Tag: 200-300

In 2008,Reisner, Erwin; Lippard, Stephen J. published 《Synthesis of dicarboxylate “”C-clamp”” 1,2-diethynylarene compounds as potential transition-metal ion hosts》.European Journal of Organic Chemistry published the findings.Formula: C7H6BrNO2 The information in the text is summarized as follows:

An efficient convergent synthesis is reported for a new type of C-clamp ligand with a 1,2-diethynylarene scaffold involving a chelate host capable of binding a guest mol. in its endo-dicarboxylate pocket. The chem. involves a combination of palladium-catalyzed Sonogashira, Heck, and Suzuki cross-coupling reactions. The compounds 2,3-bis[2-(2′-carboxybiphenyl-4-yl)ethynyl]triptycene and 4,5-bis[2-(2′-carboxybiphenyl-4-yl)ethynyl]veratrole and their 2′-carboxy-m-terphenyl-4-yl analogs were designed as dinucleating ligands to assemble carboxylate-bridged transition-metal complexes with a windmill geometry. The X-ray crystal structure of one such C-clamp compound containing co-crystallized water mols. reveals strong hydrogen bonds of the aqua guest to the endo-oriented carboxylic acid entities of the C-clamp host. In addition, two syn-N-donor ligands were prepared as a synthetic scaffold to mimic the geometric arrangement of N-donor atoms in carboxylate-bridged dinuclear proteins. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bobbio, Carla; Schlosser, Manfred published their research in European Journal of Organic Chemistry on December 31 ,2001. The article was titled 《Regiochemical flexibility: the optional functionalization of 2,3,5-trihalopyridines at the 4- or 6-position》.Product Details of 40360-44-9 The article contains the following contents:

A deprotonation study was performed using 2,3,5-trichloropyridine, 3,5-dichloro-2-fluoropyridine, and 5-chloro-2,3-difluoropyridine as the substrates. Upon reaction with lithium diisopropylamide (LDA), deprotonation occurred exclusively at the 4-position. Subsequent carboxylation and iodination led to the acids and 4-iodopyridines. The exposure of the latter compounds to lithium 2,2,6,6-tetramethylpiperidide (LITMP) caused deprotonation and immediately ensuing iodine migration. The intermediates were trapped with dry ice to afford the carboxylic acids. Upon neutralization, the 6-iodopyridines were obtained. These compounds readily exchanged the heavy halogen for metal when treated with isopropylmagnesium chloride. In this way, functional groups could be selectively introduced in the 6-position. Employing carbon dioxide routinely as the model electrophile, trihalopyridinecarboxylic acids were formed which, all unknown so far, should provide valuable new building blocks for pharmaceutical research. Moreover, the selective nucleophilic displacement of the halogen at the 2-position could give rise to an immense variety of new structures. In the experimental materials used by the author, we found 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Product Details of 40360-44-9)

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 40360-44-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridineOn October 24, 2018 ,《Extending Hypochlorite Sensing from Cells to Elesclomol-Treated Tumors in Vivo by Using a Near-Infrared Dual-Phosphorescent Nanoprobe》 was published in ACS Applied Materials & Interfaces. The article was written by Meng, Xiangchun; Shi, Yuxiang; Chen, Zejing; Song, Linna; Zhao, Menglong; Zou, Liang; Liu, Shujuan; Huang, Wei; Zhao, Qiang. The article contains the following contents:

Reactive oxygen species (ROS), when beyond the threshold, can exhaust the capacity of cellular antioxidants and ultimately trigger cell apoptosis in tumor biol. However, the roles of hypochlorite (ClO-) in this process are much less clear compared with those of ROS, and its detection is easily obstructed by tissue penetration and endogenous fluorophores. Herein, the authors first synthesized a near-IR (NIR) ratiometric ClO- probe (Ir NP) composed of two kinds of phosphorescent iridium(III) complexes (Ir1 and Ir2) encapsulated with amphiphilic DSPE-mPEG5000. Ir NPs are dual-emissive and show obvious changes in phosphorescence intensity ratios and lifetimes of two emission bands upon exposure to ClO-. During the ClO- detection, ratiometric photoluminescence imaging is much more reliable over the intensity-based one for its self-calibration, while time-resolved photoluminescence imaging (TRPI) could distinguish the phosphorescence with long lifetime of Ir NPs from short-lived autofluorescence of tissues, resulting in the high accuracy of ClO- determination With NIR emission, a long phosphorescence lifetime, fast response, and excellent biocompatibility, Ir NPs were applied to the detection of ClO- in vitro and in vivo by means of ratiometric phosphorescence imaging and TRPI with high signal-to noise-ratios (SNR). Importantly, the authors demonstrated the elevated ClO- in elesclomol-stimulated tumors in living mice for the first time, which holds great potential for the visualization of the boost of ClO- in anticarcinogen-treated tumors and the further investigation of ROS-related oncotherapeutics. The experimental process involved the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease》 was written by Pagare, Piyusha P.; Ghatge, Mohini S.; Musayev, Faik N.; Deshpande, Tanvi M.; Chen, Qiukan; Braxton, Courtney; Kim, Solyi; Venitz, Jurgen; Zhang, Yan; Abdulmalik, Osheiza; Safo, Martin K.. Electric Literature of C6H7Br2NThis research focused onvanillin pyridyl derivative preparation sickle cell disease treatment Hb; Antisickling; Aromatic aldehyde; Crystal structure; Hemoglobin; Oxygen equilibrium; Polymerization; Relaxed state; Sickle cell disease. The article conveys some information:

Hypoxia-induced polymerization of sickle Hb (Hb S) is the principal phenomenon that underlays the pathophysiol. and morbidity associated with sickle cell disease (SCD). Opportunely, as an allosteric protein, Hb serves as a convenient and potentially critical druggable target. Consequently, mols. that prevent Hb S polymerization (Hb modifiers), and the associated erythrocyte sickling have been investigated-and retain significant interest-as a viable therapeutic strategy for SCD. This group of mols., including aromatic aldehydes, form high oxygen affinity Schiff-base adducts with Hb S, which are resistant to polymerization Here, the authors report the design and synthesis of novel potent antisickling agents (SAJ-009, SAJ-310 and SAJ-270) based on the pharmacophore of vanillin and INN-312, a previously reported pyridyl derivative of vanillin. These novel derivatives exhibited superior in vitro binding and pharmacokinetic properties compared to vanillin, which translated into significantly enhanced allosteric and antisickling properties. Crystal structure studies of liganded Hb in the R2 quaternary state in complex with SAJ-310 provided important insights into the allosteric and antisickling properties of this group of compounds While these derivatives generally show similar in vitro biol. potency, significant structure-dependent differences in their biochem. profiles would help predict the most promising candidates for successful in vivo pre-clin. translational studies and inform further structural modifications to improve on their pharmacol. properties. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Versatile Coordination Modes of 2,6-Bis(2-(diphenylphosphanyl)-1H-imidazol-1-yl)pyridine in Cu(I) and Au(I) Complexes》 was published in European Journal of Inorganic Chemistry in 2020. These research results belong to Kumar, Saurabh; Mague, Joel T.; Balakrishna, Maravanji S.. Category: pyridine-derivatives The article mentions the following:

Synthesis, and copper(I) and gold(I) complexes of imidazole-based bisphosphine, [2,6-(PPh2C3H2N2)2C5H3N] are described. Reactions of [2,6-(PPh2C3H2N2)2C5H3N] with one equivalent of CuX (X = Cl, Br or I) yielded either monomeric [{2,6-{PPh2C3H2N2}2C5H3N}{CuI}], dimeric [[PPh2C3H2N2]2(C5H3N)(CuCl)2], or one-dimensional (1D) polymeric [{2,6-(PPh2-C3H2N2)2C5H3N}{Cu3Br2}]nCl complexes. Coordination polymer [{2,6-(PPh2C3H2N2)2C5H3N}{Cu3Br2}]nCl is a rare example containing alternately arranged copper atoms having tetrahedral and linear geometries. The repeating unit consists of imidazolyl nitrogen atoms from two ligands bind to a copper atom in a linear fashion, whereas two phosphorus atoms from the same ligand are chelated to a tetrahedral copper atom, thus ligand displaying tetradentate behavior. Treatment of bisphosphine with two equivalent of [AuCl(SMe2)] yielded digold complex [2,6-(PPh2C3H2N2)2C5H3N{AuCl}2]. The structures of most of these compounds were confirmed by single-crystal X-ray analyses. These complexes show good photoluminescence properties as well. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and Docking studies of 1-Phenyl-3-(4-(pyridin-2-ylmethyl)piperazin-1-yl)-1H-pyrazolo[4,3-b]pyridine》 were Srivani, K.; Laxminarayana, E.; Ramchander, M.; Chary, M. Thirumala. And the article was published in Indian Journal of Heterocyclic Chemistry in 2019. Name: 2-(Bromomethyl)pyridine hydrobromide The author mentioned the following in the article:

A simple method was developed to synthesize 1-phenyl-3-(4-(pyridin-2-ylmethyl)piperazin- 1-yl)-1H-pyrazolo[4,3-b]pyridine and docking for this compound was presented. This synthetic method was proven by an independent synthesis starting from the 3-bromopyridine-2-carboxylic acid as starting material. The structures of the compounds obtained were confirmed by spectral anal. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Name: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Name: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches》 were Whitehouse, Andrew J.; Thomas, Sherine E.; Brown, Karen P.; Fanourakis, Alexander; Chan, Daniel S.-H.; Libardo, M. Daben J.; Mendes, Vitor; Boshoff, Helena I. M.; Floto, R. Andres; Abell, Chris; Blundell, Tom L.; Coyne, Anthony G.. And the article was published in Journal of Medicinal Chemistry in 2019. HPLC of Formula: 31106-82-8 The author mentioned the following in the article:

Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis and other pre-existing chronic lung diseases. Mab pulmonary infections are difficult, or sometimes impossible, to treat and result in accelerated lung function decline and premature death. There is therefore an urgent need to develop novel antibiotics with improved efficacy. TRNA (m1G37) methyltransferase (TrmD) is a promising target for novel antibiotics. It is essential in Mab and other mycobacteria, improving reading frame maintenance on the ribosome to prevent frameshift errors. In this work, a fragment-based approach was employed with the merging of 2 fragments bound to the active site, followed by structure-guided elaboration to design potent nanomolar inhibitors against Mab TrmD. Several of these compounds exhibit promising activity against mycobacterial species, including Mycobacterium tuberculosis and Mycobacterium leprae in addition to Mab, supporting the use of TrmD as a target for the development of antimycobacterial compounds In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Chi, Xiaodong; Cen, Wanglai; Queenan, Jack A.; Long, Lingliang; Lynch, Vincent M.; Khashab, Niveen M.; Sessler, Jonathan L.. Category: pyridine-derivatives. The article was titled 《Azobenzene-Bridged Expanded “”Texas-sized”” Box: A Dual-Responsive Receptor for Aryl Dianion Encapsulation》. The information in the text is summarized as follows:

We report an expanded “”Texas-sized”” mol. box (AzoTxSB) that incorporates photoresponsive azobenzene bridging subunits and anion recognition motifs. The shape of this box can be switched through light induced E ↔ Z photoisomerization of the constituent azobenzenes. This allows various anionic substrates to be bound and released by using different forms of the box. Control can also be achieved using other environmental stimuli, such as pH and anion competition. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Naya, Leticia; Vazquez-Garcia, Digna; Fernandez, Alberto; Lopez-Torres, Margarita; Ojea, Vicente; Marcos, Ismael; Vila, Jose M.; Fernandez, Jesus J. published 《Preparation of Imidazol-2-ylidene Carbene Palladacycles with Bi- and Tridentate Schiff Bases – Analyses of the Spectroscopic, Molecular Structure, and DFT Calculation Data》.European Journal of Inorganic Chemistry published the findings.Related Products of 31106-82-8 The information in the text is summarized as follows:

The treatment of appropriate benzylideneimine palladacycles with potentially polydentate imidazol-2-ylidene silver carbene complexes produced new palladium organometallics with the N-heterocyclic carbene (NHC) coordinated to the palladium center. The NHCs bearing two carbene moieties show a bridging coordination mode across the two metal atoms and may also display a simultaneous bridging/chelating behavior. DFT calculations were performed for the compounds for which the typical fluxional behavior of hemilabile carbenes was observed upon close inspection of the 1H NMR spectra. The crystal and mol. structure of 13 was determined by x-ray crystallog. and contrasted against the computational data for 14 to determine the most favorable disposition of the fluxional equilibrium of the latter. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Related Products of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Andernach, Lars; Opatz, Till published 《Assignment of the absolute configuration and total synthesis of (+)-caripyrin》.European Journal of Organic Chemistry published the findings.Recommanded Product: 29682-15-3 The information in the text is summarized as follows:

The antifungal secondary metabolite (+)-caripyrin was studied by vibrational CD spectroscopy. Anal. of the recorded data, with the Boltzmann weighted-average of the spectra calculated at the B3LYP/6-311G(d,p) level of theory for all relevant conformers, unequivocally proved the (R,R)-configuration for the dextrorotatory natural product. Based on this finding, a short enantioselective synthesis of (+)-caripyrin was developed. The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem