Tag: 100-200

Bis(2,2,2-trifluoroethyl)(2-cyanoethyl) phosphate – a new uranium extragent was written by Nalibayeva, A. M.;Bishimbayeva, G. K.;Saidullayeva, S. A.;Verhoturova, S. I.;Arbuzova, S. N.;Gusarova, N. K.. And the article was included in Izvestiya Natsional’noi Akademii Nauk Respubliki Kazakhstan, Seriya Khimii i Tekhnologii in 2020.Application of 628-13-7 This article mentions the following:

Organophosphate compounds are widely used in industrial hydrometallurgical processes as extractants and complexones of non-ferrous, noble, rare-earth metals and transuranic elements. Among these compounds, organic phosphates occupy a special place, as they allow for the extraction processes with good selectivity and efficiency. Therefore, the search and development of new uranium effective extractants is an important task for the development of modern hydrometallurgical processes. For this functional phosphate containing a cyano group, one should expect a synergistic effect of the extraction properties of the phosphates themselves, as well as of the known extractants – contribute to an increase in its incombustibility. Thus, the use of this extractant in the production of the extraction of uranium from uranium-containing nitric acid or sulfuric acid solutions was 20.7% and 18.7%; the content of uranium in the extractant was 63.9 g/dm3 and 49. 7 g/dm3, resp. Pos. results were also obtained when studying the synergistic properties of the new extractant and the traditional – bis(2-ethylhexyl) phosphate. Using a mixture of these extractants (their weight ratio was 1:1.2) allows you to extract 57% of uranium from the uranium sulfate solution The use of bis(2,2,2-trifluoroethyl)(2-cyanoethyl) phosphate as a new extractant makes it possible to extract up to 20.7% of uranium from technol. nitrate or sulfate of uranium-containing solutions In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(III)-catalyzed chelation-assisted C-H imidation of arenes via umpolung of the imidating reagent was written by Zheng, Guangfan;Sun, Jiaqiong;Xu, Youwei;Zhou, Xukai;Gao, Hui;Li, Xingwei. And the article was included in Chinese Journal of Catalysis in 2020.SDS of cas: 4373-61-9 This article mentions the following:

Rh(III)-catalyzed, chelation-assisted oxidative C-H imidation of arenes with N-H imide was realized using PhI(OAc)₂ as an oxidant. This transformation exhibits a broad substrate scope and tolerates various functional groups. The reaction proceeded via in-situ generation of an iodine(III) imido. DFT calculations suggest that this oxidative imidation system proceeds via a Rh(III)-Rh(V)-Rh(III) pathway. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Etherification of Functionalized Phenols with Chloroheteroarenes at Low Palladium Loading: Theoretical Assessment of the Role of Triphosphane Ligands in C-O Reductive Elimination was written by Platon, Melanie;Cui, Luchao;Mom, Sophal;Richard, Philippe;Saeys, Mark;Hierso, Jean-Cyrille. And the article was included in Advanced Synthesis & Catalysis in 2011.Electric Literature of C11H9NO This article mentions the following:

The present study highlights the potential of robust tridentate ferrocenylphosphanes with controlled conformation as catalytic auxiliaries in C-O bond formation reactions. Air-stable Pd triphosphane systems are efficient for selective heteroaryl ether synthesis by using ≥0.2 mol% of catalyst. These findings represent an economically attractive and clean etherification of functionalized phenols, electron-rich, electron-poor and para-, meta- or ortho-substituted substrates, with heteroaryl chlorides, including pyridines, hydroxylated pyridine, pyrimidines and thiazole. The etherification tolerates very important functions in various positions, such as cyano, methoxy, amino, and fluoro groups, which is useful to synthesize bioactive mols. DFT studies also demonstrate that triphosphane ligands open up various new pathways for the C-O reductive elimination involving the 3rd phosphane group. In particular, the rate for one of these new pathways is ∼1000 times faster than for reductive elimination from a complex with a similar ferrocenyl ligand, but without a phosphane group on the bottom Cp-ring. Coordination of the 3rd phosphane group to the Pd(II) center is calculated to stabilize the transition state in this new pathway, thereby enhancing the reductive elimination rate. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Electric Literature of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of Phenanthridines via a Rhodium-Catalyzed C-C Bond Cleavage Reaction of Biphenylene with Nitriles was written by Korotvicka, Ales;Frejka, David;Hampejsova, Zuzana;Cisarova, Ivana;Kotora, Martin. And the article was included in Synthesis in 2016.Recommanded Product: 6-Fluoropicolinonitrile This article mentions the following:

The reaction of biphenylene with various nitriles in the presence of catalytic amount of bis[(1,2,5,6-η)-1,5-cyclooctadiene]rhodium(1+) tetrafluoroborate(1-) [i.e., [Rh(cod)₂BF₄]] and dppe under microwave irradiation afforded 9-substituted phenanthridines. The reaction with alkyl and aromatic nitriles provided the corresponding 9-substituted phenanthridines in 26-79% isolated yields. The reaction was also carried out with cyanopyridines and it provided heterocyclic compounds with the bipyridine and terpyridine scaffold. The synthesized bipyridine and terpyridine were complexed with [Rh(cod)Cl]₂. The former provided a Rh(III) complex in which the cyclooctadiene moiety was oxidized to the THF ring, whereas the latter gave a structurally fluxional complex (in solution) with only one pyridine ring coordinated to the rhodium atom. The title compounds thus formed included 6-(3-chlorophenyl)phenanthridine, 3-(6-phenanthridinyl)benzonitrile, 6-(2-thienyl)phenanthridine (thiophene), 6-(2-furanyl)phenanthridine (furan), 6-(2-pyridinyl)phenanthridine. The synthesis of the target compound was achieved by a reaction of 6-(2-pyridinyl)phenanthridine (i.e., a bipyridine analog) with di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]dirhodium [i.e., [Rh(COD)Cl]₂ cyclooctadiene-group oxidation]. The title compound thus formed was a 9-Oxabicyclo[4.2.1]nonane-(pyridinyl)phenanthridine-rhodium complex. In the experiment, the researchers used many compounds, for example, 6-Fluoropicolinonitrile (cas: 3939-15-9Recommanded Product: 6-Fluoropicolinonitrile).

6-Fluoropicolinonitrile (cas: 3939-15-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 6-Fluoropicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Directed Aromatic C-H Activation/Acetoxylation Catalyzed by Pd Nanoparticles Supported on Graphene Oxide was written by Zhang, Yi;Zhao, Yu;Luo, Yu;Xiao, Liuqing;Huang, Yuxing;Li, Xingrong;Peng, Qitao;Liu, Yizhen;Yang, Bo;Zhu, Caizhen;Zhou, Xuechang;Zhang, Junmin. And the article was included in Organic Letters in 2017.Formula: C12H11N This article mentions the following:

The first solid-supported directed aromatic C-H activation/acetoxylation has been successfully developed by using palladium nanoparticles supported on graphene oxide (PdNPs/GO) as a catalyst. The practicability of this method is demonstrated by simple preparation of catalyst, high catalytic efficiency, wide functional group tolerance, and easy scale up of the reaction. A hot filtration test and Hg(0) poisoning test indicate the heterogeneous nature of the catalytic active species. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid was written by Yuan, Yizhi;Liang, Yujie;Shi, Shihui;Liang, Yu-Feng;Jiao, Ning. And the article was included in Chinese Journal of Chemistry in 2020.Safety of 2-(m-Tolyl)pyridine This article mentions the following:

An efficient synthesis of monobromo (hetero)arenes RR¹ (R = 4-methyl-2-bromophenyl, 4-phenyl-2-bromophenyl, 4-benzyloxy-2-bromophenyl, etc.; R¹ = pyridin-2-yl, 4-methylpyridin-2-yl, isoquinolin-3-yl, etc.), dibromo (hetero)arenes R²R¹ (R² = 2,6-dibromo-4-methylphenyl, 2,6-dibromo-4-methoxyphenyl, 4-benzyloxy-2,6-dibromophenyl, 4-methyloxycarbonyl-2,6-dibromophenyl, 2,6-dibromophenyl) and 10-bromobenzo[h]quinolone through Pd-catalyzed directed C-H bromination protocol, in which DMSO is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source was developed. The DMSO/HBr(aq) system, which is novel and efficiently utilized in transition-metal catalyzed C-H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials R³R¹ (R³ = 4-methylphenyl, 4-phenylphenyl, 4-benzyloxyphenyl, etc.), and high bromide-atom economy. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic hydration of pyridinecarbonitriles in the presence of bis(ethylenediamine)copper(II) chloride dihydrate and copper(II) chloride dihydrate was written by Watanabe, Kenichi;Murayama, Kiyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1974.SDS of cas: 1620-76-4 This article mentions the following:

Spectrophotometric studies on the catalytic hydration of 2-pyridine-carbonitrile derivatives in the presence of the title catalysts under nearly neutral conditions revealed that the products are the amides. The hydration of the nitrile group was influenced by electronic and steric effects. Selective hydration of the nitrile group in the α-position was observed with dinitriles. The selectivity was applied to hydrolysis of nitriles to carboxylic acids. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4SDS of cas: 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Auxiliary hydroxy-phenanthro [9, 10-d] imidazole supported NLOphoric triphenylamine based donor-pi-acceptor compounds: Synthesis, solvatochromism and computational aspects was written by Yadav, Sagar B.;Erande, Yogesh;Ghanvatkar, Chaitanya W.;Sekar, Nagaiyan. And the article was included in Journal of Luminescence in 2020.Related Products of 628-13-7 This article mentions the following:

To study the effect of addnl. hydroxy-imidazole unit on the solvatochromic linear, and non-linear optical properties, three donor-pi-acceptor NLOphoric triphenylamine-imidazole based compounds were synthesized, and characterized. The photophys. characteristics of the synthesized compounds were examined in series of solvents. The solvatochromism in the chromophores supported by the linear (i.e. Mac-Rae, and Lippert-Mataga equations) as well as by the multi-linear (i.e. Kamlet-Taft and Catalan parameters) anal. ‘Solvent polarizability’ and ‘solvent dipolarity’ are the major components influence the shift in absorption and emission spectra resp. These compounds exhibit aggregation induced emission. The charge transfer characteristics in the chromophores are examined with the Generalized Mulliken-Hush, mol. electrostatic potential, and Frontier MO plot anal. The NLO properties of the synthesized compounds were studied using solvatochromic as well as computational methods. With the increase in the addnl. acceptor imidazole substituent on triphenylamine unit the polarizability, hyperpolarizability, and their associated mol. hyperpolarizability parameters gets enhanced. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oil-water distribution of p-alkylpyridines was written by Yeh, Kuang C.;Higuchi, William I.. And the article was included in Journal of Pharmaceutical Sciences in 1976.HPLC of Formula: 27876-24-0 This article mentions the following:

The distribution of a homologous series of p-alkylpyridines between water and six organic solvents with varying degrees of polarity was investigated. The distribution coefficients were considered as reflections of the strength of net interactions involved in the solvents. The order was chloroform > octanol > carbon tetrachloride > butyl ether > hexadecane > octane. The effect of the methylene group on the distribution coefficients differed little among the six solvents. The relative constancy was attributed to the predominance of the dispersion forces in the incremental effect. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0HPLC of Formula: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na_V1.7 with Efficacy in Rat Pain Models was written by Macsari, Istvan;Besidski, Yevgeni;Csjernyik, Gabor;Nilsson, Linda I.;Sandberg, Lars;Yngve, Ulrika;Aahlin, Kristofer;Bueters, Tjerk;Eriksson, Anders B.;Lund, Per-Eric;Venyike, Elisabet;Oerther, Sandra;Hygge Blakeman, Karin;Luo, Lei;Arvidsson, Per I.. And the article was included in Journal of Medicinal Chemistry in 2012.Reference of 199296-39-4 This article mentions the following:

The voltage-gated sodium channel Na_V1.7 is believed to be a critical mediator of pain sensation based on clin. genetic studies and pharmacol. results. Clin. utility of nonselective sodium channel blockers is limited due to serious adverse drug effects. Here, we present the optimization, structure-activity relationships, and in vitro and in vivo characterization of a novel series of Na_V1.7 inhibitors based on the oxoisoindoline core. Extensive studies with focus on optimization of Na_V1.7 potency, selectivity over Na_V1.5, and metabolic stability properties produced several interesting oxoisoindoline carboxamides (16A, 26B, 28, 51, 60, and 62) that were further characterized. The oxoisoindoline carboxamides interacted with the local anesthetics binding site. In spite of this, several compounds showed functional selectivity vs. Na_V1.5 of more than 100-fold. This appeared to be a combination of subtype and state-dependent selectivity. Compound 28 showed concentration-dependent inhibition of nerve injury-induced ectopic in an ex vivo DRG preparation from SNL rats. Compounds 16A and 26B demonstrated concentration-dependent efficacy in preclin. behavioral pain models. The oxoisoindoline carboxamides series described here may be valuable for further investigations for pain therapeutics. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Reference of 199296-39-4).

2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 199296-39-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem