Tag: 200-300

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions was written by Ni, Pufan;Yang, Lei;Shen, Yi;Zhang, Lei;Ma, Yueyue;Sun, Maolin;Cheng, Ruihua;Ye, Jinxing. And the article was included in Journal of Organic Chemistry in 2022.Category: pyridine-derivatives This article mentions the following:

A general method for the synthesis of phenols from electron-deficient aryl ammonium salts or heteroaryl ammonium salts under mild conditions was developed. Benzaldehyde oxime, acetohydroxamic acid, and hydroxylamine hydrochloride were investigated as hydroxide surrogates, resp. With these hydroxide surrogates, a series of phenols were prepared in yields of 20-98%. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Category: pyridine-derivatives).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1:1 Cocrystal of naphthalene-2,7-diol and 2,5-di-4-pyridyl-1,3,4-oxadiazole was written by Wang, Yong Tao;Tang, Gui Mei. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2006.Related Products of 15420-02-7 This article mentions the following:

Naphthalene-2,7-diol-2,5-di-4-pyridyl-1,3,4-oxadiazole 1:1 cocrystal, C₁₀H₈O₂·C₁₂H₈N₄O, was crystallized from a MeOH and H₂O solvent mixture In the crystal structure, both types of mols. are linked via intermol. O-H···N H bonds, forming 1-dimensional chains along the [101] direction. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Related Products of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hydrothermal synthesis, characterization and crystal structure of a three-dimensional (3D) Zn^II supramolecular compound with ethylenediaminetetraacetic acid ligand and 4-(carboxylate)pyridinium guests was written by Du, Miao;Guo, Jian-Hua;Zhao, Xiao-Jun. And the article was included in Journal of Molecular Structure in 2004.Synthetic Route of C12H8N4O This article mentions the following:

A new supramol. compound [Zn(H₂EDTA)(H₂O)](Q)₂(H₂O)₂ (1), where H₄EDTA = EDTA and Q = 4-(carboxylate)pyridinium, was prepared by mild hydrothermal reaction and characterized by elemental anal., IR spectrum and TGA. Single-crystal x-ray diffraction of 1 [monoclinic, space group C2/c, a 11.310(4), b 9.704(4), c 23.798(10) Å, β 97.401(10)°, Z = 4] revealed that the Zn^II ion coordinates to the chelating tetradentate ligand H₂EDTA and a H₂O mol., taking a distorted trigonal-bipyramid geometry. The mononuclear [Zn(H₂EDTA)(H₂O)] subunits are linked to form two-dimensional layered architectures by the lattice H₂O moieties through O-H···O H bonds, which are further extended to a three-dimensional (3D) supramol. network by 4-(carboxylate)pyridinium guests (resulting from the ring-opening hydrolysis of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole) through extensive H-bonding interactions. The 3-dimensional supramol. framework is also stabilized by significant face-to-face π-π stacking interactions between the aromatic pyridinium systems. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Synthetic Route of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xantphos as a Branch-Selective Ligand for the Acyclic sec-Alkyl Negishi Cross-Coupling of Heteroaryl Halides was written by Cherney, Alan H.;Hedley, Simon J.;Mennen, Steven M.;Tedrow, Jason S.. And the article was included in Organometallics in 2019.Name: 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:

We present the application of the common bidentate phosphine ligand Xantphos toward the highly selective Negishi cross-coupling of heteroaryl halides and acyclic sec-alkyl organozinc reagents to prepare pharmaceutically relevant motifs. Branched-to-linear ratios of >100:1 can be achieved for several substrates relevant to the pharmaceutical industry, and tolerance of certain acidic protons is exhibited. A high-throughput experimentation approach was taken to rapidly compare Xantphos Pd G3 to other selective Negishi coupling catalysts, leading to sep. reactivity profiles for each methodol. The utility of Xantphos Pd G3 was demonstrated through the scale-up and isolation of a complex pyridine building block. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Name: 2-Bromo-3-(trifluoromethyl)pyridine).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 2-Bromo-3-(trifluoromethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A 3D Cu(II) Coordination Framework with μ₄-/μ₂-Oxalato Anions and a Bent Dipyridyl Coligand: Unique Zeolite-Type NiP₂ Topological Network and Magnetic Properties was written by Du, Miao;Zhang, Zhi-Hui;Li, Cheng-Peng;Ribas-Arino, Jordi;Aliaga-Alcalde, Nuria;Ribas, Joan. And the article was included in Inorganic Chemistry in 2011.Formula: C12H8N4O This article mentions the following:

The reaction of Cu(II) nitrate, oxamide, and an angular bridging ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-bpo) under hydrothermal conditions affords a 3-dimensional pillared-layer coordination framework {[Cu₂(4-bpo)(ox)₂](H₂O)₄}_n (1) (ox = oxalate), featuring the unique zeolite-type NiP₂ network and interesting properties. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic studies towards the mannolides: Construction of the bowl-shaped B/C/D ring system was written by Wang, Kunkai;Xu, Zhezhe;Tan, Xiangchuang;Xie, Zhixiang. And the article was included in Tetrahedron in 2020.Safety of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole This article mentions the following:

The bowl-shaped tricyclo[6.3.1.0^4,12]dodecane moiety is the core feature of cephalotane-type diterpenoids. As part of our efforts directed towards a total synthesis of mannolide B, the bowl-shaped tricyclo[6.3.1.0^4,12]dodecane skeleton, a common intermediate of cephalotane-type diterpenoids bearing up to five contiguous stereocenters including two quaternary carbon centers had been constructed. The synthetic strategy was enabled by an efficient application of oxidative dearomatization/intramol. Diels-Alder reaction to access highly functionalized building block with the tricyclo[5.2.2.0^2,6]undecane unit from com. available materials. The key feature was firstly used the cyclic olefins with secondary alc. as dienophile for the intramol. inverse electron demand Diels-Alder reaction. Further synthetic studies led to construct ring D by a regioselective Aldol reaction. In the experiment, the researchers used many compounds, for example, (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2Safety of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole).

(S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Safety of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel bipyridinyl oxadiazole-based metal coordination complexes: High efficient and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones through the Biginelli reactions was written by Wang, Jin-Hua;Zhang, E.;Tang, Gui-Mei;Wang, Yong-Tao;Cui, Yue-Zhi;Ng, Seik Weng. And the article was included in Journal of Solid State Chemistry in 2016.Category: pyridine-derivatives This article mentions the following:

Three new metal coordination complexes, namely, [Co(BPO)₂(H₂O)₄](BS)₂(H₂O)₂ (1), [Co(BPO)₂(H₂O)₄](ABS)₂(H₂O)₂ (2), [Co(BPO)₂(H₂O)₄](MBS)₂(H₂O)₂ (3) [BPO = 2,5-di(pyridin-4-yl)-1,3,4-oxadiazole, BS = benzenesulfonate, ABS = 4-aminobenzenesulfonate, MBS = 4-methylbenzenesulfonate] were obtained under hydrothermal conditions. Complexes 1–3 were structurally characterized by single-crystal x-ray diffraction, powder X-ray diffraction, IR and thermogravimetric analyses (TGA). All of them display a zero-dimensional motif, in which strong intermol. H bonding interactions (O-H···O/N) and packing interactions (C-H···π and π···π) make them achieve a three-dimensional supramol. architecture. The primary catalytic results of these three complexes show that high efficiency for the green synthesis of a variety of 3,4-dihydropyrimidin-2(1H)-ones was observed under solvent free conditions through Biginelli reactions. The present catalytic protocols exhibit advantages such as excellent yield, easy isolation, eco-friendly conditions, and short reaction time. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Category: pyridine-derivatives).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors was written by Wang, Yonghui;Cai, Wei;Cheng, Yaobang;Yang, Ting;Liu, Qian;Zhang, Guifeng;Meng, Qinghua;Han, Fangbin;Huang, Yafei;Zhou, Ling;Xiang, Zhijun;Zhao, Yong-Gang;Xu, Yan;Cheng, Ziqiang;Lu, Sijie;Wu, Qianqian;Xiang, Jia-Ning;Elliott, John D.;Leung, Stewart;Ren, Feng;Lin, Xichen. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 175205-82-0 This article mentions the following:

A novel series of biaryl amides was identified as RORγt inhibitors through core replacement of a starting hit 1. Structure-activity relation exploration on the biaryl moiety led to discovery of potent RORγt inhibitors with good oral bioavailability and CNS penetration. Compounds 9a and 9g demonstrated excellent in vivo efficacy in EAE mice dose dependently with once daily oral administration. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Recommanded Product: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vinylogous carbinolamine tumor inhibitors. 24. Synthesis, chemistry, and antineoplastic activity of α-halopyridinium salts: potential pyridone prodrugs of acylated vinylogous carbinolamine tumor inhibitors. was written by Anderson, Wayne K.;Dean, Dennis C.;Endo, Toshiyasu. And the article was included in Journal of Medicinal Chemistry in 1990.HPLC of Formula: 89978-52-9 This article mentions the following:

A series of 4- and 5-[dihydrobis[[(alkylcarbamoyl)oxy]methyl]pyrrolizinyl]-2-halopyridinium iodides, e.g., I (R = F, Cl), were synthesized. The rates of hydrolysis of the α-halopyridinium salts to the corresponding pyridones and the reactivities of the carbamate moieties were studied as a function of pH, buffer composition, and ionic strength. The 4- and 5-pyrrolizinyl-2-halopyridinium iodides and the corresponding pyridones were evaluated against P388 lymphocytic leukemia in vivo. The α-fluoropyridinium compounds were active but the α-chloro compounds were not. This activity was correlated with the rates of hydrolysis of the α-halopyridinium compounds to the active pyridone. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9HPLC of Formula: 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of N-Aryl Piperazines as Selective mGluR₅ Potentiators with Improved In Vivo Utility was written by Zhou, Ya;Manka, Jason T.;Rodriguez, Alice L.;Weaver, C. David;Days, Emily L.;Vinson, Paige N.;Jadhav, Satyawan;Hermann, Elizabeth J.;Jones, Carrie K.;Conn, P. Jeffrey;Lindsley, Craig W.;Stauffer, Shaun R.. And the article was included in ACS Medicinal Chemistry Letters in 2010.SDS of cas: 175205-82-0 This article mentions the following:

This letter describes the discovery, structure-activity relation, and in vitro and in vivo pharmacol. profile of a novel non-MPEP-derived mGluR₅ pos. allosteric modulator (PAM) based upon an N-aryl piperazine chemotype. This mGluR₅ chemotype exhibits the ability to act as either a noncompetitive antagonist/neg. allosteric modulator or a potentiator of the glutamate response, depending on the identity of the amide substituent, i.e., a “mol. switch”. A rapidly optimized PAM, 10e (VU0364289), was shown to be potent and specific for the rat mGluR₅ receptor and subsequently demonstrated to be efficacious in a clin. relevant rodent model predictive of antipsychotic activity, thus providing the first example of a centrally active mGluR₅ PAM optimized from an HTS-derived mGluR₅ noncompetitive antagonist. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0SDS of cas: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem