Tag: 100-200

Iridium-catalyzed intermolecular directed dehydrogenative ortho C-H silylation was written by Wang, Hong;Wang, Guanghui;Li, Pengfei. And the article was included in Organic Chemistry Frontiers in 2017.Name: 2-Isopropylpyridine This article mentions the following:

An efficient method for iridium-catalyzed direct silylation of C(sp²)-H and C(sp³)-H bonds using HSiMe(OSiMe₃)₂ as the silylating reagent is described. The reaction is amenable to various directing groups under simple and mild conditions leading to the mono- and regioselective synthesis of versatile organosilane compounds In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Name: 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics was written by Shi, Wenqiang;Wang, Yu;Wu, Chunhui;Yang, Feipu;Zheng, Wei;Wu, Song;Liu, Yongjian;Wang, Zhen;He, Yang;Shen, Jingshan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Category: pyridine-derivatives This article mentions the following:

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D₂, 5-HT_1A, and 5-HT_2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D₂ receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT_2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Category: pyridine-derivatives).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Absorption measurements on diphenyl compounds in the microwave region was written by Hufnagel, F.;Klages, G.;Knobloch, P.. And the article was included in Zeitschrift fuer Naturforschung in 1962.Category: pyridine-derivatives This article mentions the following:

Recent measurements of the dielec. absorption at 0.7, 1.5, 10.1, and 60 cm. wavelengths are discussed in terms of the long wave relaxation time t_L and flattening of the absorption curve (v %) in relation to the Debye curve. The dipole moments, t_L, and v are tabulated for Ph₂CO, Ph₂O, Ph₂S, 4,4′-dibromodiphenyl sulfide, 2-pyridyl Ph ether, m-nitrophenyl Ph ether, 4-pyridyl Ph ether, Ph₂CH₂, dinaphthyl ether, biphenylyl Ph ether, hydroquinone diphenyl ether, resorcinol diphenyl ether, and phenoxathiin. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Category: pyridine-derivatives).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetics of reaction of pyridine 1-oxides with phosgene in methylene chloride was written by Chimishkyan, A. L.;Grabarnik, M. S.;Orlov, S. I.;Bodrov, D. E.. And the article was included in Zhurnal Organicheskoi Khimii in 1989.Quality Control of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Rate constants (k) were determined for the reactions of pyridine oxides I (R = 4-MeO, 4-Me, 3-Me, 2-Me, H, 3-Cl) and 2,3-, 3,5-, and 2,6-dimethylpyridine oxide with COCl₂ to give 1,1′-(carbonyldioxy)bis[pyridinium] dichlorides. Linear relations between log k and substituent constants of R and dipole moments of I were obtained. The inductive and resonance effects of electron-donating R substituents make significant and comparable contributions to stabilizing the transition state. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Quality Control of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C6H5N energy surface. III. Isomerization processes and intramolecular trapping in picolylcarbenes was written by Crow, Wilfrid D.;Khan, Amtul N.;Paddon-Row, Michael N.. And the article was included in Australian Journal of Chemistry in 1975.Formula: C7H6N2 This article mentions the following:

5-(Methyl-2-, 3-, and -4-pyridyl)tetrazoles are prepared from the corresponding picolinecarbonitriles and are used as gas-phase generators for the corresponding picolylcarbenes at 600°/0.05 mm. The normal isomerization processes in arylcarbenes are interrupted in some cases by intramolecular trapping by the Me groups to give cyclobuta[b] and -[c]pyridines. The major process competing with this is N-extrusion to give tolynitrenes, which then undergo ring contraction to form methylcyclopentadienecarbonitriles. The relative yields from these and other processes are used to deduce the preferred isomerization pathways in picolylcarbenes. In methyl-2-pyridylcarbenes there is almost exclusive insertion into the 2,3-bond, leading to the tolynitrenes. The 3- and 4-pyridylcarbenes show a tendency for the carbene center to oscillate over the 3-, 4- and 5-positions of the ring with slower leakage to the 2-position. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Formula: C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Filling environmental data gaps with QSPR for ionic liquids: Modeling n-octanol/water coefficient was written by Rybinska, Anna;Sosnowska, Anita;Grzonkowska, Monika;Barycki, Maciej;Puzyn, Tomasz. And the article was included in Journal of Hazardous Materials in 2016.Recommanded Product: 125652-55-3 This article mentions the following:

Ionic liquids (ILs) form a wide group of compounds characterized by specific properties that allow using ILs in different fields of science and industry. Regarding that the growing production and use of ionic liquids increase probability of their emission to the environment, it is important to estimate the ability of these compounds to spread in the environment. One of the most important parameters that allow evaluating environmental mobility of compound is n-octanol/water partition coefficient (K_OW). Exptl. measuring of the K_OW values for a large number of compounds could be time consuming and costly. Instead, computational predictions are nowadays being used more often. The paper presents new quant. structure-property relationship (QSPR) model that allows predicting the logarithmic values of K_OW for 335 ILs, for which the exptl. measured values had been unavailable. We also estimated bioaccumulation potential and point out which group of ILs could have neg. impact on environment. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Multifunctional Reactive MALDI Matrix Enabling High-Lateral Resolution Dual Polarity MS Imaging and Lipid C=C Position-Resolved MS² Imaging was written by Waeldchen, Fabian;Mohr, Franziska;Wagner, Andreas H.;Heiles, Sven. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.Product Details of 91-02-1 This article mentions the following:

Local lipid variations in tissues are readily revealed with mass spectrometry imaging (MSI) methods, and the resulting lipid distributions serve as bioanal. signatures to reveal cell- or tissue-specific lipids. Comprehensive MSI lipid mapping requires measurements in both ion polarities. Addnl., structural lipid characterization is necessary to link the lipid structure to lipid function. Whereas some structural elements of lipids are readily derived from high-resolution mass spectrometry (MS) and tandem-MS (MSⁿ), the localization of C=C double bonds (DBs) requires specialized fragmentation and/or functionalization methods. In this work, we identify a multifunctional matrix-assisted laser desorption/ionization (MALDI) matrix for spatially resolved lipidomics investigations that reacts with lipids in Paternó-Büchi (PB) reactions during laser irradiation facilitating DB-position assignment and allows dual-polarity high-resolution MALDI-MSI and MALDI MS²I studies. By screening 12 compounds for improved ionization efficiency in pos.-/neg.-ion mode and the functionalization yield compared to the previously introduced reactive MALDI matrix benzophenone, 2-benzoylpyridine (BzPy) is identified as the best candidate. The new matrix enables DB localization of authentic standards belonging to 12 lipid classes and helps to assign 133/58 lipid features in pos.-/neg.-ion mode from mouse cerebellum tissue. The anal. capabilities of BzPy as a multifunctional MALDI-MSI matrix are demonstrated by imaging endogenous and PB-functionalized lipids in mouse kidney sections with 7μm lateral resolution in both ion modes. Tracking diagnostic lipid DB-position fragment ions in mouse pancreatic tissue with down to 10μm pixel size allows us to identify the islets of Langerhans associated with lipid isomer upregulation and depletion. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A facile synthesis of 2-chloro-1,8-naphthyridine-3-carbaldehyde; their transformation into different functionalities and antimicrobial activity was written by Kumar, M. Ranadheer;Laxminarayana, E.;Ramesh, D.;Sreenivasulu, B.;Chary, M. Thirumala. And the article was included in International Journal of Chemical Sciences in 2010.COA of Formula: C7H9N3O This article mentions the following:

2-Chloro-1,8-naphthyridine-3-carbaldehydes (I) were synthesized through Vilsmeier-Haack cyclization treating N-(pyridin-2-yl)acetamides with POCl₃ in DMF. The cyclization was facilitated by N-(pyridin-2-yl)acetamides bearing electron-donating groups at meta position. Condensation of I with N₂H₄.H₂O and NaOAc in MeOH gave the corresponding hydrazones. Treatment of I with NaN₃ in EtOH led to cyclization to afford tetrazolo[1,5-a](1,8)naphthyridine-4-carbaldehydes via unstable 2-azido compounds Reaction of I with Na₂S in DMF yielded 2-mercapto-1,8-naphthyridine-3-carbaldehydes. The synthesized new compounds were screened for antimicrobial activity. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3COA of Formula: C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System was written by Chang, Yung-Yu;Ho, Tse-Lok;Chung, Wen-Sheng. And the article was included in Journal of Organic Chemistry in 2014.Application In Synthesis of 2-Isopropylpyridine This article mentions the following:

A 4,7-phenanthroline polycyclic 1A designed for probing the limits of the Menschutkin reaction was synthesized in a six-step sequence. The rotational barrier of the Ph ring nearby the N-Me group in rac-2A is â‰?8.1 kcal/mol from VT-NMR experiments, making them a new type of helical atropisomer. The methylation rate constants of 9 and 1A with MeI is 2.22 × 10^-4 and 9.62 × 10^-6 s^-1 mol^-1 L, resp.; thus, the formation rate of (P/M)-2A is one of the slowest rates ever reported for a Menschutkin reaction. The N-Me protons in (P/M)-2A exhibit a significant upfield shift (Δδ 1.0 ppm) in its ¹H NMR, compared to those without a nearby Ph, indicating a strong CH-π interaction is involved. Conformational flexibility in dipyridylethene 9 is clearly shown by its complexation with BH₃ to form helical atropisomers (P,P/M,M)-10. The pK_a values of the conjugate acids of 1A and 9 in acetonitrile are 4.65 and 5.07, resp., which are much smaller compared to that of pyridine 14a (pK_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of 1A and 9 are markedly decreased by the severe steric hindrance of the flanking Ph rings in the polyheterocycles. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application In Synthesis of 2-Isopropylpyridine).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 2-Isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Change of Silk Fibroin Molecular Mass During Dissolution in Ionic Liquids was written by Susanin, A. I.;Sashina, E. S.;Novoselov, N. P.;Zakharov, V. V.. And the article was included in Fibre Chemistry in 2020.Application In Synthesis of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Silk fibroin is a unique protein polymer with broad potential for medical applications. Fibroin is significantly degraded and the materials obtained from it have poor mech. characteristics if silk fiber is dissolved in traditional solvents. The present work used gel electrophoresis to study the dissolution of fibroin in ionic liquids Fibroin degradation was shown to increase with increasing temperature and dissolution time. The optimal conditions for dissolution that allowed the heavy and light chains of fibroin to be preserved intact were proposed. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Application In Synthesis of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem