Tag: 100-200

Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam was written by Fan, Zhoulong;Lu, Heng;Cheng, Zhen;Zhang, Ao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Name: 2-(m-Tolyl)pyridine This article mentions the following:

A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of physicochemical parameters of pyridine and its derivatives on the kinetics of microbiological transformation was written by Pavlyuk, M. I.;Turovskii, A. A.;Kucher, R. V.. And the article was included in Doklady Akademii Nauk Ukrainskoi SSR, Seriya B: Geologicheskie, Khimicheskie i Biologicheskie Nauki in 1988.SDS of cas: 644-98-4 This article mentions the following:

Physicochem. properties of pyridine and its derivatives affect the kinetics of biodegradation of these compounds by Arthrobacter pascens. The biodegradation rate constants are dependent on the donor properties of substituted pyridines, steric effect, and hydrophobicity parameter. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO₄ nanoparticles was written by Abinaya, R.;Mani Rahulan, K.;Srinath, S.;Rahman, Abdul;Divya, P.;Balasubramaniam, K. K.;Sridhar, R.;Baskar, B.. And the article was included in Green Chemistry in 2021.Safety of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Visible light-mediated selective and efficient oxidation of various primary benzyl alcs. RCH₂OH (R = Ph, 2-bromophenyl, pyridin-2-yl, etc.)/secondary benzyl alcs. such as 1-(phenyl)-ethanol, diphenylmethanol, 1-phenylethane-1,2-diol, etc. to aldehydes RCHO/ketones such as acetophenone, benzophenone, chalcone, etc. and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atm. while the ODH of partially saturated heterocycles under an oxygen atm. resulted in very good to excellent yields. The methodol. is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcs. and heteroaryl carbinols I (R¹ = H, C(O)OMe) followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines II in high isolated yields. This methodol. was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles e.g., III using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Safety of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd(II)-catalyzed oxidative alkoxycarbonylation of 2-phenoxypyridine derivatives with CO and alcohols was written by Liu, Bin;Jiang, Huai-Zhi;Shi, Bing-Feng. And the article was included in Organic & Biomolecular Chemistry in 2014.Recommanded Product: 2-Phenoxypyridine This article mentions the following:

A Pd(II)-catalyzed oxidative alkoxycarbonylation of phenol derivatives with atm. pressure of CO-O₂ and alcs. was achieved. The reaction provided an efficient strategy for the synthesis of carboxylic esters and can be applied to the late-stage modification of complex mols. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope was written by Robin, Aelig;Kohler, Valentin;Jones, Alison;Ali, Afruja;Kelly, Paul P.;O’Reilly, Elaine;Turner, Nicholas J.;Flitsch, Sabine L.. And the article was included in Beilstein Journal of Organic Chemistry in 2011.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

A high-throughput screening protocol for evaluating chimeric, self-sufficient P 450 biocatalysts and their mutants against a panel of substrates was developed, leading to the identification of a number of novel biooxidation activities. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium catalyzed ortho-C-H-acylation of 2-arylpyridines using phenylacetylenes and styrene epoxide was written by Zhang, Qian;Wang, Yang;Yang, Tingting;Li, Li;Li, Dong. And the article was included in Tetrahedron Letters in 2016.Category: pyridine-derivatives This article mentions the following:

A palladium-catalyzed ortho-C-H-acylation of 2-arylpyridine using phenylacetylenes and styrene epoxide as the acylated reagents was developed. With the employment of tert-Bu hydroperoxide (TBHP) as the oxidant and a phosphorous ligand, the protocol generates corresponding aryl ketones in moderated to good yields with high regioselectivity and good functional group compatibility. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions was written by Liu, Xiang;Song, Dan;Zhang, Zemin;Lin, Jiatong;Zhuang, Canzhan;Zhan, Haiying;Cao, Hua. And the article was included in Organic & Biomolecular Chemistry.Safety of 4-Methoxy-2-methylpyridine This article mentions the following:

An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives, e.g., I (R¹ = H, 8-Br, 6-Et, 7-MeO, etc., R² = Ph, 3,4-Cl₂C₆H₃, 2-furyl, etc.), were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines II (R¹ = H, 7-Me, R² = Ph, 3-FC₆H₄, 3-MeOC₆H₄) were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Safety of 4-Methoxy-2-methylpyridine).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 4-Methoxy-2-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visible-Light Activation of Electron Donor-Acceptor Complexes was written by Wang, Hui;Wu, Jingjing;Noble, Adam;Aggarwal, Varinder K.. And the article was included in Angewandte Chemie, International Edition in 2022.Computed Properties of C6H3FN2 This article mentions the following:

1,2-Bis-boronic esters are useful synthetic intermediates particularly as the two boronic esters can be selectively functionalized. Usually, the less hindered primary boronic ester reacts, but herein, we report a coupling reaction that enables the reversal of this selectivity. This is achieved through the formation of a boronate complex with an electron-rich aryllithium which, in the presence of an electron-deficient aryl nitrile, leads to the formation of an electron donor-acceptor complex. Following visible-light photoinduced electron transfer, a primary radical is generated which isomerizes to the more stable secondary radical before radical-radical coupling with the arene radical-anion, giving β-aryl primary boronic ester products. The reactions proceed under catalyst-free conditions. This method also allows stereodivergent coupling of cyclic cis-1,2-bis-boronic esters to provide trans-substituted products, complementing the selectivity observed in the Suzuki-Miyaura reaction. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Computed Properties of C6H3FN2).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Insight into the Interactions That Control the Phase Behaviour of New Aqueous Biphasic Systems Composed of Polyethylene Glycol Polymers and Ionic Liquids was written by Freire, Mara G.;Pereira, Jorge F. B.;Francisco, Maria;Rodriguez, Hector;Rebelo, Luis Paulo N.;Rogers, Robin D.;Coutinho, Joao A. P.. And the article was included in Chemistry – A European Journal in 2012.Safety of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

New polyethylene glycol (PEG)/ionic liquid aqueous biphasic systems (ABS) are presented. Distinct pairs of PEG polymers and ionic liquids can induce phase separation in aqueous media when dissolved at appropriate concentrations Phase diagrams have been determined for a large array of systems at 298, 308 and 323 K. A comparison of the binodal curves allowed the anal. of the tunable structural features of the ionic liquid (i.e., anionic nature, cationic core, cationic alkyl side chain length and functionalization, and number of alkyl substituents in the cation) and the influence of the mol. weight of the PEG polymer on the ability of these solutes to induce an ABS. It was observed that contrary to typical ABS based on ionic liquids and inorganic salts, in which the phase behavior is dominated by the formation of the hydration complexes of the ions, the interactions between the PEG polymers and ionic liquids control the phase demixing in the polymer-type ABS studied herein. It is shown that both the ionic liquids and PEG polymers can act as the salting-out species; i.e., it is an occurrence that is dependent on the structural features of the ionic liquid For the first time, PEG/ionic liquid ABS are reported and insight into the major interactions that govern the polymer/ionic liquid phase behavior in aqueous media are provided. The use of two different nonvolatile and tunable species (i.e., ionic liquids and PEG polymers) to form ABS allows the polarities of the phases to be tailored. Hence, the development of environmentally friendly separation processes that make use of these novel systems is envisaged. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Safety of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Safety of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetic study on the conversion of pyridine- and quinolinecarboxylic acids to the corresponding trichloromethyl compounds was written by Takahashi, Kazuyuki;Takeda, Koichi;Mitsuhashi, Keiryo. And the article was included in Journal of Heterocyclic Chemistry in 1978.Application of 3718-65-8 This article mentions the following:

The apparent 2nd order rate constant of the conversion of substituted picolinic and quinaldinic acids to the corresponding trichloromethylpyridines and quinolines by treatment with PCl₅ in refluxing SOCl₂ was measured. The logarithms of the rate constants (log k) are linear with the basicities (pKa) of the unsaturated ring nitrogens in the substrates. The reaction constant ρ was estimated In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem