Tag: 100-200

Sidharaj, N.; Rajarajan, G.; Senthil, M. published their research in Materials Today: Proceedings in 2021. The article was titled 《Synthesis, characterization and Ion-exchange properties of 4, 4 oxy-dianiline, 2,6 diamino-pyridine with formaldehyde terpolymer》.Product Details of 141-86-6 The article contains the following contents:

A new terpolymer ligand (DAPR) was synthesized based on condensation polymerization techniques. DAPR was named by 4,4 oxy-dianiline and 2,6 diamino-pyridine with formaldehyde. The taken monomers mole ratio is 1:1:2 in the reaction medium of DMF. The solubility behavior of the terpolymer samples have been studied in various solvents. The prepared terpolymer ligand was characterized by elemental anal., FTIR, 1H & 13C NMR and TGA studies. The synthesized terpolymer ligand mol. formula identified by elemental anal. and the most probable structure confirmed by the spectral studies of FTIR, 1H & 13C NMR. The SEM image used to establish the outward of the ligand. The thermal decomposition and thermal strength of DAPR ligand was carried out by thermo gravimetric anal. (TG-DTA). The chelation ion exchange studies of the terpolymer for the definite metal ions were also carried out by batch equipoise way under the estimation of metal ion uptake at diverse electrolytes. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Arnab; Jameei, Aida; Saha, Rupak; Garai, Aditya; Karande, Anjali A.; Chakravarty, Akhil R. published their research in Dalton Transactions in 2021. The article was titled 《BODIPY-linked cis-dichlorido zinc(II) conjugates: the strategic design of organelle-specific next-generation theranostic photosensitizers》.Recommanded Product: 1539-42-0 The article contains the following contents:

Dipicolylamine (dpa) based cis-dichlorido zinc(II) complexes [Zn(L1-3)Cl2] (1-3), where L2 and L3 are non-iodo and di-iodo BODIPY-appended dpa in 2 and 3, and L1 is dpa in control complex 1, were prepared and characterized and their photocytotoxicity was studied. Complexes 2 and 3 were developed as potential substitutes for zinc(II)-porphyrins/phthalocyanines that are photodynamic therapeutic agents with moderate activity owing to their inherent hydrophobicity and aggregation-induced deactivation mechanism. In authors approach, they strategically designed hybrid inorganic-organic zinc-BODIPY conjugates as theranostic photosensitizers. The structurally characterized diamagnetic Zn(II) cis-dichlorido complexes mimic cisplatin and serve as new-generation photosensitizers with enhanced aqueous solubility and mito-DNA targeting propensity while imparting significant physiol. stability to the heavy atom tethered BODIPY ligand, L3. The BODIPY complexes showed a visible band near 500 nm (ε ~34 000-44 000 dm3 mol-1 cm-1) and an emission band at 507 nm for 2 in 1% DMSO-Dulbecco’s phosphate buffered saline. The labile chlorido ligands (ΛM ~200 S m2 mol-1 in 9 : 1 H2O-DMSO) generated pos. charged complexes inside the cellular medium enabling them to cross the mitochondrial membrane for this organelle-selective localization and singlet oxygen-mediated apoptotic photocytotoxicity at nanomolar concentrations for 3 in HeLa and MCF-7 cells in light (400-700 nm), while being less active in the dark.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Appa, Rama Moorthy; Lakshmidevi, Jangam; Naidu, Bandameeda Ramesh; Venkateswarlu, Katta published their research in Molecular Catalysis in 2021. The article was titled 《Pd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions》.Safety of 2-Pyridinylboronic acid The article contains the following contents:

A quick and eco-friendly protocol for the synthesis of biaryls, e.g., I by an oxidative (aerobic) homocoupling of arylboronic acids RB(OH)2 (R = C6H5, pyridin-2-yl, 2-thienyl, etc.) using Pd(OAc)2 in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media is described. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result sym. biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.2-Pyridinylboronic acid(cas: 197958-29-5Safety of 2-Pyridinylboronic acid) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morales-Colon, Maria T.; See, Yi Yang; Lee, So Jeong; Scott, Peter J. H.; Bland, Douglas C.; Sanford, Melanie S. published their research in Organic Letters in 2021. The article was titled 《Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination》.Recommanded Product: 53939-30-3 The article contains the following contents:

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Konovalova, Irina S.; Muzyka, Ekaterina N.; Urzhuntseva, Victoriya V.; Shishkina, Svitlana V. published their research in Structural Chemistry in 2021. The article was titled 《Role of intermolecular interactions in formation of mono- and diaminopyridine crystals: study from the energetic viewpoint》.Computed Properties of C5H7N3 The article contains the following contents:

Abstract: The regularities of crystal structure organization in a series of mono- and diaminopyridines possessing biol. activities were studied using an approach based on comparison of interaction energies between mols. calculated by ab initio quantum chem. method. The presence of the pyridine nitrogen atom causes the formation of N-H…Npyr hydrogen bond which is the strongest in all the studied structures. Being amphiphilic in hydrogen bond formation, the amino group possesses acceptor properties only in meta-position to the pyridine nitrogen atom in mono-aminopyridines. The presence of the two amino groups results in increasing of acceptor properties of both ones. The N-H… Nlp hydrogen bonds bind primary BSM (basic structural motif) in the structures of 2,5-diaminopyridine, 2,4-diaminopyridine and 3,4-diamonpyridine and form the primary BSM alongside with N-H…Npyr hydrogen bond in the structure of 2,3-diaminopyridine. The helical primary basic structural motif and double helical secondary basic structural motif in the 2,3-diaminopyridine crystal structure are very similar to the DNA helix and double helix. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shen, Jiaxuan; Zhang, Yipin; Yu, Yanjiang; Wang, Manman published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Metal-free visible-light-induced photoredox-catalyzed intermolecular pyridylation/phosphinoylation of alkenes》.Quality Control of 4-Cyanopyridine The article contains the following contents:

Reported here is an intermol. pyridylation/phosphinoylation of alkenes using 4-cyanopyridine and diphenylphosphine oxide under visible-light-induced organic photoredox catalysis. The reaction occurs under mild metal-free conditions, possessing a broad substrate scope. The protocol can be practiced on a gram scale and applied to the modification of natural product-derived and medicinally relevant complex mols. containing a styrene unit. Mechanistic investigations suggest that triethylamine serves as both single-electron transfer (SET) and hydrogen atom transfer (HAT) agents. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ynamide-Mediated Intermolecular Esterification》 was written by Wang, Xuewei; Yang, Yang; Zhao, Yongli; Wang, Sheng; Hu, Wenchang; Li, Jinmei; Wang, Zihao; Yang, Fengling; Zhao, Junfeng. Quality Control of 2-(2-Hydroxyethyl)pyridine And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Milosevic, Milena D.; Marinkovic, Aleksandar D.; Petrovic, Predrag; Klaus, Anita; Nikolic, Milica G.; Prlainovic, Nevena Z.; Cvijetic, Ilija N.. Application of 141-86-6 The article mentions the following:

A series of sixteen bis(imino)pyridines (BIPs) I [R = Ph, 2-quinolyl, 1-naphthyl, etc.] was synthesized starting from 2,6-diaminopyridine and aromatic aldehydes, and evaluated for their antioxidant, antibacterial, antifungal and acetylcholinesterase (AChE) inhibitory activities. The formation of stable, carbon-centered radical cations in a solution was confirmed by ESR spectroscopy and DFT calculations The in vitro antioxidant potency was evaluated using four assays: free radical scavenging activity (DPPH and ABTS), reducing power and total antioxidant capacity assay. BIPs demonstrated excellent antioxidant properties, and two derivatives proved to be more potent than reference antioxidants (ascorbic acid and Trolox) in all assays. DFT calculations on ωB97XD/6-311++g(d,p) level of theory provided valuable insights into the radical scavenging mechanism of BIPs. For hydroxyl-substituted BIPs, hydrogen atom transfer (HAT) was a predominant mechanism, while the single electron transfer coupled with proton transfer (SET-PT) governed the antioxidant activity of other derivatives Intramol. hydrogen bonding (IHB) played an important role in the mechanism of antioxidant activity as revealed by noncovalent interaction anal. and rotational barrier calculations The spin d. of radical cations was localized on carbon atoms of a pyridine ring, which corroborated with g-factors and multiplicity obtained from ESR anal. The most potent compound I [R = 2-pyridyl] exhibited moderate inhibitory activity toward AChE (IC50 = 20 ± 4μM), while mol. docking suggested binding at the peripheral anionic site of AChE with the MMFF94 binding enthalpy of -43.4 kcal/mol. Moderate in vitro antimicrobial activity of BIPs had been determined against several pathogenic bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and clin. isolate of methicillin resistant S. aureus (MRSA). The antifungal activity of BIPs toward Candida albicans was also confirmed. The similarity ensemble approach combined with mol. docking suggested leucyl aminopeptidase as the probable antimicrobial target for the three most potent BIP derivatives I [R = 2-HOC6H4, 8-OH-2-quinolyl, 2-pyridyl]. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《AIBN for Ru-catalyzed meta-CAr-H alkylation》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Yang, Suling; Yan, Bingxu; Zhong, Lei; Jia, Chunqi; Yao, Dan; Yang, Chunli; Sun, Kai; Li, Gang. Reference of 2-Bromo-5-methylpyridine The article mentions the following:

The meta-CAr-H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst was presented. This development not only confirmed that ruthenium-catalyzed meta-CAr-H bond functionalization was a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which were prevalent in a diverse range of biol. active mols. and other functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Huang, Pan; Le, Xiangyang; Huang, Fei; Yang, Jie; Yang, Haofeng; Ma, Junlong; Hu, Gaoyun; Li, Qianbin; Chen, Zhuo. Category: pyridine-derivatives The article mentions the following:

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem