Tag: 200-300

In 2017,Otero-Fraga, Jorge; Suarez-Pantiga, Samuel; Montesinos-Magraner, Marc; Rhein, Dennis; Mendoza, Abraham published 《Direct and Stereospecific [3+2] Synthesis of Pyrrolidines from Simple Unactivated Alkenes》.Angewandte Chemie, International Edition published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

Pyrrolidines are important heterocyclic compounds with endless applications in organic synthesis, metal catalysis, and organocatalysis. Their potential as ligands for first-row transition-metal catalysts inspired a new method to access complex poly-heterocyclic pyrrolidines in one step from available materials. This fundamental step forward is based on the discovery of an essential organoaluminum promoter that engages unactivated and electron-rich olefins in intermol. [3+2] cycloadditions In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Pyrimidines. XLIII. Ring transformations in reactions of heterocyclic compounds with nucleophiles. IX. Conversion of N-methylpyrimidinium salts to pyridines by carbanions》 were Oostveen, E. A.; Van der Plas, H. C.. And the article was published in Recueil des Travaux Chimiques des Pays-Bas in 1974. Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid The author mentioned the following in the article:

On treatment with active methylene compounds in basic media the quaternary pyrimidinium salts were converted into pyridine derivatives. Thus, I(R = R1 = H; R = Ph, R1 = H, R = H, R1 = Ph) and CH2(CO2Et) with NaOH gave II. In the experiment, the researchers used many compounds, for example, 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Severance, Rachel C.; Ellsworth, Joe; Smith, Mark D.; Kelley, Jennifer; Peterson, LeRoy Jr.; zur Loye, Hans-Conrad published their research in Journal of Chemical Crystallography on December 31 ,2010. The article was titled 《Synthesis and Crystal Structure of the Coordination Complex Cu(ppca’)2(H2O)2 (ppca’ = 3,4′-Bipyridine-6-Carboxylic Acid)》.Formula: C11H8N2O2 The article contains the following contents:

The coordination complex Cu(ppca’)2(H2O)2 (1) was synthesized hydrothermally using the ligand 3,4′-bipyridine-6-carboxylic acid (ppca’). Complex 1 consists of pseudo-octahedral copper(II) units hydrogen bonded into a three-dimensional network that crystallizes in the monoclinic P21/n space group. In complex 1, a 5.3429(4), b 29.343(2), c 6.7940(5) Å, and β 110.635(2)°. The experimental part of the paper was very detailed, including the reaction process of [3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2Formula: C11H8N2O2)

[3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C11H8N2O2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tricyclic imidazole antagonists of the Neuropeptide S Receptor》 was written by Trotter, B. Wesley; Nanda, Kausik K.; Manley, Peter J.; Uebele, Victor N.; Condra, Cindra L.; Gotter, Anthony L.; Menzel, Karsten; Henault, Martin; Stocco, Rino; Renger, John J.; Hartman, George D.; Bilodeau, Mark T.. Quality Control of Methyl 5-bromopicolinateThis research focused ontricyclic imidazole antagonist Neuropeptide S Receptor preparation. The article conveys some information:

A new structural class of potent antagonists of the Neuropeptide S Receptor (NPSR) is reported. High-throughput screening identified a tricyclic imidazole antagonist of NPSR, and medicinal chem. optimization of this structure was undertaken to improve potency against the receptor as well as CNS penetration. Detailed herein are synthetic and medicinal chem. studies that led to the identification of antagonists I and II which demonstrate potent in vitro NPSR antagonism and central exposure in vivo. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Minimum structural requirements for inhibitors of the zinc finger protein TRAF6》 was written by Radwan, Mohamed O.; Koga, Ryoko; Hida, Tomohiro; Ejima, Tomohiko; Kanemaru, Yosuke; Tateishi, Hiroshi; Okamoto, Yoshinari; Inoue, Jun-ichiro; Fujita, Mikako; Otsuka, Masami. Recommanded Product: 31106-82-8This research focused onzing finger TRAF6 inhibitor NF kappa B; Molecular docking; NF-κB; TRAF6; Zinc finger. The article conveys some information:

Zinc fingers have rarely been regarded as drug targets. On the contrary, the zinc-binding site of enzymes has often been considered a target of inhibitors. We previously developed a dithiol compound called SN-1(I) that binds to the zinc finger protein tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppresses downstream nuclear factor-κB (NF-κB) signaling. To determine the minimal structure requirements of TRAF6 inhibitors based on I, NF-κB inhibitory activity and cytotoxicity of its derivatives including new compounds were examined SN-2(II), an oxidative type of prodrug of I with 2-nitrophenylthio groups via disulfide, has the min. structure for an inhibitor of TRAF6, as seen with cellular experiments The importance of two side chains with a thiol group was shown with mol. modeling. This study may lead to development of selective TRAF6 inhibitors in the near future. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle》 was written by Takale, Balaram S.; Thakore, Ruchita R.; Casotti, Gianluca; Li, Xaiohan; Gallou, Fabrice; Lipshutz, Bruce H.. Category: pyridine-derivativesThis research focused onwater Stille coupling triphenylphosphine palladacycle catalyst pharmaceutical preparation; Stille couplings; cross-coupling; green chemistry; nanostructures; palladium. The article conveys some information:

An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sutherland, Hamish S.; Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Palmer, Brian D.; Choi, Peter J.; Denny, William A. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis》.Quality Control of Methyl 5-bromopicolinate The author mentioned the following in the article:

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogs (such as TBAJ-876) have shown promising efficacy in patient populations and preclin. studies, resp., suggesting that selective targeting of this enzyme presents a validated therapeutic strategy for the treatment of TB. In this work, we report tetrahydronaphthalene amides (THNAs) as a new class of ATP synthase inhibitors that are effective in preventing the growth of Mycobacterium tuberculosis (M.tb) in culture. Design, synthesis and comprehensive structure-activity relationship studies for approx. 80 THNA analogs are described, with a small selection of compounds exhibiting potent (in some cases MIC90 <1 μg/mL) in vitro M.tb growth inhibition taken forward to pharmacokinetic and off-target profiling studies. Ultimately, we show that some of these THNAs possess reduced lipophilic properties, decreased hERG liability, faster mouse/human liver microsomal clearance rates and shorter plasma half-lives compared with bedaquiline, potentially addressing of the main concerns of persistence and phospholipidosis associated with bedaquiline. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Facile Synthesis of Amphiphilic Bottlebrush Block Copolymers Bearing Pyridine Pendants via Click Reaction from Protected Alkyne Side Groups》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Kim, Myung-Jin; Yu, Yong-Guen; Chae, Chang-Geun; Seo, Ho-Bin; Lee, Jae-Suk. Reference of 2-(Bromomethyl)pyridine hydrobromide The article mentions the following:

We present the facile synthetic platform for the production of amphiphilic bottlebrush block copolymers bearing pyridine pendants through combination of living anionic polymerization (LAP), ring-opening metathesis polymerization (ROMP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). ω-Norbornenyl poly(4-((trimethylsilyl)ethynyl)styrene) (NBPTMSESt) with controlled mol. weights (Mn = 3-4 kDa) and low dispersity (D = 1.03-1.08) was synthesized by LAP and the subsequent end-capping reaction with exo-N-(n-decyl-10-phenylacrylate)-5-norbornene-2,3-dicarboximide. Well-defined bottlebrush block copolymers (Mn = 134-548 kDa, D = 1.04-1.14) were achieved through sequential ROMP of ω-norbornenyl polystyrene with NBPTMSESt and subsequently deprotected with the clickable alkyne group. Amphiphilic bottlebrush block copolymers were obtained by the click reaction of alkyne and azide functional pyridines in the presence of the organic-soluble catalyst/ligand system of CuBr(PPh3)3 and N,N,N’,N”,N”-pentamethyldiethylenetriamine. These polymers exhibited the three-dimensional ordered porous films through breath-figure self-assembly. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Rational Design of Multi-Stimuli-Responsive Scaffolds: Synthesis of Luminescent Oligo(ethynylpyridine)-Containing Alkynylplatinum(II) Polypyridine Foldamers Stabilized by Pt···Pt Interactions》 were Chan, Michael Ho-Yeung; Leung, Sammual Yu-Lut; Yam, Vivian Wing-Wah. And the article was published in Journal of the American Chemical Society in 2019. Name: 2,6-Dibromopyridine The author mentioned the following in the article:

A series of oligo(ethynylpyridine)-containing alkynylplatinum(II) terpyridine/bzimpy (bzimpy = 2,6-bis(N-alkylbenzimidazol-2′-yl)pyridine) metallofoldamers [L3Pt(CC-1,3-Ar)nCCPtL3] (L3 = tpy, bzimpy; Ar = m-phenylene, 2,6-pyridinediyl) has been designed and synthesized to investigate the potential applications of metallofoldamers imparted by the rich spectroscopic responses of Pt···Pt interactions. Apart from the control of the folding/unfolding processes by solvent compositions and temperatures, this class of metallofoldamers has also been found to exhibit reversible folding/unfolding behaviors mediated by the addition of acids/bases due to the incorporation of the acid-sensitive oligo(ethynylpyridine) derivatives More importantly, the intramol. Pt···Pt interaction has been found to play a crucial role in governing the folded state conformation. The conformation of this class of metallofoldamers has been investigated by 2D ROESY NMR, electronic absorption, and emission spectroscopy, which provide further insights into the rational mol. design and multidimensional control of metallofoldamers upon the application of various external stimuli, leading to the preparation of multi-stimuli-responsive materials for potential applications in material sciences. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Peter, K.; Wietasch, H.; Peng, B.; Thelakkat, M. published an article in Applied Physics A: Materials Science & Processing. The title of the article was 《Dual-functional materials for interface modifications in solid-state dye-sensitised TiO2 solar cells》.Electric Literature of C12H10Cl2N2 The author mentioned the following in the article:

The concept of solid-state dye-sensitized TiO2 solar cells with an organic semiconductor as hole-transport medium is studied in detail by examining the dye-hole conductor interface. The facile transfer of holes from Ru-dye core to the hole conductor requires suitable interface modifiers which have the function of dye and hole transport moiety, but with exactly positioned anchor groups and antenna functions. The synthesis and characterization of such novel low mol. weight multifunctional mols. carrying dye units and triphenylamine moieties are presented and their influence as interface modifiers is studied. This interface modification results in doubling the external quantum efficiency of current conversion via improved charge transfer at the dye-hole conductor interface. Also, the recombination processes at this interface are drastically suppressed, which leads to higher open-circuit voltage and consequently higher power-conversion efficiency. The concept is also extended to polymers to obtain dye-centered polymeric hole conductors which carry a single Ru-dye unit in the middle of the poly(vinyltriphenylamine) chain that acts as hole-conductor polymer. The polymerization was carried out by atom-transfer radical polymerization of 4-bromostyrene followed by polymer amination and finally metalation with Ru-bis(bipyridyl) precursors. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Electric Literature of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Electric Literature of C12H10Cl2N2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem