Tag: 100-200

Regioselective Tandem C-H Alkylation/Coupling Reaction of ortho-Iodophenylethylenes via C,C-Pallada(II)cycles was written by Zhu, Bin-Bin;Ye, Wen-Bo;He, Zhi-Tao;Zhang, Shu-Sheng;Feng, Chen-Guo;Lin, Guo-Qiang. And the article was included in ACS Catalysis in 2021.Application of 823-61-0 This article mentions the following:

Five-membered C,C-pallada(II)cycles are a unique class of diorganopalladium species with favorable stability and an electron-rich nature, leading to efficient sequential reactions with diverse electrophiles and nucleophiles. Specifically, the development of aryl-alkenyl-palladacycle-based transformations could provide an attractive approach with regio- and stereocontrol for the construction of multifunctionalized arylethylenes. However, currently, the C,C-pallada(II)cycle formation relies on a rigid skeleton or steric congestion in the backbone to promote cyclopalladation, and the formation of aryl-alkenyl-palladacycle without an α-substituent has not been achieved. Furthermore, reactions that could discriminate between the two sp² carbon centers of such C(sp²),C(sp²)-palladacycle remain elusive. Herein, a regioselective three-component tandem alkylation/coupling reaction applicable for a variety of non-, α-, or β-substituted and α,β-disubstituted ortho-iodophenylethylenes is reported. Electron-rich 2-pyridone ligands are employed to enable the cyclopalladation process leading to aryl-alkenyl-palladacycle intermediates, of which the two C-Pd bonds are discriminated toward alkylation by their inherent steric and electronic differences. Good linear free-energy relationships between regio-/chemoselectivities and Hammett σ values are observed In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0Application of 823-61-0).

3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application of 823-61-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tunable Dielectric Responses Triggered by Dimensionality Modification in Organic-Inorganic Hybrid Phase Transition Compounds (C₅H₆N)Cd_nCl_2n+1 (n = 1 and 2) was written by Sun, Xiao-Fen;Wang, Zhongxia;Li, Peng-Fei;Liao, Wei-Qiang;Ye, Heng-Yun;Zhang, Yi. And the article was included in Inorganic Chemistry in 2017.Product Details of 628-13-7 This article mentions the following:

Two hybrids (C₅H₆N)CdCl₃ (1) and (C₅H₆N)Cd₂Cl₅ (2) were synthesized by stoichiometric regulation of reactants. 1 with a 1-dimensional chain-like structure shows a step-like dielec. anomaly at ∼158 K 2 with a layered structure undergoes a prominent phase transition in the vicinity of 182 K, accompanying obvious dielec. relaxation behavior in a broad temperature range. Systematic characterization, such as DSC, single-crystal x-ray diffraction, and dielec. measurements, demonstrated that the phase transitions of 1 and 2 are both attributable to the dynamic motion of the organic cation. Significantly, dimensionality modulation triggers the tunable dielec. responses in these two compounds Thus, regulation of the phase transition temperature and dielec. responses in the various dimensions of the structure is a potentially effective method to construct tunable dielec. phase transition materials. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Product Details of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 2-aminochromene derivatives from 1-(2-imino-2H-chromen-3-yl)pyridin-1-ium perchlorates and nitromethane in basic medium was written by Storozhenko, Olga A.;Yue, Xiaoyi;Festa, Alexey A.;Varlamov, Alexey A.;Voskressensky, Leonid G.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020.COA of Formula: C7H7ClN2 This article mentions the following:

Novel 2-amino-4-(nitromethylidene)chromenes were obtained as a result of the reaction of 1-(2-imino-2H-chromen-3-yl)pyridinium perchlorates and nitromethane by the action of DBU at reflux in trifluoroethanol. The starting 2-iminochromenes are readily accessible from the corresponding salicylic aldehydes and quaternary cyanomethyl pyridinium salts. The reaction is tolerant to substituents of different nature (alkyl, alkoxy, halogen); a limitation is the presence of strong electron-withdrawing substituents in the benzene ring of chromene. During the reaction, the products precipitate and can be isolated by filtration. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3COA of Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Cycloaddition, and Cycloreversion Reactions of Mononuclear Titanocene-oxo Complexes was written by Nguyen, Trang T.;Kortman, Gregory D.;Hull, Kami L.. And the article was included in Organometallics in 2016.SDS of cas: 3718-65-8 This article mentions the following:

Titanocene-oxo complexes of the type Cp^x₂Ti=O(L) (Cp^x = pentamethylcyclopentadienyl; tetramethylcyclopentadienyl; L = pyridine or derivatives) are synthesized from the corresponding titanocene-ethylene complexes via oxidation with pyridine N-oxides or styrene oxide. These oxo complexes react with alkynes, nitriles, and α,β-unsaturated carbonyls to form titanacycles, which undergo exchange reactions with organic substrates or react with 4-dimethylaminopyridine to regenerate the titanocene-oxo. Mechanistic experiments support a dissociative mechanism in which the first step is rate-determining retrocycloaddn. followed by trapping of the reactive [Cp^x₂Ti=O] species. In the case of the retro-[4+2]-cycloaddition from dioxatitanacyclohexene complexes, a Hammett study gives ρ values of -1.18 and -1.04 for substituents on two different Ph rings on the metallacycles, suggesting pos. charge buildup and a slightly asynchronous cycloreversion in the rate-determining step. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8SDS of cas: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Triple Passivation Approach to Laminate Perovskite Layers for Augmented UV and Ambient Stable Photovoltaics was written by Garai, Rabindranath;Gupta, Ritesh Kant;Choudhury, Anwesha;Iyer, Parameswar Krishnan. And the article was included in ACS Applied Energy Materials in 2022.Recommanded Product: 91-02-1 This article mentions the following:

The instability of the perovskite solar cells (PSCs) toward UV irradiation and moisture is a limiting factor in terms of commercialization even after achieving excellent power conversion efficiencies (PCEs). Herein, an advanced triple passivation technique has been strategically designed and demonstrated utilizing UV-absorbing 2-benzoylpyridine (BP) mols. as a passivation additive to laminate perovskites and improve PSC stability. Double layers of BP were coated on both sides of the perovskite layer, and the mol. was also incorporated into the precursor solution This strategy significantly improved the perovskite crystallinity and film quality, lowered the recombination, and enhanced the carrier transport in the PSC. The triple-passivated device exhibited a high PCE of 20.46% with almost negligible hysteresis. Further, passivated large-area (2.5 cm²) devices were also fabricated that demonstrated a PCE of 18.61%. Moreover, the triple passivation approach exhibited impressive UV and ambient stability because it can effectively shield the perovskite layer from UV illumination and moisture. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analysis of volatile and semi-volatile alkaline compounds in tobacco leaf by using comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry was written by Li, Hai-Feng;Zhong, Ke-Jun;Lu, Xin;Bai, Chang-Min;Huang, Jian-Guo;Lu, Hong-Liang;Ma, Chen-Fei;Zhu, Shu-Kui;Kong, Hong-Wei;Zhao, Ming-Yue;Xie, Jian-Ping;Niu, Sen;Xu, Guo-Wang. And the article was included in Huaxue Xuebao in 2006.HPLC of Formula: 644-98-4 This article mentions the following:

Comprehensive two-dimensional gas chromatog./time-of-flight mass spectrometry (GC × GC-TOFMS) has been applied for characterization of volatile and semi-volatile alk. compounds in oriental tobacco leaf. Simultaneous distillation extraction (SDE) was used as the sample extraction method. Two types of column set were compared, and appropriate GC × GC separation conditions were suggested. The results showed that the peaks detected by GC × GC method were far more than that by 1DGC. The separation behavior on 2D plot of different kinds of compounds was investigated. TOFMS library search combining structured chromatogram of GC × GC was used to identify the nitrogen-containing compounds in tobacco leaf. A total of 92 alk. compounds were tentatively identified. The results showed that GC × GC/TOFMS method is suitable for separation and identification of complex system. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4HPLC of Formula: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chromium-Catalyzed Reductive Cleavage of Unactivated Aromatic and Benzylic C-O Bonds was written by Yuan, Shuqing;Ling, Liang;Tang, Jinghua;Luo, Meiming;Zeng, Xiaoming. And the article was included in Synthesis in 2021.Recommanded Product: 4373-61-9 This article mentions the following:

Reductive cleavage of aromatic and benzylic C-O bonds by chromium catalysis was reported. This deoxygenative reaction was promoted by low-cost CrCl₂ precatalyst combined with poly(Me hydrogen siloxane) as the mild reducing agent, providing a strategy in forming reduced motifs by cleavage of unactivated C-O bonds. A range of functional groups such as bromide, chloride, fluoride, hydroxyl, amino and alkoxycarbonyl was retained in the reduction In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones was written by Schirok, Hartmut;Alonso-Alija, Cristina;Benet-Buchholz, Jordi;Goeller, Andreas H.;Grosser, Rolf;Michels, Martin;Paulsen, Holger. And the article was included in Journal of Organic Chemistry in 2005.Name: 3-Amino-2,6-dimethoxypyridine This article mentions the following:

A regioselective and efficient approach toward 6-amino-5-benzoyl-1-substituted 2(1H)-pyridinones, e.g., I, by reaction of acyclic ketene aminals with propiolic acid ester was developed. The effect of the solvent and temperature on the regioselectivity of the reaction and the compatibility of the target compounds to functional group manipulations was examined Substrates with an ortho substituent build atropisomers due to the restricted rotation around the C-N bond. The enantiomers were separated, and the barrier of rotation was determined exptl. Quantum chem. calculations allowed a ranking of the barrier heights, and a mechanism of rotation by deformation of the central pyridinone moiety is proposed. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Name: 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fine tuning of the Fermi level of single-walled carbon nanotubes with onium salts and application for thermoelectric materials was written by Sugiura, Hiroki;Kanazawa, Yoshinori;Nomura, Kimiatsu;Aoai, Toshiaki. And the article was included in Synthetic Metals in 2020.Reference of 628-13-7 This article mentions the following:

Fermi level is one of the most important parameters for control of semiconductor polarity and improvement of thermoelec. performances. Although single-walled C nanotubes (SWCNTs) are promising candidates for thermoelec. materials, control of the Fermi level of SWCNTs with chem. dopants is still challenging. Reported here is the fine-tuning of the Fermi level of SWCNTs with onium salts. The Fermi level of SWCNTs was very sensitive to substituent size on the cation and nucleophilicity of the anion, and the Seebeck coefficients markedly changed between -50μV K^-1 and 68μV K^-1. The optimum Fermi level of p-type SWCNTs that exhibits the maximum power factor was realized by NH₄Cl or pyridine hydrochloride, and the power factor (PF) was improved by ∼7 times as compared with nondoped SWCNTs. SWCNTs doped with onium salts were stable in both p-type and n-type states, and thermoelec. performances did not change >100 days in the air. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Reference of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes was written by Obando, Daniel;Pantarat, Namfon;Handke, Rosemary;Koda, Yasuko;Widmer, Fred;Djordjevic, Julianne T.;Ellis, David H.;Sorrell, Tania C.;Jolliffe, Katrina A.. And the article was included in Bioorganic & Medicinal Chemistry in 2009.SDS of cas: 27876-24-0 This article mentions the following:

A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the pos. charges was synthesized and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-Me,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0SDS of cas: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem