Tag: 200-300

Chiral Hexahalogenated 4,4′-Bipyridines was written by Mamane, V.;Peluso, P.;Aubert, E.;Cossu, S.;Pale, P.. And the article was included in Journal of Organic Chemistry in 2016.SDS of cas: 13472-81-6 This article mentions the following:

The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantiosepd. by high performance liquid chromatog. on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction anal. The latter revealed that various halogen bond types are responsible for crystal cohesion. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6SDS of cas: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Optical properties of stilbene-type dyes containing various terminal donor and acceptor groups was written by Qin, Chuanxiang;Zhang, Weizhou;Wang, Zhiming;Zhou, Maoyi;Wang, Xiaomei;Chen, Guoqiang. And the article was included in Optical Materials (Amsterdam, Netherlands) in 2008.Recommanded Product: 65350-59-6 This article mentions the following:

A series of “D-π-A” stilbene-type dyes, named as trans-4-[p-(N,N-hydroxyethyl) aminino-styryl]-N-methylpyridinium iodide (DHEASPI-C₁), trans-4-[p-(N,N-hydroxyethyl) aminino-styryl]-N-butylpyridinium bromide (DHEASPBr-C₄), trans-4-[p-(N,N-hydroxyethyl) aminino-styryl]-N-octylpyridinium bromide (DHEASPBr-C₈) and trans-4-[p-(N,N-hydroxyethyl) aminino-styryl]-N-dodecylpyridinium bromide (DHEASPBr-C₁₂), resp., have been synthesized and their optical properties have been exptl. investigated. When DHEASPI-C₁ are compared with trans-4-[p-(N,N-diethylamino) styryl]-N-methylpyridinium iodide (DEASPI) and trans-4-[p-(N-hydroxyethyl-N-ethylamino) styryl]-N-methylpyridinium iodide (HEASPI), both the electronegativity of two hydroxyl and intra-mol. hydrogen bond decrease the donor ability of the Et chain, there are obvious blue shifts both in single-photon absorption spectra, fluorescence spectra and two-photon excited fluorescence spectra. Interestingly, fluorescence intensity of DHEASPI-C₁ is the biggest. There are little shifts from DHEASPBr-C₄ to DHEASPBr-C₈ and to DHEASPBr-C₁₂ in their spectra. As dyes’ two-photon excited fluorescence spectra were concerned, pumped by 1064 nm, <130 fs mode-locked Nd:YAG laser, their peak locations were between 613 and 623 nm. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halogen-metal exchange on bromoheterocyclics with substituents containing an acidic proton via formation of a magnesium intermediate was written by Tian, Qingqiang;Shang, Suqin;Wang, Huajun;Shi, Guoqiang;Li, Zhiyao;Yuan, Jianyong. And the article was included in Molecules in 2017.Quality Control of 3,5-Dibromo-2-hydroxypyridine This article mentions the following:

A selective and practical bromine-metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. This protocol used a combination of i-PrMgCl and n-BuLi was not only solved the problem of intermol. quenching that often occurred when using alkyl lithium alone as the reagent for halogen-lithium exchange, but also offered a highly selective method for performing bromo-metal exchange on dibrominated arene compounds through chelation effect. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Quality Control of 3,5-Dibromo-2-hydroxypyridine).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 3,5-Dibromo-2-hydroxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of N-Heterocycles-Fused Azasilines by Palladium-Catalyzed Si-Si Bond Activation was written by Noel-Duchesneau, Ludovik;Maddaluno, Jacques;Durandetti, Muriel. And the article was included in ChemCatChem in 2019.COA of Formula: C10H13BrN2O2 This article mentions the following:

Azasilines fused nitrogen heterocycles are prepared in excellent yields (from 74 to 98 % according to the structures) for the first time in one operation with high regio- and stereoselectivities. The key step consists of an intramol. palladium-catalyzed cyclization reaction of heteroaryl disilane cores, bearing double or triple bond. We first studied the reactivity of pyridyl heterocycles, using xylenes as solvent and Pd(dba)₂-P(OEt)₃ as catalyst at 130°. The Z configuration of the adducts suggested that the reaction proceeds following a syn addition on the alkyne. This strategy has then been illustrated by the synthesis of complex polyheterocyclic scaffolds (phenothiazine, indole, carbazole, quinoline and tetrahydroquinoline) starting from other nitrogen heteroaryl compounds, to demonstrate the potential of the process, in order to obtain promising biol. scaffolds. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9COA of Formula: C10H13BrN2O2).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C10H13BrN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structural, Luminescent, and Magnetic Properties of Three Novel Three-Dimensional Metal-Organic Frameworks Based on Hexadentate N,N’-bis(4-picolinoyl)hydrazine was written by Fang, Zhen-Lan;Yu, Rong-Min;He, Jian-Gang;Zhang, Qi-Sheng;Zhao, Zhen-Guo;Lu, Can-Zhong. And the article was included in Inorganic Chemistry in 2009.COA of Formula: C12H8N4O This article mentions the following:

Three novel microporous three-dimensional (3-D) metal-organic framework materials [ML]_n [M = Ni (I); M = Co (II), M = Cd (III); L = N,N’-bis(4-picolinoyl)hydrazine] were obtained from hydrothermal reactions. The organic ligand L was formed through the in situ ring-opening hydrolysis reaction of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole with the assistance of metal ions. Single-crystal x-ray diffraction studies reveal that complexes I, II, and III adopt 6-connected 3-dimensional networks of distorted α-Po topol., which are built from noninterpenetrated (4,4) grids cross-linked by zigzag chains. These isomorphic complexes are all of high thermal stability, but some other phys. properties are quite different because of their different metal centers. Antiferromagnetic exchange was observed between the Ni(II) centers of I, while ferromagnetic exchange was observed for the Co(II) centers of II. III exhibits strong fluorescence emission. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7COA of Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.COA of Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of Novel Piperidinylthiazole Derivatives As Broad-Spectrum Fungicidal Candidates was written by Wu, Qifan;Zhao, Bin;Fan, Zhijin;Guo, Xiaofeng;Yang, Dongyan;Zhang, Nailou;Yu, Bin;Zhou, Shuang;Zhao, Jiabao;Chen, Fan. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:

Oxathiapiprolin is one of the best active fungicides discovered for oomycetes control. To develop a fungicide candidate with a broad spectrum of activity, 22 new piperidinylthiazole derivatives were designed and synthesized. Compound (I) showed the best activity against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo with 100% and 80% of inhibition, resp., at 1 mg/L, and 72.87% of field efficacy against P. cubensis at 1 g ai/667 m² validated these results. Compound (II) exhibited a broad spectrum of excellent activity against Sclerotinia sclerotiorum with EC₅₀ = 0.30 mg/L (>10 times more active than oxathiapiprolin and azoxystrobin in vitro), good activity against Botrytis cinerea, Cercospora arachidicola, and Gibberella zeae with EC₅₀ of 14.54, 5.57, and 14.03 mg/L in vitro and against P. cubensis and P. infestans with 60% and 30% inhibition rates, resp., at 1 mg/L in vivo. Mode of action studies by RNA sequencing anal. discovered oxysterol-binding protein (OSBP), chitin synthase (CHS1), and (1,3)-β-glucan synthase (FKS2) as the potent target of II against S. sclerotiorum. Quenching studies validated that OSBP was the same target of both II and oxathiapiprolin; it was quenched by both of them. Our studies discovered isothiazole-containing piperidinylthiazole as an OSBP target-based novel lead for fungicide development. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Non-iminosugar glucocerebrosidase small molecule chaperones was written by Marugan, Juan Jose;Huang, Wenwei;Motabar, Omid;Zheng, Wei;Xiao, Jingbo;Patnaik, Samarjit;Southall, Noel;Westbroek, Wendy;Lea, Wendy A.;Simeonov, Anton;Goldin, Ehud;DeBernardi, Maria A.;Sidransky, Ellen. And the article was included in MedChemComm in 2012.Formula: C11H8BrN This article mentions the following:

Small mol. chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure-activity relationship (SAR), selectivity, cell activity and pharmacokinetics. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Formula: C11H8BrN).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C11H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes was written by Li, Zhao-Ming;Shuai, Bin;Ma, Cong;Fang, Ping;Mei, Tian-Sheng. And the article was included in Chinese Journal of Chemistry in 2022.Computed Properties of C6H3BrF3N This article mentions the following:

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Computed Properties of C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Micelle-Enabled Suzuki-Miyaura Cross-Coupling of Heteroaryl Boronate Esters was written by Guo, Pengfei;Zhang, Hao;Zhou, Jianguang;Gallou, Fabrice;Parmentier, Michael;Wang, Hui. And the article was included in Journal of Organic Chemistry in 2018.Recommanded Product: 175205-82-0 This article mentions the following:

We report a micellar protocol for Suzuki-Miyaura cross-coupling of heteroaryl boronic esters with aryl or heteroaryl halides. The micellar catalysis enables this coupling reaction to run under mild conditions, which avoids the decomposition of heteroaryl boronate esters and allows for high chemoselectivity for cross-coupling reaction with 6-chloropridine-2-boronic ester. The micellar protocol expands the scope of the cross-coupling reaction with challenging heteroaryl boronic esters and complements the existing cross-coupling methods for construction of heterobiaryl building blocks. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Recommanded Product: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction was written by Pothireddy, Mohanreddy;Bhukta, Swadhapriya;Babu, P. Vijaya;Thirupathi, Barla;Dandela, Rambabu. And the article was included in Synthetic Communications in 2022.COA of Formula: C6H3BrF3N This article mentions the following:

The 2-benzylpyridines scaffolds I (R = 4-Me, 3-Cl, 2-trifluoromethyl, etc.) have been found in various drugs, bioactive natural products, and medicinally important compounds This manuscript comprises the synthesis of various fluorinated analogs of 2-benzylpyridine compounds I by using a Negishi coupling reaction as a key reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0COA of Formula: C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem