Tag: 100-200

A research of basic structure of hypoglycemic agent from (-)-multiflorine as a lead compound was written by Kubo, Hajime. And the article was included in Hoshi Yakka Daigaku Kiyo in 2006.Electric Literature of C7H9NO This article mentions the following:

(-)-Multiflorine, a member of Lupin alkaloids, has been known to have a hypoglycemic activity against streptozotocine-induced diabetic mice. Therefore, this research aimed at a searching of basic structure of hypoglycemic agent, (-)-multiflorine as a lead compound It appears that double bond(s) in the A-B ring system of multiflorine influence hypoglycemic potency. Among the tricyclic compounds, N-H and N-Me compounds had significant hypoglycemic effect the same as multiflorine had. It was suspected that the D-ring in (-)-multiflorine was not necessary for appearance of hypoglycemic effect and small substituted groups was influence on strength of hypoglycemic effect. The position of the oxo-group in A-B ring system of cause hypoglycemic effect but showed no acute the toxicity. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Electric Literature of C7H9NO).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses of sterically hindered zwitterionic pyridinium phenolates as model compounds in nonlinear optics. Part 2. was written by Diemer, Vincent;Chaumeil, Helene;Defoin, Albert;Fort, Alain;Boeglin, Alex;Carre, Christiane. And the article was included in European Journal of Organic Chemistry in 2008.Related Products of 3718-65-8 This article mentions the following:

Pyridinium phenolates possess a dissym. delocalized π-electron system providing a huge quadratic nonlinearity. They are a promising class of mols. for applications in photoelectronics and photonics. Semiempirical calculations indicate that the interplanar angle between the two aromatic rings leads to enhancement in the NLO properties of these compounds The confirmation of this feature may be provided by the study of a new series of sterically hindered pyridinium phenolates bearing two tert-Bu substituents at the ortho position(s) of the phenolate functionality. Such bulky groups would enhance the solubility of zwitterions in organic solvents and would limit the formation of aggregates. Their efficient preparations by using Suzuki cross-coupling reactions involving 3,5-dialkylated 4-bromopyridine N-oxides are described. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Related Products of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-catalyzed decarboxylative coupling of potassium oxalate monoester with 2-aryloxypyridines was written by Li, Zhongyuan;Jing, Kun;Li, Qili;Wang, Guanwu. And the article was included in Huaxue Xuebao in 2019.SDS of cas: 4783-68-0 This article mentions the following:

We disclose the efficient palladium-catalyzed decarboxylative esterification of 2-aryloxpyridines. This reaction proceeds smoothly with potassium oxalate monoester, affording the desired products in moderate to good yields (50%∼82%). Compared to our previous work, the electron-donating pyridinyloxy (PyO) group as the directing group and six-membered metallocycle intermediate dramatically enhance the practicability and substrate tolerance of the present method. In addition, one of the products has been chosen as the model compound to deprotect the directing group to get the valuable salicylate derivative The present method not only provides an efficient and convenient protocol for the synthesis of Et salicylate derivatives, but also enriches the diversity of Pd (II)/Pd (IV) catalytic reactions. A general procedure for the esterification of 2-aryloxypyridines with potassium oxalate monoester is as following: a mixture of 1 (0.5 mmol), Pd(OAc)₂ (10 mol%), K₂S₂O₈ (1.0 mmol), Ag₂CO₃ (1.0 mmol), 2 (1.0 mmol), D-CSA (0.125 mmol), and 1, 4-dioxane (2.5 mL) in a 25 mL tube was heated at 80°C for a suitable time. The reaction mixture was cooled to room temperature, and concentrated in vacuo. Purification of the residue by column chromatog. on silica gel with petroleum ether and Et acetate as the eluent provided the desired product. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

N-Methoxyamide: An Alternative Amidation Reagent in the Rhodium(III)-Catalyzed C-H Activation was written by Zhou, Chao;Zhao, Junqi;Guo, Weicong;Jiang, Jijun;Wang, Jun. And the article was included in Organic Letters in 2019.Reference of 4373-61-9 This article mentions the following:

In the field of transition-metal-catalyzed C-H activation, N-methoxyamides are widely used as C-H activation substrate. Unexpectedly, in this work N-methoxyamides were found to work as efficient amidation reagents in the rhodium(III)-catalyzed C-H activation with boric acid as a cocatalyst. This reaction features broad substrate scope and good yields. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Reference of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halogenation of N-oxides of pyridine acetylamino derivatives was written by Talik, Tadeusz;Talik, Zofia. And the article was included in Prace Naukowe Akademii Ekonomicznej imienia Oskara Langego we Wroclawiu in 1983.HPLC of Formula: 31430-47-4 This article mentions the following:

2-Acetamidopyridine N-oxide with HCl or HBr and H₂O₂ gave the 5-chloro amine oxide, the 3,5-Cl₂ analog, and the 3,5-Br₂ analog; the 3-acetamido analog gave 2,4,6-trihalo amine oxides, and the 4-acetamido analog, as well as 2-acetamido-4- and -6-picoline N-oxides, gave 3,5-dihalo amine oxides (e.g., I and II), while 2-acetamido-3-picoline N-oxide gave 5-halo amine oxides; 2-acetamido-5-picoline underwent only the hydrolysis. In the experiment, the researchers used many compounds, for example, 3,5-Dichloro-4-methylpyridin-2-amine (cas: 31430-47-4HPLC of Formula: 31430-47-4).

3,5-Dichloro-4-methylpyridin-2-amine (cas: 31430-47-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 31430-47-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of substituted phenyl 2-pyridyl ethers was written by Acharya, S. P.;Nargund, K.S.. And the article was included in Journal of Scientific and Industrial Research, Section B: Physical Sciences in 1962.COA of Formula: C11H9NO This article mentions the following:

Method A to 0.011 mole KOH in EtOH was added 0.011 mole 2,4-Cl(O₂N)C₆H₃OH, the whole refluxed 0.33 hr., 0.011 mole 2,5-Cl(O₂N)C₅H₃N (I) added, refluxed 2-3 hrs., the whole steam distilled, and the non-volatile residue washed with 5% NaOH gave 64% 2,4-Cl(O₂N)C₆H₃OC₅H₃NNO₂-5′ (II), m. 128-9°. Method B 2,6,4-Cl₂(O₂N)C₆H₂OH and I, 0.011 mole each, in 10-15 ml. MeCH(OH)CH₂OH and a trace of Cu bronze was heated 3 hrs. at 130-40°, the whole poured into H₂O, and the solid filtered off, washed with 5% NaOH, and steam distilled to give 56% 2,6,4-Cl₂(O₂N)C₆H₂OC₅H₃NNO₂-5′ (III), m. 153-4°. To 0.005 mole II, 5 g. NH₄Cl, 10 ml. H₂O, and 20 ml. EtOH at 70-80° was added 3 g. reduced Fe, portionwise; the whole stirred 0.75 hr. at 70-80°, filtered, and the filtrate concentrated gave 69% 4,5′-diamino derivative, m. 174-5°; di-N-acetyl derivative m. 147-8°. The following substituted phenyl 2-pyridyl ethers were prepared (substituents in pyridine ring, substituents in benzene ring, method of preparation, % yield, m.p., m.p. of 4,5′-diamino derivative, m.p. of di-N-acetyl derivative given): 5′-O₂N, 3,4-Cl(O₂N), A, 61, 119-20°, 145-6°, 195-6°; 5′-O₂N, 2,5,4-Cl₂(O₂N), A, 52, 151-2°, –, –; 5′-O₂N, 2,6,4-Cl₂(O₂N), Bgr, 56, 153-4°, 147-8°, 226-7°; 3,5′-Cl(O₂N), 2,4-Cl(O₂N), A, 50, 109-10°, 164-5°, 171-2°; 3′,5′-Cl(O₂N), 3,4-Cl(O₂N), A, 57, 104-5°, –, –; 3′,5′-Cl(O₂N), 2,5,4-Cl₂(O₂N), B, 56, 127-30°, –, –; and 3′,5′-Cl(O₂N), 2,6,4-Cl₂(O₂N), B, 141-2°, 54, 215-16°, 252-3°. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0COA of Formula: C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.COA of Formula: C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A low onset voltage WORM type polymer memory based on functional PES was written by Fang, Jiyong;Zhang, Haibo;Wei, Wei;Li, Yunxi;Yue, Xigui;Jiang, Zhenhua. And the article was included in Journal of Applied Polymer Science in 2015.Application of 628-13-7 This article mentions the following:

A high-performance polymer polyethersulfone (CN-Azo-PES), with a flexible ethoxyl linkage between the azobenzene chromophore side chain and the PES backbone, was designed and successfully synthesized for an application in a WORM type memory device as an active polymer layer. CN-Azo-PES has excellent thermal properties with T_g of 151° and the degradation temperature >373°, which can contribute to a better performance of the device. The device based on CN-Azo-PES exhibits a write-once read-many (WORM) type memory performance with an onset voltage ≥-1.0 V and an ON/OFF current ratio >10² at a reading voltage of 0.4 V. Also, the data can be maintained for longer than 4 × 10⁵ s once written and can be read for >400 cycles under a reading voltage of 0.4 V. Thus CN-Azo-PES can serve as an energy saving memory material in the data storage field of next generation. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42644. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Three-Point Hydrogen Bonding Assembly between a Conjugated PPV and a Functionalized Fullerene was written by Li, Yuliang;Zhu, Daoben;Xiao, Shengqiang;Liu, Huibiao. And the article was included in PMSE Preprints in 2003.Product Details of 1075-62-3 This article mentions the following:

A uracil-containing polyphenylenevinylene interacted with DAP-C₆₀ containing 2,6-diacylamidopyridine through H bonding to give a supramol. system. Fluorescence quenching experiments indicated a strong interaction between the 2 components (KSV = 5.8 × 10⁴ M^-1). An FESEM image of the system showed that the assembly consisted of particles having mean diameter 75 nm. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Product Details of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(I)-catalyzed directed trideuteromethylation of (hetero)arene C-H bonds with CD₃CO₂D was written by Zhao, Haoqiang;Zeng, Qi;Yang, Ji;Xu, Bing;Lei, Haimin;Xu, Lijin;Walsh, Patrick J.. And the article was included in Organic & Biomolecular Chemistry in 2022.Reference of 4373-61-9 This article mentions the following:

A Rh(I)-catalyzed trideuteromethylation of heteroarenes with inexpensive and readily available deuterated acetic acid (CD₃CO₂D) with the aid of a N-containing directing groups is developed. The oxidant-free reaction is applicable to a wide range of heteroarene substrates, including 2-pyridones, indoles, aryl rings, pyrroles and carbazoles. It allows installation of CD₃ groups under straightforward reaction conditions. It is expected that the salient and practical features of this trideuteromethylation protocol will be of use to academic and industrial researchers. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Reference of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure of leucenol. III. Synthesis of 2,5-dihydroxypyridine (5-hydroxy-2-pyridone) was written by Adams, Roger;Govindachari, T. R.. And the article was included in Journal of the American Chemical Society in 1947.Computed Properties of C6H7NO2 This article mentions the following:

2-Chloro-5-nitropyridine and MeONa, refluxed 10 min., give 74.5% of the 2-MeO derivative (I), m. 109°. Catalytic reduction of I (Pt oxide) in absolute EtOH at 2-3 atm. pressure gives 95% 2-methoxy-5-aminopyridine (II), b₁₀ 125-6° (monopicrate, yellow, m. 160°; picrate, yellow, m. 128°; the latter seps. 1st from the EtOH solution of the components). II (from 10 g. I), through the diazo reaction, yields 100 mg. 2-methoxy-5-hydroxypyridine, m. 81°; 90 mg. and 1 mL. HBr (d. 1.5), refluxed in a N atm. 4 h., give 70 mg. 2,5-dihydroxypyridine (5-hydroxy-2-pyridone) (III), decompose 240-50°. III is not identical with the pyrolysis product of leucenol, as shown by mixed m.p., color reactions with FeCl₃, and IR absorption spectra. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Computed Properties of C6H7NO2).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C6H7NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem