Tag: 100-200

Nickel-Catalyzed Reaction of Aryl 2-Pyridyl Ethers with Silylzinc Chlorides: Silylation of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond was written by Kong, Ying-Ying;Wang, Zhong-Xia. And the article was included in Advanced Synthesis & Catalysis in 2019.COA of Formula: C11H9NO This article mentions the following:

Ni-catalyzed C-O(Py) bond activation and silylation of aryl 2-pyridyl ethers with silylzinc chlorides were carried out. This protocol allowed the 2-pyridyloxy group to be substituted by a silyl group with short reaction times, mild reaction conditions, and good compatibility of functional groups. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0COA of Formula: C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aqueous Suzuki-Miyaura Reaction with 0.6 Equivalent of Base: Green and Efficient Access to Biaryls and Unsymmetrical Terphenyls was written by Li, Xinmin;Teng, Yong;Feng, Fangfang;Hu, Qinghong;Yuan, Zeli. And the article was included in ChemistrySelect in 2018.Related Products of 4373-61-9 This article mentions the following:

A green and efficient protocol for the synthesis of biaryls by a Pd(OAc)₂-catalyzed ligand-free Suzuki-Miyaura reaction was described. The reaction proceeded smoothly in water and gives good yields in the presence of 0.6 equivalent of base. Addnl., using bromo-N-methyliminodiacetic acid (MIDA) boronates as building block, one-pot double Suzuki-Miyaura reaction was achieved by controlling the amount of base and various unsym. terphenyls were prepared in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Related Products of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Triplet-triplet energy transfer study in hydrogen bonding systems was written by Wang, Zhijia;Zhao, Jianzhang;Guo, Song. And the article was included in Chimia in 2015.HPLC of Formula: 1075-62-3 This article mentions the following:

The 2,6-diiodoBodipy-styrylBodipy hydrogen bonding system was prepared to study the effect of hydrogen bonding on the triplet-triplet-energy-transfer (TTET) process. 2,6-DiiodoBodipy linked with N-acetyl-2,6-diaminopyridine (D-2) was used as the triplet energy donor, and the styrylBodipy connected with thymine (A-1) was used as triplet energy acceptor, thus the TTET process was established upon photoexcitation. The photophys. processes of the hydrogen bonding system were studied with steady-state UV-vis absorption spectroscopy, fluorescence spectroscopy, fluorescence lifetime measurement and nanosecond time-resolved transient absorption spectroscopies. The TTET of the intramol./hydrogen bonding/intermol. systems were compared through nanosecond transient absorption spectroscopy. The TTET process of the hydrogen bonding system is faster and more efficient (kTTET = 6.9 × 104 s-1, ΦTTET = 94.0%) than intermol. triplet energy transfer (kTTET = 6.0 × 104 s-1, ΦTTET = 90.9%), but slower and less efficient than intramol. triplet energy transfer (kTTET > 108 s-1). These results are valuable for designing self-assembly triplet photosensitizers and for the study of the TTET process of hydrogen bonding systems. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3HPLC of Formula: 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Interfering with Metabolic Profile of Triple-Negative Breast Cancers Using Rationally Designed Metformin Prodrugs was written by Babak, Maria V.;Chong, Kai Ren;Rapta, Peter;Zannikou, Markella;Tang, Hui Min;Reichert, Lisa;Chang, Meng Rui;Kushnarev, Vladimir;Heffeter, Petra;Meier-Menches, Samuel M.;Lim, Zhi Chiaw;Yap, Jian Yu;Casini, Angela;Balyasnikova, Irina V.;Ang, Wee Han. And the article was included in Angewandte Chemie, International Edition in 2021.Formula: C12H9NO This article mentions the following:

Triple-neg. breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by an aberrant metabolic phenotype with high metastatic capacity, resulting in poor patient prognoses and low survival rates. We designed a series of novel AuIII cyclometalated prodrugs of energy-disrupting Type II antidiabetic drugs namely, metformin and phenformin. Prodrug activation and release of the metformin ligand was achieved by tuning the cyclometalated AuIII fragment. The lead complex 3met was 6000-fold more cytotoxic compared to uncoordinated metformin and significantly reduced tumor burden in mice with aggressive breast cancers with lymphocytic infiltration into tumor tissues. These effects was ascribed to 3met interfering with energy production in TNBCs and inhibiting associated pro-survival responses to induce deadly metabolic catastrophe. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Mediated Perfluoroalkylation of Heteroaryl Bromides with (phen)CuR_F was written by Mormino, Michael G.;Fier, Patrick S.;Hartwig, John F.. And the article was included in Organic Letters in 2014.COA of Formula: C7H4F3NO This article mentions the following:

The attachment of perfluoroalkyl groups onto organic compounds has been a major synthetic goal over the past several decades. Previously, our group reported phenanthroline-ligated perfluoroalkyl copper reagents, (phen)CuR_F, which react with aryl iodides and aryl boronates to form the corresponding benzotrifluorides. Herein the perfluoroalkylation of a series of heteroaryl bromides with (phen)CuCF₃ and (phen)CuCF₂CF₃ is reported. The mild reaction conditions allow the process to tolerate many common functional groups. Perfluoroethylation with (phen)CuCF₂CF₃ occurs in somewhat higher yields than trifluoromethylation with (phen)CuCF₃, creating a method to generate fluoroalkyl heteroarenes that are less accessible from trifluoroacetic acid derivatives In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1COA of Formula: C7H4F3NO).

2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.COA of Formula: C7H4F3NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1 was written by Choi, Ha-Soon;Wang, Zhicheng;Richmond, Wendy;He, Xiaohui;Yang, Kunyong;Jiang, Tao;Sim, Taebo;Karanewsky, Donald;Gu, Xiang-Ju;Zhou, Vicki;Liu, Yi;Ohmori, Osamu;Caldwell, Jeremy;Gray, Nathanael;He, Yun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Category: pyridine-derivatives This article mentions the following:

(amino)(aryl)pyrrolo[2,3-d]pyrimidines such as I and II and pyridopyrimidines such as III are prepared as inhibitors of focal adhesion kinase (FAK). The structure-activity relationships for pyrrolopyrimidines are determined; electron-donating arylamino substituents at the 2-position and pyridinyl substituents at the 9-position lead to moderately active FAK inhibitors, while oxo-substituted analogs have reduced activities. I, II, and III inhibit FAK with IC₅₀ values of 0.1 μM, 0.1 μM, and 0.2 μM, resp., comparable to the initial lead compound IV (IC₅₀ = 0.1 μM). In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluoropyridine (cas: 116922-60-2Category: pyridine-derivatives).

3-Bromo-4-fluoropyridine (cas: 116922-60-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

[2+2] Halogen-bonded boxes employing azobenzenes was written by Nieland, Esther;Topornicki, Thomas;Kunde, Tom;Schmidt, Bernd M.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Herein, we report the synthesis and crystal structures of three [2+2] supramol. boxes assembled by halogen bonding [e.g., I₂.II₂]. The discrete, two-dimensional boxes with a length of 25-30 Å are based on rigid u-shaped halogen acceptors paired with highly fluorinated, azobenzenes bearing halogen bond donors. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Switch-on diketopyrrolopyrrole-based chemosensors for cations possessing Lewis acid character was written by Kumar, G. Dinesh;Banasiewicz, Marzena;Jacquemin, Denis;Gryko, Daniel T.. And the article was included in Chemistry – An Asian Journal in 2021.Category: pyridine-derivatives This article mentions the following:

For the first time diketopyrrolopyrroles (DPPs) have been synthesized directly from nitriles possessing (aza)crown ethers leading to macrocycle-dye hybrids. Depending on the nature of the linkage between DPP and macrocyclic ring, various coordination effects are found. The strong interaction of the cations possessing Lewis acid character such as Li⁺, Mg²⁺ and Zn²⁺ with 2-aminopyridin-4-yl-DPPs, leading to a bathochromic shift of both emission and absorption, as well as to strong enhancement of fluorescence was rationalized in terms of strong binding of these cations to the N=C-NR₂ functionality. The same effect has been observed for protonation. Depending on the size and the structure of the macrocyclic ring the complexation of cations by aza-crown ethers plays an important but secondary role. The interaction of Na⁺ and K⁺ with 2-aminopyridin-4-yl-DPPs leads to moderate enhancement of fluorescence due to the aza-crown ethers binding. The very weak fluorescence of DPP bearing 2-dialkylamino-pyridine-4-yl substituents is due to the closely lying T₂ state and the resulting intersystem crossing. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Category: pyridine-derivatives).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mechanism of the electrophilic substitution of heteroaromatic compounds. X. Acid-catalyzed hydrogen exchange at the α-, β-, and γ-positions of substituted pyridine 1-oxides was written by Bean, Gerritt P.;Brignell, Peter J.;Johnson, Colin David;Katritzky, Alan R.;Ridgewell, Brian J.;Tarhan, H. O.;White, Anthony Mallinson. And the article was included in Journal of the Chemical Society [Section] B: Physical Organic in 1967.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

H exchange reactions on 2,4,6-trimethyl- and 2,6-dimethylpyridine 1-oxide in the 3-position proceed on the conjugate acids. H exchange of 3,5-dimethylpyridine 1-oxide by contrast proceeds on the free base in the 2-, 4-, and 6-positions, while 3-hydroxypyridine 1-oxide also reacts on the free base, in the 2-position. For 3,5-dimethoxypyridine 1-oxide (I), changeover from 2- and 6-position exchange on the free base to exchange at the same positions on the conjugate acid is observed with increasing acidity. The orientations of acid-catalyzed H exchange and nitration in pyridine 1-oxides are compared and discussed. 20 references. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mesoporous Mn-doped hydroxyapatite nanorods obtained via pyridinium chloride enabled microwave-assisted synthesis by utilizing Donax variabilis seashells for implant applications was written by Karunakaran, Gopalu;Cho, Eun-Bum;Thirumurugan, Keerthanaa;Kumar, Govindan Suresh;Kolesnikov, Evgeny;Boobalan, Selvakumar;Janarthanan, Gopinathan;Pillai, Mamatha Muraleedharan;Rajendran, Selvakumar. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2021.Name: Pyridinehydrochloride This article mentions the following:

Manganese-doped mesoporous hydroxyapatite (MnHAp) nanorods, a bio-apatite were synthesized via pyridinium chloride mediated microwave approach using bio-waste Donax variabilis seashells to treat orthopedic infections. This is the first report on using pyridinium chloride mediated mesoporous MnHAp nanorods synthesis. Pure and Mn doped HAp samples were examined using Raman spectroscopy, X-ray powder diffraction (XRD) and Fourier transform IR spectroscopy (FTIR) studies to confirm the prepared HAp nanorods. Furthermore, the fabrication of manganese-doped HAp was successful with the formation of a hexagonal crystal lattice without disturbing the HAp phase. It is because, at the time of synthesis, PO₄^3- ions form an electrostatic interaction with the Mn ions. Furthermore, Mn-doped HAp samples showed a reduction in their sizes of 15, 10-15, 5-10 nm width, and 80-100, 10-15, 20-30 nm length with varied pore diameters and surface area. The pure HAp, MnHAp-1, MnHAp-2, and MnHAp-3 nanorods disclose the surface area of 39.4, 18.0, 49.2, and 80.4 m² g^-1, with a pore volume of 0.0102, 0.0047, 0.0143, and 0.0447 cm³ g^-1, the corresponding pore diameter was estimated to be 6, 7, 6, and 4 nm, resp. Moreover, antibacterial activity reveals effective bactericidal action against infections causing pathogens whereas cytotoxicity examination (MTT assay), and zebrafish results reveal their non-toxic behavior. Therefore, it is evident from the study, that rapid fabrication of mesoporous and diverse structured MnHAp nanorods could be convenient with pyridinium chloride enabled microwave-assisted method as a bactericidal biomaterial for implant applications. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem