Tag: 100-200

Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published their research in Journal of Hazardous Materials on December 15 ,2010. The article was titled 《A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst》.Safety of 3-Nitroisonicotinic acid The article contains the following contents:

A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. In the experimental materials used by the author, we found 3-Nitroisonicotinic acid(cas: 59290-82-3Safety of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kralova, Petra; Malon, Michal; Soural, Miroslav published their research in ACS Combinatorial Science on December 11 ,2017. The article was titled 《Stereoselective Synthesis of Benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12-diones with Two Diversity Positions》.Product Details of 59290-82-3 The article contains the following contents:

Herein, we report a stereoselective formation of tetrahydro-6H-benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12(11H)-diones. Their preparation consisted in solid-phase synthesis of linear intermediates starting from polymer-supported Ser(tBu)-OH. Using various 2-nitrobenzoic acids and bromoketones, the key intermediates were obtained in five steps and subjected to trifluoroacetic acid-mediated cleavage from the resin, followed by stereoselective reduction with triethylsilane. Subsequent catalytic hydrogenation of the nitro group and cyclization yielded the target compounds with full retention of the C12a stereocenter configuration. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3Product Details of 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2020,New Journal of Chemistry included an article by Romito, Deborah; Biot, Nicolas; Babudri, Francesco; Bonifazi, Davide. Application of 39856-58-1. The article was titled 《Non-covalent bridging of bithiophenes through chalcogen bonding grips》. The information in the text is summarized as follows:

In this work, chalcogen functionalized dithiophenes, equipped on both extremities with chalcogen-bonding recognition heterocycles, have been prepared following two synthetic pathways. The insertion of the chalcogenazolo[5,4-β]pyridine allows the control of the organization at the solid state. X-Ray diffraction anal. of the single crystals, showed that the Te-doped derivatives give the most persistant assemblies, with the mols. arranging at solid-state in wire-like polymeric structures through Te···N interactions. As expected, the introduction of the Se and Te atoms, dramatically decreases the emission properties, with the Te-bearing congeners being virtually non emissive. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Application of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tris(2-pyridyl) Bismuthines: Coordination Chemistry, Reactivity, and Anion-Triggered Pyridyl Coupling》 was written by Garcia-Romero, Alvaro; Plajer, Alex J.; Miguel, Daniel; Wright, Dominic S.; Bond, Andrew D.; Alvarez, Celedonio M.; Garcia-Rodriguez, Raul. Application In Synthesis of 2-Bromo-5-methylpyridineThis research focused ontris pyridyl bismuthine complex lithium silver mol structure iron; reductive elimination gold. The article conveys some information:

A series of new tris(2-pyridyl) bismuthine ligands of the type [Bi(2-py’)3] have been prepared, containing a range of substituents at various positions within their pyridyl rings (py’). They can act as intact ligands or, as a result of the low C-Bi bond energy, exhibit noninnocent reactivity in the presence of metal ions. Structural studies of Li+ and Ag+ complexes show that the coordination to metal ions using their pyridyl-N atoms and to anions using the Lewis acidity of their Bi(III) centers can be modified by the presence of substituents within the 2-pyridyl rings, especially at the 6- or 3-positions, which can block the donor-N or Lewis acid Bi sites. Electron withdrawing groups (like CF3 or Br) can also severely reduce their ability to act as ligands to metal ions by reducing the electron donating ability of the pyridyl-N atoms. Noninnocent character is found in the reactions with Cu+ and Cu2+, resulting in the coupling of pyridyl groups to form bipyridines, with the rate of this reaction being dependent on the anion present in the metal salts. This leads to the formation of Bi(III)/Cu(I) complexes containing hypervalent [X2Bi(2-R-py)]- (X = Cl, Br) anions. Alternatively, the tris(2-pyridyl) bismuthine ligands can act as 2-pyridyl transfer reagents, transferring 2-py groups to Au(I) and Fe(II). A series of tris(2-pyridyl) bismuthine ligands have been prepared whose cation and anion coordination properties can be controlled by substitution in the Py ring. They can act as intact ligands and display noninnocent reactivity, such as acting as 2-pyridyl transfer reagents and, as a result of the Lewis acidity of their Bi(III) centers, exhibiting anion dependent reactivity. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexes》 was written by Kurt, Baris; Temel, Hamdi; Atlan, Metin; Kaya, Savas. Category: pyridine-derivativesThis research focused ontransition metal Schiff diaminopyridine hydroxynaphthalenylmethylideneaminophenylethanone complex preparation thermal stability; magnetic susceptibility DNA binding transition metal Schiff diaminopyridine hydroxynaphthalenylmethylideneaminophenylethanone. The article conveys some information:

In this study 1-(4-{[(3-hydroxynaphthalen-2-yl)methylidene]amino}phenyl)ethan-1-one (B1 ligand) were synthesized from the reaction of 2-hydroxy-1-naphthaldehyde with 4-amino-acetophenone. Following that 1-(N-{4-[(1)-1-({6-[(Z)-[1-(4-{[(3- hydroxynaphthalen-2-yl) methylidene]amino}phenyl)ethylidene]amino]pyridin-2- yl}imino)ethyl]phenyl}carboximidoyl)naphthalen-2-ol (L1 ligand) were synthesized from the reaction of 2,6-diamino pyridine with B1 ligand. Using this Schiff base ligand Cu(II), Fe(II) and Pd(II) complexes were prepared The structure of the ligand and its complexes were determined by 1H NMR, FTIR, UV-Vis, elemental anal., thermal analyses and magnetic susceptibility spectral data. Further, DNA binding properties of the ligand and its metal complexes were investigated and docking studies were carried out. As a result ligands and copper complex showed DNA binding activity and an increase with H2O2. According to these results it can be suggested that these compounds are very suitable drug candidates. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of unsymmetrical urea from aryl- or pyridyl carboxamides and aminopyridines using PhI(OAc)2via in situ formation of aryl- or pyridyl isocyanates》 was published in New Journal of Chemistry in 2021. These research results belong to Laha, Joydev K.; Singh, Neha; Hunjan, Mandeep Kaur. COA of Formula: C5H5BrN2 The article mentions the following:

A tandem synthesis of unsym. ureas (N-aryl-N’-pyridylurea and N,N’-bipyridylurea) from aryl- or pyridyl carboxamides and aminopyridines via Hofmann rearrangement has been reported. In particular, benzamides, picolinamide, nicotinamide, and isonicotinamide generate reactive intermediate isocyanates, in situ, in the presence of PhI(OAc)2, which upon further reaction with aminopyridines form urea derivatives As the formation of pyridylisocyanates from their corresponding carboxamides via Hofmann rearrangement remained unexplored previously, attempts have been made to trap the isocyanates. While the three pyridylisocyanates were trapped as their corresponding carbamates, 3-pyridylisocyanate was isolated and characterized. Unlike closely related previous methods reported for urea synthesis, the current method avoids direct use of isocyanates or eliminates the use of toxic phosgene for the in situ generation of isocyanates. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1COA of Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2017 ,《Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication》 was published in Journal of Natural Products. The article was written by Lin, Yongsheng; Wang, Qian; Gu, Qiong; Zhang, Hongao; Jiang, Cheng; Hu, Jiayuan; Wang, Yan; Yan, Yuan; Xu, Jun. The article contains the following contents:

(+)-Rutamarin inhibits EBV lytic DNA replication with an IC50 of 7.0 μM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin. Altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. Of these, 16 compounds were found to be more potent against EBV lytic DNA replication than (-)-chalepin. Three compounds exhibited IC50 values of 1.5, 0.32, and 0.83 μM and showed selectivity index values (SI) of 801, 211, and >120, resp. Thus, these 3 compounds are considered promising leads for further laboratory investigation. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H6BNO2In 2020 ,《Reactivity of Boronic Acids toward Catechols in Aqueous Solution》 appeared in Journal of Organic Chemistry. The author of the article were Suzuki, Yota; Kusuyama, Daisuke; Sugaya, Tomoaki; Iwatsuki, Satoshi; Inamo, Masahiko; Takagi, Hideo D.; Ishihara, Koji. The article conveys some information:

Fundamental information on the reactivities of boronic acids toward catechols in aqueous solution is required in all the fields dealing with boronic acid. However, comprehensive studies on reactivity are often hindered by so-called “”proton ambiguity,”” which makes it impossible for the rate constants of boronic acid and boronate ion to be determined sep. Herein, we set up two reaction systems without proton ambiguity: (1) Alizarin Red S and (2) Tiron with several boronic acids (RB(OH)2) with different pKa’s and performed kinetic and equilibrium studies on the reaction systems. It was shown that the logarithms of the rate constants of RB(OH)2 and its conjugate boronate ion (RB(OH)3-) decreased and increased linearly, resp., with increasing pKa of RB(OH)2 for both systems. Consequently, the reactivities of RB(OH)2 and RB(OH)3- were reversed at high RB(OH)2 pKa. It was also shown that the bulky o-substituents of phenylboronic acids retarded the backward reactions, resulting in enhancement of the formation constants of boronic acid-catechol esters. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C12H12N2In 2019 ,《Synthesis, structures and spectroscopy of three new lanthanide β-diketonate complexes with 4,4′-dimethyl-2,2′-bipyridine. Near-infrared electroluminescence of ytterbium(III) complex in OLED》 appeared in Inorganica Chimica Acta. The author of the article were Santos, Hudson P.; Gomes, Emmanuel S.; dos Santos, Moliria V.; D’Oliveira, Kaique A.; Cuin, Alexandre; Martins, Jefferson S.; Quirino, Welber G.; Marques, Lippy F.. The article conveys some information:

Three new lanthanide(III) β-diketonate complexes [Ln(btfa)3(4,4′-dmbpy)] (Ln = Yb(III), Gd(III) and Nd(III); btfa = anionic 4,4,4-trifluoro-1-phenyl-1,3-butanedione and 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine) were synthesized and their characterization, including elemental anal., FTIR spectroscopy and thermal anal. (TG/DTA), is reported. The crystal description based on powder x-ray diffraction reveals that Gd(III) and Yb(III) compounds are isostructural and that lanthanide ion is eight-coordinated by oxygen and nitrogen atoms to give new tris- β-diketonates [Ln(btfa)3(4,4′-dmbpy)]. The cell parameters of Nd(III) complex are close to Gd(III) and Yb(III) ones. Phosphorescence data of Gd(III) complex shows that the triplet states (T1) of the ligands have higher energy than the emitting states of Yb(III) and Nd(III), indicating the possibility of intramol. energy transfer to these metal ions, which exhibit near-IR (NIR) emission. The authors used the Yb(III) complex as an emitting layer (EML) in a near IR organic light emitting diode (NIR-OLED) with the structure: CuPc(15 nm)/XD-03(40 nm)/Yb(60 nm)/BCP(15 nm)/Alq3(10 nm)/Al(120 nm). OLEDs exhibit both visible electroluminescence and a NIR electroluminescence at 980 nm from the 2F5/2 → 2F7/2 transition of the Yb(III). The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2020 ,《Synthesis, characterization and photoinduced CO-release by manganese(I) complexes》 appeared in New Journal of Chemistry. The author of the article were Amorim, Andre L.; Guerreiro, Ana; Glitz, Vinicius A.; Coimbra, Daniel F.; Bortoluzzi, Adailton J.; Caramori, Giovanni F.; Braga, Antonio L.; Neves, Ademir; Bernardes, Goncalo J. L.; Peralta, Rosely A.. The article conveys some information:

Herein, authors report the CO-releasing activity of three new photoCORMs, two with nonbonding pyridine moieties and one with a benzyl group. Compounds [MnBr(CO)3(bpa-κ2)] (2, where bpa = N-benzyl(2-pyridylmethyl)amine); [MnBr(CO)3(pmpea-κ2)] (3, where pmpea = N-(2-pyridylmethyl)-N’-(2-pyridylethyl)amine) and [MnBr(CO)3(bpea-κ2)] (4, where bpea = N-bis(2-pyridylethyl)amine) were synthesized and characterized by common spectroscopic techniques (UV-Vis and IR). D. functional theory studies were also performed to provide new insights into the M-C bond and to assume the orbitals involved in the absorption transitions. Their CO-releasing activities were measured both in organic and in physiol. media and compared to that of a previously published compound [Mn(CO)3(dpa-κ3)]Br (1, where dpa = N-bis(2-pyridylmethyl)amine). An increase in the number of members of the chelate from five to six influenced the release of CO, affecting both the binding mode of the ligand and the CO-release process and affecting their potential use as CO-release carriers and therapeutic agents. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem