Tag: 200-300

Metal-Free Aminothiation of Alkynes: Three-Component Tandem Annulation toward Indolizine Thiones from 2-Alkylpyridines, Ynals, and Elemental Sulfur was written by Chen, Zhengwang;Liang, Pei;Xu, Fan;Deng, Zhen;Long, Lipeng;Luo, Guotian;Ye, Min. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate This article mentions the following:

A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: Methyl 2-(5-bromopyridin-2-yl)acetate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

First Cu^II Diamondoid Net with 2-Fold Interpenetrating Frameworks. The Role of Anions in the Construction of the Supramolecular Arrays was written by Du, Miao;Bu, Xian-He;Guo, Ya-Mei;Liu, He;Batten, Stuart R.;Ribas, Joan;Mak, Thomas C. W.. And the article was included in Inorganic Chemistry in 2002.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The synthesis and crystal structure of the three-dimensional coordination polymer of an angular dipyridyl ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L) and Cu(ClO₄)₂, exhibiting the 1st Cu^II diamondoid network with 2-fold interpenetration, {[Cu(L)₂(H₂O)₂](ClO₄)(OH)(H₂O)_2.5}_n (1), together with the Cu(OAc)₂ complex of L, [Cu(L)₂(OAc)₂(H₂O)](H₂O)₂(MeOH) (2), with an unexpected mononuclear structure, are reported. Crystal data for 1: tetragonal, space group I4₁/a, a = b 13.477(3), c 46.167(13) Å, Z = 8. Crystal data for 2: triclinic, space group P1̅, a 7.847(2), b 13.189(4), c 15.948(5) Å, α 75.225(7), β 79.945(6), γ 77.540(5)°, Z = 2. The magnetic properties and anion effect are also discussed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats was written by Litchfield, John;Sharma, Raman;Atkinson, Karen;Filipski, Kevin J.;Wright, Stephen W.;Pfefferkorn, Jeffrey A.;Tan, Beijing;Kosa, Rachel E.;Stevens, Benjamin;Tu, Meihua;Kalgutkar, Amit S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 343262-51-1 This article mentions the following:

Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone-based glucokinase activators revealed a facile, non-enzymic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following i.v. administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1HPLC of Formula: 343262-51-1).

2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 343262-51-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A convergent synthesis of the imidazopyridine scaffold of fluorescent alkaloid ageladine A was written by Mineno, Tomoko;Kansui, Hisao;Yoshimitsu, Hitoshi. And the article was included in Tetrahedron Letters in 2011.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester This article mentions the following:

A convergent synthesis of the imidazopyridine scaffold of fluorescent alkaloid ageladine A was achieved, employing 3-amino-2-chloropyridine as starting material. A carboxylate was introduced using BuLi and dry ice as the key reaction. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and crystal structures of a series of complexes based on a rigid angular ligand and the magnetic properties of the Cu(II) polymer was written by Hou, Hongwei;Xie, Lixia;Li, Gang;Ge, Tiezhu;Fan, Yaoting;Zhu, Yu. And the article was included in New Journal of Chemistry in 2004.Related Products of 15420-02-7 This article mentions the following:

Treatment of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (bpodz) with AgNO₃, Cu(OAc)₂, CoSO₄, CdI₂ or MnSO₄ afforded five complexes, the coordination polymers [Ag(bpodz)(μ-NO₃)]_n (1), {[Cu₂(bpodz)(μ-OAc)₄](CH₃OH)₂}_n (2), {[Co(bpodz)(SO₄)(H₂O)₃](CH₃OH)₂}_n (3) and [Cd(bpodz)₂(μ-I)₂]_n (4), and mononuclear [Mn(bpodz)₂(SCN)₂(H₂O)₂] (5). These compounds were structurally characterized by x-ray single crystal diffraction. 1 Is a 2-dimensional network polymer constructed by ladder-like chains. In these chains, the nitrate anions are shared by two silver(I) to form a rhombic Ag₂O₂ plane. Polymer 2 is a 1-dimensional wave-like chain in which the copper(II) atoms bridged by the acetate groups are separated by a distance of 2.623 Å. Polymer 3 shows a 1-dimensional linear structure, in which interchain H-bonding interactions contribute to the final 2-dimensional networks. Polymer 4 crystallizes as infinite CdI₂ chains in which cadmium(II) ions are doubly bridged by pairs of iodine atoms; the bpodz complete the octahedral coordination of the cadmium atoms, but act as monodentate ligands so do not to link the CdI₂ chains to form extended 2-dimensional layers. Complex 5 is constructed into a 2-dimensional stair-like structure through hydrogen bonds. Magnetic susceptibility data for polymer 2, measured from 5 to 300 K, show strong antiferromagnetic coupling. These data were fitted to the appropriate equations derived from the Hamiltonian H = -2JS₁S₂, giving the parameter -2J = 320 cm^-1. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Related Products of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hydrogen-bonded oxadiazole mesogens was written by Martin, Pamela J.;Bruce, Duncan W.. And the article was included in Liquid Crystals in 2007.Recommanded Product: 15420-02-7 This article mentions the following:

Hydrogen-bonded analogs of recently reported biaxial nematic oxadiazoles have been prepared These are obtained by having oxadiazole derivatized with either one or two pyridines, leading either to sym. or unsym. materials complexed using several different benzoic acids. The new materials were studied by optical microscopy and DSC and were found to show N and SmA phases, i.e. mesomorphism characteristic of a calamitic rather than a bent-core mesogen. This mesomorphism is discussed in terms of the flexibility of the complexes and the bend angle at the center of the complexes. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lanthanoid-Based Ionic Liquids Incorporating the Dicyanonitrosomethanide Anion was written by Chesman, Anthony S. R.;Yang, Mei;Spiccia, Nicolas D.;Deacon, Glen B.;Batten, Stuart R.;Mudring, Anja-Verena. And the article was included in Chemistry – A European Journal in 2012.Safety of 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

A series of low-melting-point salts with hexakisdicyanonitrosomethanidolanthanoidate anions has been synthesized and characterized: (C₂mim)₃[Ln(dcnm)₆] (1 Ln; 1 Ln=1 La, 1 Ce, 1 Pr, 1 Nd), (C₂C₁mim)₃[Pr(dcnm)₆] (2 Pr), (C₄C₁pyr)₃[Ce(dcnm)₆] (3 Ce), (N₁₁₁₄)₃[Ln(dcnm)₆] (4 Ln; 4 Ln=4 La, 4 Ce, 4 Pr, 4 Nd, 4 Sm, 4 Gd), and (N_1112OH)₃[Ce(dcnm)₆] (5 Ce) (C₂mim=1-ethyl-3-methylimidazolium, C₂C₁mim=1-ethyl-2,3-dimethylimidazolium, C₄C₁py=N-butyl-4-methylpyridinium, N₁₁₁₄=butyltrimethylammonium, N_1112OH=2-(hydroxyethyl)trimethylammonium=choline). X-ray crystallog. was used to determine the structures of complexes 1 La, 2 Pr, and 5 Ce, all of which contain [Ln(dcnm)₆]^3- ions. Complexes 1 Ln and 2 Pr were all ionic liquids (ILs), with complex 3 Ce melting at 38.1 °C, the lowest m.p. of any known complex containing the [Ln(dcnm)₆]^3- trianion. The ammonium-based cations proved to be less suitable for forming ILs, with complexes 4 Sm and 4 Gd being the only salts with the N₁₁₁₄ cation to have m.ps. below 100 °C. The choline-containing complex 5 Ce did not melt up to 160 °C, with the increase in m.p. possibly being due to extensive hydrogen bonding, which could be inferred from the crystal structure of the complex. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Safety of 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ru(II) complexes of tetradentate ligands related to 2,9-di(pyrid-2′-yl)-1,10-phenanthroline was written by Zhang, Gang;Zong, Ruifa;Tseng, Huan-Wei;Thummel, Randolph P.. And the article was included in Inorganic Chemistry in 2008.Related Products of 89978-52-9 This article mentions the following:

1,10-Phenanthrolines were prepared having addnl. ligating substituents at the 2,9-positions. These substituents were either a 4-substituted pyrid-2-yl, quinolin-2-yl, 1,8-naphthyrid-2-yl, N-Me imidazo-2-yl, or N-Me benzimidazo-2-yl group. Addnl., 3,6-di-(pyrid-2′-yl)-dipyrido[3,2-a:2′,3′-c]phenazine was prepared All but two of these ligands coordinated Ru(II) in a tetradentate equatorial fashion with two 4-methylpyridines bound in the axial sites. An x-ray structure anal. of the diimidazolyl system indicates considerable distortion from square planar geometry in the equatorial plane. Previously reported variations in the axial ligand for such complexes appear to have a stronger effect on the electronic absorption and redox properties of the system than similar changes in the equatorial ligand. In the presence of excess Ce(IV) as a sacrificial oxidant at pH 1, all the systems examined catalyze the decomposition of H₂O to generate O. Turnover numbers are modest, ranging from 146 to 416. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Related Products of 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of the Phenylpyridal Scaffold as a Helical Peptide Mimetic was written by Bourne, Gregory T.;Kuster, Daniel J.;Marshall, Garland R.. And the article was included in Chemistry – A European Journal in 2010.Name: 2,6-Dibromo-3-hydroxypyridine This article mentions the following:

Phenylpyridal- and phenyldipyridal-based scaffolds have been designed and synthesized as novel helical peptide mimetics. The synthesis required optimization and selective alkylation in producing 2,6-functionalized 3-hydroxypyridine derivatives for a convergent scheme. The pyridine analogs were coupled by a series of Suzuki/Stille types cross-coupling reactions. A series of biaryl and teraryl substituted heterocycles, e.g. I, were produced. The synthetic approach was concise and high yielding allowing large variability at the wanted side-chain attachment points. A number of compounds were synthesized to show the versatility of the strategy. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Name: 2,6-Dibromo-3-hydroxypyridine).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 2,6-Dibromo-3-hydroxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Spontaneously Resolved Chiral Three-Fold Interpenetrating Diamondoidlike Cu(II) Coordination Polymers with Temperature-Driven Crystal-to-Crystal Transformation was written by Ma, Jian-Ping;Dong, Yu-Bin;Huang, Ru-Qi;Smith, Mark D.;Su, Cheng-Yong. And the article was included in Inorganic Chemistry in 2005.Category: pyridine-derivatives This article mentions the following:

The chiral 3-fold interpenetrating diamondoidlike Cu(II)-containing coordination polymer [Cu(2,5-bis(4-pyridyl)-1,3,4-oxadiazole)₂(H₂O)·(ClO₄)₂]_n (1a) is reported. It undergoes a temperature-driven reversible single-crystal-to-single-crystal structural transformation between room- (293 K, 1a) and low-temperature (150 K, 1b) forms. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Category: pyridine-derivatives).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem