Tag: 100-200

Sidorov, Evgeny V.; Bejar, Cynthia; Xu, Chao; Ray, Bappaditya; Gordon, David; Chainakul, Juliane; Sanghera, Dharambir K. published an article in 2021. The article was titled 《Novel Metabolites as Potential Indicators of Ischemic Infarction Volume: a Pilot Study》, and you may find the article in Translational Stroke Research.Electric Literature of C6H5NO2 The information in the text is summarized as follows:

Metabolomics may identify biomarkers for acute ischemic stroke (AIS). Previously, circulating metabolites were compared in AIS and healthy controls without accounting for stroke size. The goal of this study was to identify metabolites that associate with the volume of AIS. We prospectively analyzed 1554 serum metabolites in the acute (72 h) and chronic (3-6 mo) stages of 60 ischemic stroke patients. We calculated infarct volume using diffusion-weighted images with MR segmentation software and associated the volume with stage-specific metabolites, acute-to-chronic stage changes, and multiple mixed regression in metabolite concentrations using multivariate regression anal. We used the two-stage Benjamini and Hochberg (TSBH) procedure for multiple testing. Four unknown metabolites at the acute stage significantly associated with infarct volume: X24541, X24577, X24581, and X2482 (all p < 0.01). Nine metabolites at the chronic stage are significantly associated with infarct volume: indolpropinate, alpha ketoglutaramate, picolinate, X16087, X24637, X24576, X24577, X24582, X24581 (all p < 0.048). Infarct volume is also associated with significant changes in serum concentrations of twenty-seven metabolites, with p values from 0.01 to 1.48 x 10-7, and on five metabolites using mixed regression model. This prospective pilot study identified several metabolites associated with the volume of ischemic infarction. Confirmation of these findings on a larger dataset would help characterize putative pathways underlying the size of ischemic infarction and facilitate the identification of biomarkers or therapeutic targets. In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Electric Literature of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Electric Literature of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mambwe, Dickson; Kumar, Malkeet; Ferger, Richard; Taylor, Dale; Njoroge, Mathew; Coertzen, Dina; Reader, Janette; van der Watt, Mariette; Birkholtz, Lyn-Marie; Chibale, Kelly published their research in ACS Medicinal Chemistry Letters in 2021. The article was titled 《Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro》.Quality Control of 2-(2-Hydroxyethyl)pyridine The article contains the following contents:

In the context of drug repositioning and expanding the existing structure-activity relationship around astemizole (AST), a new series of analogs were designed, synthesized, and evaluated for their antiplasmodium activity. Among 46 analogs tested, compounds 21, 30, and 33 displayed high activities against asexual blood stage parasites (PfNF54 IC50 = 0.025-0.043μM), whereas amide compound 46 addnl. showed activity against late-stage gametocytes (stage IV/V; PfLG IC50 = 0.6 ± 0.1μM) and 860-fold higher selectivity over hERG (46, SI = 43) compared to AST. Several analogs displaying high solubility (Sol > 100μM) and low cytotoxicity in the Chinese hamster ovary (SI > 148) cell line have also been identified. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration》 was written by Auciello, Giulio; Di Marco, Annalise; Gonzalez Paz, Odalys; Malancona, Savina; Harper, Steven; Beconi, Maria; Rossetti, Ilaria; Ciammaichella, Alina; Fezzardi, Paola; Vecchi, Andrea; Bracacel, Elena; Cicero, Daniel; Monteagudo, Edith; Elbaum, Daniel. Recommanded Product: 2-(2-Hydroxyethyl)pyridine And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic acid (PPA) from vitamin B5. Restoration of central PPA levels by delivery of exogenous PPA is a recent strategy to reactivate CoA biosynthesis in PKAN patients. Fosmetpantotenate is an oral PPA prodrug. We report here the development of a new PANk2-/- knockout model that allows CoA regeneration in brain cells to be evaluated and describe two new series of cyclic phosphate prodrugs of PPA capable of regenerating excellent levels of CoA in this system. A proof-of-concept study in mouse demonstrates the potential of this new class of prodrugs to deliver PPA to the brain following oral administration and confirms incorporation of the prodrug-derived PPA into CoA. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Determination of stability constants of ternary copper(II) complexes formed with picolinic acid and several amino acids》 was published in Physics and Chemistry of Liquids in 2020. These research results belong to Hernandez, Lino; Del Carpio, Edgar; Madden, Waleska; Lubes, Giuseppe; Perez, Alejandro; Rodriguez-Lugo, Rafael E.; Landaeta, Vanessa R.; Araujo, Mary Lorena; Daniel Martinez, Jose; Lubes, Vito. Computed Properties of C6H5NO2 The article mentions the following:

In this work, the formation of ternary complexes with their resp. formation constants in the systems formed by copper (II), picolinic acid and the amino acids = histidine (His), aspartic acid (HGly), proline (HPro), α-alanine (HαAla), β-alanine (HβAla), serine (HSer), threonine (HThr), phenylalanine (HPhe) and methionine (HMet) was detected. The anal. involves the use of the potentiometric data with the least-squares program LETAGROP in aqueous solution at 25°C in 1M KNO3 solution The relative stability of the ternary complexes was compared with the binary ones considering the values of Δlog K and log χ. Subsequently using the formation constants, the species distribution diagrams were generated and are briefly discussed here. The Cu (II)-picolinic acid-glutamic acid, Cu (II)-picolinic acid-serine and Cu (II)-picolinic acid-histidine systems were characterised by UV-Vis mol. absorption spectroscopy and cyclic voltammetry, obtaining results that confirm the formation of ternary complexes with octahedral geometry. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《(2-Fluoroallyl)boration of Ketones with (2-Fluoroallyl)boronates》 was published in Journal of Organic Chemistry in 2020. These research results belong to Novikov, Maxim A.; Bobrova, Angelina Yu.; Mezentsev, Igor A.; Medvedev, Michael G.; Tomilov, Yury V.. Category: pyridine-derivatives The article mentions the following:

Efficient routes toward activation of gem-chlorofluorocyclopropane-derived (2-fluoroallyl)boronates for allylboration of various ketones including functionalized and low-reactive ones were developed. Increasing the B electrophilicity by the transformation of a boronate moiety into a borinic ester with BuLi/trifluoroacetic anhydride (TFAA) makes (2-fluoroallyl)boration of acetyl arenes/hetarenes and aliphatic ketones possible with high diastereoselectivity. For low-reactive or sterically hindered ketones (e.g., benzophenone, adamantanone), CuF-based catalysts were developed: (NHC)CuF·HF and (NHC)CuOTf in the presence of an excess of KHF2 (NHC = IPr, SIPr, IPrCl). The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1》 were Kern, Felix; Wanner, Klaus T.. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Synthetic Route of C6H4BrNO The author mentioned the following in the article:

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. Oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pKi values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pKi = 8.55 ± 0.04) was found. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Synthetic Route of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Diimidazo[4,5-b:4′,5′-e]pyridine: synthesis and nucleophilic aromatic substitution reaction》 were Razorenov, Dmitriy Yu.; Makulova, Sophia A.; Fedyanin, Ivan V.; Lyssenko, Konstantin A.; Skupov, Kirill M.; Volkova, Yulia A.; Ponomarev, Ivan I.; Ponomarev, Igor I.. And the article was published in Mendeleev Communications in 2019. Synthetic Route of C5H7N3 The author mentioned the following in the article:

The compound 1,7-dihydrodiimidazo[4,5-b:4′,5′-e]pyridine obtained by reductive heterocyclization was N-arylated with 4-fluoronitrobenzene to form two regioisomers I and II in 7 : 3 ratio. This N-arylation is considered as a model reaction for the polymer synthesis. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors》 were Huang, Chao; Xiong, Juan; Guan, Hui-Da; Wang, Chang-Hong; Lei, Xinsheng; Hu, Jin-Feng. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Quality Control of 2-Pyridinylboronic acid The author mentioned the following in the article:

Nonracemic hydroxydihydroisobenzopyranones such as I, analogs of (R)-5-methylmellein, were prepared and tested as inhibitors of monoamine oxidase A (MAO-A). Most of the hydroxydihydrobenzopyranones selectively inhibited MAO-A with IC50 values of 60 nM to 29 μM; I was the most potent and selective analog prepared, with IC50 values of 60 nM for MAO-A and >50 μM for MAO-B. Mol. docking calculations of I in the active sites of MAO-A and MAO-B were performed; the kinetics of inhibition of MAO-A by I were determined In the experimental materials used by the author, we found 2-Pyridinylboronic acid(cas: 197958-29-5Quality Control of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides》 were Cui, Xin-Feng; Ban, Zi-Hui; Tian, Wa-Fa; Hu, Fang-Peng; Zhou, Xiao-Qiang; Ma, Hao-Jie; Zhan, Zhen-Zhen; Huang, Guo-Sheng. And the article was published in Organic & Biomolecular Chemistry in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Indole is a ubiquitous structural motif with important applications in many areas of chem. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indoles I (R = Ph, 4-FC6H4, 3-ClC6H4, 2-thienyl, cyclohexyl, etc., R1 = H, 5-Me, 5-MeO, 6-F, 5-Me-6-Cl, etc., R2 = H, 5-Me, 4-Me, 5-Cl, 5-Br) via intermol. annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed This protocol provides easy access to a wide variety of useful indoles in the presence of a com. available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Organic Chemistry included an article by Nakafuku, Kohki M.; Twumasi, Raymond K.; Vanitcha, Avassaya; Wappes, Ethan A.; Namitharan, Kayambu; Bekkaye, Mathieu; Nagib, David A.. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Development of an Imine Chaperone for Selective C-H Functionalization of Alcohols via Radical Relay》. The information in the text is summarized as follows:

The design of a radical relay chaperone to promote selective C-H functionalizations is described. A saccharin-based imine was found to be uniquely suited to effect C-H amination of alcs. via an in situ generated hemiaminal. This radical chaperone facilitates the mild generation of an N-centered radical while also directing its regioselective H atom transfer (HAT) to the β carbon of an alc. Upon β C-H halogenation, aminocyclization, and reductive cleavage, an NH2 is formally added vicinal to an alc. The development, synthetic utility, and chemo-, regio-, and stereoselectivity of this imine chaperone-mediated C-H amination is presented herein. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem