Tag: 100-200

Fluorocyano-benzenes and -pyridines was written by Finger, G. C.;Dickerson, D. R.;Adl, Touradj;Hodgins, T.. And the article was included in Chemical Communications (London) in 1965.Computed Properties of C6H3FN2 This article mentions the following:

Chlorobenzonitriles stirred and heated at 160-200° with anhydrous KF in Me₂SO₂ (CA 57, 12358i; 59, 1585a) gave 50-80% of the following I (R = mono- or disubstituted) (R and m.p. CN or b.p./mm. given): 2-F, 103°/35; 4-F, 38°; 2,4-F₂, 46°; 2,6-F₂, 99°/20; 2-F-5-CF₃ (II), 99°/27. Similarly, 2-chloro-pyridinecarbonitriles afforded 54-88% of the following III (R = CN) derivatives (R and m.p. given): 3-CN, 30°; 4-CN, 33°; 5-CN, 51°; 6-CN, 34°. 3-Bromo-4-chloro-α,α,α-trifluorotoluene heated at 145° for 42 hrs. with excess CuCN and KF in HCONMe₂ produced 57% II and 43% I (R = 4-5-Cl-CF₃), m. 39°. In the experiment, the researchers used many compounds, for example, 6-Fluoropicolinonitrile (cas: 3939-15-9Computed Properties of C6H3FN2).

6-Fluoropicolinonitrile (cas: 3939-15-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Computed Properties of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The lipophilicity and hydrogen bond strength of pyridine-N-oxides and protonated pyridine-N-oxides was written by Abraham, Michael H.;Honcharova, Lesya;Rocco, Silvana A.;Acree, Jr William E. Jr.;De Fina, Karina M.. And the article was included in New Journal of Chemistry in 2011.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Water-solvent partition coefficients for 4-nitropyridine-N-oxide have been determined in six solvent systems, and solubilities measured in water and 37 solvents. The combined data are used to obtain Abraham descriptors for 4-nitropyridine-N-oxide as follows: E = 0.934, S = 1.92, A = 0.21, B = 0.76, V = 0.9082 and L = 5.246; literature data on partition coefficients were used to calculate descriptors for 11 other pyridine-N-oxides as well as quinoline-N-oxide and isoquinoline-N-oxide. In all cases, the N-oxides were shown to be stronger hydrogen bond bases than the corresponding pyridines, thus leading to a decrease in lipophilicity. An unexpected observation is that of the hydrogen bond acidity of the N-oxides due, we suggest, to the pos. nitrogen atom in the moiety N(+) → O(-). This leads to an even sharper decrease in the N-oxide lipophilicity in non-polar solvents. We have also used literature data to determine the 1 : 1 hydrogen bond basicity, βH2, of a number of pyridine-N-oxides; again, this basicity is significantly larger than that of the corresponding pyridines. Protonation of pyridine-N-oxides removes all hydrogen bond basicity (B = 0.00), but the protonated compounds are strong hydrogen bond acids. For protonated pyridine-N-oxide itself, E = 0.514, S = 2.62, A = 1.51, B = 0.00, V = 0.7555 and the ionic descriptor J⁺ = 0.894; protonated 4-nitropyridine-N-oxide with A = 2.05 is a very strong hydrogen bond acid indeed. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application In Synthesis of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polystyrene supported Dichloro-(8-aminoquinoline)-Palladium(II) complex catalyzed C-H bond activation for ortho-acylation of 2-aryl pyridines was written by Perumgani, C. Pullaiah;Parvathaneni, Sai Prathima;Kodicherla, Balaswamy;Keesara, Srinivas;Mandapati, Mohan Rao. And the article was included in Inorganica Chimica Acta in 2017.Computed Properties of C12H11N This article mentions the following:

Polystyrene-supported Dichloro-(8-aminoquinoline)-Pd(II) complex C was synthesized and its catalytic efficiency was evaluated for ortho-acylation of 2-arylpyridines with alcs. to form aryl ketones via cross dehydrogenative coupling [e.g., 2-phenylpyridine + benzyl alc. → 2-(2-pyridyl)benzophenone (91%)]. In addition in the presence of Pd(II) complex, toluene derivatives were also employed as an effective coupling partner for synthesis of aromatic ketones. Furthermore, this catalyst was highly stable and could be easily recovered by simple filtration and reused for four cycles with no significant decrease in its activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Computed Properties of C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure of 6-methylpicolinic acid N-oxide and its derivatives was written by Szafran, M.. And the article was included in Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques in 1962.COA of Formula: C7H9NO This article mentions the following:

Infrared absorption spectra in Nujol or KBr for 4-substituted 6-methylpicolinic acid N-oxides (I) and their methylation products indicate the structure II for I (R = NO₂), two contributing tautomeric structures (II and III) for I (R = H and OMe), and structure IV for I (R = NH₂). The acids I were esterified with CH₂N₂ (V) in MeOH and Et₂O. Me 4-nitro-6-methylpicolinate N-oxide, m. 128.5-29°, was prepared in 92% yield and gave the amide, m. 265-6° (decomposition), on treatment with NH₄OH. The methylation product, m. 166° from IV was obtained in 90% yield and gave on hydrolysis 4-amino-6-methylpicolinic acid, m. 296° (decomposition). Hydrolysis of methylated (CH₂N₂) 4-methoxy-6-methylpicolinic acid N-oxide (oil) with NaOH and KOH afforded a mixture of 4-methoxy-2-picoline (70-75%) and 4-methoxypicolinic acid N-oxide (21-25%). 6-Methylpicolinic acid N-oxide reacted with V to give 6-methyl-2-carbomethoxypyridine N-oxide (40%) and an ionic compound which decomposed on distillation In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1COA of Formula: C7H9NO).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The combined effects of multi ligands on novel Fe catalyst for ATRP reaction was written by Hong, Han;Chai, Christina L. L.;Soh, Ting Rina. And the article was included in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 2006.Quality Control of 2-Isopropylpyridine This article mentions the following:

Our purpose is to carry out the systematic studies on the effect of ligands on the Fe catalyzed ATRP reactions. We report some interesting results from the systemic study of 16 ligands. Based on the understanding of the ligands’ effect, we have developed a novel catalyst system of Fe complexes using a combination of ligands. The effect of the donors atoms and the steric influence of ligands on Fe catalyzed ATRP reaction was clarified in the view of the activity, solubility and stability of the Fe catalysts. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Quality Control of 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extraction of basil seed mucilage using ionic liquid and preparation of AuNps/mucilage nanocomposite for catalytic degradation of dye was written by Maqsood, Hassan;Uroos, Maliha;Muazzam, Rabia;Naz, Sadia;Muhammad, Nawshad. And the article was included in International Journal of Biological Macromolecules in 2020.Electric Literature of C10H16ClN This article mentions the following:

Basil seeds are widely cultivated throughout the world because of their extensive applications in various fields of life. The Basil seeds mucilage (BSM) exhibits remarkable phys. and chem. properties like high water absorbing capacity, emulsifying, and stabilizing properties. The extraction of this mucilage from the seed surface has always been done by phys. and chem. methods, which has certain drawbacks. Here, we report for the first time a chem. method for the effective extraction of this mucilage using ionic liquids (ILs); the green solvents. Pyridinium chloride based ILs were investigated for the effective extraction of mucilage and the process was optimized for various variables i.e. time, temperature, basil seed loading, co-solvents, anti-solvents. The extraction yield (up to 25% weight/weight of mucilage per basil seeds dry weight) was obtained at optimum conditions. Extracted mucilage was characterized by anal. techniques. The extracted BSM was used to prepare AuNps/BSM nanocomposite by stabilizing the gold nanoparticles. The AuNps/BSM nanocomposite was applied for the catalytic degradation of dyes (congo red; 12 min, methyl orange; 4 min, whereas 4-nitrophenol; 6 min). In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Electric Literature of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible-light assisted of nano Ni/g-C₃N₄ with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation was written by Hosseini-Sarvari, Mona;Akrami, Zahra. And the article was included in Journal of Organometallic Chemistry in 2020.Category: pyridine-derivatives This article mentions the following:

A selective, economical, and ecol. protocol has been described for the oxidation of Me arenes and their analogs ArCH₂R (Ar = 3-nitrophenyl, 1-naphthyl, furan-2-yl, etc.; R = H, Me, Ph, pyridin-2-yl) and 9H-fluorene to the corresponding carbonyl compounds ArC(O)R and 9H-fluoren-9-one and epoxidation reactions of alkenes, e.g., 1,3-cyclohexadiene with mol. oxygen (O₂) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C₃N₄ exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of Me arenes, methylene arenes, and epoxidation of various alkenes under visible-light irradiation without the use of an oxidizing agent and under base free conditions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Category: pyridine-derivatives).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design was written by Sabat, Mark;Dougan, Douglas R.;Knight, Beverly;Lawson, J. David;Scorah, Nicholas;Smith, Christopher R.;Taylor, Ewan R.;Vu, Phong;Wyrick, Corey;Wang, Haixia;Balakrishna, Deepika;Hixon, Mark;Madakamutil, Loui;McConn, Donavon. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 1620-76-4 This article mentions the following:

This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton’s tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clin. candidate TAK-020. Described herein are the discovery of the fragment 5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one, the subsequent optimization of this hit mol. to the candidate, and synthesis and performance in pharmacodynamic and efficacy models along with direct biophys. comparison of TAK-020 with other clin.-level assets and the marketed drug Ibrutinib. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

N-Heterocyclic aroma compounds in whiskey was written by Viro, Maija. And the article was included in Foundation for Biotechnical and Industrial Fermentation Research, [Publication] in 1984.COA of Formula: C8H11N This article mentions the following:

Twenty-six N-heterocyclic compounds were detected in 2 brands of Finnish whiskey by gas chromatog. The flavor of pyridine derivatives identified was described as astringent, earthy, buttery, caramel, and bitter. There was a correlation between a reduced concentration of pyridines and an improvement of odor and taste. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4COA of Formula: C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic cocyclization of acetylene with nitriles in the presence of bis(η²-ethene)(η⁶-toluene)iron as catalyst was written by Schmidt, U.;Zenneck, U.. And the article was included in Journal of Organometallic Chemistry in 1992.Application of 644-98-4 This article mentions the following:

The reactive arene complex bis(η²-ethene)(η⁶-toluene)iron co-cyclotrimerizes acetylene and nitriles RCN (R = CH₃, C₂H₅, n-C₃H₇, i-C₃H₇, C₆H₅) catalytically to give pyridine derivatives In the case of acrylonitrile the reaction fails. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem