Tag: 200-300

Synthesis, experimental and theoretical studies of two cocrystals in 1:1 stoichiometric ratio from 4,4′-bithiazole-2,2′-diamine with two hydrogen acceptor molecules was written by Ranjbar, Zohreh Rashidi;Morsali, Ali. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2015.Reference of 15420-02-7 This article mentions the following:

This paper reports synthesis, characterization and theor. studies of two 1:1 stoichiometric ratio cocrystals of 4,4′-bithiazole-2,2′-diamine (DABTZ) with 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (bpo) and 1,3-bis(4-pyridyl)ethane (bpa). These cocrystal compounds have been prepared by slow evaporation method and characterized by elemental and thermal anal., FTIR, ¹H and ¹³C-NMR spectroscopies and X-ray crystallog. X-ray crystal analyses show that these structures [(DABTZ) (bpo)] and [(DABTZ) (bpa)] have crystallized in monoclinic forms with space groups of P2₁/n and C _2/c, resp. These structures were studied theor. and the results are in good agreement with the exptl. data. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Reference of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Crystal structures of two substituted 2,5-diaryl-1,3,4-oxadiazoles was written by Stockhause, S.;Wickleder, M. S.;Meyer, G.;Orgzall, I.;Schulz, B.. And the article was included in Journal of Molecular Structure in 2001.Formula: C12H8N4O This article mentions the following:

The crystal structures of 2,5-di(4-pyridyl)-1,3,4-oxadiazole (I) and 2-(4-cyanophenyl)-5-(4-dimethylaminophenyl)-1,3,4-oxadiazole (II) were determined from single crystal data. I is monoclinic, space group C2/c, a 5.3129(9), b 12.142(3), c 16.771(3) Å, β 93.41(2)°, R_all = 0.0774. II is triclinic, space group P1̅, a 7.3908(12), b 8.7992(15), c 12.036(2) Å, α 77.04(2), β 89.29(2), γ 87.58(2)°, R_all = 0.0552. At. coordinates are given. In both structures the formation of stacks of the almost planar mols. is observed as known for other oxadiazoles. These compounds exhibit differences to other substituted 2,5-diaryl-1,3,4-oxadiazoles in the crystalline structure. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rh^III-Catalyzed C-H Activation with Pyridotriazoles: Direct Access to Fluorophores for Metal-Ion Detection was written by Kim, Ju Hyun;Gensch, Tobias;Zhao, Dongbing;Stegemann, Linda;Strassert, Cristian A.;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 917023-06-4 This article mentions the following:

The first C-H bond activation with pyridotriazoles as coupling partners is presented using a Rh^III catalyst. The pyridotriazoles can be used as new carbene precursors in C-H activation for direct access to novel fluorescent scaffolds. These tunable fluorophores can be applied for the detection of metal ions. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Recommanded Product: 917023-06-4).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 917023-06-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aminoalkoxide-Mediated Formation and Stabilization of Phenylpyridyllithium: Straightforward Access to Phenylpyridine Derivatives was written by Gros, Philippe;Fort, Yves. And the article was included in Journal of Organic Chemistry in 2003.Formula: C11H8BrN This article mentions the following:

This work has revealed that lithium aggregates promoted the efficient metalation of phenylpyridines and stabilization of phenylpyridyllithium. The BuLi-LiDMAE superbase prevented dimerization or nucleophilic addition encountered with t-BuLi or n-BuLi. The reported selective pyridine ring lithiation of 2-, 3-, and 4-phenylpyridine α to nitrogen opens a straightforward access to their derivatives In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Formula: C11H8BrN).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C11H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists was written by Zuo, Zeping;Chen, Miaomiao;Shao, Xiaoni;Qian, Xinying;Liu, Xiaocong;Zhou, Xia;Xiang, Jiawei;Deng, Pengchi;Li, Yan;Jie, Hui;Liu, Chunqi;Cen, Xiaobo;Xie, Yongmei;Zhao, Yinglan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole (EC₅₀ = 4.9 nM) and 2-(1-(5-ethylpyrimidin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl)-4-((2-fluoro-4(1H-tetrazol-1-yl)phenoxy)methyl)thiazole (EC₅₀ = 8.8 nM) with high GPR119 agonism activity and moderate clog P. Through single and long-term pharmacodynamic experiments, compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole showed a hypoglycemic effect and may have an effect on improving basal metabolic rate in DIO mice. Both in vitro and in vivo tests indicated that compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole was a potential potent GPR119 agonist in allusion to T2DM treatment. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arylation of Adamantanamines: X. Palladium- and Copper-Catalyzed Heteroarylation of Adamantane-Containing Amines with Bromopyridines was written by Lyakhovich, M. S.;Murashkina, A. V.;Averin, A. D.;Abel, A. S.;Maloshitskaya, O. A.;Savelyev, E. N.;Orlinson, B. S.;Beletskaya, I. P.. And the article was included in Russian Journal of Organic Chemistry in 2019.Category: pyridine-derivatives This article mentions the following:

The catalytic efficiencies of palladium(0) and copper(I) complexes in the amination of 2-bromopyridine and its fluorine-containing derivatives with (1-adamantyl)methanamine and 2-(1-adamantyloxy)ethanamine were compared. Both types of catalytic systems were shown to be applicable for the preparation of the corresponding N-pyridyl derivatives I (R = H, 3-F, 5-F, 3-CF₃, 4-CF₃, 5-CF₃, 6-CF₃; X = -OCH₂CH₂-, -CH₂-; R¹ = H, 2-pyridyl, 3-F-2-pyridyl, 3-CF₃-2-pyridyl, 5-CF₃-2-pyridyl, etc.) from 3- and 5-fluoro- and 3-, 4-, 5-, and 6-trifluoromethyl-2-bromopyridines. DavePhos was found to be the most efficient ligand in the Pd(0)-catalyzed reactions; however, the reactions with 2-bromo-4-(trifluoromethyl)pyridine and 2-bromo-5-(trifluoromethyl)pyridine were accompanied by formation of a considerable amount of the diarylation product. The diarylation process was significantly suppressed in the presence of copper(I) complexes. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Category: pyridine-derivatives).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric dipole moments of 2,4-dihalopicolines and their N-oxides was written by Puszko, A.. And the article was included in Chemical Papers in 1990.Electric Literature of C6H5Br2N This article mentions the following:

Dipole moment values of 2,4-dichloro- and 2,4-dibromopicolines and their N-oxides were calculated from the permittivity and refractive indexes measurements as well as by means of composition of groups and bonds moments vectors. The influence of substituents effects on the dipole moment values was discussed and the results obtained were compared. In the experiment, the researchers used many compounds, for example, 2,4-Dibromo-5-methylpyridine (cas: 79055-50-8Electric Literature of C6H5Br2N).

2,4-Dibromo-5-methylpyridine (cas: 79055-50-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Electric Literature of C6H5Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines was written by Navarrete-Vazquez, Gabriel;Molina-Salinas, Gloria Maria;Duarte-Fajardo, Zetel Vahi;Vargas-Villarreal, Javier;Estrada-Soto, Samuel;Gonzalez-Salazar, Francisco;Hernandez-Nunez, Emanuel;Said-Fernandez, Salvador. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Electric Literature of C12H8N4O This article mentions the following:

Twelve 4-(5-Substituted-1,3,4-oxadiazol-2-yl)pyridine derivatives were synthesized and evaluated for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against Mycobacterium tuberculosis H₃₇Rv and five clin. isolates (drug-sensitive and -resistant strains). 4-(5-Pentadecyl-1,3,4-oxadiazol-2-yl)pyridine was 10 times more active than isoniazid, 20 times more active than streptomycin, and 28 times more potent than ethambutol against drug-resistant strain CIBIN 112. 4-(5-Heptadecyl-1,3,4-oxadiazol-2-yl)pyridine showed the same behavior as 4-(5-pentadecyl-1,3,4-oxadiazol-2-yl)pyridine. Both of the above structures bear a high lipophilic chain bonded to the 5-position of the oxadiazole moiety. This fact implies that there exists a contribution of lipophilicity, which could facilitate the entrance of these mols. through lipid-enriched bacterial cell membrane. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Electric Literature of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blue-green light emission from self-assembled bipyridinium thin films was written by Zheng, Haipeng;Zhang, Ruifeng;Wu, Ying;Shen, Jiacong. And the article was included in Chemistry Letters in 1998.Safety of 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

The photoluminescence (PL) properties of a short ribbon-like conjugated bipyridinium and its application in the design and fabrication of organic LED devices are discussed. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Safety of 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Molecular Rotors for Universal Quantitation of Nanoscale Hydrophobic Interfaces in Microplate Format was written by Bisso, Paul W.;Tai, Michelle;Katepalli, Hari;Bertrand, Nicolas;Blankschtein, Daniel;Langer, Robert. And the article was included in Nano Letters in 2018.Reference of 65350-59-6 This article mentions the following:

Hydrophobic self-assembly pairs diverse chem. precursors and simple formulation processes to access a vast array of functional colloids. Exploration of this design space, however, is stymied by lack of broadly general, high-throughput colloid characterization tools. A narrow structural subset of fluorescent, zwitterionic mol. rotors, dialkylaminostilbazolium sulfonates [DASS] with intermediate-length alkyl tails, fills this major anal. void by quant. sensing hydrophobic interfaces in microplate format. DASS dyes supersede existing interfacial probes by avoiding off-target fluorogenic interactions and dye aggregation while preserving hydrophobic partitioning strength. To illustrate the generality of this approach, the authors demonstrate (i) a microplate-based technique for measuring mass concentration of small (20-200 nm), dilute (submicrogram sensitivity) drug delivery nanoparticles; (ii) elimination of particle size, surfactant chem., and throughput constraints on quantifying the complex surfactant/metal oxide adsorption isotherms critical for environmental remediation and enhanced oil recovery; and (iii) more reliable self-assembly onset quantitation for chem. and structurally distinct amphiphiles. These methods could streamline the development of nanotechnologies for a broad range of applications. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Reference of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem