Tag: 100-200

The author of 《Phosphate and polyphosphate anion recognition by a dinuclear copper(II) complex of an unsymmetrical squaramide》 were Esteves, Catarina V.; Costa, Judite; Esteban-Gomez, David; Lamosa, Pedro; Bernard, Helene; Platas-Iglesias, Carlos; Tripier, Raphael; Delgado, Rita. And the article was published in Dalton Transactions in 2019. Safety of Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

In the search for receptors suitable for the recognition of phosphate or polyphosphate anions, a new unsym. squaramide-based ligand bearing dipicolylamine (dpa) and ethylpiperazine units (L) (I) was designed and prepared The acid-base reactions of L, its copper(II) complexation behavior and the binding of phosphate and polyphosphate anions by the copper(II) complexes used as receptors were evaluated. 1H and 13C NMR titrations of L performed in D2O allowed the determination of its protonation sequence. The ligand L is able to coordinate two copper(II) cations forming thermodynamically stable dinuclear complexes likely having two water mols. bound to each metal center, as supported by DFT calculations Coordinated water mols. can be replaced by the O-donors of the phosphate/polyphosphate anions. The potentiometric studies showed that at 2 : 1 Cu2+ : L ratio the dinuclear [Cu2LH-1]3+ species predominates from pH ∼ 5 to ∼7, and hydroxodinuclear species prevail at pH > 7. 1H NMR experiments in both H2O/D2O 9 : 1 volume/volume and in DMSO proved that copper(II) coordination provokes deprotonation of the squaramide NH bound to the ethylpiperazine moiety, resulting in [Cu2LH-1]3+ species. The dicopper(II) complexes of L, [Cu2LH-i]4-i, were used as the receptor for the uptake of some phosphate and polyphosphate anions. The receptor presents very high association constants with HPPi3- and ATP4- and the determined Keff showed that at physiol. pH ATP4- is selectively taken from an aqueous solution containing phenylphosphate (PhPO42-), aminoethylphosphate (Haep-), AMP2- and ADP3-, but HPPi3- strongly interferes. DFT calculations suggest that the strong interaction with HPPi3- and ATP4- is related to the simultaneous coordination of the polyphosphate unit to the two copper(II) centers. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Kirlikovali, Kent O.; Cho, Eunho; Downard, Tyler J.; Grigoryan, Lilit; Han, Zheng; Hong, Sooji; Jung, Dahee; Quintana, Jason C.; Reynoso, Vanessa; Ro, Sooihk; Shen, Yi; Swartz, Kevin; Ter Sahakyan, Elizabeth; Wixtrom, Alex I.; Yoshida, Brandon; Rheingold, Arnold L.; Spokoyny, Alexander M. published 《Buchwald-Hartwig amination using Pd(I) dimer precatalysts supported by biaryl phosphine ligands》.Dalton Transactions published the findings.Related Products of 53939-30-3 The information in the text is summarized as follows:

The synthesis of air-stable Pd(I) dimer complexes featuring biaryl phosphine ligands was reported. Catalytic experiments suggested that these complexes were competent precatalysts that mediated cross-coupling amination reaction between aryl halides with both aliphatic and aromatic amine nucleophiles. An expansion of the air-stable precatalyst toolbox for Pd-catalyzed cross-coupling transformations were represented. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Chen, Fu-Min; Huang, Fei-Dong; Yao, Xue-Yi; Li, Tian; Liu, Feng-Shou published 《Direct C-H heteroarylation by an acenaphthyl-based α-diimine palladium complex: improvement of the reaction efficiency for bi(hetero)aryls under aerobic conditions》.Organic Chemistry Frontiers published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A bulky acenaphthyl skeleton-based α-diimine palladium complex with ortho-tert-Bu on N-aryl moieties was designed, synthesized and characterized. The developed palladium complex was applied for direct C-H arylation under aerobic reaction conditions. A range of heteroaryls, such as thiazoles, thiophenes, furans, imidazopyridines, indolizines, isoxazoles, imidazoles, triazoles, pyrazoles, indoles, pyrroles and pyrazolidinones, were used, while various coupling partners of heteroaryl bromides with wide functional groups were compatible. Upon using 0.05-0.1 mol% of a precatalyst, more than 90 examples of cross-coupling products were afforded in good to excellent yields, demonstrating that this phosphine-free catalytic system scaffold enables a general access to biheteroaryls. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bakke, Jan M.; Ranes, Eli; Riha, Jaroslav; Svensen, Harald published an article on February 28 ,1999. The article was titled 《The synthesis of β-nitropyridine compounds》, and you may find the article in Acta Chemica Scandinavica.HPLC of Formula: 59290-82-3 The information in the text is summarized as follows:

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitropyridine 36%, 3-methyl-5-nitropyridine 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, Me 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3HPLC of Formula: 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells》 was written by Horton, Timothy M.; Allegretti, Paul A.; Lee, Sooyeon; Moeller, Hannah P.; Smith, Mark; Annes, Justin P.. Electric Literature of C12H13N3This research focused onzinc DYRK1A insulin pharmacophore pancreatic beta cell; chelation; diabetes; islet; targeted compound delivery; targeting; tissue selectivity; zinc; β cell; β-cell regeneration; β-cell-replication. The article conveys some information:

Diabetes is a hyperglycemic condition characterized by pancreatic β-cell dysfunction and depletion. Whereas methods for monitoring β-cell function in vivo exist, methods to deliver therapeutics to β cells are lacking. We leveraged the rare ability of β cells to concentrate zinc to preferentially trap zinc-binding mols. within β cells, resulting in β-cell-targeted compound delivery. We determined that zinc-rich β cells and islets preferentially accumulated TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline) in a zinc-dependent manner compared with exocrine pancreas. Next, we asked whether appending a zinc-chelating moiety onto a β-cell replication-inducing compound was sufficient to confer preferential β-cell accumulation and activity. Indeed, the hybrid compound preferentially accumulated within rodent and human islets in a zinc-dependent manner and increased the selectivity of replication-promoting activity toward β cells. These data resolve the fundamental question of whether intracellular accumulation of zinc-chelating compounds is influenced by zinc content. Furthermore, application of this principle yielded a proof-of-concept method for β-cell-targeted drug delivery and bioactivity. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Proximity effects in pyridines. Proton chemical shifts in substituted methyl pyridinecarboxylates》 was published in Organic Magnetic Resonance in 1975. These research results belong to Deady, L. W.; Harrison, P. M.; Topsom, R. D.. HPLC of Formula: 29681-39-8 The article mentions the following:

The chem. shifts in 6 series of substituted Me pyridinecarboxylates were measured and interpreted in terms of proximity effects. The shifts for ring H ortho and para to the substituent were explained by additive ester, nitrogen, and substituent effects. The results for meta H indicated substituent-nitrogen interactions, especially when both substituent and H were adjacent N. Similar results were obtained for the ester H. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-methoxypicolinate(cas: 29681-39-8HPLC of Formula: 29681-39-8)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.HPLC of Formula: 29681-39-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chiral Hexahalogenated 4,4′-Bipyridines》 was written by Mamane, V.; Peluso, P.; Aubert, E.; Cossu, S.; Pale, P.. Name: 5-Bromo-2-chloropyridineThis research focused ontrihalopyridine dimerization; bipyridinedione regioselective halogenation copper Finkelstein reaction catalyst; bipyridine hexahalogenated preparation kinetic resolution; chiral hexahalogenated bipyridine preparation. The article conveys some information:

The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantiosepd. by high performance liquid chromatog. on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction anal. The latter revealed that various halogen bond types are responsible for crystal cohesion. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-AcetylpyridineIn 2022 ,《Thioamide synthesis via copper-catalyzed C-H activation of 1,2,3-thiadiazoles enabled by slow release and capture of thioketenes》 was published in Organic Chemistry Frontiers. The article was written by Lu, Changhui; Li, Xiaohong; Chang, Shunqin; Zhang, Yuqi; Xing, Donghui; Wang, Shuo; Lin, Yueping; Jiang, Huanfeng; Huang, Liangbin. The article contains the following contents:

A Cu-catalyzed thioacylation of amines via a C-H activation/coordinated stabilization protocol to ensure the slow-release of thioketenes, which are captured by various amines to afford thioamides was developed. This method was characterized by its simplicity, efficiency and broad substrate scope in both 1,2,3-thiadiazoles and amines. Its versatility was further illustrated by the late-stage thioamidation of N-containing drugs, peptides, catalysts, and ligands. Mechanism studies demonstrate that the active Cu(I) species was formed via the reduction of Cu(II) during the induction period, and the rate-determining step was the C-H activation of 1,2,3-thiadiazole. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 141-86-6In 2019 ,《Excellent toughening of 2,6-diaminopyridine derived poly (urethane urea) via dynamic cross-linkages and interfering with hydrogen bonding of urea groups from partially coordinated ligands》 was published in Polymers (Basel, Switzerland). The article was written by Sun, Ailing; Guo, Wenjuan; Zhang, Jinping; Li, Wenjuan; Liu, Xin; Zhu, Hao; Li, Yuhan; Wei, Liuhe. The article contains the following contents:

Conventional approaches to synthesize thermoplastic polyurethane (TPU) with excellent robustness are limited by a competing relationship between soft and hard segments for tuning mech. properties in terms of chain flexibility and micro-phase separation Herein, we present a facile and effective way of simultaneously improving the tensile strength, elongation, and toughness by constructing dynamic cross-linkages from metal-ligand interaction between Zn2+ and pyridine moiety in backbone of poly(urethane urea) (PUU) derived from 2,6-diaminopyridine and poly(propylene glycol). It was found that a Zn2+/pyridine ratio of 1:4 is the most effective for improving robustness. Specifically, tensile strength, elongation, and toughness could be remarkably increased to 16.0 MPa, 1286%, and 89.3 MJ/m3 with 226%, 29%, and 185% increments compared to uncomplexed PUU, resp. Results from UV-vis, Fourier transform IR spectroscopy (FTIR), cyclic tensile tests, and stress relaxation reveal that metal-ligand interaction significantly interferes with the hydrogen bonding of urea groups, thus leading to weakening of stiffness. Furthermore, half of vacant ligands enable dynamic complexation during stretching, which consequently ensures constant noncovalent cross-linkages for constraining mutual chain sliding, contributing to simultaneous improvement of tensile strength, elongation, and toughness. This work provides a promising approach for designing TPU with excellent robustness. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H5NIn 2019 ,《Screening of Three Transition Metal-Mediated Reactions Compatible with DNA-Encoded Chemical Libraries》 was published in Helvetica Chimica Acta. The article was written by Favalli, Nicholas; Bassi, Gabriele; Zanetti, Tania; Scheuermann, Joerg; Neri, Dario. The article contains the following contents:

The construction of DNA-encoded chem. libraries (DECLs) crucially relies on the availability of chem. reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium-catalyzed reactions (Suzuki cross-coupling, Sonogashira cross-coupling, and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem