Tag: 100-200

《A novel 1-D chain organic-inorganic hybrid CuII-PrIII heterometallic germanomolybdate decorated by 2-picolinic acid ligands》 was published in Inorganic Chemistry Communications in 2020. These research results belong to Hu, Huifen; Cui, Limin; Liu, Mengling; Yang, Gengxu; Chen, Lijuan. Name: Picolinic acid The article mentions the following:

A novel 1-dimensional chain organic-inorganic hybrid CuII-PrIII heterometallic germanomolybdate decorated by 2-picolinic acid ligands [NH4]2[Pr(H2O)5]2[Cu(pic)2]2[Cu(pic)2(H2O)2]3[α- GeMo12O40]2·24H2O (1) [Hpic = 2-picolinic acid] was obtained via the strategy of combining in-situ assembly reaction and stepwise synthesis in aqueous solution and structurally characterized by IR spectra, elemental analyses, single-crystal x-ray diffraction, and TGA. It should be pointed out that the polyoxoanion unit of 1 consists of two plenary Keggin [α-GeMo12O40]4- anion and an organic-inorganic hybrid 3d-4f heterometallic {[Pr(H2O)5]2[Cu(pic)2]2[Cu(pic)2(H2O)2]3}6+ segment and neighboring polyoxoanion units are further expanded into a 1-dimensional chain alignment by virtue of {Cu(pic)2} linkers. Also, the absorption properties of 1 toward the cationic dye methylene blue (MB) in water solution were studied in detail, which shows a good absorption capacity toward the dye in aqueous solution and the absorption kinetic conforms to the 2nd-order kinetic model. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy. Category: pyridine-derivatives The article mentions the following:

A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors》 were Huang, Yi-You; Yu, Yan-Fa; Zhang, Chen; Chen, Yiping; Zhou, Qian; Li, Zhuoming; Zhou, Sihang; Li, Zhe; Guo, Lei; Wu, Deyan; Wu, Yinuo; Luo, Hai-Bin. And the article was published in Journal of Medicinal Chemistry in 2019. Recommanded Product: 103-74-2 The author mentioned the following in the article:

Pulmonary arterial hypertension (PAH) causes pathol. increase in pulmonary vascular resistance, leading to right-heart failure and eventual death. Previously, phosphodiesterase-10 (PDE10) was reported to be a promising target for PAH based on the studies with a nonselective PDE inhibitor papaverine, but little progress has been made to confirm the practical application of PDE10 inhibitors. To validate whether PAH is ameliorated by PDE10 inhibition rather than other PDE isoforms, here we report an integrated strategy to discover highly selective PDE10 inhibitors as chem. probes. Structural optimization resulted in a PDE10 inhibitor 2b with subnanomolar affinity and good selectivity of >45 000-fold against other PDEs. The cocrystal structure of the PDE10-2b complex revealed an important H-bond interaction between 2b and Tyr693. Finally, compound 2b significantly decreased the arterial pressure in PAH rats and thus validated the potential of PDE10 as a novel anti-PAH target. These findings suggest that PDE10 inhibition may be a viable treatment option for PAH. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《MIL-101 supported highly active single-site metal catalysts for tricomponent coupling》 were Sun, Weng-Jie; Gao, En-Qing. And the article was published in Applied Catalysis, A: General in 2019. Application In Synthesis of 4-Ethynylpyridine The author mentioned the following in the article:

Metal-organic frameworks with regular pore structures provide powerful platforms for the design of single-site metal catalysts for chem. transformation. In this paper, we develop a facile, stable and recyclable MOF-supported Cu(II) catalyst, MIL-101-SO3Cu. It shows extremely high activity for the A3 coupling of alkynes, aldehydes and amines. The turnover frequency can reach 6.8 × 105 h-1 under neat conditions, which is the highest so far reported for the reaction. The high activity is because the specific structure of the MIL-101-SO3 support enables a single-site dispersion and an unhindered open environment for the metal ion. MIL-101-SO3Cu also exhibits high activity for the one-pot cascade reactions combining A3 coupling and 5-endo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Smart Responsive Luminescent Aptamer-Functionalized Covalent Organic Framework Hydrogel for High-Resolution Visualization and Security Protection of Latent Fingerprints》 were Hai, Jun; Wang, Hao; Sun, Panpan; Li, Tianrong; Lu, Siyu; Zhao, Yang; Wang, Baodui. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C12H13N3 The author mentioned the following in the article:

Covalent organic frameworks (COFs) have been proposed as alternative candidates for “”smart”” materials due to its ordered π-columnar structures. However, it remains a challenge to develop external-stimuli-responsive luminescent COFs for confidential information protection. Here we have designed and synthesized a water-dispersible and smart responsive luminescent CM-cellulose (CMC)-COF-LZU1 hydrogel with encapsulated 5-(Dimethylamino)-N,N-bis (pyridin-2-ylmethyl) naphthalene-1-sulfonamide (DPYNS), named CMC-COF-LZU1⊃DPYNS, for LFP imaging and encryption. We show that the fluorescence of CMC-COF-LZU1⊃DPYNS is reversibly switchable upon addition of Cu2+/H2O. This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, record, storage, and security of latent fingerprint information. It is shown that the latent fingerprint information incubated by the CMC-COF-LZU1⊃DPYNS hydrogel is invisible in the presence of Cu2+, but three levels of fingerprint features with high-resolution patterns can be readable upon addition of H2O under UV light. The design strategy provides a promising platform for the development of smart responsive luminescent COFs and their detection and protection of valuable LFP information. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes》 were Liu, Jie-Jie; Lan, Ling; Gao, Yu-Ting; Liu, Qi; Cheng, Liang; Wang, Dong; Liu, Li. And the article was published in Advanced Synthesis & Catalysis in 2019. Formula: C7H5N The author mentioned the following in the article:

A visible-light-mediated and photocatalyst/initiator-free addition to alkynes to afford iodo-substituted alkenyl derivatives I [R1 = n-Pr, Ph, 3-pyridyl, etc.; R = H, Me, n-Pr, etc.] and e.g. II were developed. An atom transfer radical addition mechanistic afforded a broad scope of valuable compounds I and e.g. II with high E/Z-selectivities, which were versatile intermediates for the synthesis of various tri- and tetra- substituted alkenes. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Pandey, Khima; Rangan, Krishnan; Kumar, Anil published 《One-Pot Tandem Amidation, Knoevenagel Condensation, and Palladium-Catalyzed Wacker Type Oxidation/C-O Coupling: Synthesis of Chromeno-Annulated Imidazopyridines》.Journal of Organic Chemistry published the findings.Synthetic Route of C6H4BrNO The information in the text is summarized as follows:

N-(2-ethoxy-2-oxoethyl)-2-aminopyridinium bromides underwent one-pot tandem intramol. amidation, Knoevenagel condensation, Wacker-type oxidation, and intramol. C-O coupling reactions with bromoaryl aldehydes and β-bromo-α,β-unsaturated aldehydes in the presence of Pd(F3CCO2)2 and mediated by Cu(OAc)2, O2, and K3PO4 in aqueous DMF to yield chromenoimidazopyridinones such as I and pyranoimidazopyridinones in 28-77% yields. The mechanism of the reaction was studied; a bromobenzylideneimidazopyridinone intermediate was isolated and found to lead to I under the reaction conditions, and potential intermediates were observed by mass spectrometry. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Synthetic Route of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Synthetic Route of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Gao, Qian; Xu, Senmiao published 《Palladium-catalyzed synthesis of fluorenones from bis(2-bromophenyl)methanols》.Organic & Biomolecular Chemistry published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

A palladium-catalyzed synthesis method of fluorenones was developed. A variety of bis(2-bromophenyl)methanols underwent the reaction smoothly in the presence of Pd(OAc)2, affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies revealed that the reaction might be triggered by oxidation of alc. followed by intramol. reductive coupling. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Bayliss, Tracy; Robinson, David A.; Smith, Victoria C.; Brand, Stephen; McElroy, Stuart P.; Torrie, Leah S.; Mpamhanga, Chido; Norval, Suzanne; Stojanovski, Laste; Brenk, Ruth; Frearson, Julie A.; Read, Kevin D.; Gilbert, Ian H.; Wyatt, Paul G. published 《Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors》.Journal of Medicinal Chemistry published the findings.Electric Literature of C7H9NO The information in the text is summarized as follows:

N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness. The authors have previously validated T. brucei NMT as a promising druggable target for the treatment of HAT in both stages 1 and 2 of the disease. The authors report on the use of the previously reported DDD85646 as a starting point for the design of a class of potent, brain penetrant inhibitors of T. brucei NMT. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Electric Literature of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Luo, Guanglin; Chen, Ling; Conway, Charles M.; Kostich, Walter; Johnson, Benjamin M.; Ng, Alicia; Macor, John E.; Dubowchik, Gene M. published 《Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis》.Journal of Organic Chemistry published the findings.SDS of cas: 128071-75-0 The information in the text is summarized as follows:

An asym. synthesis of the major metabolite, I, of the calcitonin gene-related peptide receptor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed some unexpected chem. Reactivities of epoxide and ketone functional groups on the cycloheptane ring were extensively controlled by a remote bulky TIPS group. The rate difference of the hydrogenolysis between two diastereomeric epoxide intermediates shed some light on the mechanism of epoxide hydrogenolysis; and further, deuterium labeling studies revealed more mechanistic details on this well-known chem. transformation for the first time. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem