Tag: 100-200

In 2019,Journal of Physical Chemistry C included an article by Xu, Xing; Lai, Lei; Jiang, Jiahong; He, Zhiqiao; Song, Shuang. Recommanded Product: 2,6-Diaminopyridine. The article was titled 《C,N-Codoped TiO2 with a Nitrogen-Doped Carbon Coating Derived from 2,6-Diaminopyridine for Visible Light-Induced Photocatalytic Hydrogen Evolution》. The information in the text is summarized as follows:

Nitrogen-doped carbon-wrapped C,N-codoped TiO2 (CN@C,N-TiO2) was successfully prepared using a facile and efficient method involving hydrolysis and calcination under Ar using tetra-Bu titanate and 2,6-diaminopyridine as the precursors. XPS and valence band XPS measurements reveal the successful codoping of interstitial carbon and nitrogen into TiO2, which leads to a visible-light absorption of up to ∼550 nm in the UV-vis diffuse reflectance spectra. Raman spectra and high-resolution TEM results show that N-doped carbon exists on the surface of C,N-TiO2, which gives rise to the efficient separation of photoexcited charge carriers, as determined by photoluminescence and electrochem. impedance spectroscopy. Benefiting from the combined effects of a surface-coated N-doped carbon layer and C,N-codoping, the photocatalyst calcined at 450° exhibits remarkable visible-light activity toward the hydrogen evolution reaction in the water splitting process with a H2 production rate of 833.2 μmol h-1 g-1 under 94 mW cm-2 visible-light illumination (λ > 420 nm). Moreover, the representative CN@C,N-TiO2 sample can maintain its activity for at least 40 h. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Current Organic Synthesis included an article by Chen, Mingwei; Hu, Jinyu; Tang, Xiaoli; Zhu, Qiming. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Piperazine as an Inexpensive and Efficient Ligand for Pd-Catalyzed Homocoupling Reactions to Synthesize Bipyridines and Their Analogues》. The information in the text is summarized as follows:

In the present work, a promising approach for preparation of bipyridines and their (hetero) aromatic analogs I (Ar = 2-pyridyl, 4-O2NC6H4, quinolin-2-yl, etc.) via a Pd-catalyzed reductive homocoupling reaction with simple piperazine as a ligand is discussed . The combination of Pd(OAc)2 and piperazine in DMF was observed to form an excellent catalyst system and efficiently catalyzed the homocoupling of azaarenyl halides, in which DMF was used as the solvent without excess reductants although stoichiometric reductant was generally required to generate the low-oxidation-state active metal species in the catalytic cycles. In this case, good to excellent yields of bipyridines were obtained in the presence of 2.5 mol% of Pd(OAc)2 and 5 mol% of piperazine, using K3PO4 as a base in DMF at 140°C. The coupling reaction was operationally simple and displayed good substrate compatibility.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Buysse, Ann M.; Nugent, Benjamin M.; Wang, Nick X.; Benko, Zoltan; Breaux, Nneka; Rogers, Richard; Zhu, Yuanming published 《Studies toward understanding the SAR around the sulfoximine moiety of the sap-feeding insecticide sulfoxaflor》.Pest Management Science published the findings.Name: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

BACKGROUND : The discovery of sulfoxaflor (IsoclastTM active) stemmed from a novel scaffold-based approach toward identifying bioactive mols. It exhibits broad-spectrum control of many sap-feeding insect pests, including aphids, whiteflies, hoppers and Lygus. Systematic modifications of the substituents flanking each side of the sulfoximine moiety were carried out to determine whether these changes would improve potency. Structure-activity relationship (SAR) studies showed that, with respect to the methylene linker, both mono- and disubstitution with alkyl groups of varying sizes as well as cyclic analogs exhibited excellent control of cotton aphids. However, against green peach aphids a decrease in activity was observed with substituents larger than Et as well as larger cycloalkyl groups. At the terminal tail there appeared to be a narrow steric tolerance as well, with linear groups or small rings more active against green peach aphids than bulkier groups. A novel series of compounds exploring the substituents flanking the sulfoximine moiety of sulfoxaflor were prepared and tested for bioactivity against cotton aphids and green peach aphids. SAR studies indicated that a decrease in green peach aphid potency was observed at the methylene linker as well as at the terminal tail with bulkier substituents. A quant.structure-activity relationship anal. of the compounds revealed significant correlation of activity with two mol. descriptors, vol (volumeof a mol.) and GCUT_SMR_3 (molar refractivity). This predictive model helps to explain the observed activity with the various substituents. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-Amino-2-picolineOn March 18, 2020, Chen, Ying-Chu; Faver, John C.; Ku, Angela F.; Miklossy, Gabriella; Riehle, Kevin; Bohren, Kurt M.; Ucisik, Melek N.; Matzuk, Martin M.; Yu, Zhifeng; Simmons, Nicholas published an article in Bioconjugate Chemistry. The article was 《C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis》. The article mentions the following:

DNA-encoded chem. library (DECL) screens are a rapid and economical tool to identify chem. starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chem. matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.4-Amino-2-picoline(cas: 18437-58-6Recommanded Product: 4-Amino-2-picoline) was used in this study.

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Chemistry Frontiers included an article by Zhou, Chunhui; Hu, Jinsong; Wang, Yuan; Yao, Changguang; Chakraborty, Priyanka; Li, Huaifeng; Guan, Chao; Huang, Mei-Hui; Huang, Kuo-Wei. HPLC of Formula: 141-86-6. The article was titled 《Selective carbonylation of benzene to benzaldehyde using a phosphorus-nitrogen PN3P-rhodium(I) complex》. The information in the text is summarized as follows:

A PN3P pincer pyridinediamine ligand 2,6-(R2PNH)C5H3N (1; R = cyclopentyl, C5H5N = pyridine) bearing dicyclopentylphosphine substituents reacts with [Rh(COD)Cl]2 (COD = 1,5-cyclooctadiene) to produce the complex (PN3P)RhCl (2). Treatment of a benzene solution of 2 with KN(SiMe3)2 stimulates a dearomatization process, and C-H activation of benzene is achieved through the rearomatization of the central pyridine ring. This deprotonation/reprotonation of the NH arm of 2 gives the Ph complex (PN3P)Rh(C6H5) (3). The subsequent introduction of CO gas into 3 yields the benzoyl complex (PN3P)RhCO (C6H5) (4), which can release benzaldehyde upon treatment with diluted HCl solution and regenerates 2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6HPLC of Formula: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Nuclear Medicine and Biology included an article by Li, Junling; Gray, Brian D.; Pak, Koon Y.; Ng, Chin K.. Safety of Bis(pyridin-2-ylmethyl)amine. The article was titled 《Targeting phosphatidylethanolamine and phosphatidylserine for imaging apoptosis in cancer》. The information in the text is summarized as follows:

Thus the objective was to determine whether PE-targeting 18F-duramycin and PS-targeting 18F-Zn-DPA could be used for imaging apoptosis. Duramycin and Zn-DPA were labeled with either 18F-Al or 18F-SFB. U937 cells were incubated with four different concentrations of camptothecin (CPT). For assessing the effect of incubation time on uptake, 37 MBq of radiotracer was added to cells incubated for 15, 30, 60, and 120 min at 37°C. Both FITC-Zn-DPA and FITC-duramycin localized mainly on the cell membrane during early apoptosis and then translocated to the inside during late apoptosis. Uptake of FITC-duramycin, however, was higher than that of FITC-Zn-DPA. Cellular uptake of four different radiotracers was also proportional to the degree of apoptosis, increasing slightly over time and reaching a plateau at about 1 h. The blocking experiments demonstrated that uptake in all the control groups was predominantly non-specific, whereas the specific uptake in all the treated groups was at least 50% for both 18F labeled duramycin and Zn-DPA. Both PE-targeting 18F-duramycin and PS-targeting 18F-Zn-DPA could be considered as potential radiotracers for imaging cellular apoptosis. Advances in knowledge and implications for patient care: Cellular data support the further development of radiotracers targeting either PE or PS for imaging apoptosis, which can associate with clin. outcome for cancer patients. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesOn March 31, 1997, Epsztajn, J.; Plotka, M. W.; Grabowska, A. published an article in Synthetic Communications. The article was 《Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids》. The article mentions the following:

The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C3-halogenated derivatives, is described. In the experiment, the researchers used many compounds, for example, Methyl 3-chloropicolinate(cas: 116383-98-3Category: pyridine-derivatives)

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H7N3In 2019 ,《Synthesis, Characterization and Fluorescence Quantum Yields of Thermally Resisted Shinning Polymers Containing Thiophene and Azomethine Units》 was published in Journal of Fluorescence. The article was written by Temizkan, Kevser; Kaya, Ismet. The article contains the following contents:

Poly(azomethine)s containing thiophene with bridges pyridine, sulfur and oxygen were synthesized in two steps. Before, thiophene centric dialdehyde (DIAL-Th) compound was synthesized via elimination reaction of 4-hydroxy benzaldehyde with thiophene bromide. Then, poly(azomethine)s containing thiophene (PAZ-Th) unit were synthesized from condensation reactions of DIAL-Th with pyridine-3,5-diamine, 4,4′-thiodianiline and 4,4′-oxydianiline. The obtained dialdehyde and poly(azomethine- thiophene)s were ratified by Fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), hydrogen and carbon NMR spectroscopy. The some properties of poly(azomethine-thiophene)s were investigated such as optic, electronic, surface and thermal. Electrochem. and fluorescence properties of compounds were made by cyclic voltammetry (CV) and fluorescence anal., resp. According to fluorescence measurement, PAZ-Th-1 was interestingly demonstrated five different colors in DMF solution Blue, green, yellow, orange and red were observed at 420, 440, 480, 500 and 520 nm, resp., in this solution The fluorescence quantum yields of PAZ-Th-1 were found. According to thermogravimetric (TG) and differential scanning calorimetry (DSC) analyses, Tonset and glass transition temperature of PAZ-Th-1, PAZ-Th-2 and PAZ-Th-3 were found. Also, surface analyses of synthesized poly(azomethine-thiophene)s were photographed by scanning electron microscope (SEM) at room temperature The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Photoluminescent report on red light emitting europium(III) complexes with heterocyclic acid》 appeared in Spectroscopy Letters. The author of the article were Dhankhar, Priyanka; Bedi, Manisha; Khanagwal, Jyoti; Taxak, Vinod B.; Khatkar, Satyender P.; Doon, Priti Boora. The article conveys some information:

Five luminescent europium (III) carboxylate complexes have been synthesized by using ligand 3-isopropylpyrazole-5-carboxylic acid as primary ligand and 4,4′-dimethyl-2,2′-bipyridyl, 2,2′-bipyridyl, 5,6-dimethyl-1,10-phenanthroline and 1,10-phenanthroline as secondary ligands and characterized through various techniques. These complexes exhibit excellent thermal stability and characteristic europium centered photoemission spectra under the excitation of UV light. Luminescence decay curves, Judd-Ofelt anal., internal quantum efficiency and energy transfer mechanism have also been discussed. The color coordinates and color purity are calculated to investigate red emission of the complexes. The study results reveal that these complexes can be potentially used as red light emitting materials in various optoelectronic devices.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 98-98-6In 2021 ,《Highly efficient actinide(III)/lanthanide(III) separation by novel pillar[5]arene-based picolinamide ligands: A study on synthesis, solvent extraction and complexation》 appeared in Journal of Hazardous Materials. The author of the article were Cai, Yimin; Ansari, Seraj A.; Fu, Kuirong; Zhu, Beichen; Ma, Haoyang; Chen, Lixi; Conradson, Steven D.; Qin, Song; Fu, Haiying; Mohapatra, Prasanta K.; Yuan, Lihua; Feng, Wen. The article conveys some information:

Selective extraction of highly radiotoxic actinides(III) is an important and challenging task in nuclear wastewater treatment. Many proposed ligands containing S or P atoms have drawbacks including high reagent consumption and possible secondary pollution after incineration. The present work reports five novel pillar[5]arene-based extractants that are anchored with picolinamide substituents of different electronic nature by varying spacer. These ligands reveal highly efficient separation of actinides(III) over lanthanides(III). Specifically, almost all of these ligands could extract Am(III) over Eu(III) selectively at around pH 3.0 (SFAm/Eu > 11) with fast extraction kinetics. Variation of the pyridine nitrogen basicity via changing para-substitution leads to an increase in the distribution ratios by a factor of over 300 times for Am(III) with an electron-withdrawing group compared to those with an electron donating group. Investigation of complexation mechanism by slope anal., NMR, IR, EXAFS, and DFT techniques indicates that each ligand binds two metal ions by pyridine nitrogen and amide oxygen. Finally, these ligands do not show obvious decrease in both extraction and separation ability after being exposed to 250 kGy absorbed gamma radiation. These results demonstrate the potential application of pillar[5]arene-picolinamides for actinide(III) separation In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem