Tag: 100-200

《Six new palladium(II) mixed ligand complexes of 2-, 3-, 4-monosubstituted derivative of pyridine ring with caffeine moiety: Synthesis, spectroscopic, morphological structures, thermal, antimicrobial and anticancer properties》 was written by Al-Saif, Foziah A.; Al-Humaidi, Jehan Y.; Binjawhar, Dalal N.; Refat, Moamen S.. Reference of Picolinic acid And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

In the present article, new complexes of mononuclear palladium, formed by the interaction of PdCl2 with nicotinamide (nta), picolinic acid (pia), and isonicotinic acid (ina) have been isolated in the solid state with 1:2 M ratio affords the new compounds [Pd(nta)2(Cl)2] (I), [Pd(pia)2] (II), and [Pd(ina)2] (III). The mixed ligand complexes with caffeine (caf) as a secondary ligand have been synthesized and formulated as [Pd(nta)(caf)(Cl)2] (IV), [Pd(pia)(caf)(Cl)] (V), and [Pd(ina)(caf)(Cl)] (VI) with ratio of metal: ligand: ligand is 1:1:1. Structures of these products has been established by elemental analyses, conductivity, FTIR, 1H NMR and thermal anal. data. The shifts of the ν(N-H) amino, ν(C=N1) pyridine, ν(C=O) carboxylic, and ν(C=N9) caffeine stretches have been monitored in order to find out the donor sites of the ligands. According to the exptl. data, the six complexes can be characterized in the solid state as mononuclear, with a four-coordinate stereochem. SEM, TEM, and XRD anal. determined the characteristics of synthesized nanoparticles. The in vitro antibacterial efficiency of the compounds were evaluated by paper disk diffusion method. Compounds were also screened for their anti-cancer activity against colorectal adenocarcinoma (Caco-2) and breast cancer (Mcf-7) cell lines. This study reveals that [Pd(pia)2] complex has a potent cytotoxic agent against human colorectal adenocarcinoma and breast cancer. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Reference of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Reference of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electronic Finetuning of 8-Methoxy Psoralens by Palladium-Catalyzed Coupling: Acidochromicity and Solvatochromicity》 was written by Geenen, Sarah R.; Presser, Lysander; Hoelzel, Torsten; Ganter, Christian; Mueller, Thomas J. J.. Formula: C7H5N And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Differently 5-substituted 8-methoxypsoralens can be synthesized by an efficient synthetic route with various cross-coupling methodologies, such as Suzuki, Sonogashira and Heck reaction. Compared to previously synthesized psoralens, thereby promising daylight absorbing compounds as potentially active agents against certain skin diseases can be readily accessed. Extensive investigations of all synthesized psoralen derivatives reveal fluorescence in the solid state as well as several distinctly emissive derivatives in solution Donor-substituted psoralens exhibit remarkable photophys. properties, such as high fluorescence quantum yields and pronounced emission solvatochromicity and acidochromicity, which were scrutinized by Lippert-Mataga and Stern-Volmer plots. The results indicate that the compounds exceed the limit of visible light, a significant factor for potential applications as an active agent. In addition, (TD)DFT calculations were performed to elucidate the underlying electronic structure and to assign exptl. obtained data. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electron-Donating Effect Enabled Simultaneous Improvement on the Mechanical and Self-Healing Properties of Bromobutyl Rubber Ionomers》 was written by Zhang, Linjun; Wang, Hao; Zhu, Yong; Xiong, Hui; Wu, Qi; Gu, Shiyu; Liu, Xikui; Huang, Guangsu; Wu, Jinrong. Name: 4-Cyanopyridine And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Due to the dynamic nature of networks and high mobility of mol. chains, self-healing elastomers are usually confronted with the trade-off between self-healing efficiency and mech. properties. Herein, a self-healing ionomer with both high mech. performance and high self-healing efficiency has been successfully developed by grafting bromobutyl rubber (BIIR) with pyridine-based derivatives Interestingly, the substituents on the pyridine ring can be used to regulate the interaction forces of ionic clusters and mol. dynamics. The electron-donating effect of the substituents facilitates stable π-π stacking between pyridyl ions, inducing the formation of regular and large ion aggregates, thereby improving the mech. strength of the ionomer. Meanwhile, the plasticizing effect of the substituents reduces the activation energy and relaxation temperature of the ionic aggregates, thus endowing the ionomer with a high self-healing efficiency. As a result, the ionomer shows tensile strength as high as 8.1 ± 0.3 MPa under room temperature and self-healing efficiency of 100 ± 3% at 60°C. Therefore, this strategy can be easily extended to other halogen-containing polymers, leading to a novel class of self-healing ionomers that hold great promise in diverse applications. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Immobilization of Au nanoparticles on poly(glycidyl methacrylate)-functionalized magnetic nanoparticles for enhanced catalytic application in the reduction of nitroarenes and Suzuki reaction》 was published in Applied Organometallic Chemistry in 2020. These research results belong to Pourjavadi, Ali; Kohestanian, Mohammad; Keshavarzi, Nahid. Safety of 2,6-Diaminopyridine The article mentions the following:

The synthesis of magnetic nanocomposite for highly efficient catalysis was reported. Poly(glycidyl methacrylate) (PGMA) chains were grafted to the surface of magnetic nanoparticles (MNPs) through surface-initiated reversible addition-fragmentation chain transfer polymerization Then, the oxirane rings in the PGMA chains were opened with 2,6-diamino pyridine (DAP) mols. as ligands was to prepare the solid support. Finally, this magnetic nanocomposite was used for the immobilization of gold nanoparticles. Fourier-transform IR spectroscopy, X-ray diffraction, thermogravimetric anal., transmission electron microscopy, SEM, gel permeation chromatog., vibrating sample magnetometry, and at. absorption spectroscopy were used for characterization of the catalyst. The loading of gold nanoparticles on the solid support was 0.52 mmol/g. The catalytic activity of the prepared catalyst (MNP@PGMA@DAP@Au) was evaluated for the reduction of nitro compounds and C-C coupling reaction in water. The catalyst was easily recovered and reused seven times without significant loss of catalytic activity. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible-Light-Induced Tandem Cyclization of Alkynoates and Phenylacetylenes to Naphtho[2,1-c]coumarins》 were Wang, Zhihui; Wang, Lei; Wang, Zhiming; Li, Pinhua. And the article was published in Asian Journal of Organic Chemistry in 2019. SDS of cas: 2510-22-7 The author mentioned the following in the article:

An efficient visible-light-induced tandem cyclization of alkynoates and phenylacetylenes to naphtho[2,1-c]coumarins was developed. The reaction could be carried out at room temperature under an air atm. in one pot. Preliminary mechanistic investigations indicated that the present reaction was involved in a free-radical process. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Towards Identification of Essential Structural Elements of Organoruthenium(II)-Pyrithionato Complexes for Anticancer Activity》 were Kladnik, Jerneja; Kljun, Jakob; Burmeister, Hilke; Ott, Ingo; Romero-Canelon, Isolda; Turel, Iztok. And the article was published in Chemistry – A European Journal in 2019. Reference of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

An organoruthenium(II) complex with pyrithione (2-mercaptopyridine N-oxide) 1 a has previously been identified by our group as a compound with promising anticancer potential without cytotoxicity towards non-cancerous cells. To expand the rather limited research on compounds of this type, an array of novel chlorido and 1,3,5-triaza-7-phosphaadamantane (pta) organoruthenium(II) complexes with methyl-substituted pyrithiones has been prepared After thorough investigation of the aqueous stability of these complexes, their modes of action have been elucidated at the cellular level. Minor structural alterations in the ruthenium-pyrithionato compounds resulted in fine-tuning of their cytotoxicities. The best performing compounds, 1 b and 2 b, with a chlorido or pta ligand bound to ruthenium, resp., and a Me group at the 3-position of the pyrithione scaffold, have been further investigated. Both compounds trigger early apoptosis, induce the generation of reactive oxygen species and G1 arrest in A549 cancer cells, and show no strong interaction with DNA. However, only 1 b also inhibits thioredoxin reductase. Wound healing assays and mitochondrial function evaluation have revealed differences between these two compounds at the cellular level. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical & Pharmaceutical Bulletin included an article by Togo, Takaya; Sohma, Youhei; Kuninobu, Yoichiro; Kanai, Motomu. COA of Formula: C6H6BrN. The article was titled 《Palladium-catalyzed C-H heteroarylation of 2,5-disubstituted imidazoles》. The information in the text is summarized as follows:

A palladium-catalyzed C-H N-heteroarylation of N-protected-2,5-disubstituted imidazoles at the C4-position using N-heteroaryl halides as a coupling partner was developed. Intensive reaction condition screening led to identify fluorinated bathophenanthroline as the optimum ligand for the palladium catalyst. This reaction enhanced optimization of drug candidates by facilitating the synthesis of heterobiaryl compounds containing an imidazole ring. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Monatshefte fuer Chemie included an article by de Aguiar, Sara R. M. M.; Schroeder-Holzhacker, Christian; Pecak, Jan; Stoeger, Berthold; Kirchner, Karl. Safety of 2,6-Diaminopyridine. The article was titled 《Synthesis and characterization of TADDOL-based chiral group six PNP pincer tricarbonyl complexes》. The information in the text is summarized as follows:

The new chiral PNP pincer ligand N2,N6-bis((3aR, 8aR)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl)pyridine-2,6-diamine (PNP-TADDOL) was synthesized in 80% isolated yield. [M(PNP-TADDOL)(CO)3] (M = Cr, Mo, and W) were prepared via a solvothermal approach. This methodol. constitutes a fast, simple, and practical synthetic method to obtain complexes of that type in high isolated yields. The x-ray structure of the Mo complex is presented. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Yan, Xiao-Wei; Xie, Yong-Rong; Jin, Zhi-Min; Hu, Mao-Lin; Zhou, Liang-Pu published 《Three Arene-Ru(II) compounds of 2-halogen-5-aminopyridine: Synthesis, characterization, and cytotoxicity》.Applied Organometallic Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Three novel compounds, (η6-p-cymene)RuCl2(2-fluoro-5-aminopyridine) (compound 1), (η6-p-cymene)RuCl2(5-amino-2-chloropyridine) (compound 2) and (η6-p-cymene)RuCl2(2-bromo- 5-aminopyridine) (compound 3), were synthesized and characterized. The structures of compound 1 and 3 were determined by x-ray diffraction, showing a distorted piano-stool type of geometry with similar bond lengths and angles around the Ru. Compound 2 exhibited moderate in vitro activity against A549 and MCF-7 human cancer cells, the other two lower activities. The UV-visible and fluorescent absorption titrations showed that the three compounds bonded with CT-DNA in a minor groove. The intrinsic binding constants (Kb) were calculated to be 2.13(±0.03) × 105 M-1, 2.89(±0.03) × 105 M-1 and 2.45(±0.03) × 105 M-1 for compound 1, 2 and 3, resp., by using UV-visible absorption titrations data. Among the three compound, the highest value of intrinsic binding constant of compound 2 was consistent with its high cytotoxicity against A549 and MCF-7 human cancer cells in vitro. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Faggyas, Reka J.; Calder, Ewen D. D.; Wilson, Claire; Sutherland, Andrew published 《One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis》.Journal of Organic Chemistry published the findings.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asym. synthesis of 3-methyleneindanes bearing a tertiary alc. center. Bronsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alc. scaffolds. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem