Tag: 200-300

Kroth, Heiko et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 205676-84-2

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation was written by Kroth, Heiko;Sreenivasachary, Nampally;Hamel, Anne;Benderitter, Pascal;Varisco, Yvan;Giriens, Valerie;Paganetti, Paolo;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate This article mentions the following:

It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer’s disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor-acceptor-donor hydrogen bond formation. A series of pyridine derivatives, e.g., I•3HCl, were synthesized and tested regarding their potential to inhibit the aggregation of Aβ. The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation. Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shoberu, Adedamola et al. published their research in Organic Chemistry Frontiers in 2021 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 175205-82-0

Copper-catalyzed, N-auxiliary group-controlled switchable transannulation/nitration initiated by nitro radicals: selective synthesis of pyridoquinazolones and 3-nitroindoles was written by Shoberu, Adedamola;Li, Cheng-Kun;Qian, Hai-Feng;Zou, Jian-Ping. And the article was included in Organic Chemistry Frontiers in 2021.Reference of 175205-82-0 This article mentions the following:

Herein, a strategy based on the judicious choice of N-auxiliaries, which stabilize the substrates as well as allow precise and predictable control over their reactivity with tert-Bu nitrite was described. Thus, the stage was set for the copper-assisted, controllable synthesis of pyridoquinazolones or 3-nitroindoles. Mechanistic studies implicate a switch in the mechanism, in which N-2-pyridylindoles reacted via a nitrosation/transannulation process and N-2-pyridoylindoles underwent an amide bond dissociation/nitration sequence. Notably, the subsequent removal of the auxiliary groups was not required in these reactions. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Reference of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Marugan, Juan Jose et al. published their research in Journal of Medicinal Chemistry in 2005 | CAS: 205676-84-2

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 205676-84-2

Design, Synthesis, and Biological Evaluation of Novel Potent and Selective αvβ3/αvβ5 Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core was written by Marugan, Juan Jose;Manthey, Carl;Anaclerio, Beth;Lafrance, Lou;Lu, Tianbao;Markotan, Tom;Leonard, Kristi A.;Crysler, Carl;Eisennagel, Stephen;Dasgupta, Malini;Tomczuk, Bruce. And the article was included in Journal of Medicinal Chemistry in 2005.Application of 205676-84-2 This article mentions the following:

A novel series of potent and selective αvβ3/αvβ5 dual inhibitors was designed, synthesized, and evaluated against several integrins. These compounds were synthesized through a Mitsunobu reaction between the guanidinium mimetics and the corresponding central templates. Guanidinium mimetics with enhanced rigidity [i.e., [(2-pyridinyl)amino]propoxy vs. the 2-(6-methylamino-2-pyridinyl)ethoxy] led to improved activity toward αvβ3. Exemplary oral bioavailability in mice was achieved using the indole central scaffold. Although, oral bioavailability was maintained when the indole mol. core was replaced with the bioisosteric benzofuran or benzothiophene ring systems, it was found to not significantly impact the integrin activity or selectivity. However, the indole series displayed the best in vivo pharmacokinetic properties. Thus, the indole series was selected for further structure-activity relationships to obtain more potent αvβ3/αvβ5 dual antagonist with improved oral bioavailability. The compounds thus prepared and studied included 5-[3-(2-pyridinylamino)propoxy]-1H-indole-1-propanoic acid (I), 5-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-1H-indole-1-propanoic acid, 6-[2-[6-(methylamino)-2-pyridinyl]ethoxy]benzo[b]thiophene-3-propanoic acid (II), and 6-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-benzofuranpropanoic acid (III). In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Application of 205676-84-2).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 205676-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frischmann, Peter D. et al. published their research in Chemistry – A European Journal in 2015 | CAS: 1073354-14-9

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde

Subcomponent Self-Assembly of a 4 nm M4L6 Tetrahedron with ZnII Vertices and Perylene Bisimide Dye Edges was written by Frischmann, Peter D.;Kunz, Valentin;Stepanenko, Vladimir;Wuerthner, Frank. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde This article mentions the following:

Formation of a tetrahedron with >4 nm perylene bisimide (PBI) dye edges and ZnII vertexes in a 1-pot 22 component self-assembly reaction is reported. The luminescent polyhedron equilibrates to a Zn2L3 helicate and disassembles upon dilution Insights into the subcomponent self-assembly of extended PBI ligands help to refine design rules for constructing large photofunctional metallosupramol. hosts. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9Application In Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lee, Jae Chul et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C6H3BrF3N

Tetrahydroindazole inhibitors of CDK2/cyclin complexes was written by Lee, Jae Chul;Hong, Kwon Ho;Becker, Andreas;Tash, Joseph S.;Schonbrunn, Ernst;Georg, Gunda I.. And the article was included in European Journal of Medicinal Chemistry in 2021.Synthetic Route of C6H3BrF3N This article mentions the following:

Over 50 tetrahydroindazoles I [R = 2-pyridyl, thiazol-2-yl, pyrimidin-4-yl, etc.] were synthesized after I [R = 2-pyridyl] was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogs was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogs I [R = thiazol-2-yl, pyrimidin-4-yl] showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogs to a CDK2/cyclin complex is favored over binding to free CDK2. Computational anal. was used to predict a potential binding site at the CDK2/cyclin E1 interface. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Synthetic Route of C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lewicka, Krystyna et al. published their research in Roczniki Chemii in 1966 | CAS: 6602-33-1

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 6602-33-1

Substitution reactions of 3-hydroxypyridine N-oxide. II. Bromination was written by Lewicka, Krystyna;Plazek, Edwin. And the article was included in Roczniki Chemii in 1966.Related Products of 6602-33-1 This article mentions the following:

The bromination of 3-hydroxypyridine N-oxide (I) in aqueous NaOH led to 2-bromo-3-hydroxypyridine N-oxide (II) or 2,4,6-tribromo-3-hydroxypyridine N-oxide (III). II was also formed under the action of Br solution in H2O or C5H5N. When treated with Br in alk. solution, II afforded 2,6-dibromo-3-hydroxypyridine N-oxide (IV). Reduction of I bromo derivatives led to the known 3-hydroxypyridine (V) derivatives It was, moreover, found that the bromination of V with an alk. Br solution gave 2-bromo-3-hydroxypyridine (VI). Thus, a solution of 2 g. I in 20 ml. 10% aqueous NaOH was treated dropwise during 30 min. with 1 ml. Br in 20 ml. 10% NaOH. The whole kept 21 hrs. and acidified dropwise under cooling with HCl afforded 1.6 g. II, m. 178-80° (H2O, alc.). Similarly, bromination of 3.5 g. II in 35 ml. 10% aqueous NaOH with 1.75 ml. Br in 35 ml. 10% NaOH yielded 36% IV, m. 2O4-5° (H2O). Bromination of 2 g. I with Br water yielded 78% III, m. 136-8° (aqueous alc.). III was also prepared either in 48% yield by bromination of I in C5H5N or in 50% yield by bromination of I in 10% aqueous NaOH. A solution of 1 g. V in 10 ml. 10% aqueous NaOH was treated dropwise with 0.6 g. Br in 10 ml. 10% aqueous NaOH and worked up as above to give 0.6 g. VI, m. 185-6° (H2O). VI was also prepared in 47% yield by reduction of 1.5 g. II in 15 ml. AcOH with 2 g. Fe dust. Similarly, reduction of IV with Fe dust yielded 77% 2,6-dibromo-3-hydroxypyridine, m. 168-9° (H2O). Reduction of 2 g. III in 20 ml. AcOH at the water bath temperature, during 1 hr., with 2.7 g. Fe dust followed by neutralization to pH 4 with (NH4)2CO3, dilution with 12 ml. H2O and continuous extraction 12 hrs. with Et2O, gave 1.5 g. 2,4,6-tribromo-3-hydroxypyridine, m. 91-2° (H2O). I.HBr, m. 157-8°, was isolated in an attempt at bromination of I with Br in AcOH or aqueous HBr. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Related Products of 6602-33-1).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 6602-33-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Orjales, A. et al. published their research in Anales de Quimica (1968-1979) in 1972 | CAS: 13472-81-6

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 13472-81-6

Alkaloids containing the α-pyridone ring was written by Orjales, A.;Ribas, I.;Varela, A.. And the article was included in Anales de Quimica (1968-1979) in 1972.Recommanded Product: 13472-81-6 This article mentions the following:

Cytisine and anagyrine form dications in 6N HCl that have an aromatic character similar to that of 2-ethoxypyridine. Their dihydrobromides were isolated and arise from a amide-zwitterion equilibrium Halogenation of cytisine occurs in the 3- and 5-positions. PCl5 or POCl3 treatment of cytisine or its dichloro derivative gave 2-(4-chloromethyl-3-piperidyl)-3,5,6-trichloropyridine, which was oxidized with KMnO4 to 3,5,6-trichloropicolinic acid. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Recommanded Product: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scott, Neil W. J. et al. published their research in Journal of the American Chemical Society in 2021 | CAS: 54151-74-5

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 54151-74-5

A Dichotomy in Cross-Coupling Site Selectivity in a Dihalogenated Heteroarene: Influence of Mononuclear Pd, Pd Clusters, and Pd Nanoparticles-the Case for Exploiting Pd Catalyst Speciation was written by Scott, Neil W. J.;Ford, Mark J.;Jeddi, Neda;Eyles, Anthony;Simon, Lauriane;Whitwood, Adrian C.;Tanner, Theo;Willans, Charlotte E.;Fairlamb, Ian J. S.. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 54151-74-5 This article mentions the following:

Mechanism, regioselectivity and kinetics of Suzuki-Miyaura coupling of 2,4-dibromopyridine with arylboronic acids catalyzed with a variety of palladium catalysts and additives, were explored. Site-selective dihalogenated heteroarene cross-coupling with organometallic reagents usually occurs at the halogen proximal to the heteroatom, enabled by intrinsic relative electrophilicity, particularly in strongly polarized systems. An archetypical example is the Suzuki-Miyaura cross-coupling (SMCC) of 2,4-dibromopyridine with organoboron species, which typically exhibit C2-arylation site-selectivity using mononuclear Pd (pre)catalysts. Given that Pd speciation, particularly aggregation, is known to lead to the formation of catalytically competent multinuclear Pdn species, the influence of these species on cross-coupling site-selectivity remains largely unknown. Herein, we disclose that multinuclear Pd species, in the form of Pd3-type clusters and nanoparticles, switch arylation site-selectivity from C2 to C4, in 2,4-dibromopyridine cross-couplings with both organoboronic acids (SMCC reactions) and Grignard reagents (Kumada-type reactions). The Pd/ligand ratio and the presence of suitable stabilizing salts were found to be critically important in switching the site-selectivity. More generally, this study provides exptl. evidence that aggregated Pd catalyst species not only are catalytically competent but also alter reaction outcomes through changes in product selectivity. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Recommanded Product: 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Ya Mei et al. published their research in Acta Crystallographica, Section E: Structure Reports Online in 2003 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

catena-Poly[[silver(I)-μ-2,5-bis(4-pyridyl)-1,3,4-oxadiazole] nitrate], a one-dimensional coordination polymer exhibiting a double-chain supramolecular structure through hydrogen bonds was written by Guo, Ya Mei;Liu, He;Leng, Xue Bing. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2003.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

Crystals of the title compound are. Each Ag(I) center is coordinated by two N atoms of the pyridine rings of the bridging ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole and one O donor of the nitrate anion, giving a trigonal coordination geometry. The ligands bridge the Ag(I) centers to form a 1-dimensional linear structure, which is further linked into a double-chain motif through intermol. C-H···O H bonds. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gaca, Magdalena et al. published their research in Sensors and Actuators, B: Chemical in 2021 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 1-Butyl-4-methylpyridin-1-ium bromide

Impact of ionic liquids on the processing and photo-actuation behavior of SBR composites containing graphene nanoplatelets was written by Gaca, Magdalena;Ilcikova, Marketa;Mrlik, Miroslav;Cvek, Martin;Vaulot, Cyril;Urbanek, Pavel;Pietrasik, Robert;Krupa, Igor;Pietrasik, Joanna. And the article was included in Sensors and Actuators, B: Chemical in 2021.Safety of 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

The effects of butylpyridinium bromide-based ionic liquids (ILs) on the vulcanization kinetics, mech. properties and photo-actuation ability of styrene-butadiene rubber (SBR) composites filled with graphene nanoplatelets (GnPs) were investigated. Two different ILs, 1-butylpyridinium bromide (BBP) and 4-methyl-1-butylpyridinium bromide (BMBP), were introduced into rubber compounds The methodol. of IL incorporation into the rubber compounds was studied as well. The ILs were added either directly as a single component or after immobilization onto the GnPs surface. High values of the modulus and tensile strength, which are important mech. properties, were observed for the composites filled with immobilized BMBP. Freely dispersed BBP resulted in composites with the fastest scorch time, highest thermal and elec. conductivity, and best photo-actuation response of 0.230 mm. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Safety of 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem