Tag: 100-200

In 2017,Wang, Shao-Bo; Gu, Qing; You, Shu-Li published 《Rhodium(III)-Catalyzed C-H Alkynylation of Ferrocenes with Hypervalent Iodine Reagents》.Journal of Organic Chemistry published the findings.Product Details of 128071-75-0 The information in the text is summarized as follows:

Rapid access to mono- or dialkynylation of ferrocene with ethynylbenziodoxolones as the alkynylation reagents was achieved via Rh-catalyzed direct C-H bond functionalization at room temperature Mono- and dialkynylation were easily modulated by varying the sterical volume of the directing group, such as pyridine and isoquinoline, and amount of hypervalent I reagents. A wide range of ferrocene-based alkynylation products could be obtained in up to 94% yield, and a gram-scale reaction also proceeded smoothly with high efficiency. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Product Details of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Venkateshwarlu, Rapolu; Nath Singh, Shambhu; Siddaiah, Vidavalur; Ramamohan, Hindupur; Dandela, Rambabu; Pal, Manojit published their research in Tetrahedron Letters on December 26 ,2019. The article was titled 《Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents》.Related Products of 39856-58-1 The article contains the following contents:

Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives I [W = CH, N; X = CH, N; Y = CH, N; Z = CH, N; Ar1 = Ph, 4-ClC6H4, 4-MeC6H4; Ar2 = 4-CNC6H4, 4-MeOC6H4, 4-Me(SO2)C6H4, etc.] was achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodol. involved initial C-N bond forming reaction (step 1) between an appropriate o-bromo substituted amino pyridine and iodoarene followed by C-C and C-N bond formation (step 2) between the resulting N-aryl substituted intermediate and a terminal alkyne in the same pot. A variety of azaindoles were prepared by using this method. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDA-MB-231 and MCF-7. Compounds I [W = Y = Z = CH, X = N, Ar1 = 4-MeC6H4, Ar2 = 4-MeOC6H4], I [W = Y = Z = CH, X = N, Ar1 = Ph, Ar2 = 4-MeOC6H4] and I [W = Y = Z = CH, X = N, Ar1 = 4-ClC6H4, Ar2 = 3,5-di-MeOC6H3] showed promising growth inhibition of these cell lines and SIRT1 inhibition in vitro. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Related Products of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Albaneze-Walker, Jennifer; Bazaral, Charles; Leavey, Tanya; Dormer, Peter G.; Murry, Jerry A. published an article in Organic Letters. The title of the article was 《Improved Carbonylation of Heterocyclic Chlorides and Electronically Challenging Aryl Bromides》.HPLC of Formula: 116383-98-3 The author mentioned the following in the article:

Optimized conditions are described that effect the carbonylation of diverse heterocyclic chlorides to yield the desired alkyl esters. In addition, bromoanilines and bromoanisoles, which normally are poor substrates under standard carbonylation protocols, were efficiently converted to the desired products under these new conditions. The nature of the metal bidentate ligand complex was found to be critical Specifically, a correlation between ligand bite angle and catalytic efficiency is documented. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-chloropicolinate(cas: 116383-98-3HPLC of Formula: 116383-98-3)

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 116383-98-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zn(II) and Cd(II) monomer, dimer and polymer compounds coordinated by benzoic acid and 4-acetylpyridine: Synthesis and crystal structures》 was written by Moreno-Gomez, Laura; Sanchez-Ferez, Francisco; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina. SDS of cas: 1122-54-9This research focused onzinc cadmium benzoate acetylpyridine complex preparation fluorescence; crystal structure zinc cadmium benzoate acetylpyridine. The article conveys some information:

Reaction of MO (MO = Metal oxide, M = Zn(II) or Cd(II)) with benzoic acid (HBz) in H2O/MeOH mixture as solvent yields two benzoate compounds: [Zn(μ-Bz)2]n (1) and [Cd(Bz)2(H2O)3] (2). In addition, the reaction between M(MeCO2)2 (M = Zn(II) or Cd(II)) with HBz and 4-acetylpyridine (4-Acpy) in a 1:2:4 M ratio and in MeOH solution, leads to the formation of [Zn(μ-Bz)2(4-Acpy)]2 (3) and [Cd(μ-Bz)2(4-Acpy)2]2 (4). These four compounds have been fully characterized by anal. and spectroscopic techniques. Besides, their crystal structures have been elucidated revealing a 1D coordination polymer (1), a monomer (2), a paddle-wheel (3) and a dimer (4). In 1, the Zn(II) ion is four-coordinated in a tetrahedral geometry while in 3 is penta-coordinated in a square-pyramidal geometry. By contrast, compounds 2 and 4 exhibit seven-coordinated Cd(II) ions in a pentagonal-bipyramidal geometry. In these set of compounds, the benzoate ligand presents different coordination modes such as bidentate bridged (μ2-η1:η1) (1 and 3), chelate (μ1-η2) (2) and both bridged and chelate (μ2-η2:η1) (4). Besides, their extended structures have been analyzed. Finally, the UV-Vis and fluorescence spectra of all the compounds have been recorded as well as their quantum yields calculated4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines》 was written by Lu, Ju-You; Zhao, Bo; Du, Yongmei; Yang, Jianxin; Lu, Jian. Electric Literature of C6H6BrNThis research focused ontransition metal free nucleophilic substitution carboranyl lithium halopyridine; pyridinyl carborane preparation. The article conveys some information:

A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C12H12N2In 2021 ,《A straightforward synthesis of neutral hexacoordinated silicon(IV) complexes with SiN6 skeleton》 was published in Inorganica Chimica Acta. The article was written by Cruz-Lopez, Juan F.; Palacios-Chavez, Jesus A.; Guajardo-Garcia, Joel A.; Gonzalez-Garcia, Andres; Baez, Jose E.; Lopez, Jorge A.; Orozco-Castellanos, Luis M.; Gonzalez-Garcia, Gerardo. The article contains the following contents:

Three neutral hexacoordinate silicon(IV) complexes with SiN6 skeleton were obtained via one-pot synthesis by using tetra(thiocyanato-N)silane, Si(NCS)4 with an equimolar amount of 2,2′-bipyridyl (bipy), 4,4′-dimethyl-2,2′-dipyridyl (dmp) and 1,10-phenanthroline (phen) resp. The complexes obtained; (bipy)Si(NCS)4 (1), (dmp)Si(NCS)4 (2), and (phen)Si(NCS)4 (3) belong to a family of neutral hexacoordinate silicon(IV) with SiN6 coordinating framework, which has been less studied both by single-crystal x-ray diffraction and 29Si NMR spectroscopies. All the complexes were characterized by single-crystal x-ray diffraction, solution 1H, 13C{H}, 29Si, solid-state 29Si CP/MAS NMR spectroscopies, and elemental anal. was used to confirm the structures. Comparison of the 29Si chem. shieldings of the complexes 1-3 in the solution and solid-state indicated that all complexes maintain the hexacoordination at silicon atom in DMSO-D6 solution This works demonstrated the synthetic potential of Si(NCS)4 for the synthesis of new neutral hexacoordinate silicon complexes with SiN6 skeleton via one-pot synthesis. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2020 ,《Synthesis of selective bioactive pyridylpyridones: in silico studies and biological evaluations》 appeared in Asian Journal of Chemistry. The author of the article were Ramasamy, Suresh; Ponnuchamy, Singanan; Ponnusamy, Sivakumar. The article conveys some information:

Twenty three substituted pyridylpyridones I (X = CH, N; Y = N, CH; R = H, 2,5-F2, 4-Cl, 4-OMe, etc.) were designed and performed for mol. docking studies against α-amylase enzyme. Exptl. biol. applications were studied for the top three hit compounds (X = N, Y = CH, R = 2-Cl; X = CH, Y = N, R = H; X = CH, Y = N, R = 2,5-F2). The DFT calculations were executed for the hit compounds In addition, mol. electrostatic potential mapping was also executed for addnl. support. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1122-54-9In 2021 ,《3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo》 appeared in Journal of Medicinal Chemistry. The author of the article were Dayal, Neetu; Reznickova, Eva; Hernandez, Delmis E.; Perina, Miroslav; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Skerlova, Jana; Ajani, Haresh; Djukic, Stefan; Vojackova, Veronika; Lepsik, Martin; Rezacova, Pavlina; Krystof, Vladimir; Jorda, Radek; Sintim, Herman O.. The article conveys some information:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC50 values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2019 ,《Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal-Organic Frameworks》 appeared in ACS Applied Materials & Interfaces. The author of the article were Qu, Shumei; Li, Zheng; Jia, Qiong. The article conveys some information:

Uric acid (UA) is a purine metabolite closely related to the metabolic function of human. Fluorescence anal. is a very effective method because of high selectivity and sensitivity but still remains a great challenge for direct UA detection. In this work, a fluorescent sensor based on postfunctionalized metal organic framework (UiO-PSM) was designed focusing on the direct detection of UA. UiO-PSM was synthesized from a zirconium-based MOF (UiO-66-NH2) and 2-picolinic acid (PA) through an amidation reaction. Because UA could quench the fluorescence of UiO-PSM through coordination, hydrogen bonding, and π-π interactions, the sensor could detect UA directly. UiO-PSM exhibited the advantages of short reaction time, high selectivity, high sensitivity, and wide linear range for UA detection. This work provided a novel method for UA detection and had potential application value in clin. diagnosis. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 6-Bromopyridin-3-amineIn 2010 ,《Catalytic Chain-Breaking Pyridinol Antioxidants》 appeared in Journal of Organic Chemistry. The author of the article were Kumar, Sangit; Johansson, Henrik; Kanda, Takahiro; Engman, Lars; Muller, Thomas; Bergenudd, Helena; Jonsson, Mats; Pedulli, Gian Franco; Amorati, Riccardo; Valgimigli, Luca. The article conveys some information:

The synthesis of 3-pyridinols carrying alkyltelluro, alkylseleno, and alkylthio groups is described together with a detailed kinetic, thermodn., and mechanistic study of their antioxidant activity. When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than α-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. In homogeneous phase, inhibition of styrene autoxidation absolute rate constants kinh for quenching of peroxyl radical were as large as 1 × 107 M-1/s-1, thus outperforming the best phenolic antioxidants including α-tocopherol. Tellurium-containing 3-pyridinols could be quant. regenerated in homogeneous phase by N-tert-butoxycarbonyl cysteine Me ester, a lipid-soluble analog of N-acetylcysteine. In the presence of an excess of the thiol, a catalytic mode of action was observed, similar to the one in the two-phase system. Overall, compounds bearing the alkyltelluro moiety ortho to the OH group were much more effective antioxidants than the corresponding para isomers. The origin of the high reactivity of these compounds was explored using pulse-radiolysis thermodn. measurements, and a mechanism for their unusual antioxidant activity was proposed. The tellurium-containing 3-pyridinols were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agents, thereby acting as multifunctional (preventive and chain-breaking) catalytic antioxidants. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Quality Control of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Quality Control of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem