Tag: 100-200

In 2019,Chemistry – A European Journal included an article by Sinha, Narayan; Champagne, Pier Alexandre; Rodriguez, Michael J.; Lu, Yu; Kopach, Michael E.; Mitchell, David; Organ, Michael G.. Quality Control of 5-Bromo-2-chloropyridine. The article was titled 《One-Pot Sequential Kumada-Tamao-Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard-Sensitive Functional Groups Using Pd-PEPPSI-IPentCl》. The information in the text is summarized as follows:

We report a general and rapid chemoselective Kumada-Tamao-Corriu (KTC) cross-coupling of aryl bromides in the presence of chlorides or triflates with functionalized Grignard reagents at 0 °C in 15 min by using Pd-PEPPSI-IPentCl (C4) [e.g., 1-bromo-4-chlorobenzene + (4-cyanophenyl)magnesium bromide → 4′-chlorobiphenyl-4-carbonitrile (91% isolated) in presence of C4 (I)].. Nucleophiles and electrophiles (or both) can contain Grignard-sensitive functional groups (-CN, -COOR, etc.). Control experiments together with DFT calculations suggest that transmetallation is rate limiting for the selective cross-coupling of Br in the presence of Cl/OTf with functionalized Grignard reagents. One-pot sequential KTC/KTC cross-couplings with bromo-chloro arenes have been demonstrated for the first time. We also report the one-pot sequential KTC/Negishi cross-couplings using C4 showcasing the versatility of this methodol.5-Bromo-2-chloropyridine(cas: 53939-30-3Quality Control of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Molecular Structure included an article by Ishak, Syarmila; Yeap, Guan-Yeow; Shanmugapriya; Sasidharan, Sreenivasan; Ito, Masato M.. Recommanded Product: 1539-42-0. The article was titled 《Synthesis, molecular structure and cytotoxic studies of fluorene compound with potential anti-cancer properties》. The information in the text is summarized as follows:

A new fluorene derivative, I has been successfully synthesized through condensation reaction of bis(2-pyridylmethyl)amine and 2,7-bis-bromomethyl-9,9-dihexyl-9H-fluorene with exceptionally good yield. The mol. structure of the synthesized compound was well characterized by NMR (NMR), IR (FTIR), UV-vis absorption and fluorescence techniques. The in-vitro anticancer activity of the title compound against human cervical (HeLa) cancer cell line was validated wherein the target mol. exhibits IC50 value of 28.58 μg/mL (37.76 μM). The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(Chloromethyl)-4-methoxypyridine hydrochlorideOn March 20, 1992, Kohl, Bernhard; Sturm, Ernst; Senn-Bilfinger, Joerg; Simon, W. Alexander; Krueger, Uwe; Schaefer, Hartmann; Rainer, Georg; Figala, Volker; Klemm, Kurt published an article in Journal of Medicinal Chemistry. The article was 《(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate》. The article mentions the following:

[(Pyridylmethyl)sulfinyl]benzimidazoles I (R = OCF2H, OCH2CF3, OCF2CF2H; R1 = H, OMe; RR1 = OCF2O; R2, R3 = H, Me, OMe) were prepared and tested for (H+,K+)-ATPase inhibitory activity. The aim of this study was to identify compounds with high (H+,K+)-ATPase inhibitory activity in stimulated gastric glands possessing acidic pH, but low reactivity (high chem. stability) at neutral pH as reflected by in vitro (Na+,K+)-ATPase inhibitory activity. The critical influence of substituents flanking the pyridine 4-MeO substituent present in all derivatives was carefully studied. The introduction of a 3-MeO group gave inhibitors possessing a combination of high potency, similar to omeprazole and lansoprazole, but increased stability. As a result I (R = OCF2H, R1 = R3 = H, R2 = OMe; pantoprazole) was selected as a candidate drug and is currently undergoing phase III clin. studies. In the experimental materials used by the author, we found 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride)

2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H8N2On June 11, 2020, Wang, Chunting; Pei, Yameng; Wang, Lin; Li, Shuo; Jiang, Chao; Tan, Xu; Dong, Yi; Xiang, Ye; Ma, Yao; Liu, Gang published an article in Journal of Medicinal Chemistry. The article was 《Discovery of (1H-Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogues as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint》. The article mentions the following:

Hepatitis B virus (HBV) capsid assembly modulators (CAMs) have been suggested to be effective anti-HBV agents in both preclin. and clin. studies. In addition to blocking HBV replication, CAMs could reduce the formation of covalently closed circular DNA (cccDNA), which accounts for the persistence of HBV infection. Here, we describe the discovery of (1H-indazole-5-yl)sulfonamides and (1H-pyrazolo[3,4-c]pyridin-5-yl)sulfonamides as new CAM chemotypes by constraining the conformation of the sulfamoylbenzamide derivatives Lead optimization resulted in compound 56 with an EC50 value of 0.034μM and good metabolic stability in mouse liver microsomes. To increase the solubility, the amino acid prodrug (65) and its citric acid salt (67) were prepared Compound 67 dose dependently inhibited HBV replication in a hydrodynamic injection-based mouse model of HBV infection, while 56 did not show in vivo anti-HBV activity, likely owing to its suboptimal solubility This class of compounds may serve as a starting point to develop novel anti-HBV drugs. In addition to this study using 4-Amino-2-picoline, there are many other studies that have used 4-Amino-2-picoline(cas: 18437-58-6Electric Literature of C6H8N2) was used in this study.

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Using fluoroform for constructing aromatic and heterocyclic trifluoromethylselenyl compounds》 was written by Aharon, Cheryl; Rozen, Shlomo. SDS of cas: 197958-29-5This research focused ontrifluoromethylselenium compound preparation; aromatic selenium cyanide trifluoromethyl copper trifluoromethylation; heterocyclic selenium cyanide trifluoromethyl copper trifluoromethylation. The article conveys some information:

Fluoroform is used to prepare CuCF3 according to literature procedures. This nucleophilic trifluoromethyl moiety was reacted with aromatic and heterocyclic selenium cyanide derivatives 3-R-4-N(R1)(R2)-5-R3C6H2SeCN (R = H, Me, Br; R1 = H, Et, Ac; R2 = H, Et, Ac; R3 = H, Me), 3-R4-4-R5-C6H3SeCN (R4 = H, Me; R5 = Me, t-Bu, Cl, etc.), I (R6 = H, Br; R7 = H, SeCN; R8 = H, SeCN) and II (X = O, S) resp. to form the corresponding trifluoromethylselenium compounds 3-R-4-N(R1)(R2)-5-R3C6H2SeCF3, 3-R4-4-R5-C6H3SeCF3, III (R9 = H, SeCF3; R10 = H, SeCF3) and IV. Selenium cyanides were made with 1,3-dicyanotriselenide prepared in situ from malononitrile and selenium dioxide. The electrophilicity of the reagent (δ+SeCN) was enough to attack aniline derivatives 3-R-4-N(R1)(R2)-5-R3C6H3 at the para position, but with other aromatics it was advantageous to use the corresponding boronic acids 3-R4-4-R5-C6H3B(OH)2, V (R11 = H, B(OH)2; R12 = H, B(OH)2) and VI as the moiety was easily displaced by the selenium cyanate moiety. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Experimental, quantum computational study and in vitro antidiabetic activity of oxidovanadium(IV) complexes incorporating 2,2′-bis(pyridylmethyl)amine and polypyridyl ligands》 was written by Patel, Neetu; Prajapati, A. K.; Jadeja, R. N.; Tripathi, I. P.; Dwivedi, N.. Computed Properties of C12H13N3This research focused onvanadyl pyridylmethyl amine diimine complex preparation DFT calculation; magnetic property cyclic voltammetry vanadyl pyridylmethyl amine diimine complex; antidiabetic activity vanadyl pyridylmethyl amine diimine complex. The article conveys some information:

This article describes synthesis and characterization of three oxidovanadium(IV) complexes using BPA (BPA = 2,2′-bis(pyridylmethyl)amine), 2,2-bipyridyl and 1,10-phenanthroline. These complexes were characterized by elemental anal., spectroscopic (UV-visible, IR and EPR) and electrochem. methods. Room temperature magnetic susceptibility data show the paramagnetic nature of the complexes. Complexes were also characterized by EPR spectral techniques. The optimized mol. structures show N3O3/N5O donor atoms in six-coordinate geometry. These complexes were evaluated and compared using TGA and powder x-ray diffraction techniques. The species exhibit only one-electron reduction wave at a more neg. potential. The catalytic activity of these complexes was also explored to mimic α-glucosidase and α-amylase activity. Moderate α-glucosidase and α-amylase inhibitors are shown by all complexes. These observations are expected to expand the possibility of designing new oxidovanadium(IV) complexes with significant anti-diabetic properties. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》 was written by Heinrich, Timo; Sala-Hojman, Ada; Ferretti, Roberta; Petersson, Carl; Minguzzi, Stefano; Gondela, Andrzej; Ramaswamy, Shivapriya; Bartosik, Anna; Czauderna, Frank; Crowley, Lindsey; Wahra, Pamela; Schilke, Heike; Boepple, Pia; Dudek, Lukasz; Les, Marcin; Niedziejko, Paulina; Olech, Kamila; Pawlik, Henryk; Wloszczak, Lukasz; Zuchowicz, Karol; Suarez Alvarez, Jose Ramon; Martyka, Justyna; Sitek, Ewa; Mikulski, Maciej; Szczesniak, Joanna; Jaeckel, Sven; Krier, Mireille; Krol, Marcin; Wegener, Ansgar; Galezowski, Michal; Nowak, Mateusz; Becker, Frank; Herhaus, Christian. Recommanded Product: 39856-58-1 And the article was included in Journal of Medicinal Chemistry on August 26 ,2021. The article conveys some information:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors》 was written by Yuan, Xinrui; Wu, Hanshu; Bu, Hong; Zheng, Peiyuan; Zhou, Jinpei; Zhang, Huibin. Synthetic Route of C6H8N2 And the article was included in Bioorganic & Medicinal Chemistry on April 1 ,2019. The article conveys some information:

Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways. A series of pyridone-aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Several compounds exhibited great inhibitory activity against MNK1/2 and selected compounds showed moderate to excellent anti-proliferative potency against hematol. cancer cell lines. In particular, compound 42i (MNK1 IC50 = 7.0 nM; MNK2 IC50 = 6.1 nM) proved to be the most potent compound against TMD-8 cell line with IC50 value of 0.91 μM. Furthermore, 42i could block the phosphorylation level of eIF4E in CT-26 cell line, and 42i inhibited the tumor growth of CT-26 allograft model significantly. These results indicated that compound 42i was a promising MNK1/2 inhibitor for the potent treatment of colon cancer. In the experiment, the researchers used many compounds, for example, 4-Amino-2-picoline(cas: 18437-58-6Synthetic Route of C6H8N2)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cesium Fluoride and Copper-Catalyzed One-Pot Synthesis of Benzoxazoles via a Site-Selective Amide C-N Bond Cleavage》 was published in Advanced Synthesis & Catalysis in 2019. These research results belong to Luo, Zhongfeng; Wu, Hongxiang; Li, Yue; Chen, Yuwen; Nie, Jingyi; Lu, Siqi; Zhu, Yulin; Zeng, Zhuo. Safety of 2-Bromopyridin-3-amine The article mentions the following:

We report herein a two-step one-pot strategy for the synthesis of benzoxazoles from amides by using cesium fluoride/copper as catalysts. This approach involves the in situ generation of acyl fluorides from the corresponding amides, and the acyl fluorides undergo transamidation and cyclization to give benzoxazoles in good yields. In this work, the amide C-N bonds are activated by CsF to form the acyl fluoride intermediates, which further react with o-bromoanilines to efficiently yield benzoxazoles. Notably, this methodol. demonstrates a broad substrate scope, as primary/secondary benzamides are well tolerated, and this process might facilitate the development of one-pot transformations of amides. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Safety of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Safety of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 3510-66-5In 2019 ,《Thermochromism of bromotellurates(IV): experimental insights》 was published in New Journal of Chemistry. The article was written by Shayapov, Vladimir R.; Usoltsev, Andrey N.; Adonin, Sergey A.; Sokolov, Maxim N.; Samsonenko, Denis G.; Fedin, Vladimir P.. The article contains the following contents:

Thermally induced changes in optical properties (thermochromism) in an extended series of 16 bromotellurate(IV) complexes (TeBr6·substituted-pyridinium) were investigated; regularities valid for this class of compounds were established. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem