Tag: 200-300

Synthesis and characterization of binuclear half-sandwich metal (Co, Ir and Ru) complexes containing ancillary ortho-carborane-1,2-dithiolato ligands was written by Liu, Shuang;Zhang, Jiasheng;Wang, Xin;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2006.HPLC of Formula: 15420-02-7 This article mentions the following:

Pyrazine-, 4,4′-bipyridine-, 1,2-ethenediylbis-4,4′-pyridine-, 2,5-bis(4-pyridinyl)-1,3,4-oxadiazole-bridged binuclear half-sandwich Co, Ir and Ru o-carborane-1,2-dithiolates were prepared by reacting of the corresponding monomeric η⁵-C₅Me₅– (for Co and Ir) and η⁶-p-cymene (for Ru) dithiolates with the heterocyclic bidentate ligands. The prepared complexes are soluble and air-stable. The complexes [[(p-cymene)Ru[S₂C₂(B₁₀H₁₀)]]₂(μ-pyrazine-κN¹κN⁴)] (4), [[Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-pyrazine-κN¹κN⁴)] (5), [[Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-4,4′-bipyridine)] (6), [Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-bpe) (7, bpe = 4-C₅H₄NCH:CHC₅H₄N-4) and [[Cp^*Ir[E₂C₂(B₁₀H₁₀)]]₂(μ-bpo)] [8a,b; E = S, Se; bpo = 2,5-bis(4-pyridinyl-κN)-1,3,4-oxadiazole], in which organometallic units are bridged by pyridyl-based organic linkers, were prepared The crystal structures of 4, 5, 6, 7 and 8 are reported. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7HPLC of Formula: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors was written by Labadie, Sharada;Barrett, Kathy;Blair, Wade S.;Chang, Christine;Deshmukh, Gauri;Eigenbrot, Charles;Gibbons, Paul;Johnson, Adam;Kenny, Jane R.;Kohli, Pawan Bir;Liimatta, Marya;Lupardus, Patrick J.;Shia, Steven;Steffek, Micah;Ubhayakar, Savita;Abbema, Anne van;Zak, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Computed Properties of C10H13ClN2O2 This article mentions the following:

A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the mol. was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Computed Properties of C10H13ClN2O2).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H13ClN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation was written by Kroth, Heiko;Sreenivasachary, Nampally;Hamel, Anne;Benderitter, Pascal;Varisco, Yvan;Giriens, Valerie;Paganetti, Paolo;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate This article mentions the following:

It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer’s disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor-acceptor-donor hydrogen bond formation. A series of pyridine derivatives, e.g., I•3HCl, were synthesized and tested regarding their potential to inhibit the aggregation of Aβ. The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation. Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-catalyzed, N-auxiliary group-controlled switchable transannulation/nitration initiated by nitro radicals: selective synthesis of pyridoquinazolones and 3-nitroindoles was written by Shoberu, Adedamola;Li, Cheng-Kun;Qian, Hai-Feng;Zou, Jian-Ping. And the article was included in Organic Chemistry Frontiers in 2021.Reference of 175205-82-0 This article mentions the following:

Herein, a strategy based on the judicious choice of N-auxiliaries, which stabilize the substrates as well as allow precise and predictable control over their reactivity with tert-Bu nitrite was described. Thus, the stage was set for the copper-assisted, controllable synthesis of pyridoquinazolones or 3-nitroindoles. Mechanistic studies implicate a switch in the mechanism, in which N-2-pyridylindoles reacted via a nitrosation/transannulation process and N-2-pyridoylindoles underwent an amide bond dissociation/nitration sequence. Notably, the subsequent removal of the auxiliary groups was not required in these reactions. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Reference of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxygen-Bridged Triphenylamine Units Tuning the Photophysical Properties of Classical Phosphorescent Iridium(III) Complex was written by Cao, Yibo;Song, Jialiang;Li, Gang;Zheng, Ying;Shi, Chao;Li, Qiuxia;Yuan, Aihua. And the article was included in ChemistrySelect in 2021.Application of 54151-74-5 This article mentions the following:

A new yellow phosphorescent iridium(III) complex Ir(ppybop)₂acac with two oxygen-bridged triphenylamine units were prepared and investigated. The cyclometalating ligand ppybop was synthesized by the efficient Suzuki-Miyaura cross-coupling reaction of oxygen-bridged triarylamine unit based boron reagent 1-a and 2-(4-Bromophenyl)pyridine, and the acetylacetone (acac) was used as an auxiliary ligand. Notably, the complex Ir(ppybop)₂acac measured with a fluorescence spectrophotometer can show a larger red shift emission (λ_em = 568 nm), a narrower full width at half maximum (FWHM = 59 nm), a longer emission lifetime (τ[b] = 3127 ns) and a better solubility in comparison with the classical green complex Ir(ppy)2acac (λ_em = 520 nm, FWHM = 70 nm, τ[b] = 1206 ns). In addition, the DFT calculation results indicate that the strong electron-donating ability of the unit can lead to the unusual ligand-to-metal charge transfer (3LMCT) excited state characteristics of Ir(ppybop)2acac, which is completely different from the metal-to-ligand charge transfer (3MLCT) in Ir(ppy)₂acac. This result can provide a new strategy for the design of new phosphorescent iridium(III) complexes. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Application of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Insight into the mechanism of oxidative kinetic resolution of racemic secondary alcohols by using manganese(III)(salen) complexes as catalysts was written by Li, Zhen;Tang, Zhong H.;Hu, Xiao X.;Xia, Chun G.. And the article was included in Chemistry – A European Journal in 2005.HPLC of Formula: 65350-59-6 This article mentions the following:

The oxidative kinetic resolution of various racemic secondary alcs. with PhI(OAc)₂ catalyzed by chiral [Mn^III(salen)] complexes in the presence of KBr was studied in a water/organic solvent mixture The dramatic, synergetic effect of additives, organic solvent, and the substituents of chiral salen ligands on the enantioselectivities of the reactions is reported. Results from UV/Vis spectroscopy and ESI-MS studies provide evidence that these reactions are induced by the formation of a high-valent manganese intermediate. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6HPLC of Formula: 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of Well-Defined Poly(2-alkoxypyridine-3,5-diyl) via Ni-Catalyst-Transfer Condensation Polymerization was written by Nanashima, Yutaka;Yokoyama, Akihiro;Yokozawa, Tsutomu. And the article was included in Macromolecules (Washington, DC, United States) in 2012.Category: pyridine-derivatives This article mentions the following:

Ni-catalyzed Kumada-Tamao coupling polymerization of 5-bromo-3-chloromagnesio-2-(2-(2-methoxyethoxy)ethoxy)pyridine (1) was investigated. Monomer 1, which was obtained quant. by treatment of the corresponding bromoiodopyridine 3 with 1.0 equiv of ⁱPrMgCl at 0°, was polymerized with Ni(dppp)Cl₂ (dppp = 1,3-bis(diphenylphospino)propane) in the presence of 2.0 equiv of LiCl in THF at room temperature to yield poly(2-(2-(2-methoxyethoxy)ethoxy)pyridine-3,5-diyl) (m-PMEEOPy) with narrow polydispersity. The M_n value was controlled by the feed ratio of the monomer precursor 3 to Ni(dppp)Cl₂. MALDI-TOF mass spectra showed that m-PMEEOPy uniformly had a bromine atom at one end and a hydrogen atom at the other. Both end groups could be converted to aryl groups by addition of an excess of aryl magnesium chloride to the reaction mixture after completion of the polymerization These results indicate that the polymerization of 1 with Ni(dppp)Cl₂ involves the intramol. catalyst-transfer polymerization mechanism. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Category: pyridine-derivatives).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solvothermal aluminophosphate zeotype synthesis with ionic liquid precursors was written by Wragg, David S.;Fullerton, Grace M.;Byrne, Peter J.;Slawin, Alexandra M. Z.;Warren, John E.;Teat, Simon J.;Morris, Russell E.. And the article was included in Dalton Transactions in 2011.Product Details of 65350-59-6 This article mentions the following:

The authors have carried out a study of aluminophosphate framework synthesis using several amine based ionic liquids and their parent amines as solvent and template. The results suggest that in the presence of fluoride ions from hydrofluoric acid the ionic liquids and their parent amines produce the same frameworks, while in synthesis without fluoride ions the products are not related. The results include the synthesis and crystal structure of a novel extra-large pore material using 1-methylpyrrolidine as solvent and template. The relation between this and sodalite, which can be synthesized in cobalt aluminophosphate form using an ionic liquid prepared from 1-methylpyrrolidine is described. The crystal structures of two other new layered materials are also presented. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Product Details of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and characterization of binuclear half-sandwich metal (Co, Ir and Ru) complexes containing ancillary ortho-carborane-1,2-dithiolato ligands was written by Liu, Shuang;Zhang, Jiasheng;Wang, Xin;Jin, Guo-Xin. And the article was included in Dalton Transactions in 2006.HPLC of Formula: 15420-02-7 This article mentions the following:

Pyrazine-, 4,4′-bipyridine-, 1,2-ethenediylbis-4,4′-pyridine-, 2,5-bis(4-pyridinyl)-1,3,4-oxadiazole-bridged binuclear half-sandwich Co, Ir and Ru o-carborane-1,2-dithiolates were prepared by reacting of the corresponding monomeric η⁵-C₅Me₅– (for Co and Ir) and η⁶-p-cymene (for Ru) dithiolates with the heterocyclic bidentate ligands. The prepared complexes are soluble and air-stable. The complexes [[(p-cymene)Ru[S₂C₂(B₁₀H₁₀)]]₂(μ-pyrazine-κN¹κN⁴)] (4), [[Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-pyrazine-κN¹κN⁴)] (5), [[Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-4,4′-bipyridine)] (6), [Cp^*Co[S₂C₂(B₁₀H₁₀)]]₂(μ-bpe) (7, bpe = 4-C₅H₄NCH:CHC₅H₄N-4) and [[Cp^*Ir[E₂C₂(B₁₀H₁₀)]]₂(μ-bpo)] [8a,b; E = S, Se; bpo = 2,5-bis(4-pyridinyl-κN)-1,3,4-oxadiazole], in which organometallic units are bridged by pyridyl-based organic linkers, were prepared The crystal structures of 4, 5, 6, 7 and 8 are reported. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7HPLC of Formula: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors was written by Labadie, Sharada;Barrett, Kathy;Blair, Wade S.;Chang, Christine;Deshmukh, Gauri;Eigenbrot, Charles;Gibbons, Paul;Johnson, Adam;Kenny, Jane R.;Kohli, Pawan Bir;Liimatta, Marya;Lupardus, Patrick J.;Shia, Steven;Steffek, Micah;Ubhayakar, Savita;Abbema, Anne van;Zak, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Computed Properties of C10H13ClN2O2 This article mentions the following:

A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the mol. was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Computed Properties of C10H13ClN2O2).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H13ClN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem