Jouha, Jabrane et al. published their research in Tetrahedron Letters in 2018 | CAS: 54151-74-5

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C11H8BrN

Room temperature dehalogenation of (hetero)aryl halides with magnesium/methanol was written by Jouha, Jabrane;Khouili, Mostafa;Hiebel, Marie-Aude;Guillaumet, Gerald;Suzenet, Franck. And the article was included in Tetrahedron Letters in 2018.Formula: C11H8BrN This article mentions the following:

Magnesium in methanol was found to be an effective and inexpensive reagent for the dehalogenation of (hetero)aryl chlorides, bromides and iodides under mild conditions. The halogen/hydrogen exchange proceeded at room temperature and tolerated functional groups such as esters, nitriles, alcs., and alkenes. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Formula: C11H8BrN).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C11H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takei, Tohru et al. published their research in Tetrahedron Letters in 2012 | CAS: 13472-81-6

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 13472-81-6

Preparation of dibromopyridines having -(CH2)m-SO3Na groups as monomers for new polypyridines was written by Takei, Tohru;Ohki, Takumi;Harada, Yosuke;Kumagai, Naoto;Fukumoto, Hiroki;Koizumi, Take-aki;Maeda, Akihiro;Kojima, Takahiro;Sei, Yoshihisa;Shiramizu, Kohei;Abe, Masahiro;Oota, Masashi;Yamamoto, Takakazu. And the article was included in Tetrahedron Letters in 2012.HPLC of Formula: 13472-81-6 This article mentions the following:

Dibromopyridines or dibromopyridone with -(CH2)m-SO3Na group(s) has been prepared via the reactions of the corresponding dibromopyridines with -OH and -NH2 groups with sultone. These compounds were converted into polymers with the -(CH2)m-SO3H groups via organometallic polycondensation. The polymer showed proton conducting properties and high stability toward oxidation In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6HPLC of Formula: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jack, John J. et al. published their research in Analytical Chemistry in 1971 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 65350-59-6

Electron spectroscopy of quaternary nitrogen compounds was written by Jack, John J.;Hercules, David M.. And the article was included in Analytical Chemistry in 1971.Related Products of 65350-59-6 This article mentions the following:

Electron spectroscopy offers great potential as a technique for chem. structure determination The N(1s) binding energies of tetraalkylammonium, and mono-, bi, and tricyclic aromatic quaternary N systems have been determined The order found in terms of decreasing binding energy was R4N+, pyridinium > isoquinolinium > quinolinium > acridinium, benzoquinolizinium. The effect of counterion on the binding energy was determined in the tetraalkyl series; ring substituent effects were investigated in the pyridinium series. The results are discussed in terms of MO calculations, electronegativity, crystal structure, and effects on basicity and electrophilic attack. The trend of the data indicates that certain structural information can be obtained from a single-atom correlation. However, the >5 eV spread observed for quaternary compounds indicates that single-atom correlations will be of limited value. The anion effects are sufficiently large that the counterion must be determined to correct for its effect. Some adjustment must also be made for substituent effects. The conclusion is that a multiple-atom correlation must be the approach used. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Related Products of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Aisen et al. published their research in Materials Chemistry Frontiers in 2019 | CAS: 408352-58-9

2,6-Dibromoisonicotinonitrile (cas: 408352-58-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 2,6-Dibromoisonicotinonitrile

Pressure-induced remarkable luminescence switch of a dimer form of donor-acceptor-donor triphenylamine (TPA) derivative was written by Li, Aisen;Chu, Ning;Liu, Jianwei;Liu, Hao;Wang, Jing;Xu, Shuping;Cui, Haining;Zhang, Hongyu;Xu, Weiqing;Ma, Zhiyong. And the article was included in Materials Chemistry Frontiers in 2019.Application In Synthesis of 2,6-Dibromoisonicotinonitrile This article mentions the following:

Two newly synthesized mols. with a twisted donor-acceptor-donor (D-A-D) structure were achieved, noted as TPA-Ph-CN and TPA-Py-CN, and their solvatochromic effects and mechanochromic properties upon grinding and/or under hydrostatic pressure were investigated deeply. The comparison of their solvatochromic behaviors demonstrates that TPA-Py-CN shows a stronger intramol. charge transfer (ICT) effect than TPA-Ph-CN due to the substitution of electron-deficient acceptor from Ph-CN to Py-CN. Photophys. characterizations together with the anal. of crystal structures indicate that TPA-Py-CN exhibits a distinct dimer structure with C-H···π interactions, but TPA-Ph-CN does not. As a result, TPA-Py-CN shows green emission with three bands and the peak at 538 nm is assigned to excimer, while TPA-Ph-CN presents blue emission with only one band. Upon grinding, TPA-Py-CN shows more sensitive responsiveness to pressure than TPA-Ph-CN and exhibits a size-dependent emission property. TPA-Ph-CN only displays continuous red-shifted and broadened emission under hydrostatic pressure. In contrast, high pressure experiments and theor. calculations of TPA-Py-CN demonstrate that the excimer fluorescence wavelength is pressure-independent. This study is helpful for better understanding intrinsic essences of the mol. structure and the properties of mechano-responsive organic mols. In the experiment, the researchers used many compounds, for example, 2,6-Dibromoisonicotinonitrile (cas: 408352-58-9Application In Synthesis of 2,6-Dibromoisonicotinonitrile).

2,6-Dibromoisonicotinonitrile (cas: 408352-58-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 2,6-Dibromoisonicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Niu, Chuansheng et al. published their research in Tetrahedron in 1998 | CAS: 209798-48-1

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 209798-48-1

Synthesis of 3-amino-2-pyridinecarboxaldehyde thiosemicarbazone (3-AP) was written by Niu, Chuansheng;Li, Jun;Doyle, Terrence W.;Chen, Shu-Hui. And the article was included in Tetrahedron in 1998.Reference of 209798-48-1 This article mentions the following:

Palladium-catalyzed cross-coupling of methylboronic acid with 2-chloro-3-nitropyridine produced 2-methyl-3-nitropyridine in one step in high yield. Oxidation of the latter with selenium dioxide gave an aldehyde. Alternatively, condensation of 2-methyl-3-nitropyridine with DMFDMA followed by oxidation gave 3-nitro-2-pyridinecarboxaldehyde in a two step higher yielding conversion. Subsequent direct coupling of 3-nitro-2-pyridinecarboxaldehyde with thiosemicarbazide followed by reduction of the nitro group using stannous chloride or sodium sulfide provided 3-AP. Reduction with sodium hydrosulfite gave 3-HAP. Finally a route which avoids the reduction of a nitro function was devised. Thus direct coupling of styrene with 2-chloro-3-aminopyridine under Heck reaction conditions gave a product which was converted to an aldehyde and converted to 3-AP with in situ deblocking of the BOC functionality. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Reference of 209798-48-1).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 209798-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Puszko, Aniela et al. published their research in Polish Journal of Chemistry in 1991 | CAS: 79055-50-8

2,4-Dibromo-5-methylpyridine (cas: 79055-50-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 2,4-Dibromo-5-methylpyridine

Synthesis of sulfur derivatives of pyridine and its N-oxide was written by Puszko, Aniela;Talik, Zofia. And the article was included in Polish Journal of Chemistry in 1991.Application In Synthesis of 2,4-Dibromo-5-methylpyridine This article mentions the following:

2,4-Pyridinedithiol N-oxide and three isomeric 2,4-picoline (3-Me, 5-Me, 6-Me) dithiol N-oxides were obtained by reaction of 2,4-dichloropyridine N-oxide and 2,4-dihalogenopicoline N-oxides with thioacetamide. 2,4-Pyridinedithiol N-oxide and 3-methylpyridine-2,4-dithiol N-oxide were deoxidized by treatment with PBr3. In the experiment, the researchers used many compounds, for example, 2,4-Dibromo-5-methylpyridine (cas: 79055-50-8Application In Synthesis of 2,4-Dibromo-5-methylpyridine).

2,4-Dibromo-5-methylpyridine (cas: 79055-50-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 2,4-Dibromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palat, Karel et al. published their research in Acta Fac. Pharm. Brun. Bratislav. in 1962 | CAS: 89978-52-9

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 89978-52-9

Tuberculostatic substances from derivatives of pyridinecarboxylic acids was written by Palat, Karel;Celadnik, Milan;Novacek, Libor;Polster, Miroslav;Urbancik, Richard;Matuskova, Elsa. And the article was included in Acta Fac. Pharm. Brun. Bratislav. in 1962.Reference of 89978-52-9 This article mentions the following:

Among various hydrazides, amides, thioamides, hydroxamic acids, and Na salts of pyridinecarboxylic acids substituted in the ring by alkoxy, hydroxy, mercapto, or halogen, the greatest activity in vitro was shown by the hydrazide of 2,6-diethoxyisonicotinic acid, partly effective in a concentration 0.1 γ/ml. completely inhibitive of growth in a concentration of 1 γ/ml. Also effective were 2-propoxynicotinic acid hydrazide, active at 1 γ/ml., and 3- bromoisonicotinic acid hydrazide, active at 10 γ/ml. In vivo, the most effective was Na 3-iodoisonicotinate, which was inactive in vitro. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Reference of 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Yu-Bin et al. published their research in Dalton Transactions in 2003 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Synthesis and characterization of new coordination polymers generated from oxadiazole-containing ligand and inorganic M(II) [M = Cu(II), Co(II)] salts was written by Dong, Yu-Bin;Ma, Jian-Ping;Huang, Ru-Qi;Liang, Fang-Zhen;Smith, Mark D.. And the article was included in Dalton Transactions in 2003.Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The coordination chem. of the oxadiazole-containing ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L5) with inorganic Cu(II) and Co(II) salts was studied. Three new coordination polymers (13) and one H-bonded polymer (4), [Cu(L5)2(H2O)3(ClO4)](ClO4).H2O, were prepared by solution reactions. [Cu(L5)(H2O)(SO4)]·2(H2O) (1) adopts a novel chiral three-dimensional motif with rhombus channels (∼6.04 × 14.09 Å). [Co(L5)(MeOH)2(SO4)](MeOH)(H2O)3.5 (2) features a novel two-dimensional network. [Cu(L5)2(H2O)2](L5)2(ClO4)2(MeOH)(H2O) (3) features a two-dimensional rhombus-grid-type layer with inner grid cavity dimensions of 13.22 × 13.22 Å2. Compound 4, however, is a mol. complex that is bound together by strong N···H-O and O···H-O H bonds into a three-dimensional H-bonded network. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kodani, Sean D. et al. published their research in ACS Omega in 2018 | CAS: 214834-18-1

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C11H20N2O2S

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors was written by Kodani, Sean D.;Wan, Debin;Wagner, Karen M.;Hwang, Sung Hee;Morisseau, Christophe;Hammock, Bruce D.. And the article was included in ACS Omega in 2018.Formula: C11H20N2O2S This article mentions the following:

Fatty acid amide hydrolase (FAAH) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide (AEA). Multiple FAAH inhibitors have been developed for clin. trials and have failed to demonstrate efficacy at treating pain, despite promising preclin. data. One approach towards increasing the efficacy of FAAH inhibitors is to concurrently inhibit other targets responsible for regulating pain. Here, the authors designed dual inhibitors targeting the enzymes FAAH and soluble epoxide hydrolase (sEH), which are targets previously shown to synergize at reducing inflammatory and neuropathic pain. Exploration of the sEH/FAAH inhibitor structure activity relationship started with PF-750, a FAAH inhibitor (IC50 = 19 nM) that weakly inhibited sEH (IC50 = 640 nM). Potency was optimized resulting in an inhibitor with improved potency on both targets (11, sEH IC50 = 5 nM, FAAH IC50 = 8 nM). This inhibitor demonstrated good target selectivity, pharmacokinetic properties (AUC = 1200 h*nM, t1/2=4.9 h in mice) and in vivo target engagement. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Formula: C11H20N2O2S).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C11H20N2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shang-Yuan et al. published their research in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry in 2011 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Syntheses, Crystal Structures, and Thermal Stability of Metal-Directed Co(II) and Cu(II) Coordination Assemblies with Mixed Ligands of 5-Methylisophthalic Acid and 2,5-Bis(4-Pyridyl)-1,3,4-Oxadiazole was written by Liu, Shang-Yuan;Chen, Jing;Li, Cheng-Peng. And the article was included in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry in 2011.Category: pyridine-derivatives This article mentions the following:

Two mixed-ligand Co(II) and Cu(II) coordination complexes were prepared by using a similar hydrothermal method, from a bent dipyridyl building block 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-bpo) and 5-methylisophthalic acid (H2i.p.-CH3). Complexes 1 and 2 show the distinct coordination structures, such as 1D polymeric ribbon and dinuclear paddle-wheel motif, resp. Furthermore, H-bonding interactions extend the coordination patterns into a 3D scaffold architecture for 1 and a 2D 2-fold entangled network of both polyrotaxane and polycatenane features for 2. The interesting structural architectures of such two complexes are mainly directed by the different coordination capability of metal ions, as well as the H-bonding interactions. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Category: pyridine-derivatives).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem