《A Novel 2,6-Diaminopyridine-base Polymer with Thermo-/Water-responsive Shape Memory Effect》. The information in the text is summarized as follows:

Shape memory polymers with multiple stimuli have obtained increasing attention. This study illustrates a strategy for synthesizing polymers with thermo-/water-responsive shape memory effect. The novel polymer with excellent nature was proved to synthesized correctly using 2,6-diaminopyridine (DAP), polyethylene glycol (PEG1000) and hexamethylene diisocyanate (HDI). The result shows that the thermal stability of polyurethane can be improved with increasing of the DAP, embed into mol. chain. Moreover, the polymer which possesses excellent thermo-responsive, can be deformed and restored when in contact with water. The finding in this contribution, strongly promote diversified applications of shape-memory polymers, especially in engineering fields. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem