Tag: 100-200

《Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Guo, Zhen; Liu, Tao; Liang, Xiujuan; Wu, Yuting; Yao, Tuanli. Recommanded Product: 2-Bromonicotinaldehyde The article mentions the following:

Synthesis of a wide variety of 3-amino-1H-inden-1-ones I [R1 = H, 5-F, 6-Cl, etc.; R2 = Ph, 2-MeC6H4, 4-CO2EtC6H4, etc.] from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramol. aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant was developed. This highly atom-efficient, transition-metal-free reaction proceeded under thermal conditions. The reaction proceeded through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols was proposed.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Perrhenate-ions adsorption by N-substituted chitosan derivatives》 were Melchakova, O. V.; Pestov, A. V.; Pechishcheva, N. V.; Shunyaev, K. Yu.. And the article was published in Russian Chemical Bulletin in 2019. SDS of cas: 103-74-2 The author mentioned the following in the article:

A comparative study of the sorption properties of N-(2-carboxyethyl)chitosan (CEC), N-(2-sulfoethyl)chitosan (SEC), N-(2,3-dihydroxy)propyl chitosan (HPC) and N-2-(2-pyridyl)ethyl chitosan (PEC) with respect to perrhenate ions in an acidic medium was carried out. From the anal. of the adsorption isotherms and the perrhenate ion adsorption degrees as functions of pH, the efficiency of adsorbents decreases in the sequence PEC > SEC > HPC > CEC. The studied chitosan derivatives are characterized by a higher rate of sorption of perrhenate ions in comparison with known com. anionites. In the case of PEC, accompanying ions have the least effect on the sorption. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial.》 were Nafrialdi, Nafrialdi; Hudyono, Johannes; Suyatna, Frans D; Setiawati, Arini. And the article was published in Acta medica Indonesiana in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

BACKGROUND: the use of statin to lower blood cholesterol is often associated with bothersome adverse effects such as myopathy and liver dysfunction. NC120 is herbal lipid lowering drug containing red yeast rice (RYR) extract, guggulipid, and chromium picolinate, and expected to have better safety profile. The aim of this study was to evaluate the efficacy and safety profiles of NC120 in lowering blood lipid. METHODS: this was a double blind randomized clinical trial comparing NC120 with placebo in subjects with hypercholesterolemia. Two capsules of NC120 or placebo were administered twice a day for 28 days. Blood total-cholesterol, LDL-cholesterol, and triglyceride were measured on day-0, day-7, and day-28. Unpaired t-test was used to compare study parameter between groups, and one-way ANOVA was used to compare within group. RESULTS: 25 subjects received NC120 and 24 subjects received placebo. Significant decrease of total cholesterol and LDL-cholesterol were observed since day-7 in NC120 group, while the changes in placebo group were not significant at all time of observation. No significant decrease of triglyceride was observed in NC120 group and in placebo group. Side effects were minor and comparable between the two groups. CONCLUSION: NC120 is effective in reducing total cholesterol and LDL-cholesterol, but not triglyceride. This drug shows a good safety profile, and thus can be considered for patients who can not tolerate statin drugs. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A nickel pyridine-selenolate complex for the photocatalytic evolution of hydrogen from aqueous solutions》 were Xie, An; Tao, Yun-Wen; Peng, Cheng; Luo, Geng-Geng. And the article was published in Inorganic Chemistry Communications in 2019. Quality Control of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

A nickel pyridine-selenolate complex, [Ni(4,4′-dmbpy)(2-pySe)2] (1, where 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine, and 2-pySe = pyridine-2-selenolate), was synthesized, and studied for photocatalytic production of H2 from aqueous solution Electrochem. studies show that the nickel complex 1 can efficiently electrocatalyze H2 evolution from weakly acidic solutions Under visible-light irradiation (λ > 420 nm), the complex 1 displays impressive H2 evolution activity with a TON of 1340 (based on a catalyst) in a noble-metal-free system, which contains fluorescein (Fl) as photosensitizer and triethylamine (TEA) as sacrificial electron donor in acetonitrile-water solution It should be noted that complex 1 is the rare example of nickel pyridine-selenolate complex as mol. photocatalyst for water reduction After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Study of zero-field splitting in Ni(II) complexes with near octahedral geometry》 were Lomjansky, Dominik; Rajnak, Cyril; Titis, Jan; Moncol, Jan; Boca, Roman. And the article was published in Inorganica Chimica Acta in 2019. HPLC of Formula: 1134-35-6 The author mentioned the following in the article:

Four novel Ni(II) complexes, [Ni(dppmO,O)2(NCS)2] (1), [Ni(dppmO,O)3][NiCl4] (2), [Ni(dmbpy)(H2O)2Br2] (3) and [Ni(dppmO,O)3][NiCl4]·[Ni(dppm)Cl2] (4) (dppm = bis(diphenylphosphino)methane, dppmO,O = bis(diphenylphosphanoxido)methane, dmbpy = 4,4′-dimethyl-2,2′-bipyridine), were synthesized and structurally and magnetically characterized. 1 And 3 are pseudooctahedral, while 2 and 4 are unique due to the existence of hexa- or tetracoordination in two/three independent Ni(II) atoms. For hexacoordinated systems the magnetic data confirm small magnetic anisotropy expressed through the axial zero-field splitting parameter D/hc = -4.5 to +4.4 cm-1. For [NiCl4]2- tetrahedral units (in complexes 2 and 4) the magnetic anisotropy is substantially larger. Exptl. findings were confirmed by ab initio calculations and forwarded to magnetostructural D-correlations. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Study of energy transfer mechanism in the EuIII and GdIII homobimetallic complexes containing the anti-inflammatory drug naproxen and N,N-donors ligands》 were Gomes, Emmanuel M.; Franco, Douglas F.; Scarpari, Sergio L.; Colaco, Marcos V.; Ferreira, Monica S.; Freire, Ricardo O.; Marques, Lippy F.. And the article was published in Journal of Luminescence in 2019. Application of 1134-35-6 The author mentioned the following in the article:

In this work, we present the synthesis, solid state characterization and complete photoluminescence study of new important homobimetallic lanthanide complexes containing the non-steroidal anti-inflammatory drug (NSAID) naproxen. The anal. and spectroscopic techniques reveals the formation of eight compounds of general formula [Ln2(nap)6(H2O)4] (Eu 1 and Gd 2), [Ln2(nap)6(bpy)2] (Eu 3 and Gd 4), [Ln2(nap)6(4,4′-dmbpy)2] (Eu 5 and Gd 6) and [Ln2(nap)6(phen)2] (Eu 7 and Gd 8), where: nap = naproxen ligand, bpy =2,2′-bipyridine, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. Using the RM1 model, the mol. structures of the EuIII complexes were calculated, with your optimized ground state geometries used to obtain all details involved in the energy transfer process. From the resp. GdIII complexes were obtained the lowest ligand triplet states, proving that the photoluminescence in the EuIII naproxen complexes is proposed to be a ligand sensitized luminescence process. On the other hand, the position of the triplet states also explains the non-effective energy transfer in the TbIII naproxen complexes. The presence of N,N-donors ligands (bpy, 4,4′-dmbpy and phen) results in an 3-4-fold increase in the quantum efficiency when compared with the EuIII complex without nitrogen ligands. The high values of emission quantum efficiency (η ∼ 70 – 98%) show the EuIII complexes can be potential candidates as emitters in biol. assays. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and structure of lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents》 were Slepukhin, P. A.; Boltacheva, N. S.; Filyakova, V. I.; Charushin, V. N.. And the article was published in Russian Chemical Bulletin in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

Lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents were synthesized. The specific features of the crystal structures of Li (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-3-yl)- and (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-4-yl)but-2-en-2-olates were revealed by x-ray diffraction. These compounds have a polymeric structure with Li cations in different coordination modes. The 1,3-diketonate group is involved in chelation and formation of O bridges, thereby linking two types of Li atoms. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Push-pull isomers of indolizino[6,5,4,3-def]phenanthridine decorated with a triarylboron moiety》 were Dong, Lei; Saraci, Felix; Yuan, Kang; Wang, Xiang; Wang, Suning. And the article was published in Organic & Biomolecular Chemistry in 2019. Computed Properties of C6H6BrN The author mentioned the following in the article:

1,3-Dipolar cycloaddition reactions between a new azomethine ylide and three BPhMes2-functionalized internal alkynes produced three pairs of fluorescent push-pull regioisomers I and II (R = 2,4,6-Me3C6H2; 1a-3a, 1b-3b, resp., Ar = C6F5, 5-trifluoromethyl-2-pyridyl, 5-methyl-2-pyridyl), which show distinct electronic and photophys. properties. All the six compounds are found to exhibit charge-transfer (CT) fluorescence, and some of which show rare and interesting temperature “”turn-on”” fluorescence. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry – A European Journal included an article by Ramu, Vadde; Upendar Reddy, Gandra; Liu, Jingjing; Hoffmann, Patrick; Sollapur, Rudrakant; Wyrwa, Ralf; Kupfer, Stephan; Spielmann, Christian; Bonnet, Sylvestre; Neugebauer, Ute; Schiller, Alexander. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine. The article was titled 《Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells》. The information in the text is summarized as follows:

Phototherapeutic applications of carbon monoxide (CO)-releasing mols. are limited because they require harmful UV and blue light for activation. We describe two-photon excitation with NIR light (800 nm)-induced CO-release from two MnI tricarbonyl complexes bearing 1,8-naphthalimide units (1, 2). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single- (405 nm) and two-photon (800 nm) excitation. The photophys. properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chem. calculations Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Separation Science included an article by Jadda, Ramana; Madhumanchi, Sreenu; Suedee, Roongnapa. Product Details of 141-86-6. The article was titled 《Novel adsorptive materials by adenosine 5′-triphosphate imprinted-polymer over the surface of polystyrene nanospheres for selective separation of adenosine 5′-triphosphate biomarker from urine》. The information in the text is summarized as follows:

The authors have developed a method to assess ATP by adsorptive extraction using surface ATP-imprinted polymer over polystyrene nanoparticles (412 ± 16 nm) for selective recognition/separation from urine. Molecularly imprinted polymer was synthesized by emulsion copolymerization reaction using ATP as a template, functional monomers (methacrylic acid, N-iso-Pr acrylamide, and dimethylamino ethylmethacrylate) and a crosslinker, methylenebisacrylamide. The binding capacities of imprinted and non-imprinted polymers were measured using HPLC with UV detection with a detection limit of 1.6 ± 0.02μM of ATP in the urine. High binding affinity (QMIP, 42.65μmol/g), and high selectivity and specificity to ATP compared to other competitive nucleotides including ADP, AMP, and analogs such as adenosine, adenine, uridine, uric acid, and creatinine were observed The imprinting efficiency of imprinted polymer is 2.11 for urine (QMIP, 100.3μmol/g) and 2.51 for synthetic urine (QMIP, 48.5μmol/g). The extraction protocol was successfully applied to the direct extraction of ATP from spiked human urine indicating that this synthesized molecularly imprinted polymer allowed ATP to be preconcd. while simultaneously interfering compounds were removed from the matrix. These submicron imprinted polymers over nano polystyrene spheres have a potential in the pharmaceutical industries and clin. anal. applications. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem