Tag: 100-200

Effect of substituents on the nickel-induced contact shifts in aromatic amines. Comparison with spin delocalization in phenyl, benzyl, and related radicals was written by Underwood, Graham R.;Clyde, William C.;Zitter, Mark S.. And the article was included in Journal of Physical Chemistry in 1981.Reference of 644-98-4 This article mentions the following:

Ni[CH(COMe)₂]₂ (I)-induced proton and ¹³C NMR contact shifts were studied in a series of anilines, pyridines and heterocycles. Substituents have little effect on the shifts unless bonded directly to N or separated from it by just 1 atom. INDO calculations on 2-substituted Ph radicals suggest that the singly occupied orbital is bent slightly away from the substituent; the ESR hyperfine splitting constants as well as the Ni-induced shifts reflect this distortion. The specificity of I for the N lone pair, the relative constancy of its induced shifts, and their ready interpretation make this a useful NMR shift reagent for amines. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Reference of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cost Efficient Synthesis of Diaryl Ethers Catalyzed by CuI, Imidazolium Chloride and Cs₂CO₃ was written by Paul, Sudeep;Joy, Bony P.;Rajendran, Rajarajan;Gudimetla, Vittal B.. And the article was included in ChemistrySelect in 2019.HPLC of Formula: 4783-68-0 This article mentions the following:

Synthetically versatile imidazolium chlorides, especially 1,3-bis-(2,6-diisopropylphenyl)-imidazolium chloride (IPrHCl) along with copper (I) iodide and cesium carbonate, were found to be useful to form C-O bonds via O-arylation of phenols with aryl halides to afford diaryl ethers ArOAr¹ [Ar = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; Ar¹ = Ph, 4-MeOC₆H₄, 2-pyridyl, etc.]. In this catalysis, the metal:ligand (Cu:IPr) loading was optimized to 1.0 mol%, making it an inexpensive and a simple one pot catalytic route for synthesizing a variety of diaryl ethers. The catalytic cycle was probed by UV-Vis, FT-IR and HRMS techniques confirming involvement of a copper-imidazolium-carbonate complex. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New Strategic Reactions for Organic Synthesis: Catalytic Asymmetric C-H Activation α to Nitrogen as a Surrogate for the Mannich Reaction was written by Davies, Huw M. L.;Venkataramani, Chandrasekar;Hansen, Tore;Hopper, Darrin W.. And the article was included in Journal of the American Chemical Society in 2003.Electric Literature of C10H17NO2 This article mentions the following:

The asym. C-H activation reactions of Me aryldiazoacetates are readily induced by the rhodium prolinate catalyst Rh₂(S-DOSP)₄ [DOSP = (4-dodecylphenylsulfonyl)prolinato] or the bridged prolinate catalysts, and the donor/acceptor-substituted carbenoids generated displayed remarkable chemoselectivity, which allows for highly regioselective, diastereoselective, and enantioselective reactions to be achieved. For example, the C-H activation/rhodium carbenoid induced insertion reactions of N-Boc-protected cyclic amines I (n = 1, 3, 4) with Me phenyldiazoacetate gave the corresponding esters II with excellent diastereoselectivity and enantioselectivity. Furthermore, the reactions can display high levels of double stereodifferentiation and kinetic resolution, as shown in the studies of the double C-H activation/carbenoid insertion reactions. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Electric Literature of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and dissolving power of 1-Alkyl-3-methylpyridinium-based ionic liquids was written by Sashina, E. S.;Kashirskii, D. A.;Zaborski, M.;Jankowski, S.. And the article was included in Russian Journal of General Chemistry in 2012.Name: 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

1-Alkyl-3-methylpyridinium-based ionic liquids with substituents from C₂ to C₁₀ and anions Cl^– and Br^– were synthesized, and their dissolving power toward the cellulose was investigated. The results of quantum-chem. calculations of mols. of ionic liquids are presented. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Name: 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermal stability of some organic compounds was written by Johns, I. B.;McElhill, E. A.;Smith, J. O.. And the article was included in Journal of Chemical and Engineering Data in 1962.Safety of 2-Phenoxypyridine This article mentions the following:

Decomposition temps, as defined previously (Ind. Eng. Chem., Prod. Res. Develop. 1, 2-6(1962)) are given for approx. 90 compds, in the classes: aromatic, substituted aromatic, heterocyclic, s-triazine, Si, B, P, and F compounds Decomposition products of 42 of the compounds are identified. Vapor pressure data for 16 of the compounds are given as constants in the equation log P_mm = b – a/T. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Safety of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of alkylpyridine structure on the reaction of diphenylphosphinic acid hydrazide with phenyl isothiocyanate was written by Yanchuk, N. I.;Bodrov, V. P.;Tsareva, N. V.. And the article was included in Zhurnal Obshchei Khimii in 1986.SDS of cas: 644-98-4 This article mentions the following:

The catalytic effect of 2-, 3- or 4-methyl-, 2-ethyl-, 2-isopropyl-, 2,4- or 2,6-dimethyl-, and 2,4,6-trimethylpyridine on the rate of Ph₂P(O)NHNH₂ addition with PhNCS to give Ph₂P(O)NHNHCSNHPh was studied. The reaction proceeds via 2 parallel mechanisms, catalytic and noncatalytic. The pyridines with the N atom shielded by alkyl radicals have very low catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of meta-substituted [¹⁸F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N-oxides was written by Brugarolas, P.;Freifelder, R.;Cheng, S.-H.;DeJesus, O.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 116922-60-2 This article mentions the following:

A methodol. for the preparation of 3-fluoro-4-aminopyridine was developed via two-step procedure involving fluorination of 3-bromo-4-nitropyridine N-oxide to yield 3-fluoro-4-nitropyridine N-oxide as an intermediate in first step and its reduction via catalytic hydrogenation in second step. Furthermore, this approach was successfully applied for the preparation of [¹⁸F]3-fluoro-4-aminopyridine. The use of pyridine N-oxides for the preparation of fluoropyridines was unprecedented in chem. literature and had potential to offer a new way for the synthesis of these important structures in pharmaceuticals and radiopharmaceuticals. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluoropyridine (cas: 116922-60-2Related Products of 116922-60-2).

3-Bromo-4-fluoropyridine (cas: 116922-60-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 116922-60-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recyclable Pd(II)complex catalyzed oxidative sp² C-H bond acylation of 2-aryl pyridines with toluene derivatives was written by Perumgani, Pullaiah C.;Parvathaneni, Sai Prathima;Keesara, Srinivas;Mandapati, Mohan Rao. And the article was included in Journal of Organometallic Chemistry in 2016.COA of Formula: C12H11N This article mentions the following:

A recyclable polymer-anchored Pd(II) complex C was synthesized and characterized using different spectroscopic techniques. In addition the catalytic efficiency of the Pd (II) complex C was evaluated for ortho-acylation of 2-aryl pyridines with toluene derivatives to form aryl ketones via cross dehydrogenative coupling. In this catalytic process toluene acts as an effective coupling partner upon sp³ C-H bond oxidation for sp² C-H bond acylation of 2-aryl pyridines in the presence of Pd(II)/TBHP system on water. Furthermore, the catalyst C was highly stable and could be easily recovered and reused for four cycles with no significant decrease in its activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability was written by Chino, Ayaka;Masuda, Naoyuki;Amano, Yasushi;Honbou, Kazuya;Mihara, Takuma;Yamazaki, Mayako;Tomishima, Masaki. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine This article mentions the following:

In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening hit compound from an inhouse library. Next, optimization of the imidazopyridine moiety to improve inhibitory activity gave imidazopyridinone 10b. Following further structure-activity relationship development by reducing lipophilicity and introducing substituents, we acquired 35, which exhibited both improved metabolic stability and reduced CYP3A4 time-dependent inhibition. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine).

2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Molecular spectra and molecular structure of heterocyclic compounds. Infrared and near ultraviolet absorption spectra of pyridine N-oxide derivatives was written by Ghersetti, Sergio;Maccagnani, Gaetano;Mangini, Angelo;Montanari, F.. And the article was included in Journal of Heterocyclic Chemistry in 1969.Formula: C7H9NO This article mentions the following:

The IR and UV spectra of many pyridine N-oxide derivatives (I) have been studied. The UV spectra show a strong solvent effect in going from aprotic to hydroxylic solvents due to strong H bonding. Values of ΔH° for several systems MeOH-I in tetrachloroethylene solution were evaluated by IR techniques and a linear correlation ΔH° vs.Δ MeOH was found. Features of the IR and UV characteristic absorption bands were also investigated. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem