Tag: 100-200

A [4 + 1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp²-H Bond Functionalization was written by Chen, Xun;Hu, Xinwei;Deng, Yuanfu;Jiang, Huanfeng;Zeng, Wei. And the article was included in Organic Letters in 2016.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

A Co(III)-catalyzed [4+1] cycloaddition of 2-arylpyridines or 2-alkenylpyridines with aldehydes through Csp²-H bond activation has been developed. This protocol provides a facile approach to structurally diverse indolizines including benzoindolizines with a broad range of functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions was written by Li, Xiao-Hua;Ye, Ai-Hui;Liang, Cui;Mo, Dong-Liang. And the article was included in Synthesis in 2018.Quality Control of 2-Phenoxypyridine This article mentions the following:

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives was developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y₁ lead compound analog I could be prepared in good yield over two steps. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological activities of 3-methoxy-6-substituted-5,6-dihydropyrrolo[3,4-b]pyridin-7-ones was written by Sun, Guanglong;Zhang, Weiwei;Zhan, Xiaoping;Liu, Zenglu;Mao, Zhenmin. And the article was included in Youji Huaxue in 2014.Safety of Methyl 3-methylpicolinate This article mentions the following:

A series of thalidomide derivatives named 3-methoxy-6-substituted 5,6-dihydropyrrolo[3,4-b]pyridin-7-ones 1a-1l, which have never been reported in literature, were synthesized from 3-methoxypyridine-2-carboxylic acid Me ester (I) and different amines by cyclization reaction. The intermediate I was produced via hydrolysis, esterification, nitration reaction, methoxy substitution, bromination reaction using 3-methyl-pyridine-2-carbonitrile as the starting material. The structures of all compounds have been confirmed by ¹H NMR, ¹³C NMR and HRMS techniques. The target compounds were evaluated for their inhibitory activity against HCT-116, MG-63, MCF-7, HUVEC and HMVEC cells by MTT (thiazolyl blue tetrazolium bromide) method, and the results indicated that almost all of them had no obvious inhibitory effect on normal human cells, some compounds only displayed obvious inhibitory effect on MG-63 cells while other compounds presented excellent inhibitory activities against all the three kinds of tumor cells, among which compounds two compounds exhibited most potent activities. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Safety of Methyl 3-methylpicolinate).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of Methyl 3-methylpicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qualitative and quantitative structure activity relationships for the inhibitory effects of cationic head groups, functionalized side chains and anions of ionic liquids on acetylcholinesterase was written by Arning, Juergen;Stolte, Stefan;Boeschen, Andrea;Stock, Frauke;Pitner, William-Robert;Welz-Biermann, Urs;Jastorff, Bernd;Ranke, Johannes. And the article was included in Green Chemistry in 2008.HPLC of Formula: 17281-59-3 This article mentions the following:

To contribute to a deeper insight into the hazard potential of ionic liquids to humans and the environment, an acetylcholinesterase (AchE) inhibition screening assay was used to identify toxicophore substructures and interaction potentials mediating enzyme inhibition. The pos. charged nitrogen atom, a widely delocalized aromatic system, and the lipophilicity of the side chains connected to the cationic head groups can be identified as the key structural elements in binding to the enzymes active site. With respect to this, the dimethylaminopyridinium, the quinolinium and the pyridinium head groups exhibit a very strong inhibitory potential to the enzyme with IC₅₀ values around 10 μM. In contrast, the polar and non-aromatic morpholinium head group is found to be only weakly inhibiting to the enzyme activity, with IC₅₀ values > 500 μM. The introduction of polar hydroxy, ether or nitrile functions into the alkyl side chain is shown to be a potent structural alteration to shift the corresponding ionic liquids to a lower inhibitory potential. Supporting this fact, for a series of imidazolium cations, a QSAR correlation was set up by the linear regression of the log IC₅₀ vs. the logarithm of the HPLC-derived lipophilicity parameter k₀. Addnl., a broad set of anion species (inorganic, organic and complex borate anions), commonly used as ionic liquid counterions, was tested and the vast majority exhibited no effect on AchE. Only the fluoride and fluoride containing anion species which readily undergo hydrolytic cleavage can be identified to act as AchE inhibitors. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3HPLC of Formula: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides was written by Zhang, Zhucheng;He, Qian;Zhang, Xiaofei;Yang, Chunhao. And the article was included in Organic & Biomolecular Chemistry in 2022.Recommanded Product: 2-Isopropylpyridine This article mentions the following:

A method of direct C-4 selective alkylation of pyridines under visible light irradiation at room temperature was reported using simple maleate-derived pyridinium salts as pyridine precursors and the readily available carboxylic acid-derived N-(acyloxy)phthalimides as alkyl radical precursors, affording good to excellent yields without using stoichiometric oxidants and acids. A broad range of primary, secondary and tertiary carboxylates were used as alkylation reagents. Oxidant and acid-sensitive functional groups were tolerated well. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Influence of Guest/Host Morphology on Room Temperature Phosphorescence Properties of Pure Organic Doped Systems was written by Liu, Xiaoqing;Pan, Yanyan;Lei, Yunxiang;Liu, Nannan;Dai, Wenbo;Liu, Miaochang;Cai, Zhengxu;Wu, Huayue;Huang, Xiaobo;Dong, Yuping. And the article was included in Journal of Physical Chemistry Letters in 2021.Recommanded Product: 91-02-1 This article mentions the following:

Guest/host phosphorescence materials have attracted much attention; traditionally, researchers have focused on the influence of the electronic properties and energy levels of the mols. on the phosphorescence activities. The effects of the morphol. on the phosphorescence are ignored. Three isoquinoline guests with different aliphatic rings and 3 hosts are selected to construct guest/host materials. The guests are dispersed in the host as clusters. The morphols. of the guest/host directly affect the phosphorescence. In these systems, the guests have strong intermol. interactions, which are beneficial to stabilize the triplet excitons; meanwhile, the hosts should have weak intermol. interactions with easily changed morphol. to accept the guest clusters, which synergistically ensure that the doped materials have excellent RTP properties. This is the 1st work focusing on the effect of mol. morphol. on the phosphorescence of guest/host systems. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(III)-Catalyzed Directed C-H Coupling with Methyl Trifluoroacrylate: Diverse Synthesis of Fluoroalkenes and Heterocycles was written by Gong, Tian-Jun;Xu, Meng-Yu;Yu, Shang-Hai;Yu, Chu-Guo;Su, Wei;Lu, Xi;Xiao, Bin;Fu, Yao. And the article was included in Organic Letters in 2018.SDS of cas: 4373-61-9 This article mentions the following:

An example of Rh-catalyzed C-H activation with Me trifluoroacrylate for the synthesis of fluoroolefins and heterocycles (benzoindolizines) is reported. The types of products were determined by the directing group. The benzoindolizines and fluoroolefins were obtained by using pyridine and pyrazole as the directing group, correspondingly. These transformations present a number of advantages, such as oxidant-free reaction conditions and broad functional group tolerance. Moreover, this reaction greatly extends the application of fluoroolefins. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design of potent IGF1-R inhibitors related to bis-azaindoles was written by Nemecek, Conception;Metz, William A.;Wentzler, Sylvie;Ding, Fa-Xiang;Venot, Corinne;Souaille, Catherine;Dagallier, Anne;Maignan, Sebastien;Guilloteau, Jean-Pierre;Bernard, Francois;Henry, Alain;Grapinet, Sandrine;Lesuisse, Dominique. And the article was included in Chemical Biology & Drug Design in 2010.HPLC of Formula: 882033-66-1 This article mentions the following:

From an azaindole lead (I), identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on an in silico binding mode hypothesis. Although the resulting compounds produced the expected improved potency, the model was not validated by the co-crystallization experiments with IGF1-R. General synthetic schemes for preparing the compounds tested are given in the paper. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine (cas: 882033-66-1HPLC of Formula: 882033-66-1).

4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine (cas: 882033-66-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 882033-66-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS was written by Bencheva, Leda Ivanova;De Matteo, Marilenia;Ferrante, Luca;Ferrara, Marco;Prandi, Adolfo;Randazzo, Pietro;Ronzoni, Silvano;Sinisi, Roberta;Seneci, Pierfausto;Summa, Vincenzo;Gallo, Mariana;Veneziano, Maria;Cellucci, Antonella;Mazzocchi, Nausicaa;Menegon, Andrea;Di Fabio, Romano. And the article was included in ACS Medicinal Chemistry Letters in 2019.COA of Formula: C6H3FN2 This article mentions the following:

Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chem. starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound I is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6COA of Formula: C6H3FN2).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

QSAR studies related to toxicity of aromatic compounds on Tetrahymena pyriformis was written by Laszlo, Tarko;Beteringhe, Adrian. And the article was included in QSAR & Combinatorial Science in 2006.Reference of 15128-90-2 This article mentions the following:

Results of some QSAR studies in which the training set contained aromatic compounds with toxic effect on Tetrahymena pyriformis are presented. The QSAR studies reveal the existence of two classes of compounds – with and without hydrogen bonds – for which the calculation of some QSAR separated equations are recommended. QSAR equations obtained for the two classes of aromatic compounds have good predictive powers: N = 87, p = 6, r² = 0.7962, s = 0.3178, and N = 113, p = 5, r² = 0.8950, s = 0.2637, resp. For the compounds with hydrogen bonds, “moment of inertia B” and “QSPR of percentage of mass fragments” are mol. characteristics with a powerful influence on toxicity values, and log K_ow has a moderate influence. For compounds without hydrogen bonds “bonds number weighted total energy” and “LUMO-HOMO gap weighted mol. volume” are the mol. characteristics with a powerful effect on toxicity values, and topol. descriptor AAA has a moderate effect. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Reference of 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem